Follow
Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
-
NOV 06, 2020Immunology
The virus that causes COVID-19, SARS-CoV-2, uses its spike protein to gain access to cells, by binding to the ACE2 recep ...Written By: Tara FernandesNOV 04, 2020Cancer
For decades, modern medicine has relied on chemists’ work to produce compounds that could one day be used as a dru ...Written By: Jasper CantrellNOV 02, 2020Cell & Molecular Biology
Cells have to be flexible and move with each other and our bodies. When cells get overstretched, they have to be able to ...Written By: Carmen LeitchNOV 01, 2020Microbiology
SARS-CoV-2, which causes COVID-19 has to get into cells to cause infection. It does so with a spike protein on its surfa ...Written By: Carmen LeitchOCT 28, 2020Cancer
Radiotherapy alone or with chemotherapy is the go-to treatment for head and neck cancers. Unfortunately, head and neck t ...Written By: Jasper CantrellOCT 26, 2020Cancer
Researchers from the Max Planck Institute of Biochemistry have developed a new approach to targeting leukemic stem cells ...Written By: Kathryn DeMuth SullivanOCT 25, 2020Cell & Molecular Biology
Ewing sarcoma is a rare kind of cancer that tends to impact young people and occurs in bones or the tissue around them. ...Written By: Carmen LeitchOCT 24, 2020Immunology
A team of researchers at Duke University have developed an imaging technology for tagging structures at a cellular level ...Written By: Tara FernandesOCT 22, 2020Microbiology
Since the pandemic virus SARS-CoV-2 emerged on the scene late last year, it's left a trail of devastation around the glo ...Written By: Carmen LeitchOCT 21, 2020Microbiology
Ebola virus can pass from animals to humans, and between people. Rarely, it causes outbreaks but when it does, they can ...Written By: Carmen LeitchOCT 19, 2020Cancer
Cancer is a disease characterized by DNA mutations. These mutations, while sometimes small, can cause havoc in a cell&rs ...Written By: Jasper CantrellOCT 12, 2020Drug Discovery & Development
Introduction The importance of Fc glycosylation of monoclonal antibodies (mAbs) with regard to biological activity is wi ...Sponsored By: Roche DiagnosticsOCT 04, 2020Cell & Molecular Biology
Many drugs can have a wide range of impacts on the patients that take them; doctors often have to adjust a person's dosa ...Written By: Carmen LeitchSEP 23, 2020Immunology
Antibodies are Y-shaped proteins that play a central role in the immune system’s arsenal of germ-busting weapons. ...Written By: Tara FernandesSEP 23, 2020Cell & Molecular Biology
In order to infect a cell, the SARS-CoV-2 virus has to find a way in. It can use receptors on the surface of cells that ...Written By: Carmen LeitchSEP 21, 2020Genetics & Genomics
Cold Spring Harbor Laboratory scientists have used cryo-EM to learn more about how the human genome is replicated.Written By: Carmen LeitchSEP 20, 2020Drug Discovery & Development
As the COVID-19 pandemic rages on, the search for drugs to combat the virus is ongoing. Now, scientists have found that ...Written By: Annie LennonSEP 20, 2020Cell & Molecular Biology
Recent studies have demonstrated that hallucinogenic drugs like LSD, psilocybin, and mescaline have therapeutic potentia ...Written By: Carmen LeitchSEP 14, 2020Cell & Molecular Biology
It was once thought that cellular machines called organelles, which are structures bound by membranes, directed most of ...Written By: Carmen LeitchSEP 13, 2020Cell & Molecular Biology
The surface of a cell carries many features to help it carry out its functions, communicate with other cells, gather inf ...Written By: Carmen LeitchSEP 06, 2020Microbiology
Effective vaccines have to trigger an immune response, which is intended to create an immune 'memory' of a specific infe ...Written By: Carmen LeitchSEP 01, 2020Drug Discovery & Development
Researchers from the University of Michigan Rogel Cancer Center have worked on creating a therapeutic-based compound tha ...Written By: Nouran AminAUG 31, 2020Cancer
Chemoresistance is a serious problem for many cancer therapies. Solutions to this problem are harder to come by than the ...Written By: Jasper CantrellAUG 25, 2020Drug Discovery & Development
What exactly are antivitamins? They are substances no less that have the power to target the biological function of a ge ...Written By: Nouran Amin
NOV 06, 2020
Immunology
The virus that causes COVID-19, SARS-CoV-2, uses its spike protein to gain access to cells, by binding to the ACE2 recep
...
