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    Gene Silencing

    Gene Silencing: describes the epigenetic regulation of a gene, at the level of transcription or translation, to prevent gene expression. Mechanisms include DNA methylation, histone modification and RNAi. Methods to silence genes are exploited by researchers to study gene function, and for the development of therapeutics for diseases including cancer, infectious diseases and neurodegenerative disorders.

    Trending News

    • JUN 07, 2021
      Genetics & Genomics
      Tumor Growth in NF1 Kids May Begin When Optic Nerve Fires
      Tumor Growth in NF1 Kids May Begin When Optic Nerve Fires
      Young children who are born with neurofibromatosis type 1 are at heightened risk of having vision problems because they ...
      Written By: Carmen Leitch
      1
      JUN 02, 2021
      Genetics & Genomics
      A Genetic Form of ALS is Discovered
      A Genetic Form of ALS is Discovered
      Some medical mysteries have become much easier to solve because of advanced genetic techniques that have enabled researc ...
      Written By: Carmen Leitch
      2
      MAY 05, 2021
      Chemistry & Physics
      Chemical nose sniffs out DNA irregularities
      Chemical nose sniffs out DNA irregularities
      A new study published in the journal Nature Chemistry details the development of a chemical nose that can identify ...
      Written By: Kathryn DeMuth Sullivan
      2
      APR 18, 2021
      Cell & Molecular Biology
      Controlling the Epigenome with CRISPRoff & CRISPRon
      Controlling the Epigenome with CRISPRoff & CRISPRon
      Some parts of the genome are simple; many genes encode for proteins, and if there is an error in one of those protein-co ...
      Written By: Carmen Leitch
      1
      MAR 30, 2021
      Genetics & Genomics
      A Pest Hijacked a Plant Gene To Use as a Toxin Shield
      A Pest Hijacked a Plant Gene To Use as a Toxin Shield
      Bacteria can share genetic material in a process called horizontal gene transfer, and recent work has shown that in anim ...
      Written By: Carmen Leitch
      2
      FEB 08, 2021
      Cell & Molecular Biology
      Stem Cell Therapy is Now Suitable for Dogs
      Stem Cell Therapy is Now Suitable for Dogs
      With good food and exercise, many dogs can live a long and healthy life. But some suffer from chronic conditions that ca ...
      Written By: Carmen Leitch
      2
      OCT 20, 2020
      Immunology
      The Immune Pause Button Slowing MS Progression
      The Immune Pause Button Slowing MS Progression
        Scientists have a new theory about the genetics behind the progressive, debilitating effects of multiple sclerosi ...
      Written By: Tara Fernandes
      2
      OCT 05, 2020
      Immunology
      Can't Shed Those Extra Pounds? An Inflammatory Gene Could Be to Blame.
      Can't Shed Those Extra Pounds? An Inflammatory Gene Could Be to Blame.
        Australian scientists have zeroed in on a gene linked to an increased obesity risk: a regulator of inflammation c ...
      Written By: Tara Fernandes
      2
      SEP 27, 2020
      Genetics & Genomics
      There's More to the Y Chromosome Than We Knew
      There's More to the Y Chromosome Than We Knew
      While humans beings carry mostly the same genes on two copies of 23 chromosomes, the sex chromosomes are a bit different ...
      Written By: Carmen Leitch
      2
      SEP 16, 2020
      Genetics & Genomics
      Epigenetic Defects Are More Common in People Than Thought
      Epigenetic Defects Are More Common in People Than Thought
      The genome still holds many secrets, some of which probably have a direct relationship to human disease. Beyond genes th ...
      Written By: Carmen Leitch
      2
      SEP 13, 2020
      Genetics & Genomics
      Men and Women Express Many Genes at Different Levels
      Men and Women Express Many Genes at Different Levels
      Most humans carry the same genes in their genome, but how are genes expressed differently in men and women?
      Written By: Carmen Leitch
      1
      SEP 01, 2020
      Genetics & Genomics
      Women's Genes May Help Protect Against the Worst Alzheimer's Cases
      Women's Genes May Help Protect Against the Worst Alzheimer's Cases
      Women tend to get Alzheimer's more than men, but the female genome gives them some protection from the worst aspects of ...
      Written By: Carmen Leitch
      1
      AUG 28, 2020
      Genetics & Genomics
      'Jumping' Genes Can Regulate Gene Expression in Human Neurons
      'Jumping' Genes Can Regulate Gene Expression in Human Neurons
      Even though genes that code for protein have been an intense focus of biomedical research for decades, the human genome ...
      Written By: Carmen Leitch
      1
      AUG 09, 2020
      Genetics & Genomics
      Using CRISPR to Silence Essential Developmental Genes
      Using CRISPR to Silence Essential Developmental Genes
