Gene Editing: a type of genetic engineering in which DNA is inserted, deleted or replaced in the genome of a living organism using engineered nucleases, or "molecular scissors". These nucleases create site-specific double-strand breaks (DSBs) at desired locations in the genome. The induced double-strand breaks are repaired through nonhomologous end-joining (NHEJ) or homologous recombination (HR), resulting in targeted mutations.
DATE: February 8, 2017TIME: 9:00am PT, 12:00pm ETThere are many factors involved in rabbit breeding that impact performance. In this evaluation of a Dutch Belted rabbit breeding c...
DATE: February 8, 2017TIME: 9:00am PT, Noon ETTraining programs for animal care and use personnel are integral to both animal welfare and quality research outcomes. There are a variety...
DATE: February 8, 2017TIME: 7:30am PT, 10:30am ETMany of us who believe in the importance of aseptic rodent surgery have lived through the frustration of trying to implement rodent asep...
DATE: February 8, 2017TIME: 6:00am PT, 9:00 ETSeveral regulatory bodies require that animals used in biomedical and behavioral research exposed to procedures that may cause more th...
DATE: February 8, 2017TIME: 6:00am PT, 9:00am ETDevelopment of assisted reproductive technologies in the dog has lagged behind many other domestic and laboratory animal species, due in...
Inherited retinal degenerative disorders such as retinitis pigmentosa are characterized by death of the light sensing photoreceptive neurons of the outer retina. Like the rest of the CNS, the...
Culture systems for pluripotent stem cell (PSC) expansion enable generation of a nearly unlimited pool of cells for downstream differentiation, disease modeling, drug discovery, and therapeut...
The isolation of human embryonic stem cells (hESCs) and the discovery of human induced pluripotent stem cell (hiPSC) reprogramming have sparked a renaissance in stem cell biology, in vitro di...
The reprogramming of somatic cells into induced Pluripotent Stem Cells (iPSC) has great potential of applications, not only in basic research, but also in drug screening and cell therapy. Wit...
DATE: June 22, 2016
TIME: 9am Pacific time, 12pm Eastern time, 6pm Central European time
A large fraction of the RNA transcribed in eukaryotic cells is rapidly degraded in the nucleus. A ...
DNA methylation is an essential mechanism of epigenetic gene regulation with broad relevance in development and disease. Its localization on genomic DNA and general stability make this epigen...
DATE: March 31, 2016
TIME: 8am PT, 11am ET, 4pm GMT
In this webinar, you will learn:
Basics of homology-directed repair (HDR) using CRISPR-Cas9
Selection of CRISP...
Precision medicine requires understanding the mechanistic basis of complex disorders, and to precisely manipulate these mechanisms to better human health. This is partly enabled by the recent...
A crucial part of providing animals for research is successful breeding. Still, in many mouse facilities breeding efficiency is complicated by problems with reproduction, such as pre-weaning...
Science continues to evolve at a rapid pace. Our understanding of laboratory animal behavior and welfare is also growing. The biomedical research community continues to receive criticisms fro...
Optimising experimental design needs a sound understanding of basic principles and a good appreciation of a range of designs and when to use them. More than ten years ago it was clear t...
Working with animals carries legal, scientific and ethical responsibilities. These responsibilities merge as we strive to humanely use the least number of animals necessary to provide t...
The reproducibility of animal studies is now critical to ensure that limited resources are used wisely and that efforts yield useable knowledge. At this time, IACUCs and other similar a...
Historically, rodent disease models have mainly used a single sex or did not stratify outcomes by sex when both sexes were studied. These experimental approaches were based on the assumption...
The environment has been found to be a major contributor to data variability and many aspects of the laboratory environment are stressful to rodents and do not accurately reflect the human ex...
The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is leading an initiative to improve the design and reporting of animal research. The ARRIVE (A...
The fate of all but a very few laboratory animals is to be killed at the end of their experimental lives. There is a moral responsibility to give the animals used in science a humane death by...
Public, legal & ethical acceptability of animal research not only warrants respect for animal welfare & the 3Rs, but also that the perceived benefits can outweigh the pain, discomfort...
