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    ADME-Tox

    ADME is an abbreviation in pharmacokinetics and pharmacology for "absorption, distribution, metabolism, and excretion". ADME-Tox studies are essential for the drug discovery process, as they can save development costs and time, and reduce the likelihood of failure.

    Webinars

    • FEB 26, 2020 | 7:30 AM
      Keynote Presentation: Emerging Drug Combinations: Evolution From Pre-Clinical Discovery to Clinical Development
      Keynote Presentation: Emerging Drug Combinations: Evolution From...
      Recent advances in DNA sequencing and omics-based capabilities are revealing incredible therapeutic opportunities and quickly transforming drug discovery. Molecularly targeted drugs aim to e...
      Speaker: Khyati Shah, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Vancomycin:  How might Urinary Biomarkers and Precision Dosing create Precision Medicine for the most frequently utilized antibiotic in the hospital?
      Vancomycin: How might Urinary Biomarkers and Precision Dosing...
      Learning Objectives: 1. Describe the exposure response relationships with vancomycin and acute kidney injury 2. Define biomarkers that may be useful to improve Precision Dosing...
      Speaker: Marc Scheetz, PharmD, MSc, FCCP, FCP
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Microphysiological Systems for Human Focused Drug Discovery
      Microphysiological Systems for Human Focused Drug Discovery
      Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
      Speaker: Tomasz Kostrzewski, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      3
      JAN 01, 2020 | 6:00 AM
      3D-Micro Tissues in Translational Toxicology and Disease Modelling
      3D-Micro Tissues in Translational Toxicology and Disease Modelling
      The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
      Speaker: Armin Wolf, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Human Tissue models for better therapies
      Human Tissue models for better therapies
      The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture chambers that allow co-culture o...
      Speaker: Sebastiaan Trietsch, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Generation of expanded primary liver cells
      Generation of expanded primary liver cells
      The use of primary cells in vitro is compromised by the limited quantity of cells that can be isolated from one donor, a lack of or very restricted proliferation capacity (e.g. hepatocytes)...
      Speaker: Astrid Nörenberg, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
      Uncovering the mechanism of stress-resistant DNA replication in...
      Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
      Speaker: Chames Kermi, PhD, PharmD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      CK18 as a Biomarker in NASH Clinical Trials
      CK18 as a Biomarker in NASH Clinical Trials
      Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in developed countries, and it affects over 25% of the population worldwide. Within the next five y...
      Speaker: Jessica Tuohy, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      2
      JAN 01, 2020 | 6:00 AM
      Measuring What Matters:  Proliferation and Cell Death Biomarkers for Oncology Research
      Measuring What Matters: Proliferation and Cell Death Biomarkers...
      Biomarkers are critical tools for all stages of cancer research, from drug development through clinical applications. Cancer is fundamentally a disease of unregulated cell growth and circumv...
      Speaker: Olivia Stricker, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Organoids: A Revolutionary New Tool for Drug Screening
      Organoids: A Revolutionary New Tool for Drug Screening
      “The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
      Speaker: Rekha Pal, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Microfabricated Human Liver Tissues for Drug Development
      Microfabricated Human Liver Tissues for Drug Development
      The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug fai...
      Speaker: Salman Khetani, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Using 3D cell culture models and high content confocal imaging to evaluate efficacy and expose toxic liabilities in the drug development pipeline
      Using 3D cell culture models and high content confocal imaging...
      With an increasing push to improve safety, efficacy, and efficiency throughout the drug development pipeline, researchers are evermore looking to improve the predictive capacity of their in...
      Speaker: Erin Edwards, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      OCT 29, 2019 | 7:00 AM
      Optimizing high-content screening tools for physiologically-relevant 3D in vitro models
      Optimizing high-content screening tools for physiologically-relevant...
      DATE: October 29, 2019TIME: 7:00am PDT3D cell culture systems have recently emerged as tools for reproducing the cellular environment and the organization of tissues/organs, where cel...
      Speaker: Elodie Vandenhaute , Zied Souguir , Daniel O'Connor
      Sponsored By: Molecular Devices
      8
      AUG 27, 2019 | 9:00 AM
      Akoya Biosciences Webinar Series:  Comprehensive Meta-analysis of Biomarker Technologies for Predictive Response of PD-1/PD-L1 Checkpoint Therapies
      Akoya Biosciences Webinar Series: Comprehensive Meta-analysis...
      DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
      Speaker: Cliff Hoyt, PhD , Steve Lu
      Sponsored By: Akoya Biosciences
      5
      JUN 19, 2019 | 10:00 AM
      Getting started in 3D:  Ask an Expert
      Getting started in 3D: Ask an Expert
      DATE: June 19, 2019TIME: 10:00am PDT, 1:00pm EDT As we develop new methods to create more biologically relevant models for research in understanding disease etiology and in...
