Protein Engineering: is the process of developing useful or valuable proteins. It is a young discipline, with much research taking place into the understanding of protein folding and recognition for protein design principles.
Epigenetics refers to the study of nuclear architecture and gene regulation. Epigenetic mechanisms govern many physiological processes such as cell differentiation, x-inactivation, and genomi...
Healthcare is becoming more proactive and data-rich than anything before possible – and will increasingly focus on maintaining and enhancing wellness more than just reacting to disease....
Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
Cell growth and regulation involve vast networks of interacting DNAs, RNAs, proteins, lipids and sugars. Through a fundamental strategy of life, these interactions push multiple cellular proc...
In this era of precision molecular medicine, knowledge changes rapidly and is highly dispersed. Physicians and patients are faced with conflicting expert opinions and a shortage of acti...
Clinical whole genome sequencing (cWGS) is rapidly gaining acceptance as cost is decreasing and success rates in identifying disease-causing variants are increasing. While the application of...
Although there have been enormous advances in gene sequencing, the results give massive amounts of data that only point to disease risk. Major health factors, including diet, lifestyle, envir...
Psychiatric disorders are among the leading causes of disability worldwide. One fifth of the population will suffer from a psychiatric disorder in their lifetime. Antipsychotic and antidepres...
Best practices for developing precision medicine diagnostics can include completing a retrospective analysis. Obtaining enough samples to have a statistically significant study typicall...
Liquid Biopsies are gaining acceptance in the Oncology community as a surrogate or complement to the gold standard of tissue biopsy. A liquid biopsy provides biomarker information that...
Biobanks are a powerful resource in the advancement of precision medicine, and integrating large scale genomics data across Biobank cohorts offer opportunities to further enhance and expedite...
Challenges in achieving comparability, reproducibility and accuracy in biological assays has driven a demand for improved confidence in measurements that support development of regenerative m...
In this talk, I will use examples from my research using big data analytics to define ideals of precision medicine and digital health across a variety of diseases. Specifically, I will i...
Much has been made in the popular press about importance of our "genes" in everything from our weight, intelligence, and our risk of disease. While there is a scientific basis...
Identification of the many complex genetic aberrations associated with cancers, and deciphering their role in disease progression and response to treatment is one of the major challenges face...
Gastrointestinal (GI) disorders are now widely recognized as a clinical symptom of autism spectrum disorder (ASD), and research into the microbiome-gut-brain axis is beginning to reveal the i...
Launched in early 2015, the Precision Medicine Initiative (PMI) takes advantage of the progress made in genomic testing – progress largely driven by rapid advances in DNA sequencing tec...
The starting point for an interaction between a patient and a clinician is almost always a set of clinical facts (aka a phenotype). Phenotype-first medicine is the standard way in which the p...
Recent advances in DNA sequencing have now made it possible to characterize genomes, transcriptomes and even methylomes which is transforming both basic research and clinical practice. Whole...
The CRISPR-Cas9 system is being widely used for genome engineering in many different biological applications. It was originally adapted from the bacterial Type II CRISPR system and uses a Cas...
This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway wil...
The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. In early 2016 we developed a pipe...
DATE: September 20, 2016
TIME: 8:00am PST, 11:00 EST
Studies of cell-substrate interactions are important for an array of biotechnology applications. The nature of specific, recepto...
It is well accepted that microorganisms can exist as self-organized communities attached to surfaces and one another (i.e., biofilm), often surrounded by extracellular polymeric substances (E...
Epigenetics refers to the study of nuclear architecture and gene regulation. Epigenetic mechanisms govern many physiological processes such as cell differentiation, x-inactivation, and genomi...
Healthcare is becoming more proactive and data-rich than anything before possible – and will increasingly focus on maintaining and enhancing wellness more than just reacting to disease....
Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
Cell growth and regulation involve vast networks of interacting DNAs, RNAs, proteins, lipids and sugars. Through a fundamental strategy of life, these interactions push multiple cellular proc...
In this era of precision molecular medicine, knowledge changes rapidly and is highly dispersed. Physicians and patients are faced with conflicting expert opinions and a shortage of acti...
Clinical whole genome sequencing (cWGS) is rapidly gaining acceptance as cost is decreasing and success rates in identifying disease-causing variants are increasing. While the application of...
Although there have been enormous advances in gene sequencing, the results give massive amounts of data that only point to disease risk. Major health factors, including diet, lifestyle, envir...
Psychiatric disorders are among the leading causes of disability worldwide. One fifth of the population will suffer from a psychiatric disorder in their lifetime. Antipsychotic and antidepres...
Best practices for developing precision medicine diagnostics can include completing a retrospective analysis. Obtaining enough samples to have a statistically significant study typicall...
Liquid Biopsies are gaining acceptance in the Oncology community as a surrogate or complement to the gold standard of tissue biopsy. A liquid biopsy provides biomarker information that...
Biobanks are a powerful resource in the advancement of precision medicine, and integrating large scale genomics data across Biobank cohorts offer opportunities to further enhance and expedite...
Challenges in achieving comparability, reproducibility and accuracy in biological assays has driven a demand for improved confidence in measurements that support development of regenerative m...
In this talk, I will use examples from my research using big data analytics to define ideals of precision medicine and digital health across a variety of diseases. Specifically, I will i...
Much has been made in the popular press about importance of our "genes" in everything from our weight, intelligence, and our risk of disease. While there is a scientific basis...
Identification of the many complex genetic aberrations associated with cancers, and deciphering their role in disease progression and response to treatment is one of the major challenges face...
Gastrointestinal (GI) disorders are now widely recognized as a clinical symptom of autism spectrum disorder (ASD), and research into the microbiome-gut-brain axis is beginning to reveal the i...
Launched in early 2015, the Precision Medicine Initiative (PMI) takes advantage of the progress made in genomic testing – progress largely driven by rapid advances in DNA sequencing tec...
The starting point for an interaction between a patient and a clinician is almost always a set of clinical facts (aka a phenotype). Phenotype-first medicine is the standard way in which the p...
Recent advances in DNA sequencing have now made it possible to characterize genomes, transcriptomes and even methylomes which is transforming both basic research and clinical practice. Whole...
The CRISPR-Cas9 system is being widely used for genome engineering in many different biological applications. It was originally adapted from the bacterial Type II CRISPR system and uses a Cas...
This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway wil...
The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. In early 2016 we developed a pipe...
DATE: September 20, 2016
TIME: 8:00am PST, 11:00 EST
Studies of cell-substrate interactions are important for an array of biotechnology applications. The nature of specific, recepto...
It is well accepted that microorganisms can exist as self-organized communities attached to surfaces and one another (i.e., biofilm), often surrounded by extracellular polymeric substances (E...
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