      The CRISPR gene-editing tool has changed research and is now making impacts in clinical medicine.
      Written By: Carmen Leitch
      3
      JUL 31, 2020
      Genetics & Genomics
      Researchers Create an Epigenetic Map of Development
      Researchers Create an Epigenetic Map of Development
      The protein-coding genes in the genome produce protein when they're active, or expressed. Learning how gene activity is ...
      Written By: Carmen Leitch
      2
      JUL 30, 2020
      Immunology
      Gene Silencing Therapy Stops the Itch of Psoriasis
      Gene Silencing Therapy Stops the Itch of Psoriasis
      A team of Harvard researchers has identified a promising new approach for treating psoriasis — a topical lotion co ...
      Written By: Tara Fernandes
      2
      JUL 29, 2020
      Cancer
      Regulating Apoptosis in Prostate Cancer
      Regulating Apoptosis in Prostate Cancer
      Cancer treatments tend to work in one of a few ways. They can target the immune system, prevent cancer proliferation and ...
      Written By: Jasper Cantrell
      1
      JUN 22, 2020
      Drug Discovery & Development
      New Drug Shows Promise in Fatty Liver Disease
      New Drug Shows Promise in Fatty Liver Disease
      A scientist leads a team to discover the first-of-its-class drug that can inhibit a key enzyme safely and effectively in ...
      Written By: Nouran Amin
      2
      JUN 11, 2020
      Genetics & Genomics
      Restoring Hearing by Editing Only One Base of a Gene
      Restoring Hearing by Editing Only One Base of a Gene
      Errors in genes can cause serious diseases. Some of those errors are large, while others are due to a change in only one ...
      Written By: Carmen Leitch
      1
      MAY 28, 2020
      Cancer
      The Oncogenic Hazard of a Potential Alzheimer's Treatment
      The Oncogenic Hazard of a Potential Alzheimer's Treatment
      Breast cancer remains one of the most common cancers around the world. Triple-Negative Breast Cancer (TNBC) is a sub-typ ...
      Written By: Jasper Cantrell
      1
      APR 23, 2020
      Cell & Molecular Biology
      Do Organisms Have to Pass Down More Than Just DNA?
      Do Organisms Have to Pass Down More Than Just DNA?
      A new theory of heredity is proposed, which takes into account more than just genes in a genome.
      Written By: Carmen Leitch
      2
      FEB 26, 2020
      Neuroscience
      Immunotherapy Could Be Used to Treat Traumatic Brain Injury
      Immunotherapy Could Be Used to Treat Traumatic Brain Injury
      Video:  Further explaination of microglia and their various functions.  Traumatic Brain Injuries are physical ...
      Written By: Amanda Mikyska
      1
      FEB 09, 2020
      Cell & Molecular Biology
      Learning More About X Chromosome Inactivation
      Learning More About X Chromosome Inactivation
      The X chromosome carries a thousand genes, so in females, one of the X chromosomes must be silenced to avoid serious dev ...
      Written By: Carmen Leitch
      1
      JAN 03, 2020
      Drug Discovery & Development
      New Drug Combo Reverses Breast Cancer
      New Drug Combo Reverses Breast Cancer
      Researchers from Georgetown University have found that combining a drug used for epilepsy, bipolar disorder, and migrain ...
      Written By: Annie Lennon
      1
    JUN 07, 2021
    Genetics & Genomics
    Tumor Growth in NF1 Kids May Begin When Optic Nerve Fires
    Tumor Growth in NF1 Kids May Begin When Optic Nerve Fires
    Young children who are born with neurofibromatosis type 1 are at heightened risk of having vision problems because they ...
    Written By: Carmen Leitch
    1
    JUN 02, 2021
    Genetics & Genomics
    A Genetic Form of ALS is Discovered
    A Genetic Form of ALS is Discovered
    Some medical mysteries have become much easier to solve because of advanced genetic techniques that have enabled researc ...
    Written By: Carmen Leitch
    2
    MAY 05, 2021
    Chemistry & Physics
    Chemical nose sniffs out DNA irregularities
    Chemical nose sniffs out DNA irregularities
    A new study published in the journal Nature Chemistry details the development of a chemical nose that can identify ...
    Written By: Kathryn DeMuth Sullivan
    2
    APR 18, 2021
    Cell & Molecular Biology
    Controlling the Epigenome with CRISPRoff & CRISPRon
    Controlling the Epigenome with CRISPRoff & CRISPRon
    Some parts of the genome are simple; many genes encode for proteins, and if there is an error in one of those protein-co ...
    Written By: Carmen Leitch
    1
    MAR 30, 2021
    Genetics & Genomics
    A Pest Hijacked a Plant Gene To Use as a Toxin Shield
    A Pest Hijacked a Plant Gene To Use as a Toxin Shield
    Bacteria can share genetic material in a process called horizontal gene transfer, and recent work has shown that in anim ...
    Written By: Carmen Leitch
    2
     
