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    Follow

    Gene Silencing

    Gene Silencing: describes the epigenetic regulation of a gene, at the level of transcription or translation, to prevent gene expression. Mechanisms include DNA methylation, histone modification and RNAi. Methods to silence genes are exploited by researchers to study gene function, and for the development of therapeutics for diseases including cancer, infectious diseases and neurodegenerative disorders.

    Trending News

    • APR 15, 2025
      Genetics & Genomics
      Novel Parkinson's Linked Genes Revealed by CRISPR
      Novel Parkinson's Linked Genes Revealed by CRISPR
      Parkinson's disease is the second most common neurodegenerative disease in the world...
      Written By: Carmen Leitch
      3
      FEB 20, 2024
      Genetics & Genomics
      Ancient Viruses Boosted Vertebrate Brain Evolution
      Ancient Viruses Boosted Vertebrate Brain Evolution
      In DNA, retrotransposons can move around and insert themselves into other parts of genomes with a kind of copy and paste ...
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      6 1
      FEB 02, 2024
      Genetics & Genomics
      Why do Women Get More Autoimmune Disease? Scientists Find an Answer
      Why do Women Get More Autoimmune Disease? Scientists Find an Answer
      Millions of people have autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis  but it's estim ...
      Written By: Carmen Leitch
      6 1
      JAN 18, 2024
      Immunology
      Novel Work Informs How a Cell Pathway Activates Innate Immunity
      Novel Work Informs How a Cell Pathway Activates Innate Immunity
      Different pathways within the cell are activated or silenced dependent on the external signals acting on a cell. One suc ...
      Written By: Brian G. Morreale
      5
      JAN 17, 2024
      Genetics & Genomics
      Lassoing Gene Expression with Genomic Loops
      Lassoing Gene Expression with Genomic Loops
      DNA molecules are very lengthy, and most cells in the body have to fit the entire genome into the nucleus. To do so, the ...
      Written By: Carmen Leitch
      5
      SEP 26, 2023
      Genetics & Genomics
      New Insights Into How to Treat a Common Form of Muscular Dystrophy
      New Insights Into How to Treat a Common Form of Muscular Dystrophy
      Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common forms of muscular dystrophy that impacts almost ...
      Written By: Carmen Leitch
      5
      SEP 08, 2023
      Drug Discovery & Development
      Double dose of this cancer treatment rejuvenates immune cells in Head and Neck Cancer
      Double dose of this cancer treatment rejuvenates immune cells in Head and Neck Cancer
      Groundbreaking clinical trial that unveils the power of neoadjuvant anti-PD-1 therapy in head and neck squamous cell car ...
      Written By: Amielle Moreno
      5
      APR 27, 2023
      Cell & Molecular Biology
      Researchers Slow Aging in Cells
      Researchers Slow Aging in Cells
      Scientists are still determining whether humans will reach a maximum possible age or if we can extend lifespan indefinit ...
      Written By: Carmen Leitch
      3
      JAN 23, 2023
      Neuroscience
      Tau tangles unravel when these three genes are silenced
      Tau tangles unravel when these three genes are silenced
      By controling the activity of an enzyme called CHIP, three proteins regulate tau. Now the genes for these three trouble ...
      Written By: Amielle Moreno
      1
      NOV 10, 2022
      Neuroscience
      HUSH - A Complex That Silences Genes & Helps Control Brain Architecture
      HUSH - A Complex That Silences Genes & Helps Control Brain Architecture
      The HUSH (human silencing hub) protein complex is known to silence genes, and researchers have thought that it could be ...
      Written By: Carmen Leitch
      1
      OCT 31, 2022
      Genetics & Genomics
      Ancient Viral DNA in Our Genome Has a Protective Function
      Ancient Viral DNA in Our Genome Has a Protective Function
      There is viral DNA in the human genome, and each instance traces back to an ancestor who was infected with a retrovirus. ...
      Written By: Carmen Leitch
      4
      OCT 25, 2022
      Cell & Molecular Biology
      Liver Disease Discovery Resolves Controversy
      Liver Disease Discovery Resolves Controversy
      Liver diseases are a serious health problem. Chronic liver disease is estimated to impact over 1.5 billion people.
      Written By: Carmen Leitch
      4
      OCT 18, 2022
      Genetics & Genomics
      Mitochondrial DNA Can Move to the Genome to Trigger Human Evolution
      Mitochondrial DNA Can Move to the Genome to Trigger Human Evolution
      Mitochondria are often called the powerhouse of the cell, and these organelles are well-known for their energy-generatin ...
      Written By: Carmen Leitch
      3
      OCT 12, 2022
      Plants & Animals
      New Antimicrobial Discovered in Bacteria That Infects Potatoes
      New Antimicrobial Discovered in Bacteria That Infects Potatoes