      Speaker: Mark Kennedy, Ph.D. , Richard Josephson, PhD
      Sponsored By: Thermo Fisher Scientific
      6
      APR 17, 2019 | 9:00 AM
      You've cultured an organoid and spheroid... now what?
      You've cultured an organoid and spheroid... now what?
      DATE:  April 17, 2019TIME:  9:00am PDT...
      Speaker: Takanori Takebe
      Sponsored By: Thermo Fisher Scientific
      5
      APR 03, 2019 | 9:00 AM
      How to analyze/characterize your 3D culture
      How to analyze/characterize your 3D culture
      DATE:  April 3, 2019TIME:  9:00am PDT...
      Speaker: Chris Langsdorf
      Sponsored By: Thermo Fisher Scientific
      6
      MAR 20, 2019 | 9:00 AM
      Getting started in 3D - Setting up your lab and reviewing common pitfalls of researchers new to 3D
      Getting started in 3D - Setting up your lab and reviewing common...
      DATE:  March 20, 2019TIME:  9:00am PDT...
      Speaker: Mark Kennedy, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      7
      FEB 27, 2019 | 3:00 PM
      BASKET Trials: Biomarker Driven Drug Development
      BASKET Trials: Biomarker Driven Drug Development
      Dramatic responses observed with targeted agents in the ‘right’ genomic context have fueled large scale sequencing efforts to identify ‘effective’ treatments for a giv...
      Speaker: Shivaani Kummar, MD, FACP
      Presented at: Drug Discovery Virtual Event Series 2019
      2
      FEB 27, 2019 | 3:00 PM
      Do You Have the Gut-on-a-Chip?
      Do You Have the Gut-on-a-Chip?
      In-vitro epithelial barrier models that are more representative of in-vivo tissues are urgently needed. Here we present extracellular matrix-supported intestinal tubules in a perfused microfl...
      Speaker: Elena Naumovska, PhD
      Presented at: Drug Discovery Virtual Event Series 2019
      2
      FEB 27, 2019 | 3:00 PM
      Targeted Cancer Chemotherapy: Developing NextGen Antibody-Drug Conjugates
      Targeted Cancer Chemotherapy: Developing NextGen Antibody-Drug...
      In today's presentation I will give an overview to developing NextGen ADCs. We will discuss everything from the beginning stages of development to the varying ADC combination therapies av...
      Speaker: Jagath Reddy Junutula, PhD
      Presented at: Drug Discovery Virtual Event Series 2019
      1
      FEB 27, 2019 | 3:00 PM
      Automation Meets Cell Separation: Primary Cells for Drug Discovery Assays
      Automation Meets Cell Separation: Primary Cells for Drug Discovery...
      Whether you are performing killing assays, immunophenotyping of TILs, characterizing the tumor microenvironment, or investigating immunogenicity, primary cells are essential for the discovery...
      Speaker: Lotta Raty
      Presented at: Drug Discovery Virtual Event Series 2019
      Sponsored By: Miltenyi Biotec
      2
      FEB 27, 2019 | 1:30 PM
      Advanced Liver Tissue Model for Improved in Vitro Prediction
      Advanced Liver Tissue Model for Improved in Vitro Prediction
      Isolated hepatocytes or their enzymes comprise the basis of most in vitro DMPK and toxicity assays used to predict human hepatic outcomes. Because hepato-specific functions are typically lost...
      Speaker: Matthew Shipton, MS
      Presented at: Drug Discovery Virtual Event Series 2019
      1
      FEB 27, 2019 | 1:30 PM
      Comprehensive NTRK Fusion Detection, Agnostic of the Fusion Partner, for Optimal Identification of Rare Genomic Events Using TruSightTM Oncology 500
      Comprehensive NTRK Fusion Detection, Agnostic of the Fusion Partner,...
      NTRK fusions are rare but important recent biomarkers linked to response to new TRK inhibitors. Comprehensive genomic profiling on all solid tumors permits detection of rare genomic events an...
      Speaker: Phillip Febbo, MD , Maude Champagne
      Presented at: Drug Discovery Virtual Event Series 2019
      Sponsored By: Illumina
      4
    FEB 26, 2020 | 7:30 AM
    Keynote Presentation: Emerging Drug Combinations: Evolution From Pre-Clinical Discovery to Clinical Development
    Keynote Presentation: Emerging Drug Combinations: Evolution From...
    Recent advances in DNA sequencing and omics-based capabilities are revealing incredible therapeutic opportunities and quickly transforming drug discovery. Molecularly targeted drugs aim to e...
    Speaker: Khyati Shah, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Vancomycin:  How might Urinary Biomarkers and Precision Dosing create Precision Medicine for the most frequently utilized antibiotic in the hospital?
    Vancomycin: How might Urinary Biomarkers and Precision Dosing...
    Learning Objectives: 1. Describe the exposure response relationships with vancomycin and acute kidney injury 2. Define biomarkers that may be useful to improve Precision Dosing...
    Speaker: Marc Scheetz, PharmD, MSc, FCCP, FCP
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Microphysiological Systems for Human Focused Drug Discovery
    Microphysiological Systems for Human Focused Drug Discovery
    Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
    Speaker: Tomasz Kostrzewski, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    3
    JAN 01, 2020 | 6:00 AM
    3D-Micro Tissues in Translational Toxicology and Disease Modelling
    3D-Micro Tissues in Translational Toxicology and Disease Modelling
    The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
    Speaker: Armin Wolf, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Human Tissue models for better therapies
    Human Tissue models for better therapies
    The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture chambers that allow co-culture o...
    Speaker: Sebastiaan Trietsch, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
     