     
  • FEB 08, 2021
    Cell & Molecular Biology
    Stem Cell Therapy is Now Suitable for Dogs
    Stem Cell Therapy is Now Suitable for Dogs
    With good food and exercise, many dogs can live a long and healthy life. But some suffer from chronic conditions that ca ...
    Written By: Carmen Leitch
    2
    OCT 20, 2020
    Immunology
    The Immune Pause Button Slowing MS Progression
    The Immune Pause Button Slowing MS Progression
      Scientists have a new theory about the genetics behind the progressive, debilitating effects of multiple sclerosi ...
    Written By: Tara Fernandes
    2
    OCT 05, 2020
    Immunology
    Can't Shed Those Extra Pounds? An Inflammatory Gene Could Be to Blame.
    Can't Shed Those Extra Pounds? An Inflammatory Gene Could Be to Blame.
      Australian scientists have zeroed in on a gene linked to an increased obesity risk: a regulator of inflammation c ...
    Written By: Tara Fernandes
    2
    SEP 27, 2020
    Genetics & Genomics
    There's More to the Y Chromosome Than We Knew
    There's More to the Y Chromosome Than We Knew
    While humans beings carry mostly the same genes on two copies of 23 chromosomes, the sex chromosomes are a bit different ...
    Written By: Carmen Leitch
    2
    SEP 16, 2020
    Genetics & Genomics
    Epigenetic Defects Are More Common in People Than Thought
    Epigenetic Defects Are More Common in People Than Thought
    The genome still holds many secrets, some of which probably have a direct relationship to human disease. Beyond genes th ...
    Written By: Carmen Leitch
    2
     
