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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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Researchers know that the viruses including SARS-CoV-2 have a Spike protein that allows them to bind to receptors on hos ...Written By: Carmen LeitchAUG 22, 2020Drug Discovery & Development
Researchers have found that a drug currently used to treat bipolar disorder and hearing loss may also treat COVID-19 tha ...Written By: Annie LennonAUG 14, 2020Cell & Molecular Biology
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We're often exposed to irritants as mild as garlic or horseradish and as serious as smoke, which trigger a protective re ...Written By: Carmen LeitchJUL 31, 2020Genetics & Genomics
The protein-coding genes in the genome produce protein when they're active, or expressed. Learning how gene activity is ...Written By: Carmen LeitchJUL 29, 2020Genetics & Genomics
A phenomenon called liquid-liquid phase separation can be easily demonstrated by mixing oil and vinegar. It's not only f ...Written By: Carmen LeitchJUL 26, 2020Genetics & Genomics
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Cell biologist Carolyn Machamer has studied viruses for the past 35 years, and has seen outbreaks caused by several path ...Written By: Carmen LeitchJUL 21, 2020Genetics & Genomics
If you've seen a representation of a DNA molecule, you've seen the double helix, in which two strands of genetic materia ...Written By: Carmen LeitchJUL 20, 2020Cell & Molecular Biology
The diseases cat scratch fever and trench fever are both caused by Bartonella bacteria. Animals can transmit these patho ...Written By: Carmen LeitchJUL 17, 2020Immunology
When it comes to clinical countermeasures against COVID-19, one class of molecules stands out among the others: antibodi ...Written By: Tara FernandesJUL 17, 2020Cancer
Chemotherapy has been one of the primary methods of cancer treatment for decades. Usually, a doctor applies a chemothera ...Written By: Jasper CantrellJUL 15, 2020Microbiology
Heparin is a very common drug that's been approved as an anticoagulant since 1992. Researchers have now found that the m ...Written By: Carmen LeitchJUL 14, 2020Immunology
Scientists all over the world are racing to develop a vaccine that effectively and safely prompts protective immunity to ...Written By: Kara MarkerJUL 14, 2020Immunology
Scientists are working on developing an arsenal of nano-sized weapons in the war against COVID-19. These molecules, call ...Written By: Tara FernandesJUL 13, 2020Drug Discovery & Development
Researchers at the University of Texas Medical Branch at Galveston have uncovered a new antiviral mechanism for the new ...Written By: Nouran AminJUL 13, 2020Microbiology
There is intense competition for resources in the microbial world, and bacteria have an arsenal of weapons to help them ...Written By: Carmen LeitchJUL 10, 2020Cancer
The most important part of cancer treatment is the first step, diagnosis. Many cancers can lie dormant for years, reachi ...Written By: Jasper CantrellJUL 07, 2020Microbiology
Urinary tract infections can be very painful and can cause nausea, chills, and fever. A pathogenic strain of E. coli is ...Written By: Carmen LeitchJUL 07, 2020Immunology
Acute flaccid myelitis, or AFM, is a rare but devastatingly debilitating neurologic disease in children caused by a resp ...Written By: Tara FernandesJUL 04, 2020Cardiology
Pulmonary Arterial Hypertension (PAH) is a progressive and fatal disease characterized by the muscularization of blood c ...Written By: Jasper Cantrell
AUG 24, 2020
Cell & Molecular Biology
Researchers know that the viruses including SARS-CoV-2 have a Spike protein that allows them to bind to receptors on hos
...
Written By:
Carmen Leitch
AUG 22, 2020
Drug Discovery & Development
Researchers have found that a drug currently used to treat bipolar disorder and hearing loss may also treat COVID-19 tha
...
Written By:
Annie Lennon
AUG 14, 2020
Cell & Molecular Biology
There are several coronaviruses that we know about, and they cause a wide range of illnesses. Some, like SARS-CoV-2, are
...
