Drug development: describes the process of developing a new drug that energetically targets a specific weakness in a cell. The process consist of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.
The proper surgical techniques represent a key opportunity to improve the welfare of laboratory rodents, while meeting legal and ethical obligations. Use of inappropriate or poor surgical tec...
The 2011 Guide for the Care and Use of Laboratory Animals has required that institutions place importance on assuring that staff working with animals are trained and competent to perform thei...
The new animal facility is designed to breed and house rodents with the best quality of macro and micro environment and house the maximum possible number of rodents per sf2. This new facilit...
The question of pain in fish has been subject to much debate and, since fish are a popular experimental model globally and commercially important in fisheries, recreational angling and aquac...
The utility of dried blood spot (DBS) sampling technology for rodent colony health monitoring was investigated using a two-tiered approach. In the first approach, groups of mice and rats were...
Although a growing body of evidence indicates that environmental enrichment (EE) facilitates normal development and behaviour in laboratory mice, few studies were conducted to demonstrate it...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
It is increasingly recognized that the genetic background (i.e., all genomic sequences other than the gene(s) of interest) can have profound influences on the phenotype of an animal model. I...
With the growth and expansion of mouse and rat transgenic models in recent years, the demand for surgically altered models mimicking human diseases is growing at an amazing rate. Surgical pro...
Training for researchers using animals is a requirement in most European countries. However, somewhat surprisingly, the main actor in providing specific guidelines for such training is a scie...
It is commonly recognized that technicians are the backbone of a successful animal research program. Unfortunately, the invisible contributions that they make as well as the valuable high lev...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...
All personnel involved in an animal care and use program are expected to have an appropriate level of education, training and/or qualifications to perform their duties as defined through laws...
An anesthesia system designed to accommodate the physiological characteristics of small animals, including rats and mice, has the potential to provide great practical value to the life scien...
Public concerns over animal experimentation are becoming felt on both sides of the Atlantic, and a dangerous chasm is appearing between those who conduct such experiments and those who are o...
The city of Valdivia is located in Chile, South America, 841 km south of its capital city Santiago. I moved to Valdivia early in 2004 to participate in the development of a new animal facilit...
The development of CDx assays minimally requires a partnership between a pharmaceutical and a diagnostic company. It is not uncommon for the drug to be developed through an alliance of two ph...
As the scientific evidence base for pharmacogenetics continues to expand, the use of such information in clinical management and drug development will be in demand.
The FDA advises that the...
Molecular chaperones help nascent polypeptides fold correctly and multimeric protein complexes assemble productively, while minimizing the danger of aggregation in the protein-rich intracellu...
Pancreatic cancer is the 4th most common cause of cancer deaths in the United States. Due to the aggressive nature of this cancer and the lack of biomarkers for early detection, the incidence...
Curative therapy for metastatic disease in solid malignancies remains frustratingly elusive due to the long recognized problem of tumor cell heterogeneity and emergence of treatment resistant...
Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
Whenever there is cell death, apoptotic cell free DNA fragments appear in the circulation of the host. These fragments, typically 145-160 base pairs in size, represent a minute fraction of to...
The proper surgical techniques represent a key opportunity to improve the welfare of laboratory rodents, while meeting legal and ethical obligations. Use of inappropriate or poor surgical tec...
The 2011 Guide for the Care and Use of Laboratory Animals has required that institutions place importance on assuring that staff working with animals are trained and competent to perform thei...
The new animal facility is designed to breed and house rodents with the best quality of macro and micro environment and house the maximum possible number of rodents per sf2. This new facilit...
The question of pain in fish has been subject to much debate and, since fish are a popular experimental model globally and commercially important in fisheries, recreational angling and aquac...
The utility of dried blood spot (DBS) sampling technology for rodent colony health monitoring was investigated using a two-tiered approach. In the first approach, groups of mice and rats were...
Although a growing body of evidence indicates that environmental enrichment (EE) facilitates normal development and behaviour in laboratory mice, few studies were conducted to demonstrate it...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
It is increasingly recognized that the genetic background (i.e., all genomic sequences other than the gene(s) of interest) can have profound influences on the phenotype of an animal model. I...
With the growth and expansion of mouse and rat transgenic models in recent years, the demand for surgically altered models mimicking human diseases is growing at an amazing rate. Surgical pro...
Training for researchers using animals is a requirement in most European countries. However, somewhat surprisingly, the main actor in providing specific guidelines for such training is a scie...
It is commonly recognized that technicians are the backbone of a successful animal research program. Unfortunately, the invisible contributions that they make as well as the valuable high lev...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...
All personnel involved in an animal care and use program are expected to have an appropriate level of education, training and/or qualifications to perform their duties as defined through laws...
An anesthesia system designed to accommodate the physiological characteristics of small animals, including rats and mice, has the potential to provide great practical value to the life scien...
Public concerns over animal experimentation are becoming felt on both sides of the Atlantic, and a dangerous chasm is appearing between those who conduct such experiments and those who are o...
The city of Valdivia is located in Chile, South America, 841 km south of its capital city Santiago. I moved to Valdivia early in 2004 to participate in the development of a new animal facilit...
The development of CDx assays minimally requires a partnership between a pharmaceutical and a diagnostic company. It is not uncommon for the drug to be developed through an alliance of two ph...
As the scientific evidence base for pharmacogenetics continues to expand, the use of such information in clinical management and drug development will be in demand.
The FDA advises that the...
Molecular chaperones help nascent polypeptides fold correctly and multimeric protein complexes assemble productively, while minimizing the danger of aggregation in the protein-rich intracellu...
Pancreatic cancer is the 4th most common cause of cancer deaths in the United States. Due to the aggressive nature of this cancer and the lack of biomarkers for early detection, the incidence...
Curative therapy for metastatic disease in solid malignancies remains frustratingly elusive due to the long recognized problem of tumor cell heterogeneity and emergence of treatment resistant...
Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
Whenever there is cell death, apoptotic cell free DNA fragments appear in the circulation of the host. These fragments, typically 145-160 base pairs in size, represent a minute fraction of to...
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