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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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Microbiology
Millions of people around the world have been infected with the coronavirus called SARS-CoV-2, which causes COVID-19. Th
...
Written By:
Carmen Leitch
JUL 03, 2020
Cancer
One of the challenges of facing cancer researchers is coming up with a clearly defined classification system. Cancer is
...
Written By:
Jasper Cantrell
JUL 02, 2020
Cell & Molecular Biology
Scientists have now learned more about a critical protein in the brain called the NMDA receptor, tracking every atom as
...
Written By:
Carmen Leitch
JUL 01, 2020
Cancer
Angiogenesis is the vascularization, or generation of blood vessels, of a part of the body. It is a normal function of h
...
Written By:
Jasper Cantrell
JUN 29, 2020
Genetics & Genomics
The microbial pathogens of the world have shown us how powerful they can be, most recently proven by the current pandemi
...
Written By:
Carmen Leitch
JUN 23, 2020
Immunology
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...
Written By:
Tara Fernandes
JUN 22, 2020
Cancer
Diagnostic tests are the unsung heroes of cancer treatment. While there are more treatments for cancer coming out every
...
Written By:
Jasper Cantrell
JUN 20, 2020
Cancer
One of the things a cancer patient can hear from their doctor is “recurrence.” Modern cancer therapies are a
...
Written By:
Jasper Cantrell
JUN 06, 2020
Cancer
Cancer has been one of the most persistent diseases modern medicine has faced. Due to its nature, treatments are often t
...
Written By:
Jasper Cantrell
JUN 06, 2020
Cell & Molecular Biology
Reporting in Nature, scientists have learned more about a critical channel that sits in cell membranes, called PANX1. Th
...
Written By:
Carmen Leitch
JUN 04, 2020
Microbiology
Sepsis and bacterial meningitis are life-threatening diseases caused by meningococci bacteria.
Written By:
Carmen Leitch
JUN 03, 2020
Cell & Molecular Biology
Insulin is a hormone that's produced by a specific set of cells in the pancreas, and it functions to regulate blood
...
Written By:
Carmen Leitch
MAY 27, 2020
Cell & Molecular Biology
The surfaces of cells are decorated with receptors, and the interactions between receptors and their binding partners ar
...
Written By:
Carmen Leitch
MAY 18, 2020
Cancer
Genetics can be complicated to say the least. Sometimes it can be as simple as a single mutation in one gene that causes
...
Written By:
Jasper Cantrell
MAY 18, 2020
Microbiology
SARS-CoV caused an outbreak of SARS in 2003. Samples collected from those patients back then may help us against SARS-Co
...
Written By:
Carmen Leitch
MAY 17, 2020
Cell & Molecular Biology
Treatment options are limited for people that have suffered swelling-inducing injuries to their brain and spinal cord. N
...
Written By:
Carmen Leitch
MAY 16, 2020
Cannabis Sciences
Researchers have found that anandamide, often referred to as the body’s own cannabis, may help us forget traumatic
...
Written By:
Annie Lennon
MAY 10, 2020
Drug Discovery & Development
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...
Written By:
Nouran Amin
APR 29, 2020
Clinical & Molecular DX
According to the World Health Organization (WHO), sepsis occurs when the body’s response to an infection injures i
...
Written By:
Lawrence Renna
APR 26, 2020
Cell & Molecular Biology
This work may help explain why the virus is so easy to transmit.
Written By:
Carmen Leitch
APR 16, 2020
Health & Medicine
As mortality and infection rates rise globally, it appears that SARS-CoV-2, the virus responsible for the COVID-19 pande
...
Written By:
Stephanie Leon Quinonez
APR 14, 2020
Cell & Molecular Biology
Proteins usually work together, whether as part of a pathway or a complex, and there are several ways to investigate pro
...
Written By:
Carmen Leitch
APR 14, 2020
Clinical & Molecular DX
For researchers at the Missouri University of Science and Technology developing a new class of nanodiagnostics, good thi
...
Written By:
Tara Fernandes
APR 13, 2020
Cancer
In the past, the go-to drugs have always been small molecules. These small molecules would interact with the cell and ac
...
Written By:
Jasper Cantrell