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    High Content Screening

    High Content Screening: a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells. Phenotypic changes may include increases or decreases in the production of cellular products such as proteins and/or changes in the morphology (visual appearance) of the cell. High content screening includes any method used to analyze whole cells or components of cells with simultaneous readout of several parameters.

    Webinars

    • JUL 28, 2021 | 8:00 AM
      Disease model generation: 5 steps to a 3D cancer spheroid model
      Disease model generation: 5 steps to a 3D cancer spheroid model
      Date: July 28, 2021 Time: 8:00am PDT Breast cancer is the most common form of cancer in women. It is estimated that 1 out of 8 women in the US will develop invasive breast cancer during her...
      Speaker: Edwin Golez, M.S.
      Sponsored By: Thermo Fisher Scientific
      9
      JUN 16, 2021 | 8:00 AM
      Simplicity that defies complexity - the MACSimaâ„¢ Platform for ultrahigh-content imaging
      Simplicity that defies complexity - the MACSimaâ„¢ Platform for...
      Date: June 16, 2021 Time: 8:00am PDT The MACSima™ Imaging Platform is the only complete solution for ultrahigh-content imaging of hundreds of markers, allowing you to understand the tu...
      Speaker: Dr. Ali Kinkhabwala , Dr. Markus Habich
      Sponsored By: Miltenyi Biotec
      7
      MAY 25, 2021 | 8:00 AM
      Complete Workflow Solution from Gene-to-Protein
      Complete Workflow Solution from Gene-to-Protein
      Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
      Speaker: Stephan Fath, PhD
      Sponsored By: Thermo Fisher Scientific
      16 1
      MAY 18, 2021 | 7:00 AM
      Hitting the Achilles' Heel of Cancers with Confidence - Robust Validation of Neoantigens
      Hitting the Achilles' Heel of Cancers with Confidence - Robust...
      Date: May 18, 2021 Time: 7:00am PDT, 10:00am EDT Proteins encoded by mutant genes in cancers can be processed and presented on tumor cell surface by human leukocyte antigen (HLA) molecules,...
      Speaker: Qing Wang, PhD, MHS, MS
      Sponsored By: Agilent
      5 2
      MAY 11, 2021 | 10:00 AM
      Secure Your Next Great Discovery
      Secure Your Next Great Discovery
      Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
      Speaker: Paulina Kocjan , Kate Meola , Zareh Zurabyan
      Presented at: Eppendorf Planet of Knowledge - A New Dimension
      Sponsored By: Eppendorf
      8
      APR 13, 2021 | 3:00 PM
      A physiologically-relevant 3D ECM for in vitro oncology research and intelligent high-content imaging of 3D models
      A physiologically-relevant 3D ECM for in vitro oncology research...
      Date: April 13, 2021 Time: 07:00am PST Trends continue towards the development of more sophisticated and physiologically relevant 3D in vitro models, such as stem cell-derived models, organo...
      Speaker: Elodie Vandenhaute , Guillaume Frugier
      Sponsored By: Molecular Devices
      4
      MAR 11, 2021 | 8:00 AM
      A highly quantitative in vitro method for mechanistic genotoxicity screening
      A highly quantitative in vitro method for mechanistic genotoxicity...
      Date: March 11, 2021 Time: 8:00am (PST), 11:00am (EST) g the toxicity profile of a compound is a necessity across industries and the various stages of drug development. Early stage mechanism...
      Speaker: Urmi Roy, PhD , Dr. Giel Hendriks
      Sponsored By: Miltenyi Biotec
      14
      FEB 24, 2021 | 10:00 AM
      Biosafety Enclosures and the Automated Lab: Steps for Success
      Biosafety Enclosures and the Automated Lab: Steps for Success
      DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
      Speaker: David Wasescha , Simon Fogarty
      Sponsored By: Labconco
      15
      FEB 03, 2021 | 12:30 PM
      Optimizing High-Content Imaging of 3D Models for Drug Discovery
      Optimizing High-Content Imaging of 3D Models for Drug Discovery
      In vitro spheroid models are fast becoming the de facto standard for drug discovery applications, largely due to their human-like physiological and morphological characteristics, tissue-like...
      Speaker: Arvonn Tully , Judi Wardwell-Swanson
      Presented at: 7th Annual Conference: SBI2 High Content
      Sponsored By: SBI2, InSphero , Yokogawa
      11 10
      JAN 12, 2021 | 8:00 AM
      Storage and Logistics of Vaccines at Ultra Low Temperatures
      Storage and Logistics of Vaccines at Ultra Low Temperatures
      DATE: January 12, 2021 TIME: 8:00 am PST, 11:00 am EST, 5:00pm CET Transferring a biologic candidate from the research and development phase to commercial production usually requires increas...
      Speaker: Dr. Alex Esmon
      Sponsored By: Thermo Fisher Scientific
      9
      DEC 09, 2020 | 11:00 AM
      Introduction to Image Processing for High-Content Screening
      Introduction to Image Processing for High-Content Screening
      Image-based screens require the use of automated microscopes which generates hundreds, if not thousands of images at a time. With such large image sets, automatic image analysis is more obje...
      Speaker: Mark-Anthony Bray, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      5
      DEC 02, 2020 | 8:00 AM
      Optimize your bioprocess - From shaker to bioreactor
      Optimize your bioprocess - From shaker to bioreactor
      DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
      Speaker: Ines Hartmann , David Solbach
      Sponsored By: Eppendorf
      12
      NOV 18, 2020 | 11:00 AM
      Basic Concepts in Imaging-based High-Throughput Screening and High-Throughput Profiling Assay Development
      Basic Concepts in Imaging-based High-Throughput Screening and...
      This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
      Speaker: Joshua Harrill, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      1
      NOV 18, 2020 | 8:00 AM
      Whole-organ mapping using AI and light sheet microscopy
      Whole-organ mapping using AI and light sheet microscopy
      DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