     
  • SEP 13, 2020
    Genetics & Genomics
    Men and Women Express Many Genes at Different Levels
    Men and Women Express Many Genes at Different Levels
    Most humans carry the same genes in their genome, but how are genes expressed differently in men and women?
    Written By: Carmen Leitch
    1
    SEP 01, 2020
    Genetics & Genomics
    Women's Genes May Help Protect Against the Worst Alzheimer's Cases
    Women's Genes May Help Protect Against the Worst Alzheimer's Cases
    Women tend to get Alzheimer's more than men, but the female genome gives them some protection from the worst aspects of ...
    Written By: Carmen Leitch
    1
    AUG 28, 2020
    Genetics & Genomics
    'Jumping' Genes Can Regulate Gene Expression in Human Neurons
    'Jumping' Genes Can Regulate Gene Expression in Human Neurons
    Even though genes that code for protein have been an intense focus of biomedical research for decades, the human genome ...
    Written By: Carmen Leitch
    1
    AUG 09, 2020
    Genetics & Genomics
    Using CRISPR to Silence Essential Developmental Genes
    Using CRISPR to Silence Essential Developmental Genes
    The CRISPR gene-editing tool has changed research and is now making impacts in clinical medicine.
    Written By: Carmen Leitch
    3
    JUL 31, 2020
    Genetics & Genomics
    Researchers Create an Epigenetic Map of Development
    Researchers Create an Epigenetic Map of Development
    The protein-coding genes in the genome produce protein when they're active, or expressed. Learning how gene activity is ...
    Written By: Carmen Leitch
    2
     
     
  • JUL 30, 2020
    Immunology
    Gene Silencing Therapy Stops the Itch of Psoriasis
    Gene Silencing Therapy Stops the Itch of Psoriasis
    A team of Harvard researchers has identified a promising new approach for treating psoriasis — a topical lotion co ...
    Written By: Tara Fernandes
    2
    JUL 29, 2020
    Cancer
    Regulating Apoptosis in Prostate Cancer
    Regulating Apoptosis in Prostate Cancer
    Cancer treatments tend to work in one of a few ways. They can target the immune system, prevent cancer proliferation and ...
    Written By: Jasper Cantrell
    1
    JUN 22, 2020
    Drug Discovery & Development
    New Drug Shows Promise in Fatty Liver Disease
    New Drug Shows Promise in Fatty Liver Disease
    A scientist leads a team to discover the first-of-its-class drug that can inhibit a key enzyme safely and effectively in ...
    Written By: Nouran Amin
    2
    JUN 11, 2020
    Genetics & Genomics
    Restoring Hearing by Editing Only One Base of a Gene
    Restoring Hearing by Editing Only One Base of a Gene
    Errors in genes can cause serious diseases. Some of those errors are large, while others are due to a change in only one ...
    Written By: Carmen Leitch
    1
    MAY 28, 2020
    Cancer
    The Oncogenic Hazard of a Potential Alzheimer's Treatment
    The Oncogenic Hazard of a Potential Alzheimer's Treatment
    Breast cancer remains one of the most common cancers around the world. Triple-Negative Breast Cancer (TNBC) is a sub-typ ...
    Written By: Jasper Cantrell
    1
     
     
  • APR 23, 2020
    Cell & Molecular Biology
    Do Organisms Have to Pass Down More Than Just DNA?
    Do Organisms Have to Pass Down More Than Just DNA?
    A new theory of heredity is proposed, which takes into account more than just genes in a genome.
    Written By: Carmen Leitch
    2
    FEB 26, 2020
    Neuroscience
    Immunotherapy Could Be Used to Treat Traumatic Brain Injury
    Immunotherapy Could Be Used to Treat Traumatic Brain Injury
    Video:  Further explaination of microglia and their various functions.  Traumatic Brain Injuries are physical ...
    Written By: Amanda Mikyska
    1
    FEB 09, 2020
    Cell & Molecular Biology
    Learning More About X Chromosome Inactivation
    Learning More About X Chromosome Inactivation
    The X chromosome carries a thousand genes, so in females, one of the X chromosomes must be silenced to avoid serious dev ...
    Written By: Carmen Leitch
    1
    JAN 03, 2020
    Drug Discovery & Development
    New Drug Combo Reverses Breast Cancer
    New Drug Combo Reverses Breast Cancer
    Researchers from Georgetown University have found that combining a drug used for epilepsy, bipolar disorder, and migrain ...
    Written By: Annie Lennon
    1
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