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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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JUN 13, 2021Cell & Molecular Biology
Cells have to maintain the right size; bacterial and eukaryotic cells tend to have a characteristic size, but that may a ...Written By: Carmen LeitchJUN 07, 2021Cardiology
It's thought that in the United States, there is a heart attack once every 40 seconds, or that each year, about 80,0 ...Written By: Carmen LeitchJUN 04, 2021Clinical & Molecular DX
Scientists have developed miniaturized 3-dimensional bone marrow models that could help physicians to predict whi ...Written By: Tara FernandesJUN 02, 2021Genetics & Genomics
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Protein synthesis, protein engineering, and synthetic biology researchers can research their protein of interest using e ...Sponsored By: Integrated DNA Technologies, Inc.MAY 24, 2021Clinical & Molecular DX
Over 1.5 billion vaccine doses have been administered worldwide, but SARS-CoV-2 variants are now threatening efforts to ...Written By: Tara FernandesMAY 21, 2021Cell & Molecular Biology
Researchers have now found evidence of a stunning overlap between two groups of biological molecules that were thought t ...Written By: Carmen LeitchMAY 12, 2021Health & Medicine
Doctors at the Children's Hospital of Philadelphia discovered a new genetic disease that prevents B cell development.Written By: Caroline WallaceMAY 10, 2021Microbiology
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You can see the spike protein of the virus in action in this video.Written By: Carmen LeitchAPR 28, 2021Cell & Molecular Biology
Sugar is something sweet to add to your food, but just like fat, different types of sugars play important roles in biolo ...Written By: Carmen LeitchAPR 25, 2021Cell & Molecular Biology
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For simplicity's sake, DNA is though of as a double-stranded molecule made of nucleotide bases A, G, C, and T, and RNA a ...Written By: Carmen LeitchAPR 15, 2021Clinical & Molecular DX
Duke University scientists have created a highly sensitive Ebola virus portable diagnostic device, 1000 times more sensi ...Written By: Tara FernandesAPR 14, 2021Cancer
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The human genome contains the genes that make us who we are, because of how and when those genes are expressed. Gene exp ...Written By: Carmen LeitchMAR 22, 2021Microbiology
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How do drugs work? Well, they work when they stick to their target protein. Of course, there is much more complicated pr ...Written By: Nouran Amin
JUN 13, 2021
Cell & Molecular Biology
Cells have to maintain the right size; bacterial and eukaryotic cells tend to have a characteristic size, but that may a
...
Written By:
Carmen Leitch
JUN 07, 2021
Cardiology
It's thought that in the United States, there is a heart attack once every 40 seconds, or that each year, about 80,0
...
Written By:
Carmen Leitch
JUN 04, 2021
Clinical & Molecular DX
Scientists have developed miniaturized 3-dimensional bone marrow models that could help physicians to predict whi
...
Written By:
Tara Fernandes
JUN 02, 2021
Genetics & Genomics
Some medical mysteries have become much easier to solve because of advanced genetic techniques that have enabled researc
...
Written By:
Carmen Leitch
MAY 25, 2021
Cell & Molecular Biology
Protein synthesis, protein engineering, and synthetic biology researchers can research their protein of interest using e
...
Sponsored By:
Integrated DNA Technologies, Inc.
MAY 24, 2021
Clinical & Molecular DX
Over 1.5 billion vaccine doses have been administered worldwide, but SARS-CoV-2 variants are now threatening efforts to
...
Written By:
Tara Fernandes
MAY 21, 2021
Cell & Molecular Biology
Researchers have now found evidence of a stunning overlap between two groups of biological molecules that were thought t
...
Written By:
Carmen Leitch
MAY 12, 2021
Health & Medicine
Doctors at the Children's Hospital of Philadelphia discovered a new genetic disease that prevents B cell development.
Written By:
Caroline Wallace
MAY 10, 2021
Microbiology
The pandemic virus SARS-CoV-2 has changed the world in devastating ways, taking hundreds of thousands of lives & new var
...
Written By:
Carmen Leitch
MAY 10, 2021
Cell & Molecular Biology
RNA molecules serve several functions, one of which is to help the cell generate proteins from active genes. It also may
...
Written By:
Carmen Leitch
MAY 06, 2021
Clinical & Molecular DX
Digital networks have changed the world by integrating into almost every aspect of our lives, but they have yet to direc
...
Sponsored By:
Cardea Bio
MAY 05, 2021
Chemistry & Physics
A new study published in the journal Nature Chemistry details the development of a chemical nose that can identify
...
Written By:
Kathryn DeMuth Sullivan
MAY 04, 2021
Immunology
There are currently five variants of concern in the U.S., genetically distinct forms of the COVID-causing coronavirus th
...
Written By:
Tara Fernandes
MAY 04, 2021
Cell & Molecular Biology
You can see the spike protein of the virus in action in this video.
Written By:
Carmen Leitch
APR 28, 2021
Cell & Molecular Biology
Sugar is something sweet to add to your food, but just like fat, different types of sugars play important roles in biolo
...
Written By:
Carmen Leitch
APR 25, 2021
Cell & Molecular Biology
When we're exposed to a pathogen, our immune system normally mounts a robust response against it. Antibodies are generat
...
Written By:
Carmen Leitch
APR 22, 2021
Genetics & Genomics
For simplicity's sake, DNA is though of as a double-stranded molecule made of nucleotide bases A, G, C, and T, and RNA a
...
Written By:
Carmen Leitch
APR 15, 2021
Clinical & Molecular DX
Duke University scientists have created a highly sensitive Ebola virus portable diagnostic device, 1000 times more sensi
...
Written By:
Tara Fernandes
APR 14, 2021
Cancer
Written By: Author As I pondered the title of this article, my thoughts immediately went back to a request by my Ph.D. a
...
MAR 25, 2021
Genetics & Genomics
The human genome contains the genes that make us who we are, because of how and when those genes are expressed. Gene exp
...
Written By:
Carmen Leitch
MAR 22, 2021
Microbiology
There are many microbes that live in the human mouth, and while some are harmless, others like Streptococcus mutans are
...
Written By:
Carmen Leitch
MAR 22, 2021
Cell & Molecular Biology
Immunotherapy aims to make a patient's immune cells better at fighting cancer. The immune system has to be used carefull
...
Written By:
Carmen Leitch
MAR 21, 2021
Genetics & Genomics
Did life originate with RNA? Scientists are still trying to learn more about how the first molecules arose out of primor
...
Written By:
Carmen Leitch
MAR 16, 2021
Drug Discovery & Development
How do drugs work? Well, they work when they stick to their target protein. Of course, there is much more complicated pr
...
Written By:
Nouran Amin