      Resistance to antibiotics and antimicrobials has become an increasingly common concern around the globe. Due to high rat ...
      Written By: Ryan Vingum
      2
      OCT 07, 2022
      Genetics & Genomics
      Epigenetic Marks Can Pass Down to Multiple Generations
      Epigenetic Marks Can Pass Down to Multiple Generations
      The earliest studies of genetic inheritance were very straightforward - Gregor Mendel documented the passage of certain ...
      Written By: Carmen Leitch
      3
      SEP 14, 2022
      Genetics & Genomics
      Neurodegeneration is Linked to Jumping Genes
      Neurodegeneration is Linked to Jumping Genes
      Scientists are beginning to reveal the secrets of the long, repetitive sequences in the human genome that were once writ ...
      Written By: Carmen Leitch
      1
      JUN 25, 2022
      Genetics & Genomics
      Similar 'Jumping Genes' are Active in Human and Octopus Brains
      Similar 'Jumping Genes' are Active in Human and Octopus Brains
      Cephalopods, including octopuses, have exceptionally large and complex nervous systems; the octopod brain is thought to ...
      Written By: Carmen Leitch
      1
      MAY 25, 2022
      Cell & Molecular Biology
      Molecular Biology: What is it, and how is it used?
      Molecular Biology: What is it, and how is it used?
      The words “molecular biology” might sound intimidating to most, but it’s not quite as bad as you think ...
      Written By: Laurence Tognetti, MSc
      8
      APR 28, 2022
      Genetics & Genomics
      A Genetic Cause of Lupus is Identified
      A Genetic Cause of Lupus is Identified
      Lupus is an autoimmune disease that can impact anyone, but tends to affects women between the ages of 15 and 45. The dis ...
      Written By: Carmen Leitch
      3
      APR 25, 2022
      Microbiology
      How a Serious Infection Can Cause Mood Disorders
      How a Serious Infection Can Cause Mood Disorders
      When a pathogen invades the body, the immune system has to mount a response, which involves inflammation. But inflammati ...
      Written By: Carmen Leitch
      4
      JAN 19, 2022
      Genetics & Genomics
      Targeting Proteins Linked to Huntington's & ALS With a New Gene Editing Tool
      Targeting Proteins Linked to Huntington's & ALS With a New Gene Editing Tool
      The CRISPR gene editing tool is often used with an enzyme called Cas9, which targets and cuts genomic DNA. While this te ...
      Written By: Carmen Leitch
      1
      JUL 08, 2021
      Cancer
      Activating p53 May Boost Efficacy of Cancer Immunotherapy
      Activating p53 May Boost Efficacy of Cancer Immunotherapy
      Pharmacological activation of the p53 protein in cancer cells leads to an anti-tumor immune response in lab tests. These ...
      Written By: Annie Lennon
      1
      JUL 02, 2021
      Genetics & Genomics
      Fish Models Provide New Insight Into Rare Genetic Diseases
      Fish Models Provide New Insight Into Rare Genetic Diseases
      Fish can serve as good research models. They can develop quickly, outside of the mother where they can be observed. Some ...
      Written By: Carmen Leitch
      1
      JUN 21, 2021
      Cardiology
      Researchers Find Evidence That Gut Microbes Affect Stroke Severity
      Researchers Find Evidence That Gut Microbes Affect Stroke Severity
      Research has indicated that there is a connection between gut microbes and heart health. Now scientists are revealing so ...
      Written By: Carmen Leitch
      1
    APR 15, 2025
    Genetics & Genomics
    Novel Parkinson's Linked Genes Revealed by CRISPR
    Novel Parkinson's Linked Genes Revealed by CRISPR
    Parkinson's disease is the second most common neurodegenerative disease in the world...
    Written By: Carmen Leitch
    3
    FEB 20, 2024
    Genetics & Genomics
    Ancient Viruses Boosted Vertebrate Brain Evolution
    Ancient Viruses Boosted Vertebrate Brain Evolution
    In DNA, retrotransposons can move around and insert themselves into other parts of genomes with a kind of copy and paste ...
    Written By: Carmen Leitch
    6 1
    FEB 02, 2024
    Genetics & Genomics
    Why do Women Get More Autoimmune Disease? Scientists Find an Answer
    Why do Women Get More Autoimmune Disease? Scientists Find an Answer
    Millions of people have autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis  but it's estim ...
    Written By: Carmen Leitch
    6 1
    JAN 18, 2024
    Immunology
    Novel Work Informs How a Cell Pathway Activates Innate Immunity
    Novel Work Informs How a Cell Pathway Activates Innate Immunity
    Different pathways within the cell are activated or silenced dependent on the external signals acting on a cell. One suc ...
    Written By: Brian G. Morreale
    5
    JAN 17, 2024
    Genetics & Genomics
    Lassoing Gene Expression with Genomic Loops
    Lassoing Gene Expression with Genomic Loops
    DNA molecules are very lengthy, and most cells in the body have to fit the entire genome into the nucleus. To do so, the ...
    Written By: Carmen Leitch
    5
     
     
  • SEP 26, 2023
    Genetics & Genomics
    New Insights Into How to Treat a Common Form of Muscular Dystrophy
    New Insights Into How to Treat a Common Form of Muscular Dystrophy
    Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common forms of muscular dystrophy that impacts almost ...
    Written By: Carmen Leitch
    5
    SEP 08, 2023
    Drug Discovery & Development
    Double dose of this cancer treatment rejuvenates immune cells in Head and Neck Cancer
    Double dose of this cancer treatment rejuvenates immune cells in Head and Neck Cancer
    Groundbreaking clinical trial that unveils the power of neoadjuvant anti-PD-1 therapy in head and neck squamous cell car ...
    Written By: Amielle Moreno
    5
    APR 27, 2023
    Cell & Molecular Biology
    Researchers Slow Aging in Cells
    Researchers Slow Aging in Cells
    Scientists are still determining whether humans will reach a maximum possible age or if we can extend lifespan indefinit ...
    Written By: Carmen Leitch
    3
    JAN 23, 2023
    Neuroscience
    Tau tangles unravel when these three genes are silenced
    Tau tangles unravel when these three genes are silenced
    By controling the activity of an enzyme called CHIP, three proteins regulate tau. Now the genes for these three trouble ...
    Written By: Amielle Moreno
    1
    NOV 10, 2022
    Neuroscience
    HUSH - A Complex That Silences Genes & Helps Control Brain Architecture
    HUSH - A Complex That Silences Genes & Helps Control Brain Architecture
    The HUSH (human silencing hub) protein complex is known to silence genes, and researchers have thought that it could be ...
    Written By: Carmen Leitch
    1
     
