Mutation: the changing of the structure of a gene, resulting in a variant form that may be transmitted to subsequent generations, caused by the alteration of single base units in DNA, or the deletion, insertion, or rearrangement of larger sections of genes or chromosomes.
-
Employing a metagenomic search, we identified a family of miniature CRISPR-Cas type V-L systems capable of RNA-guided dsDNA target cleavage without a tracrRNA. A bacterial depletion screen r...
Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
Single-cell ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing, scATAC-seq) is a relatively new and powerful technique that allows researchers to identify open chromatin r...
Our understanding of cancer mechanisms, genetics and complexities continues to expand rapidly. Without a streamlined, standardized and easy to understand organizational system to keep track...
Characterization of rare cells remains a major challenge for the evaluation and understanding of key biological systems, such as circulating tumor cells (CTCs) from liquid biopsy, stem cells...
Accurate prediction of anticancer drug efficacy on each patient’s cancer before the initiation of therapy has the potential to significantly reduce the treatment burden and enhance cli...
Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases....