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    Translational Research

    Translational Research: involves the application of knowledge gained through basic research to studies that could support the development of new products. For example, translational research in the field of medicine may involve using knowledge of the biology of a disease to identify and evaluate chemical compounds in disease models, with a view to selecting potential candidate drugs to advance into clinical trials.

    Webinars

    • OCT 17, 2013 | 12:00 PM
      C.E. CREDITS
      Embracing the Complexity of Cancer: Seeing the Forest and the Trees
      Embracing the Complexity of Cancer: Seeing the Forest and the...
      Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
      Speaker: Kenneth Buetow, PhD, FACMI
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      34
      OCT 17, 2013 | 9:00 AM
      C.E. CREDITS
      Subtyping Circulating Tumor Cells in Breast Cancer for Personalized Therapeutics
      Subtyping Circulating Tumor Cells in Breast Cancer for Personalized...
      Cancer metastases develop when tumor cells known as circulating tumor cells (CTCs) are shed from a tumor, circulate through the blood stream and colonize a distant tissue. The number of CTCs...
      Speaker: Lori M. Millner, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      86
      OCT 17, 2013 | 7:00 AM
      Advancing Translational Cancer Research through Automated RNASeq Sample Preparation from Archival FFPE Tissue Specimens
      Advancing Translational Cancer Research through Automated RNASeq...
      RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
      Speaker: Michaela Bowden, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      98
      OCT 16, 2013 | 1:00 PM
      C.E. CREDITS
      Resistance to AR Signaling Inhibitors in Castration Resistant Prostate Cancer
      Resistance to AR Signaling Inhibitors in Castration Resistant...
      While androgen deprivation therapy (ADT) remains the primary treatment modality for patients with metastatic prostate cancer (PCa), treatment is uniformly marked by progression to castration-...
      Speaker: Elahe A Mostaghel, MD, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      80
      OCT 16, 2013 | 12:00 PM
      C.E. CREDITS
      New therapeutic strategies and new modes of drug resistance: From the bench to bedside and back again with the oncogene eIF4E
      New therapeutic strategies and new modes of drug resistance: From...
      The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well a...
      Speaker: Katherine LB Borden, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      60
      OCT 16, 2013 | 12:00 PM
      Fast-Tracking Molecular Diagnostics in Oncology via Antibody-Based Proteomics and Digital Pathology
      Fast-Tracking Molecular Diagnostics in Oncology via Antibody-Based...
      The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Th...
      Speaker: William M. Gallagher, PhD.
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      98
      OCT 16, 2013 | 11:00 AM
      Molecular Prognosis in the Management of Early Stage Lung Cancer
      Molecular Prognosis in the Management of Early Stage Lung Cancer
      Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, a...
      Speaker: Michael J Mann, MD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      58
      OCT 16, 2013 | 7:00 AM
      C.E. CREDITS
      Prognostic, predictive, and surrogate biomarkers in men with castration resistant metastatic prostate cancer
      Prognostic, predictive, and surrogate biomarkers in men with castration...
      With the rapid rise in the number of therapeutic options for men with castration-resistant prostate cancer (CRPC) comes increasingly complicated treatment decision-making, emphasizing the nee...
      Speaker: Andrew Armstrong, MD ScM FACP
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      96
      OCT 16, 2013 | 6:00 AM
      Building an Ion AmpliSeq Colon and Lung Cancer Panel - Consortium development of a tool for clinical research applications
      Building an Ion AmpliSeq Colon and Lung Cancer Panel - Consortium...
      The knowledge of molecular alterations involved in colon carcinoma (CRC) and non-small-cell lung carcinoma (NSCLC) has significantly increased in the past few years. Molecular subgroups of t...
      Speaker: Nicola Normanno, MD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      102
      AUG 22, 2013 | 5:00 PM
      Clinical Utility Potential of Epigenetic Aberrations in Human Solid Tumors
      Clinical Utility Potential of Epigenetic Aberrations in Human...
      As Chief of Scientific Intelligence at the John Wayne Cancer Institute, Dr. Hoon interacts with external academic, industry, and government agencies to develop innovative translational rese...
      Speaker: Dave S Hoon, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      104
      AUG 22, 2013 | 3:00 PM
      C.E. CREDITS
      Evaluation challenges and regulatory considerations for next-generation sequencing and other high throughput genomic technology based clinical applications
      Evaluation challenges and regulatory considerations for next-generation...
      The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
      Speaker: Živana Težak, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      282
      AUG 22, 2013 | 2:00 PM
      Translation and Clinical Application of Innovative Genomic Analysis: Challenges Remain
      Translation and Clinical Application of Innovative Genomic Analysis:...
      The role of the human genome in normal and patho-biology is crucial. Applied in cancer care and in a variety of unknown disorder settings, it can provide key insights and crucial diagnostic/p...
      Speaker: Paul Billings, MD, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      92
      AUG 22, 2013 | 1:00 PM
      Embracing the Complexity of Cancer: Seeing the Forest and the Trees
      Embracing the Complexity of Cancer: Seeing the Forest and the...
      Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
      Speaker: Kenneth Buetow, PhD, FACMI
      Presented at: Genetics and Genomics Virtual Event Series 2013
      92
      AUG 22, 2013 | 1:00 PM
      Dominant regulation of gene expression by microRNAs
      Dominant regulation of gene expression by microRNAs
      MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half o...
      Speaker: Noam Shomron, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      121
      AUG 22, 2013 | 9:00 AM
      C.E. CREDITS
