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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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APR 12, 2020Drug Discovery & Development
Can spider venom offer pain relief? Apparently, yes! According to researchers at University of Queensland, compounds iso ...Written By: Nouran AminAPR 12, 2020Cancer
A researcher from the James Graham Brown Cancer Center at the University of Louisville claims to have figured out the mo ...Written By: Kathryn DeMuth SullivanAPR 09, 2020Cancer
The research to find effective treatments and diagnosing tools in the fight against cancer has led to a thorough investi ...Written By: Jasper CantrellAPR 07, 2020Chemistry & Physics
Now more than ever we are all thinking about germs. Germs, microbes, bacteria, viruses – it’s a constant min ...Written By: Kathryn DeMuth SullivanAPR 03, 2020Genetics & Genomics
Less than a millisecond after a cell is stretched out, genes are activated, which will result in the production of prote ...Written By: Carmen LeitchAPR 02, 2020Cancer
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As panic is spreading over the novel coronavirus, the time is ripe for both misinformation and disinformation to thrive. ...Written By: Annie LennonMAR 17, 2020Immunology
Structurally, SARS-CoV-2 (the virus that causes COVID-19) are spherical shells consisting of a lipid membrane, with a co ...Written By: Tara FernandesMAR 16, 2020Genetics & Genomics
The genetic material from a sperm and an egg merges to form a new human genome, and now we know more details about the p ...Written By: Carmen LeitchMAR 08, 2020Cell & Molecular Biology
Scientists have identified a strategy used by cells to shield them from the toxins that can be released by dangerous bac ...Written By: Carmen LeitchMAR 08, 2020Microbiology
It is seeming more likely that COVID-19, caused by the coronavirus SARS-CoV-2, will impact many people.Written By: Carmen LeitchMAR 08, 2020Genetics & Genomics
Cells have to store the entire genome in the nucleus, and this lengthy DNA molecule has to be carefully packaged by prot ...Written By: Carmen LeitchMAR 04, 2020Genetics & Genomics
An international team of researchers has analyzed cartilage from a baby duckbilled dinosaur, and they have identified bi ...Written By: Carmen LeitchFEB 17, 2020Cell & Molecular Biology
Some individuals are morning people to the extreme. Some genetic mutations give the body clock a 20 instead of 24-hour c ...Written By: Carmen LeitchFEB 10, 2020Immunology
Scientists discovered a new mechanism by which cancer cells evade the immune system to further their own agenda: invade, ...Written By: Kara MarkerFEB 09, 2020Cell & Molecular Biology
The X chromosome carries a thousand genes, so in females, one of the X chromosomes must be silenced to avoid serious dev ...Written By: Carmen LeitchFEB 07, 2020Clinical & Molecular DX
Intrinsic biophysical properties of proteins hold valuable clues about how they function and their role in disease. Take ...Written By: Tara FernandesJAN 23, 2020Cancer
New research published in the journal Cancer Cell investigates the role of circular RNAs in the spread of melanoma. Mela ...Written By: Kathryn DeMuth SullivanJAN 17, 2020Neuroscience
Approximately 1% of the world’s population have schizophrenia, with 3.2 million Americans having the disorder. Now ...Written By: Annie LennonJAN 15, 2020Cell & Molecular Biology
Cell division is a carefully regulated process, cancer is the result when it gets out of control.Written By: Carmen LeitchDEC 27, 2019Genetics & Genomics
It's been estimated that there are around 70 million pet dogs in the United States, with around 36 percent of househ ...Written By: Carmen Leitch
APR 12, 2020
Drug Discovery & Development
Can spider venom offer pain relief? Apparently, yes! According to researchers at University of Queensland, compounds iso
...
Written By:
Nouran Amin
APR 12, 2020
Cancer
A researcher from the James Graham Brown Cancer Center at the University of Louisville claims to have figured out the mo
...
Written By:
Kathryn DeMuth Sullivan
APR 09, 2020
Cancer
The research to find effective treatments and diagnosing tools in the fight against cancer has led to a thorough investi
...
Written By:
Jasper Cantrell
APR 07, 2020
Chemistry & Physics
Now more than ever we are all thinking about germs. Germs, microbes, bacteria, viruses – it’s a constant min
...
Written By:
Kathryn DeMuth Sullivan
APR 03, 2020
Genetics & Genomics
Less than a millisecond after a cell is stretched out, genes are activated, which will result in the production of prote
...
Written By:
Carmen Leitch
APR 02, 2020
Cancer
Thyroid cancer is the most common of the endocrine cancers, with papillary thyroid carcinomas (PTCs) being the mo
...
Written By:
Jasper Cantrell
MAR 27, 2020
Genetics & Genomics
CRISPR gene-editing technology has sparked a revolution in biomedical research and is poised to have far-reaching applic
...
Written By:
Carmen Leitch
MAR 25, 2020
Clinical & Molecular DX
A group of Canadian researchers is responding to a desperate need for COVID-19 diagnostic kits with their fluorescent im
...
Written By:
Tara Fernandes
MAR 24, 2020
Cell & Molecular Biology
ACEIs and ARBs may make coronavirus infections worse, which can help explain why older adults are faring so much worse.
Written By:
Carmen Leitch
MAR 19, 2020
Drug Discovery & Development
As panic is spreading over the novel coronavirus, the time is ripe for both misinformation and disinformation to thrive.
...
Written By:
Annie Lennon
MAR 17, 2020
Immunology
Structurally, SARS-CoV-2 (the virus that causes COVID-19) are spherical shells consisting of a lipid membrane, with a co
...
Written By:
Tara Fernandes
MAR 16, 2020
Genetics & Genomics
The genetic material from a sperm and an egg merges to form a new human genome, and now we know more details about the p
...
Written By:
Carmen Leitch
MAR 08, 2020
Cell & Molecular Biology
Scientists have identified a strategy used by cells to shield them from the toxins that can be released by dangerous bac
...
Written By:
Carmen Leitch
MAR 08, 2020
Microbiology
It is seeming more likely that COVID-19, caused by the coronavirus SARS-CoV-2, will impact many people.
Written By:
Carmen Leitch
MAR 08, 2020
Genetics & Genomics
Cells have to store the entire genome in the nucleus, and this lengthy DNA molecule has to be carefully packaged by prot
...
Written By:
Carmen Leitch
MAR 04, 2020
Genetics & Genomics
An international team of researchers has analyzed cartilage from a baby duckbilled dinosaur, and they have identified bi
...
Written By:
Carmen Leitch
FEB 17, 2020
Cell & Molecular Biology
Some individuals are morning people to the extreme. Some genetic mutations give the body clock a 20 instead of 24-hour c
...
Written By:
Carmen Leitch
FEB 10, 2020
Immunology
Scientists discovered a new mechanism by which cancer cells evade the immune system to further their own agenda: invade,
...
Written By:
Kara Marker
FEB 09, 2020
Cell & Molecular Biology
The X chromosome carries a thousand genes, so in females, one of the X chromosomes must be silenced to avoid serious dev
...
Written By:
Carmen Leitch
FEB 07, 2020
Clinical & Molecular DX
Intrinsic biophysical properties of proteins hold valuable clues about how they function and their role in disease. Take
...
Written By:
Tara Fernandes
JAN 23, 2020
Cancer
New research published in the journal Cancer Cell investigates the role of circular RNAs in the spread of melanoma. Mela
...
Written By:
Kathryn DeMuth Sullivan
JAN 17, 2020
Neuroscience
Approximately 1% of the world’s population have schizophrenia, with 3.2 million Americans having the disorder. Now
...
Written By:
Annie Lennon
JAN 15, 2020
Cell & Molecular Biology
Cell division is a carefully regulated process, cancer is the result when it gets out of control.
Written By:
Carmen Leitch
DEC 27, 2019
Genetics & Genomics
It's been estimated that there are around 70 million pet dogs in the United States, with around 36 percent of househ
...
Written By:
Carmen Leitch