      Speaker: Ali Ertürk
      Sponsored By: Miltenyi Biotec
      14
      NOV 05, 2020 | 11:00 AM
      Image and Data Processing for HCS toxicology
      Image and Data Processing for HCS toxicology
      The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
      Speaker: David Egan, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      4
      NOV 04, 2020 | 8:00 AM
      Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
      Overcoming barriers to productivity in HCS - An image-to-answer...
      Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
      Speaker: William Marshall , David Egan, PhD
      Sponsored By: Cytiva
      2
      OCT 26, 2020 | 11:00 AM
      Introduction to FLIM-FRET techniques
      Introduction to FLIM-FRET techniques
      This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
      Speaker: David Andrews, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      1
      OCT 22, 2020 | 11:00 AM
      Impact of Segmentation Quality on Assay Endpoints - Deep Learning for High Content Screening
      Impact of Segmentation Quality on Assay Endpoints - Deep Learning...
      Sponsored by Cytiva....
      Speaker: Fuhui Long, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      1
      OCT 21, 2020 | 10:30 AM
      Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
      Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
      Solid phase extraction has become a preferable technique for reducing matrix effects for sample preparation due to its ease of use and limited time requirements. MilliporeSigma has launched...
      Speaker: M. James Ross, PhD
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      3
      OCT 21, 2020 | 9:00 AM
      Keynote Presentation: Functional properties and digestibility of starch and flour under high-temperature cooking conditions
      Keynote Presentation: Functional properties and digestibility...
      Learning Objectives: 1. Understand the functionality and digestibility of starches at high heating temperatures as measured jointly by RVA 4800 and DSC 2. Acquire new knowledge on the behavi...
      Speaker: Dr. Yongfeng Ai
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 7:30 AM
      The Use of Dispersive Solid Phase Extraction in the Analysis of Pesticides in Cannabis Matrix
      The Use of Dispersive Solid Phase Extraction in the Analysis of...
      Cannabis is a complex and difficult matrix to work with and the analysis of pesticides in cannabis is a notoriously problematic task. There is major ion suppression present from the signific...
      Speaker: Adam Floyd
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      Sponsored By: JEOL
      2
      OCT 21, 2020 | 12:00 AM
      Developing a Complete Workflow Including N-Linked Glycans Analysis for Monoclonal Antibodies with High Resolution Mass Spectrometry and Fluorescence Detection
      Developing a Complete Workflow Including N-Linked Glycans Analysis...
      Accurate characterization of monoclonal antibodies is essential to development of biotherapeutics. Thorough understanding of biotherapeutic properties aids in the optimization of bioprocess...
      Speaker: Brian Domanski
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 12:00 AM
      Overcoming the challenges of pesticide detection in food: Integrated workflow solutions to screen and confirm multi-residue contaminants
      Overcoming the challenges of pesticide detection in food: Integrated...
      Pesticides are routinely applied to crops to prevent or control pests and are therefore routinely tested for the presence of pesticide residues and to check for compliance with permitted Max...
      Speaker: Scott M. Peterman, PhD
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 12:00 AM
      Cannabis Testing labs; Quality Control and Standardization
      Cannabis Testing labs; Quality Control and Standardization
      Cannabis testing laboratories play a pivotal role in the multidimensional cannabis industry. Production companies to the consumers, whole cannabis community rely on the analytical results pr...
      Speaker: Niranjan Aryal, PhD
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
    JUL 28, 2021 | 8:00 AM
    Disease model generation: 5 steps to a 3D cancer spheroid model
    Disease model generation: 5 steps to a 3D cancer spheroid model
    Date: July 28, 2021 Time: 8:00am PDT Breast cancer is the most common form of cancer in women. It is estimated that 1 out of 8 women in the US will develop invasive breast cancer during her...
    Speaker: Edwin Golez, M.S.
    Sponsored By: Thermo Fisher Scientific
    9
    JUN 16, 2021 | 8:00 AM
    Simplicity that defies complexity - the MACSimaâ„¢ Platform for ultrahigh-content imaging
    Simplicity that defies complexity - the MACSimaâ„¢ Platform for...
    Date: June 16, 2021 Time: 8:00am PDT The MACSima™ Imaging Platform is the only complete solution for ultrahigh-content imaging of hundreds of markers, allowing you to understand the tu...
    Speaker: Dr. Ali Kinkhabwala , Dr. Markus Habich
    Sponsored By: Miltenyi Biotec
    7
    MAY 25, 2021 | 8:00 AM
    Complete Workflow Solution from Gene-to-Protein
    Complete Workflow Solution from Gene-to-Protein
    Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
    Speaker: Stephan Fath, PhD
    Sponsored By: Thermo Fisher Scientific
    16 1
    MAY 18, 2021 | 7:00 AM
    Hitting the Achilles' Heel of Cancers with Confidence - Robust Validation of Neoantigens
    Hitting the Achilles' Heel of Cancers with Confidence - Robust...
    Date: May 18, 2021 Time: 7:00am PDT, 10:00am EDT Proteins encoded by mutant genes in cancers can be processed and presented on tumor cell surface by human leukocyte antigen (HLA) molecules,...
    Speaker: Qing Wang, PhD, MHS, MS
    Sponsored By: Agilent
    5 2
    MAY 11, 2021 | 10:00 AM
    Secure Your Next Great Discovery
    Secure Your Next Great Discovery
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    Speaker: Paulina Kocjan , Kate Meola , Zareh Zurabyan
    Presented at: Eppendorf Planet of Knowledge - A New Dimension
    Sponsored By: Eppendorf
    8
     