      Return of Genome Sequencing Results to Physicians and Patients
      Return of Genome Sequencing Results to Physicians and Patients
      There has been considerable debate in the scientific and clinical communities regarding the return of results from genome sequencing to physicians and patients. Questions surrounding which he...
      Speaker: Cinnamon S Bloss, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      56
      AUG 22, 2013 | 9:00 AM
      C.E. CREDITS
      Management and Analysis of Pre-implantation Genetic Diagnosis Data
      Management and Analysis of Pre-implantation Genetic Diagnosis...
      During IVF procedures pre-implantation genetic diagnosis (PGD) allows for genetic profiling of embryos prior to replacement. Most PGD procedures during IVF are performed to select chromosomal...
      Speaker: Deanne Taylor, MS, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      34
      AUG 21, 2013 | 4:00 PM
      C.E. CREDITS
      Development of Targeted Next Generation Sequencing for Pharmacogenomics
      Development of Targeted Next Generation Sequencing for Pharmacogenomics
      The goal of personalized medicine is to customize healthcare to the individual patient. Pharmacogenomics, the analysis of how a patient's genetic makeup affects the individual's response to c...
      Speaker: Edward Ki Yun Leung, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      42
      AUG 21, 2013 | 2:00 PM
      C.E. CREDITS
      Comprehensive Chromosome Screening in the Human Embryo
      Comprehensive Chromosome Screening in the Human Embryo
      The human species is particularly prone to chromosome segregation errors during maternal meiosis in the egg and during post zygotic mitosis in the preimplantation embryo. In fact, aneuploidy...
      Speaker: Nathan R Treff, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      33
      AUG 21, 2013 | 2:00 PM
      Claritas Genomics: The Future of Pediatric Diagnostics is Now
      Claritas Genomics: The Future of Pediatric Diagnostics is Now
      Increasingly genome sequence knowledge is unraveling the complexity of rare Mendelian disorders offering hope for our children's medical care through better disease diagnosis and ultimately p...
      Speaker: Patrice Milos, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      96
      AUG 21, 2013 | 1:00 PM
      C.E. CREDITS
      Codon optimization: new safety concerns for gene therapy and genetic vaccines
      Codon optimization: new safety concerns for gene therapy and genetic...
      Codon-optimization describes gene engineering approaches that use synonymous codon changes to increase protein production. It is used extensively for expressing recombinant protein drugs, gen...
      Speaker: Vincent P Mauro, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      86
      AUG 21, 2013 | 10:00 AM
      C.E. CREDITS
      Genomic Approaches to Discover Biomarkers of Drug Response in Cancer
      Genomic Approaches to Discover Biomarkers of Drug Response in...
      Massively parallel sequencing technology has proven to enable the identification of driver genetic alterations in patients' tumors that may be suppressed by targeted therapies. Through retros...
      Speaker: Michael F Berger, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      117
      AUG 21, 2013 | 8:00 AM
      Post Genome-Wide Association Studies
      Post Genome-Wide Association Studies
      In this presentation I describe some of the approaches we are taking to identify the genetic architecture of common complex cancers with a particular focus on the etiology of lung cancer. Can...
      Speaker: Christopher I Amos, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      105
      MAY 30, 2013 | 9:00 AM
      Molecular Prognosis in the Management of Early Stage Lung Cancer
      Molecular Prognosis in the Management of Early Stage Lung Cancer
      Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, as...
      Speaker: Michael J Mann, MD
      Presented at: Clinical Diagnostics Virtual Event Series 2013
      19
      MAY 10, 2013 | 9:00 AM
      Renin: Clinical Utility of Renin Measurement in Hypertension
      Renin: Clinical Utility of Renin Measurement in Hypertension
       Measurement of renin and its activity is increasingly used in the evaluation of circulatory function. This is primarily driven by a higher than previously realized prevalence of primary hype...
      Speaker: Jonathan Williams, MD, MMSc
      Sponsored By: DiaSorin no, Diasorin
      49
    OCT 17, 2013 | 12:00 PM
    C.E. CREDITS
    Embracing the Complexity of Cancer: Seeing the Forest and the Trees
    Embracing the Complexity of Cancer: Seeing the Forest and the...
    Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
    Speaker: Kenneth Buetow, PhD, FACMI
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    34
    OCT 17, 2013 | 9:00 AM
    C.E. CREDITS
    Subtyping Circulating Tumor Cells in Breast Cancer for Personalized Therapeutics
    Subtyping Circulating Tumor Cells in Breast Cancer for Personalized...
    Cancer metastases develop when tumor cells known as circulating tumor cells (CTCs) are shed from a tumor, circulate through the blood stream and colonize a distant tissue. The number of CTCs...
    Speaker: Lori M. Millner, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    86
    OCT 17, 2013 | 7:00 AM
    Advancing Translational Cancer Research through Automated RNASeq Sample Preparation from Archival FFPE Tissue Specimens
    Advancing Translational Cancer Research through Automated RNASeq...
    RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
    Speaker: Michaela Bowden, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    98
    OCT 16, 2013 | 1:00 PM
    C.E. CREDITS
    Resistance to AR Signaling Inhibitors in Castration Resistant Prostate Cancer
    Resistance to AR Signaling Inhibitors in Castration Resistant...
    While androgen deprivation therapy (ADT) remains the primary treatment modality for patients with metastatic prostate cancer (PCa), treatment is uniformly marked by progression to castration-...
    Speaker: Elahe A Mostaghel, MD, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    80
    OCT 16, 2013 | 12:00 PM
    C.E. CREDITS
    New therapeutic strategies and new modes of drug resistance: From the bench to bedside and back again with the oncogene eIF4E
    New therapeutic strategies and new modes of drug resistance: From...
    The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well a...
    Speaker: Katherine LB Borden, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    60
     