     
  • JAN 01, 2020 | 6:00 AM
    Generation of expanded primary liver cells
    Generation of expanded primary liver cells
    The use of primary cells in vitro is compromised by the limited quantity of cells that can be isolated from one donor, a lack of or very restricted proliferation capacity (e.g. hepatocytes)...
    Speaker: Astrid Nörenberg, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
    Uncovering the mechanism of stress-resistant DNA replication in...
    Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
    Speaker: Chames Kermi, PhD, PharmD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    CK18 as a Biomarker in NASH Clinical Trials
    CK18 as a Biomarker in NASH Clinical Trials
    Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in developed countries, and it affects over 25% of the population worldwide. Within the next five y...
    Speaker: Jessica Tuohy, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    2
    JAN 01, 2020 | 6:00 AM
    Measuring What Matters:  Proliferation and Cell Death Biomarkers for Oncology Research
    Measuring What Matters: Proliferation and Cell Death Biomarkers...
    Biomarkers are critical tools for all stages of cancer research, from drug development through clinical applications. Cancer is fundamentally a disease of unregulated cell growth and circumv...
    Speaker: Olivia Stricker, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Organoids: A Revolutionary New Tool for Drug Screening
    Organoids: A Revolutionary New Tool for Drug Screening
    “The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
    Speaker: Rekha Pal, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
     
     
  • JAN 01, 2020 | 6:00 AM
    Microfabricated Human Liver Tissues for Drug Development
    Microfabricated Human Liver Tissues for Drug Development
    The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug fai...
    Speaker: Salman Khetani, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Using 3D cell culture models and high content confocal imaging to evaluate efficacy and expose toxic liabilities in the drug development pipeline
    Using 3D cell culture models and high content confocal imaging...
    With an increasing push to improve safety, efficacy, and efficiency throughout the drug development pipeline, researchers are evermore looking to improve the predictive capacity of their in...
    Speaker: Erin Edwards, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    OCT 29, 2019 | 7:00 AM
    Optimizing high-content screening tools for physiologically-relevant 3D in vitro models
    Optimizing high-content screening tools for physiologically-relevant...
    DATE: October 29, 2019TIME: 7:00am PDT3D cell culture systems have recently emerged as tools for reproducing the cellular environment and the organization of tissues/organs, where cel...
    Speaker: Elodie Vandenhaute , Zied Souguir , Daniel O'Connor
    Sponsored By: Molecular Devices
    8
    AUG 27, 2019 | 9:00 AM
    Akoya Biosciences Webinar Series:  Comprehensive Meta-analysis of Biomarker Technologies for Predictive Response of PD-1/PD-L1 Checkpoint Therapies
    Akoya Biosciences Webinar Series: Comprehensive Meta-analysis...
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    Speaker: Cliff Hoyt, PhD , Steve Lu
    Sponsored By: Akoya Biosciences
    5
    JUN 19, 2019 | 10:00 AM
    Getting started in 3D:  Ask an Expert
    Getting started in 3D: Ask an Expert
    DATE: June 19, 2019TIME: 10:00am PDT, 1:00pm EDT As we develop new methods to create more biologically relevant models for research in understanding disease etiology and in...
    Speaker: Mark Kennedy, Ph.D. , Richard Josephson, PhD
    Sponsored By: Thermo Fisher Scientific
    6
     