Written By:
Carmen Leitch
AUG 07, 2020
Chemistry & Physics
Excipients are chemical additives to medications. They are incorporated into all kinds of pharmaceuticals to fulfil
...
Written By:
Daniel Duan
AUG 03, 2020
Cancer
New research is published by scientists at Dana-Farber Cancer Institute have discovered new information that may help pa
...
Written By:
Kathryn DeMuth Sullivan
AUG 03, 2020
Cancer
Diagnostics is one of the essential tools in a physician’s toolkit. A good diagnostic test can identify whether a
...
Written By:
Jasper Cantrell
AUG 02, 2020
Cell & Molecular Biology
We're often exposed to irritants as mild as garlic or horseradish and as serious as smoke, which trigger a protective re
...
Written By:
Carmen Leitch
JUL 31, 2020
Genetics & Genomics
The protein-coding genes in the genome produce protein when they're active, or expressed. Learning how gene activity is
...
Written By:
Carmen Leitch
JUL 29, 2020
Genetics & Genomics
A phenomenon called liquid-liquid phase separation can be easily demonstrated by mixing oil and vinegar. It's not only f
...
Written By:
Carmen Leitch
JUL 26, 2020
Genetics & Genomics
Mucosal-associated invariant T cells appear to be a critical part of the human immune system, and dysfunction in these c
...
Written By:
Carmen Leitch
JUL 26, 2020
Cell & Molecular Biology
Cell biologist Carolyn Machamer has studied viruses for the past 35 years, and has seen outbreaks caused by several path
...
Written By:
Carmen Leitch
JUL 21, 2020
Genetics & Genomics
If you've seen a representation of a DNA molecule, you've seen the double helix, in which two strands of genetic materia
...
Written By:
Carmen Leitch
JUL 20, 2020
Cell & Molecular Biology
The diseases cat scratch fever and trench fever are both caused by Bartonella bacteria. Animals can transmit these patho
...
Written By:
Carmen Leitch
JUL 17, 2020
Immunology
When it comes to clinical countermeasures against COVID-19, one class of molecules stands out among the others: antibodi
...
Written By:
Tara Fernandes
JUL 17, 2020
Cancer
Chemotherapy has been one of the primary methods of cancer treatment for decades. Usually, a doctor applies a chemothera
...
Written By:
Jasper Cantrell
JUL 15, 2020
Microbiology
Heparin is a very common drug that's been approved as an anticoagulant since 1992. Researchers have now found that the m
...
Written By:
Carmen Leitch
JUL 14, 2020
Immunology
Scientists all over the world are racing to develop a vaccine that effectively and safely prompts protective immunity to
...
Written By:
Kara Marker
JUL 14, 2020
Immunology
Scientists are working on developing an arsenal of nano-sized weapons in the war against COVID-19. These molecules, call
...
Written By:
Tara Fernandes
JUL 13, 2020
Drug Discovery & Development
Researchers at the University of Texas Medical Branch at Galveston have uncovered a new antiviral mechanism for the new
...
Written By:
Nouran Amin
JUL 13, 2020
Microbiology
There is intense competition for resources in the microbial world, and bacteria have an arsenal of weapons to help them
...
Written By:
Carmen Leitch
JUL 10, 2020
Cancer
The most important part of cancer treatment is the first step, diagnosis. Many cancers can lie dormant for years, reachi
...
Written By:
Jasper Cantrell
JUL 07, 2020
Microbiology
Urinary tract infections can be very painful and can cause nausea, chills, and fever. A pathogenic strain of E. coli is
...
Written By:
Carmen Leitch
JUL 07, 2020
Immunology
Acute flaccid myelitis, or AFM, is a rare but devastatingly debilitating neurologic disease in children caused by a resp
...
Written By:
Tara Fernandes
JUL 04, 2020
Cardiology
Pulmonary Arterial Hypertension (PAH) is a progressive and fatal disease characterized by the muscularization of blood c
...
Written By:
Jasper Cantrell