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    Mechanism of Action

    Mechanism of action refers to the specific biological process through which the drug treats the underlying cause. It describes the more general response or effect of the drug. It is the interaction that allows a drug substance to produce it pharmacological effect.

    Webinars

    • MAR 15, 2017 | 12:00 PM
      Oscillations, deep brain stimulation and the functional network in Gilles de la Tourette syndrome
      Oscillations, deep brain stimulation and the functional network...
      Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder exhibiting both motor and behavioral impairment. Like most neuropsychiatric disorders, its pathophysiology has yet to be...
      Speaker: Rowshanak Hashemiyoon, PhD
      Presented at: Neuroscience Virtual Event Series 2017
      3
      FEB 20, 2017 | 8:00 AM
      Getting started with siRNA: considerations and recommendations
      Getting started with siRNA: considerations and recommendations
      This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway wil...
      Speaker: Louise Baskin
      Presented at: Protein Research Live
      3
      FEB 24, 2016 | 10:00 AM
      Harnessing the Power of Healthcare Data with Causal Machine Learning to drive Personalized and Effective Treatment Interventions
      Harnessing the Power of Healthcare Data with Causal Machine Learning...
      Every day, vast amounts of healthcare data are collected from clinical trials as well as real world medical visits on patient treatment regimens and subsequent clinical outcomes. This big dat...
      Speaker: Iya Khalil, PhD
      Presented at: Precision Medicine Virtual Event Series 2016
      2
      DEC 09, 2015 | 10:00 AM
      WEBINAR: Emerging Trends in Heart Failure Therapy and the Importance of Natriuretic Peptides
      WEBINAR: Emerging Trends in Heart Failure Therapy and the Importance...
      Date: December 9, 2015 10AM Pacific, 1PM Eastern July 7, 2015, the U.S. Food and Drug Administration reviewed and approved ENTRESTO™ (sacubitril/valsartan) tablets to reduce the risk...
      Speaker: Robert Fitzgerald, PhD
      Sponsored By: Roche Diagnostics, Roche Diagnostics
      5 1
      SEP 30, 2015 | 7:30 AM
      How do I choose? Androgen Biosynthesis Inhibitor, Androgen Receptor Antagonist, or both for treatment of mCRPC?
      How do I choose? Androgen Biosynthesis Inhibitor, Androgen Receptor...
      The landscape for treatment options in metastatic castration resistant prostate cancer has changed dramatically since 2010. There have been more therapies approved since 2010 than in the prio...
      Speaker: Lawrence Karsh MD FACS
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2015
      2
      SEP 09, 2015 | 9:00 AM
      WEBINAR: Clinically actionable gene fusions, CNVs and SNVs detected by NGS-based comprehensive profiling
      WEBINAR: Clinically actionable gene fusions, CNVs and SNVs detected...
      DATE: September 9, 2015TIME: 9:00am PDT, 12:00PM EDTDriver mutations are causally implicated in tumorigenesis and disease progression, and they are defined by molecular abnormalities such as ...
      Speaker: A. John Iafrate, MD, PhD
      Sponsored By: Archer DX, Archer DX
      7 1
      SEP 02, 2015 | 7:30 AM
      Keynote: The Science of Biofilm Control with Antimicrobial Agents
      Keynote: The Science of Biofilm Control with Antimicrobial Agents
      This presentation will discuss fundamental physical, chemical, and biological concepts important to understanding control of detrimental biofilms. Four phenomena that are important in the act...
      Speaker: Phil Stewart, PhD
      Presented at: Microbiology Virtual Event Series 2015
      3
      MAR 19, 2015 | 6:00 AM
      Nobel Prize Winner presents: Clinical Studies of a Candidate Drug (OSU6162) Capable of Alleviating Dysregulation of the Dopaminergic System
      Nobel Prize Winner presents: Clinical Studies of a Candidate Drug...
      This presentation will include both preclinical and small clinical studies with details on mechanism of action, safety and efficacy of a candidate drug that has the capability of alleviating...
      Speaker: Arvid Carlsson, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2015
      12
      JAN 26, 2015 | 8:00 AM
      How stem cells speak with immune cells
      How stem cells speak with immune cells
      Advances in stem cell biology have raised great expectations that diseases of the central nervous system may be ameliorated by the development of non-haematopoietic stem cell medicines. Yet,...
      Speaker: Stefano Pluchino, MD, PhD
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      19 2
      SEP 16, 2014 | 10:00 AM
      Expanded clinical research opportunities for Crizotinib identified from an analysis of over 5,000 exomes
      Expanded clinical research opportunities for Crizotinib identified...
      Patients with chromosomal rearrangements resulting in fusion proteins are among the most responsive to published targeted therapy. For example, targeting of the EML4-ALK fusion in non-small c...
      Speaker: Sean Eddy, PhD
      Presented at: Advanced Genomics in Clinical and Translational Research - Informing end-to-end cancer drug development with bioinformatics
      12
      SEP 16, 2014 | 8:30 AM