A number of elements come into the mix when trying to optimise experimental design. Among these are having clear objectives, setting up valid comparisons, knowing how to avoid bias during the...
DATE: February 8, 2017TIME: 9:00am PT, 12:00pm ETThere are many factors involved in rabbit breeding that impact performance. In this evaluation of a Dutch Belted rabbit breeding c...
DATE: February 8, 2017TIME: 9:00am PT, Noon ETTraining programs for animal care and use personnel are integral to both animal welfare and quality research outcomes. There are a variety...
DATE: February 8, 2017TIME: 7:30am PT, 10:30am ETMany of us who believe in the importance of aseptic rodent surgery have lived through the frustration of trying to implement rodent asep...
DATE: February 8, 2017TIME: 6:00am PT, 9:00 ETSeveral regulatory bodies require that animals used in biomedical and behavioral research exposed to procedures that may cause more th...
DATE: February 8, 2017TIME: 6:00am PT, 9:00am ETDevelopment of assisted reproductive technologies in the dog has lagged behind many other domestic and laboratory animal species, due in...
Inherited retinal degenerative disorders such as retinitis pigmentosa are characterized by death of the light sensing photoreceptive neurons of the outer retina. Like the rest of the CNS, the...
Culture systems for pluripotent stem cell (PSC) expansion enable generation of a nearly unlimited pool of cells for downstream differentiation, disease modeling, drug discovery, and therapeut...
The isolation of human embryonic stem cells (hESCs) and the discovery of human induced pluripotent stem cell (hiPSC) reprogramming have sparked a renaissance in stem cell biology, in vitro di...
The reprogramming of somatic cells into induced Pluripotent Stem Cells (iPSC) has great potential of applications, not only in basic research, but also in drug screening and cell therapy. Wit...
DATE: June 22, 2016
TIME: 9am Pacific time, 12pm Eastern time, 6pm Central European time
A large fraction of the RNA transcribed in eukaryotic cells is rapidly degraded in the nucleus. A ...
DNA methylation is an essential mechanism of epigenetic gene regulation with broad relevance in development and disease. Its localization on genomic DNA and general stability make this epigen...
DATE: March 31, 2016
TIME: 8am PT, 11am ET, 4pm GMT
In this webinar, you will learn:
Basics of homology-directed repair (HDR) using CRISPR-Cas9
Selection of CRISP...
Precision medicine requires understanding the mechanistic basis of complex disorders, and to precisely manipulate these mechanisms to better human health. This is partly enabled by the recent...
A crucial part of providing animals for research is successful breeding. Still, in many mouse facilities breeding efficiency is complicated by problems with reproduction, such as pre-weaning...
Science continues to evolve at a rapid pace. Our understanding of laboratory animal behavior and welfare is also growing. The biomedical research community continues to receive criticisms fro...
Optimising experimental design needs a sound understanding of basic principles and a good appreciation of a range of designs and when to use them. More than ten years ago it was clear t...
Working with animals carries legal, scientific and ethical responsibilities. These responsibilities merge as we strive to humanely use the least number of animals necessary to provide t...
The reproducibility of animal studies is now critical to ensure that limited resources are used wisely and that efforts yield useable knowledge. At this time, IACUCs and other similar a...
Historically, rodent disease models have mainly used a single sex or did not stratify outcomes by sex when both sexes were studied. These experimental approaches were based on the assumption...
The environment has been found to be a major contributor to data variability and many aspects of the laboratory environment are stressful to rodents and do not accurately reflect the human ex...
The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is leading an initiative to improve the design and reporting of animal research. The ARRIVE (A...
The fate of all but a very few laboratory animals is to be killed at the end of their experimental lives. There is a moral responsibility to give the animals used in science a humane death by...
Public, legal & ethical acceptability of animal research not only warrants respect for animal welfare & the 3Rs, but also that the perceived benefits can outweigh the pain, discomfort...
A number of elements come into the mix when trying to optimise experimental design. Among these are having clear objectives, setting up valid comparisons, knowing how to avoid bias during the...
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