Written By:
Tara Fernandes
NOV 04, 2020
Cancer
For decades, modern medicine has relied on chemists’ work to produce compounds that could one day be used as a dru
...
Written By:
Jasper Cantrell
NOV 02, 2020
Cell & Molecular Biology
Cells have to be flexible and move with each other and our bodies. When cells get overstretched, they have to be able to
...
Written By:
Carmen Leitch
NOV 01, 2020
Microbiology
SARS-CoV-2, which causes COVID-19 has to get into cells to cause infection. It does so with a spike protein on its surfa
...
Written By:
Carmen Leitch
OCT 28, 2020
Cancer
Radiotherapy alone or with chemotherapy is the go-to treatment for head and neck cancers. Unfortunately, head and neck t
...
Written By:
Jasper Cantrell
OCT 26, 2020
Cancer
Researchers from the Max Planck Institute of Biochemistry have developed a new approach to targeting leukemic stem cells
...
Written By:
Kathryn DeMuth Sullivan
OCT 25, 2020
Cell & Molecular Biology
Ewing sarcoma is a rare kind of cancer that tends to impact young people and occurs in bones or the tissue around them.
...
Written By:
Carmen Leitch
OCT 24, 2020
Immunology
A team of researchers at Duke University have developed an imaging technology for tagging structures at a cellular level
...
Written By:
Tara Fernandes
OCT 22, 2020
Microbiology
Since the pandemic virus SARS-CoV-2 emerged on the scene late last year, it's left a trail of devastation around the glo
...
Written By:
Carmen Leitch
OCT 21, 2020
Microbiology
Ebola virus can pass from animals to humans, and between people. Rarely, it causes outbreaks but when it does, they can
...
Written By:
Carmen Leitch
OCT 19, 2020
Cancer
Cancer is a disease characterized by DNA mutations. These mutations, while sometimes small, can cause havoc in a cell&rs
...
Written By:
Jasper Cantrell
OCT 12, 2020
Drug Discovery & Development
Introduction The importance of Fc glycosylation of monoclonal antibodies (mAbs) with regard to biological activity is wi
...
Sponsored By:
Roche Diagnostics
OCT 04, 2020
Cell & Molecular Biology
Many drugs can have a wide range of impacts on the patients that take them; doctors often have to adjust a person's dosa
...
Written By:
Carmen Leitch
SEP 23, 2020
Immunology
Antibodies are Y-shaped proteins that play a central role in the immune system’s arsenal of germ-busting weapons.
...
Written By:
Tara Fernandes
SEP 23, 2020
Cell & Molecular Biology
In order to infect a cell, the SARS-CoV-2 virus has to find a way in. It can use receptors on the surface of cells that
...
Written By:
Carmen Leitch
SEP 21, 2020
Genetics & Genomics
Cold Spring Harbor Laboratory scientists have used cryo-EM to learn more about how the human genome is replicated.
Written By:
Carmen Leitch
SEP 20, 2020
Drug Discovery & Development
As the COVID-19 pandemic rages on, the search for drugs to combat the virus is ongoing. Now, scientists have found that
...
Written By:
Annie Lennon
SEP 20, 2020
Cell & Molecular Biology
Recent studies have demonstrated that hallucinogenic drugs like LSD, psilocybin, and mescaline have therapeutic potentia
...
Written By:
Carmen Leitch
SEP 14, 2020
Cell & Molecular Biology
It was once thought that cellular machines called organelles, which are structures bound by membranes, directed most of
...
Written By:
Carmen Leitch
SEP 13, 2020
Cell & Molecular Biology
The surface of a cell carries many features to help it carry out its functions, communicate with other cells, gather inf
...
Written By:
Carmen Leitch
SEP 06, 2020
Microbiology
Effective vaccines have to trigger an immune response, which is intended to create an immune 'memory' of a specific infe
...
Written By:
Carmen Leitch
SEP 01, 2020
Drug Discovery & Development
Researchers from the University of Michigan Rogel Cancer Center have worked on creating a therapeutic-based compound tha
...
Written By:
Nouran Amin
AUG 31, 2020
Cancer
Chemoresistance is a serious problem for many cancer therapies. Solutions to this problem are harder to come by than the
...
Written By:
Jasper Cantrell
AUG 25, 2020
Drug Discovery & Development
What exactly are antivitamins? They are substances no less that have the power to target the biological function of a ge
...
Written By:
Nouran Amin