Peptides: are short chains of amino acid monomers linked by peptide (amide) bonds. The covalent chemical bonds are formed when the carboxyl group of one amino acid reacts with the amino group of another.
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Mass spectrometry (MS)-based proteomic biomarker discovery pipeline commonly begins with large-scale profiling techniques detecting thousands of candidate biomarkers. Efficiently triaging th...
Antibodies are a major component of adaptive immunity against invading pathogens. In this presentation, we will describe an analytical approach to characterize the antigen-specific antibody...
Dec 4, 2024 | 8am PT, 11am ET, 16:00 GMT, 17:00 CET
Immunopeptidomics is a cutting-edge field focused on identifying and characterizing peptides presented by major histocompatibility complex (MHC) Class I and II molecules on cell surfaces. Th...
Advances in proteomics and mass spectrometry enable the study of limited cell populations such as performing mouse models. Low-protein load studies often requires two steps to perform differ...
Translational research strives to identify, verify, and validate biomarker candidates that can be used in clinical settings to collectively stratify biology. With the recent introduction of...
Proteomics – a unique source for a vast pool of information is also very complex when it comes to analysis. In the last decade and half, there has been some significant advancements fo...
Cancer immunotherapy approaches such as adoptive transfer of chimeric antigen receptor (CAR) T cells or tumor-infiltrating lymphocytes have yielded promising results in hematological maligna...
MAY 07, 2024 | 8:00 AM
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Antibodies against ribonucleoprotein (RNP) are an important serologic marker for mixed connective tissue disease (MCTD). RNP interacts with Smith (Sm) proteins to form the Sm/RNP complex. An...
In light of the numerous US FDA-approved humanized monoclonal antibodies (mAbs) for cancer immunotherapy, it is surprising that the advancement of B-cell epitope vaccines designed to elicit...
Cell and gene therapies are on the brink of transforming the pharmaceutical industry, presenting unique challenges such as ensuring the quality and consistent supply of reagents. Reagents pl...
Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key featu...
Neoantigens are peptides derived from patient-specific and tumor-specific mutations, which can be recognized by the immune system and mediate tumor recognition that leads to immune destructi...
Isobaric labeling enables the multiplexed analysis of up to 18 proteomes or PTMomes in a single analysis and provides information on protein and peptide abundance across all samples simultan...