     
  • APR 17, 2019 | 9:00 AM
    You've cultured an organoid and spheroid... now what?
    You've cultured an organoid and spheroid... now what?
    DATE:  April 17, 2019TIME:  9:00am PDT...
    Speaker: Takanori Takebe
    Sponsored By: Thermo Fisher Scientific
    5
    APR 03, 2019 | 9:00 AM
    How to analyze/characterize your 3D culture
    How to analyze/characterize your 3D culture
    DATE:  April 3, 2019TIME:  9:00am PDT...
    Speaker: Chris Langsdorf
    Sponsored By: Thermo Fisher Scientific
    6
    MAR 20, 2019 | 9:00 AM
    Getting started in 3D - Setting up your lab and reviewing common pitfalls of researchers new to 3D
    Getting started in 3D - Setting up your lab and reviewing common...
    DATE:  March 20, 2019TIME:  9:00am PDT...
    Speaker: Mark Kennedy, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    7
    FEB 27, 2019 | 3:00 PM
    BASKET Trials: Biomarker Driven Drug Development
    BASKET Trials: Biomarker Driven Drug Development
    Dramatic responses observed with targeted agents in the ‘right’ genomic context have fueled large scale sequencing efforts to identify ‘effective’ treatments for a giv...
    Speaker: Shivaani Kummar, MD, FACP
    Presented at: Drug Discovery Virtual Event Series 2019
    2
    FEB 27, 2019 | 3:00 PM
    Do You Have the Gut-on-a-Chip?
    Do You Have the Gut-on-a-Chip?
    In-vitro epithelial barrier models that are more representative of in-vivo tissues are urgently needed. Here we present extracellular matrix-supported intestinal tubules in a perfused microfl...
    Speaker: Elena Naumovska, PhD
    Presented at: Drug Discovery Virtual Event Series 2019
    2
     
     
  • FEB 27, 2019 | 3:00 PM
    Targeted Cancer Chemotherapy: Developing NextGen Antibody-Drug Conjugates
    Targeted Cancer Chemotherapy: Developing NextGen Antibody-Drug...
    In today's presentation I will give an overview to developing NextGen ADCs. We will discuss everything from the beginning stages of development to the varying ADC combination therapies av...
    Speaker: Jagath Reddy Junutula, PhD
    Presented at: Drug Discovery Virtual Event Series 2019
    1
    FEB 27, 2019 | 3:00 PM
    Automation Meets Cell Separation: Primary Cells for Drug Discovery Assays
    Automation Meets Cell Separation: Primary Cells for Drug Discovery...
    Whether you are performing killing assays, immunophenotyping of TILs, characterizing the tumor microenvironment, or investigating immunogenicity, primary cells are essential for the discovery...
    Speaker: Lotta Raty
    Presented at: Drug Discovery Virtual Event Series 2019
    Sponsored By: Miltenyi Biotec
    2
    FEB 27, 2019 | 1:30 PM
    Advanced Liver Tissue Model for Improved in Vitro Prediction
    Advanced Liver Tissue Model for Improved in Vitro Prediction
    Isolated hepatocytes or their enzymes comprise the basis of most in vitro DMPK and toxicity assays used to predict human hepatic outcomes. Because hepato-specific functions are typically lost...
    Speaker: Matthew Shipton, MS
    Presented at: Drug Discovery Virtual Event Series 2019
    1
    FEB 27, 2019 | 1:30 PM
    Comprehensive NTRK Fusion Detection, Agnostic of the Fusion Partner, for Optimal Identification of Rare Genomic Events Using TruSightTM Oncology 500
    Comprehensive NTRK Fusion Detection, Agnostic of the Fusion Partner,...
    NTRK fusions are rare but important recent biomarkers linked to response to new TRK inhibitors. Comprehensive genomic profiling on all solid tumors permits detection of rare genomic events an...
    Speaker: Phillip Febbo, MD , Maude Champagne
    Presented at: Drug Discovery Virtual Event Series 2019
    Sponsored By: Illumina
    4
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