      The use of transcriptional signatures for clinical population selection
      The use of transcriptional signatures for clinical population...
      The use of biomarkers for the stratification of populations for therapy is a concept that holds the potential to revolutionize clinical trial design, the economics of healthcare, and most imp...
      Speaker: Mary Ellen Urick, PhD
      Presented at: Advanced Genomics in Clinical and Translational Research - Informing end-to-end cancer drug development with bioinformatics
      18
      MAR 20, 2014 | 2:00 PM
      Cross-talk & Developmental Programs A Key to Translational Stem Cell Biology
      Cross-talk & Developmental Programs A Key to Translational...
      The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
      Speaker: Evan W. Snyder, M.D., Ph.D., F.A.A.P
      Presented at: Neuroscience Virtual Event Series 2014
      94
      MAR 20, 2014 | 8:00 AM
      Cross-talk & Developmental Programs A Key to Translational Stem Cell Biology
      Cross-talk & Developmental Programs A Key to Translational Stem...
      The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
      Speaker: Evan W. Snyder, M.D., Ph.D., F.A.A.P
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      1
      MAR 19, 2014 | 9:00 AM
      Remyelinating the adult central nervous system: Repairing injury in  MS
      Remyelinating the adult central nervous system: Repairing injury...
      Multiple Sclerosis is a debilitating neurodegnerative disease of the central nervous system in which the immune system targets and destroys myelin sheaths surrounding axons. Progressive a...
      Speaker: Ari Green, MD
      Presented at: Neuroscience Virtual Event Series 2014
      0
      OCT 17, 2013 | 12:00 PM
      C.E. CREDITS
      Cells in Action: Why Cancer Cells Leave the Tumors?
      Cells in Action: Why Cancer Cells Leave the Tumors?
      Invading cancer cells leave the tumor to form distant metastases and are ultimately responsible for 90% of deaths in cancer. Reducing the ability of cancer cells to invade and metastasize cou...
      Speaker: Daniel Irimia, MD, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      140
      OCT 17, 2013 | 7:00 AM
      Advancing Translational Cancer Research through Automated RNASeq Sample Preparation from Archival FFPE Tissue Specimens
      Advancing Translational Cancer Research through Automated RNASeq...
      RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
      Speaker: Michaela Bowden, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      98
      OCT 16, 2013 | 1:00 PM
      C.E. CREDITS
      Resistance to AR Signaling Inhibitors in Castration Resistant Prostate Cancer
      Resistance to AR Signaling Inhibitors in Castration Resistant...
      While androgen deprivation therapy (ADT) remains the primary treatment modality for patients with metastatic prostate cancer (PCa), treatment is uniformly marked by progression to castration-...
      Speaker: Elahe A Mostaghel, MD, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      80
    MAR 15, 2017 | 12:00 PM
    Oscillations, deep brain stimulation and the functional network in Gilles de la Tourette syndrome
    Oscillations, deep brain stimulation and the functional network...
    Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder exhibiting both motor and behavioral impairment. Like most neuropsychiatric disorders, its pathophysiology has yet to be...
    Speaker: Rowshanak Hashemiyoon, PhD
    Presented at: Neuroscience Virtual Event Series 2017
    3
    FEB 20, 2017 | 8:00 AM
    Getting started with siRNA: considerations and recommendations
    Getting started with siRNA: considerations and recommendations
    This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway wil...
    Speaker: Louise Baskin
    Presented at: Protein Research Live
    3
    FEB 24, 2016 | 10:00 AM
    Harnessing the Power of Healthcare Data with Causal Machine Learning to drive Personalized and Effective Treatment Interventions
    Harnessing the Power of Healthcare Data with Causal Machine Learning...
    Every day, vast amounts of healthcare data are collected from clinical trials as well as real world medical visits on patient treatment regimens and subsequent clinical outcomes. This big dat...
    Speaker: Iya Khalil, PhD
    Presented at: Precision Medicine Virtual Event Series 2016
    2
    DEC 09, 2015 | 10:00 AM
    WEBINAR: Emerging Trends in Heart Failure Therapy and the Importance of Natriuretic Peptides
    WEBINAR: Emerging Trends in Heart Failure Therapy and the Importance...
    Date: December 9, 2015 10AM Pacific, 1PM Eastern July 7, 2015, the U.S. Food and Drug Administration reviewed and approved ENTRESTO™ (sacubitril/valsartan) tablets to reduce the risk...
    Speaker: Robert Fitzgerald, PhD
    Sponsored By: Roche Diagnostics, Roche Diagnostics
    5 1
    SEP 30, 2015 | 7:30 AM
    How do I choose? Androgen Biosynthesis Inhibitor, Androgen Receptor Antagonist, or both for treatment of mCRPC?
    How do I choose? Androgen Biosynthesis Inhibitor, Androgen Receptor...
    The landscape for treatment options in metastatic castration resistant prostate cancer has changed dramatically since 2010. There have been more therapies approved since 2010 than in the prio...
    Speaker: Lawrence Karsh MD FACS
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2015
    2
     