     
  • OCT 16, 2013 | 12:00 PM
    Fast-Tracking Molecular Diagnostics in Oncology via Antibody-Based Proteomics and Digital Pathology
    Fast-Tracking Molecular Diagnostics in Oncology via Antibody-Based...
    The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Th...
    Speaker: William M. Gallagher, PhD.
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    98
    OCT 16, 2013 | 11:00 AM
    Molecular Prognosis in the Management of Early Stage Lung Cancer
    Molecular Prognosis in the Management of Early Stage Lung Cancer
    Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, a...
    Speaker: Michael J Mann, MD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    58
    OCT 16, 2013 | 7:00 AM
    C.E. CREDITS
    Prognostic, predictive, and surrogate biomarkers in men with castration resistant metastatic prostate cancer
    Prognostic, predictive, and surrogate biomarkers in men with castration...
    With the rapid rise in the number of therapeutic options for men with castration-resistant prostate cancer (CRPC) comes increasingly complicated treatment decision-making, emphasizing the nee...
    Speaker: Andrew Armstrong, MD ScM FACP
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    96
    OCT 16, 2013 | 6:00 AM
    Building an Ion AmpliSeq Colon and Lung Cancer Panel - Consortium development of a tool for clinical research applications
    Building an Ion AmpliSeq Colon and Lung Cancer Panel - Consortium...
    The knowledge of molecular alterations involved in colon carcinoma (CRC) and non-small-cell lung carcinoma (NSCLC) has significantly increased in the past few years. Molecular subgroups of t...
    Speaker: Nicola Normanno, MD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    102
    AUG 22, 2013 | 5:00 PM
    Clinical Utility Potential of Epigenetic Aberrations in Human Solid Tumors
    Clinical Utility Potential of Epigenetic Aberrations in Human...
    As Chief of Scientific Intelligence at the John Wayne Cancer Institute, Dr. Hoon interacts with external academic, industry, and government agencies to develop innovative translational rese...
    Speaker: Dave S Hoon, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    104
     