     
  • APR 13, 2021 | 3:00 PM
    A physiologically-relevant 3D ECM for in vitro oncology research and intelligent high-content imaging of 3D models
    A physiologically-relevant 3D ECM for in vitro oncology research...
    Date: April 13, 2021 Time: 07:00am PST Trends continue towards the development of more sophisticated and physiologically relevant 3D in vitro models, such as stem cell-derived models, organo...
    Speaker: Elodie Vandenhaute , Guillaume Frugier
    Sponsored By: Molecular Devices
    4
    MAR 11, 2021 | 8:00 AM
    A highly quantitative in vitro method for mechanistic genotoxicity screening
    A highly quantitative in vitro method for mechanistic genotoxicity...
    Date: March 11, 2021 Time: 8:00am (PST), 11:00am (EST) g the toxicity profile of a compound is a necessity across industries and the various stages of drug development. Early stage mechanism...
    Speaker: Urmi Roy, PhD , Dr. Giel Hendriks
    Sponsored By: Miltenyi Biotec
    14
    FEB 24, 2021 | 10:00 AM
    Biosafety Enclosures and the Automated Lab: Steps for Success
    Biosafety Enclosures and the Automated Lab: Steps for Success
    DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
    Speaker: David Wasescha , Simon Fogarty
    Sponsored By: Labconco
    15
    FEB 03, 2021 | 12:30 PM
    Optimizing High-Content Imaging of 3D Models for Drug Discovery
    Optimizing High-Content Imaging of 3D Models for Drug Discovery
    In vitro spheroid models are fast becoming the de facto standard for drug discovery applications, largely due to their human-like physiological and morphological characteristics, tissue-like...
    Speaker: Arvonn Tully , Judi Wardwell-Swanson
    Presented at: 7th Annual Conference: SBI2 High Content
    Sponsored By: SBI2, InSphero , Yokogawa
    11 10
    JAN 12, 2021 | 8:00 AM
    Storage and Logistics of Vaccines at Ultra Low Temperatures
    Storage and Logistics of Vaccines at Ultra Low Temperatures
    DATE: January 12, 2021 TIME: 8:00 am PST, 11:00 am EST, 5:00pm CET Transferring a biologic candidate from the research and development phase to commercial production usually requires increas...
    Speaker: Dr. Alex Esmon
    Sponsored By: Thermo Fisher Scientific
    9
     