     
  • SEP 09, 2015 | 9:00 AM
    WEBINAR: Clinically actionable gene fusions, CNVs and SNVs detected by NGS-based comprehensive profiling
    WEBINAR: Clinically actionable gene fusions, CNVs and SNVs detected...
    DATE: September 9, 2015TIME: 9:00am PDT, 12:00PM EDTDriver mutations are causally implicated in tumorigenesis and disease progression, and they are defined by molecular abnormalities such as ...
    Speaker: A. John Iafrate, MD, PhD
    Sponsored By: Archer DX, Archer DX
    7 1
    SEP 02, 2015 | 7:30 AM
    Keynote: The Science of Biofilm Control with Antimicrobial Agents
    Keynote: The Science of Biofilm Control with Antimicrobial Agents
    This presentation will discuss fundamental physical, chemical, and biological concepts important to understanding control of detrimental biofilms. Four phenomena that are important in the act...
    Speaker: Phil Stewart, PhD
    Presented at: Microbiology Virtual Event Series 2015
    3
    MAR 19, 2015 | 6:00 AM
    Nobel Prize Winner presents: Clinical Studies of a Candidate Drug (OSU6162) Capable of Alleviating Dysregulation of the Dopaminergic System
    Nobel Prize Winner presents: Clinical Studies of a Candidate Drug...
    This presentation will include both preclinical and small clinical studies with details on mechanism of action, safety and efficacy of a candidate drug that has the capability of alleviating...
    Speaker: Arvid Carlsson, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2015
    12
    JAN 26, 2015 | 8:00 AM
    How stem cells speak with immune cells
    How stem cells speak with immune cells
    Advances in stem cell biology have raised great expectations that diseases of the central nervous system may be ameliorated by the development of non-haematopoietic stem cell medicines. Yet,...
    Speaker: Stefano Pluchino, MD, PhD
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    19 2
    SEP 16, 2014 | 10:00 AM
    Expanded clinical research opportunities for Crizotinib identified from an analysis of over 5,000 exomes
    Expanded clinical research opportunities for Crizotinib identified...
    Patients with chromosomal rearrangements resulting in fusion proteins are among the most responsive to published targeted therapy. For example, targeting of the EML4-ALK fusion in non-small c...
    Speaker: Sean Eddy, PhD
    Presented at: Advanced Genomics in Clinical and Translational Research - Informing end-to-end cancer drug development with bioinformatics
    12
     
     
  • SEP 16, 2014 | 8:30 AM
    The use of transcriptional signatures for clinical population selection
    The use of transcriptional signatures for clinical population...
    The use of biomarkers for the stratification of populations for therapy is a concept that holds the potential to revolutionize clinical trial design, the economics of healthcare, and most imp...
    Speaker: Mary Ellen Urick, PhD
    Presented at: Advanced Genomics in Clinical and Translational Research - Informing end-to-end cancer drug development with bioinformatics
    18
    MAR 20, 2014 | 2:00 PM
    Cross-talk & Developmental Programs A Key to Translational Stem Cell Biology
    Cross-talk & Developmental Programs A Key to Translational...
    The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
    Speaker: Evan W. Snyder, M.D., Ph.D., F.A.A.P
    Presented at: Neuroscience Virtual Event Series 2014
    94
    MAR 20, 2014 | 8:00 AM
    Cross-talk & Developmental Programs A Key to Translational Stem Cell Biology
    Cross-talk & Developmental Programs A Key to Translational Stem...
    The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
    Speaker: Evan W. Snyder, M.D., Ph.D., F.A.A.P
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    1
    MAR 19, 2014 | 9:00 AM
    Remyelinating the adult central nervous system: Repairing injury in  MS
    Remyelinating the adult central nervous system: Repairing injury...
    Multiple Sclerosis is a debilitating neurodegnerative disease of the central nervous system in which the immune system targets and destroys myelin sheaths surrounding axons. Progressive a...
    Speaker: Ari Green, MD
    Presented at: Neuroscience Virtual Event Series 2014
    0
    OCT 17, 2013 | 12:00 PM
    C.E. CREDITS
    Cells in Action: Why Cancer Cells Leave the Tumors?
    Cells in Action: Why Cancer Cells Leave the Tumors?
    Invading cancer cells leave the tumor to form distant metastases and are ultimately responsible for 90% of deaths in cancer. Reducing the ability of cancer cells to invade and metastasize cou...
    Speaker: Daniel Irimia, MD, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    140
     
     
  • OCT 17, 2013 | 7:00 AM
    Advancing Translational Cancer Research through Automated RNASeq Sample Preparation from Archival FFPE Tissue Specimens
    Advancing Translational Cancer Research through Automated RNASeq...
    RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
    Speaker: Michaela Bowden, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    98
    OCT 16, 2013 | 1:00 PM
    C.E. CREDITS
    Resistance to AR Signaling Inhibitors in Castration Resistant Prostate Cancer
    Resistance to AR Signaling Inhibitors in Castration Resistant...
    While androgen deprivation therapy (ADT) remains the primary treatment modality for patients with metastatic prostate cancer (PCa), treatment is uniformly marked by progression to castration-...
    Speaker: Elahe A Mostaghel, MD, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    80
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