Gene: is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function.
-
Central Nervous System (CNS) therapies have significantly progressed in the last decade, propelled by emerging treatment modalities including gene therapies. Neurological indications remain...
Spatial analysis of protein or gene expression is vital to understanding the distribution, phenotypes, and interactions between cells within tumor microenvironment (TME). Traditionally, mult...
Across many cancers, mortality is associated with metastasis and acquired drug resistance, both of which often manifest in recurrent disease. Central to these phenomena is epithelial to mese...
The downstream processing of virus particles, vesicles, RNAs, plasmids and other forms of DNA, contains multiple interdependent steps, each requiring optimization for best results. This webi...
The clinical interpretation of genetic testing results remains one of the most significant hurdles in effectively applying genomics in modern medicine. Errors in variant interpretation, whet...
Determining the purity of LNPs loaded with nucleic acids can be challenging due to their size heterogeneity. Here, we present analytical ultracentrifugation (AUC) methods that use multiwavel...
An estimated 48.5 million couples suffer from infertility worldwide, driving up usage of assisted reproductive technologies around the globe. As a result, preimplantation genetic testing (PG...
As the vast landscape of genetic oncology continues to expand, the ability to understand and utilize the full potential of this rich data becomes increasingly challenging. As a result, resea...
CGX10 Cell Isolation System: Introduction, Utility, and Assessment in a GMP-grade Environment for Multiparametric Cell Sorting A future of long-term, minimally toxic immunotherapy personaliz...
High content screening at speed requires compromise: sacrificing resolution, sample coverage or both. This has limited high content screening’s utility as a high throughput tool. In or...
Tumor genomic profiling can be complicated, especially for diseases that commonly have multiple different genomic biomarkers of interest, such as non-small cell lung cancer (NSCLC) and color...
In this talk we will explore the application of Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH) technology to decode spatially regulated disease drivers in human heart...
Quantitative genetic analysis plays a critical role in the research and development of novel biotherapeutics. As a sensitive and precise method for quantitating specific nucleic acid targets...
When building your own infectious disease molecular panels there are many paths to consider. In this interview, we ask Marcus Cognetti and Dr. Ari Frenkel what approach is required to create...