     
  • DEC 09, 2020 | 11:00 AM
    Introduction to Image Processing for High-Content Screening
    Introduction to Image Processing for High-Content Screening
    Image-based screens require the use of automated microscopes which generates hundreds, if not thousands of images at a time. With such large image sets, automatic image analysis is more obje...
    Speaker: Mark-Anthony Bray, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    5
    DEC 02, 2020 | 8:00 AM
    Optimize your bioprocess - From shaker to bioreactor
    Optimize your bioprocess - From shaker to bioreactor
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    Speaker: Ines Hartmann , David Solbach
    Sponsored By: Eppendorf
    12
    NOV 18, 2020 | 11:00 AM
    Basic Concepts in Imaging-based High-Throughput Screening and High-Throughput Profiling Assay Development
    Basic Concepts in Imaging-based High-Throughput Screening and...
    This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
    Speaker: Joshua Harrill, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    1
    NOV 18, 2020 | 8:00 AM
    Whole-organ mapping using AI and light sheet microscopy
    Whole-organ mapping using AI and light sheet microscopy
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    Speaker: Ali Ertürk
    Sponsored By: Miltenyi Biotec
    14
    NOV 05, 2020 | 11:00 AM
    Image and Data Processing for HCS toxicology
    Image and Data Processing for HCS toxicology
    The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
    Speaker: David Egan, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    4
     
     
  • NOV 04, 2020 | 8:00 AM
    Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
    Overcoming barriers to productivity in HCS - An image-to-answer...
    Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
    Speaker: William Marshall , David Egan, PhD
    Sponsored By: Cytiva
    2
    OCT 26, 2020 | 11:00 AM
    Introduction to FLIM-FRET techniques
    Introduction to FLIM-FRET techniques
    This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
    Speaker: David Andrews, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    1
    OCT 22, 2020 | 11:00 AM
    Impact of Segmentation Quality on Assay Endpoints - Deep Learning for High Content Screening
    Impact of Segmentation Quality on Assay Endpoints - Deep Learning...
    Sponsored by Cytiva....
    Speaker: Fuhui Long, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    1
    OCT 21, 2020 | 10:30 AM
    Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
    Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
    Solid phase extraction has become a preferable technique for reducing matrix effects for sample preparation due to its ease of use and limited time requirements. MilliporeSigma has launched...
    Speaker: M. James Ross, PhD
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    3
    OCT 21, 2020 | 9:00 AM
    Keynote Presentation: Functional properties and digestibility of starch and flour under high-temperature cooking conditions
    Keynote Presentation: Functional properties and digestibility...
    Learning Objectives: 1. Understand the functionality and digestibility of starches at high heating temperatures as measured jointly by RVA 4800 and DSC 2. Acquire new knowledge on the behavi...
    Speaker: Dr. Yongfeng Ai
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
     
     
  • OCT 21, 2020 | 7:30 AM
    The Use of Dispersive Solid Phase Extraction in the Analysis of Pesticides in Cannabis Matrix
    The Use of Dispersive Solid Phase Extraction in the Analysis of...
    Cannabis is a complex and difficult matrix to work with and the analysis of pesticides in cannabis is a notoriously problematic task. There is major ion suppression present from the signific...
    Speaker: Adam Floyd
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    Sponsored By: JEOL
    2
    OCT 21, 2020 | 12:00 AM
    Developing a Complete Workflow Including N-Linked Glycans Analysis for Monoclonal Antibodies with High Resolution Mass Spectrometry and Fluorescence Detection
    Developing a Complete Workflow Including N-Linked Glycans Analysis...
    Accurate characterization of monoclonal antibodies is essential to development of biotherapeutics. Thorough understanding of biotherapeutic properties aids in the optimization of bioprocess...
    Speaker: Brian Domanski
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    OCT 21, 2020 | 12:00 AM
    Overcoming the challenges of pesticide detection in food: Integrated workflow solutions to screen and confirm multi-residue contaminants
    Overcoming the challenges of pesticide detection in food: Integrated...
    Pesticides are routinely applied to crops to prevent or control pests and are therefore routinely tested for the presence of pesticide residues and to check for compliance with permitted Max...
    Speaker: Scott M. Peterman, PhD
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    OCT 21, 2020 | 12:00 AM
    Cannabis Testing labs; Quality Control and Standardization
    Cannabis Testing labs; Quality Control and Standardization
    Cannabis testing laboratories play a pivotal role in the multidimensional cannabis industry. Production companies to the consumers, whole cannabis community rely on the analytical results pr...
    Speaker: Niranjan Aryal, PhD
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
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