     
  • AUG 22, 2013 | 3:00 PM
    C.E. CREDITS
    Evaluation challenges and regulatory considerations for next-generation sequencing and other high throughput genomic technology based clinical applications
    Evaluation challenges and regulatory considerations for next-generation...
    The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
    Speaker: Živana Težak, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    282
    AUG 22, 2013 | 2:00 PM
    Translation and Clinical Application of Innovative Genomic Analysis: Challenges Remain
    Translation and Clinical Application of Innovative Genomic Analysis:...
    The role of the human genome in normal and patho-biology is crucial. Applied in cancer care and in a variety of unknown disorder settings, it can provide key insights and crucial diagnostic/p...
    Speaker: Paul Billings, MD, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    92
    AUG 22, 2013 | 1:00 PM
    Embracing the Complexity of Cancer: Seeing the Forest and the Trees
    Embracing the Complexity of Cancer: Seeing the Forest and the...
    Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
    Speaker: Kenneth Buetow, PhD, FACMI
    Presented at: Genetics and Genomics Virtual Event Series 2013
    92
    AUG 22, 2013 | 1:00 PM
    Dominant regulation of gene expression by microRNAs
    Dominant regulation of gene expression by microRNAs
    MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half o...
    Speaker: Noam Shomron, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    121
    AUG 22, 2013 | 9:00 AM
    C.E. CREDITS
    Return of Genome Sequencing Results to Physicians and Patients
    Return of Genome Sequencing Results to Physicians and Patients
    There has been considerable debate in the scientific and clinical communities regarding the return of results from genome sequencing to physicians and patients. Questions surrounding which he...
    Speaker: Cinnamon S Bloss, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    56
     
     
  • AUG 22, 2013 | 9:00 AM
    C.E. CREDITS
    Management and Analysis of Pre-implantation Genetic Diagnosis Data
    Management and Analysis of Pre-implantation Genetic Diagnosis...
    During IVF procedures pre-implantation genetic diagnosis (PGD) allows for genetic profiling of embryos prior to replacement. Most PGD procedures during IVF are performed to select chromosomal...
    Speaker: Deanne Taylor, MS, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    34
    AUG 21, 2013 | 4:00 PM
    C.E. CREDITS
    Development of Targeted Next Generation Sequencing for Pharmacogenomics
    Development of Targeted Next Generation Sequencing for Pharmacogenomics
    The goal of personalized medicine is to customize healthcare to the individual patient. Pharmacogenomics, the analysis of how a patient's genetic makeup affects the individual's response to c...
    Speaker: Edward Ki Yun Leung, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    42
    AUG 21, 2013 | 2:00 PM
    C.E. CREDITS
    Comprehensive Chromosome Screening in the Human Embryo
    Comprehensive Chromosome Screening in the Human Embryo
    The human species is particularly prone to chromosome segregation errors during maternal meiosis in the egg and during post zygotic mitosis in the preimplantation embryo. In fact, aneuploidy...
    Speaker: Nathan R Treff, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    33
    AUG 21, 2013 | 2:00 PM
    Claritas Genomics: The Future of Pediatric Diagnostics is Now
    Claritas Genomics: The Future of Pediatric Diagnostics is Now
    Increasingly genome sequence knowledge is unraveling the complexity of rare Mendelian disorders offering hope for our children's medical care through better disease diagnosis and ultimately p...
    Speaker: Patrice Milos, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    96
    AUG 21, 2013 | 1:00 PM
    C.E. CREDITS
    Codon optimization: new safety concerns for gene therapy and genetic vaccines
    Codon optimization: new safety concerns for gene therapy and genetic...
    Codon-optimization describes gene engineering approaches that use synonymous codon changes to increase protein production. It is used extensively for expressing recombinant protein drugs, gen...
    Speaker: Vincent P Mauro, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    86
     
     
  • AUG 21, 2013 | 10:00 AM
    C.E. CREDITS
    Genomic Approaches to Discover Biomarkers of Drug Response in Cancer
    Genomic Approaches to Discover Biomarkers of Drug Response in...
    Massively parallel sequencing technology has proven to enable the identification of driver genetic alterations in patients' tumors that may be suppressed by targeted therapies. Through retros...
    Speaker: Michael F Berger, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    117
    AUG 21, 2013 | 8:00 AM
    Post Genome-Wide Association Studies
    Post Genome-Wide Association Studies
    In this presentation I describe some of the approaches we are taking to identify the genetic architecture of common complex cancers with a particular focus on the etiology of lung cancer. Can...
    Speaker: Christopher I Amos, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    105
    MAY 30, 2013 | 9:00 AM
    Molecular Prognosis in the Management of Early Stage Lung Cancer
    Molecular Prognosis in the Management of Early Stage Lung Cancer
    Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, as...
    Speaker: Michael J Mann, MD
    Presented at: Clinical Diagnostics Virtual Event Series 2013
    19
    MAY 10, 2013 | 9:00 AM
    Renin: Clinical Utility of Renin Measurement in Hypertension
    Renin: Clinical Utility of Renin Measurement in Hypertension
     Measurement of renin and its activity is increasingly used in the evaluation of circulatory function. This is primarily driven by a higher than previously realized prevalence of primary hype...
    Speaker: Jonathan Williams, MD, MMSc
    Sponsored By: DiaSorin no, Diasorin
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