     
  • OCT 31, 2022
    Genetics & Genomics
    Ancient Viral DNA in Our Genome Has a Protective Function
    Ancient Viral DNA in Our Genome Has a Protective Function
    There is viral DNA in the human genome, and each instance traces back to an ancestor who was infected with a retrovirus. ...
    Written By: Carmen Leitch
    4
    OCT 25, 2022
    Cell & Molecular Biology
    Liver Disease Discovery Resolves Controversy
    Liver Disease Discovery Resolves Controversy
    Liver diseases are a serious health problem. Chronic liver disease is estimated to impact over 1.5 billion people.
    Written By: Carmen Leitch
    4
    OCT 18, 2022
    Genetics & Genomics
    Mitochondrial DNA Can Move to the Genome to Trigger Human Evolution
    Mitochondrial DNA Can Move to the Genome to Trigger Human Evolution
    Mitochondria are often called the powerhouse of the cell, and these organelles are well-known for their energy-generatin ...
    Written By: Carmen Leitch
    3
    OCT 12, 2022
    Plants & Animals
    New Antimicrobial Discovered in Bacteria That Infects Potatoes
    New Antimicrobial Discovered in Bacteria That Infects Potatoes
    Resistance to antibiotics and antimicrobials has become an increasingly common concern around the globe. Due to high rat ...
    Written By: Ryan Vingum
    2
    OCT 07, 2022
    Genetics & Genomics
    Epigenetic Marks Can Pass Down to Multiple Generations
    Epigenetic Marks Can Pass Down to Multiple Generations
    The earliest studies of genetic inheritance were very straightforward - Gregor Mendel documented the passage of certain ...
    Written By: Carmen Leitch
    3
     
     
  • SEP 14, 2022
    Genetics & Genomics
    Neurodegeneration is Linked to Jumping Genes
    Neurodegeneration is Linked to Jumping Genes
    Scientists are beginning to reveal the secrets of the long, repetitive sequences in the human genome that were once writ ...
    Written By: Carmen Leitch
    1
    JUN 25, 2022
    Genetics & Genomics
    Similar 'Jumping Genes' are Active in Human and Octopus Brains
    Similar 'Jumping Genes' are Active in Human and Octopus Brains
    Cephalopods, including octopuses, have exceptionally large and complex nervous systems; the octopod brain is thought to ...
    Written By: Carmen Leitch
    1
    MAY 25, 2022
    Cell & Molecular Biology
    Molecular Biology: What is it, and how is it used?
    Molecular Biology: What is it, and how is it used?
    The words “molecular biology” might sound intimidating to most, but it’s not quite as bad as you think ...
    Written By: Laurence Tognetti, MSc
    8
    APR 28, 2022
    Genetics & Genomics
    A Genetic Cause of Lupus is Identified
    A Genetic Cause of Lupus is Identified
    Lupus is an autoimmune disease that can impact anyone, but tends to affects women between the ages of 15 and 45. The dis ...
    Written By: Carmen Leitch
    3
    APR 25, 2022
    Microbiology
    How a Serious Infection Can Cause Mood Disorders
    How a Serious Infection Can Cause Mood Disorders
    When a pathogen invades the body, the immune system has to mount a response, which involves inflammation. But inflammati ...
    Written By: Carmen Leitch
    4
     
     
  • JAN 19, 2022
    Genetics & Genomics
    Targeting Proteins Linked to Huntington's & ALS With a New Gene Editing Tool
    Targeting Proteins Linked to Huntington's & ALS With a New Gene Editing Tool
    The CRISPR gene editing tool is often used with an enzyme called Cas9, which targets and cuts genomic DNA. While this te ...
    Written By: Carmen Leitch
    1
    JUL 08, 2021
    Cancer
    Activating p53 May Boost Efficacy of Cancer Immunotherapy
    Activating p53 May Boost Efficacy of Cancer Immunotherapy
    Pharmacological activation of the p53 protein in cancer cells leads to an anti-tumor immune response in lab tests. These ...
    Written By: Annie Lennon
    1
    JUL 02, 2021
    Genetics & Genomics
    Fish Models Provide New Insight Into Rare Genetic Diseases
    Fish Models Provide New Insight Into Rare Genetic Diseases
    Fish can serve as good research models. They can develop quickly, outside of the mother where they can be observed. Some ...
    Written By: Carmen Leitch
    1
    JUN 21, 2021
    Cardiology
    Researchers Find Evidence That Gut Microbes Affect Stroke Severity
    Researchers Find Evidence That Gut Microbes Affect Stroke Severity
    Research has indicated that there is a connection between gut microbes and heart health. Now scientists are revealing so ...
    Written By: Carmen Leitch
    1
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