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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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SEP 24, 2021Drug Discovery & Development
Two drugs delivered via the nose have shown promise for improving symptoms of Parkinson's disease in mice. The corre ...Written By: Annie LennonSEP 24, 2021Drug Discovery & Development
The World Health Organization (WHO) has recommended a combination of two antibody treatments for patients at risk of adv ...Written By: Annie LennonSEP 20, 2021Cancer
For the past several decades, cancer antigen 125 (CA 125), a protein located on the surface of ovarian cancer cells, has ...Written By: Katie KokolusAUG 31, 2021Clinical & Molecular DX
Cellular stains are organic fluorescent dyes or fluorescent conjugates designed to localize to a specific organelle or c ...AUG 27, 2021Health & Medicine
Since their discovery, there has been an interest in how ABO blood groups and infectious diseases may be related. In add ...Written By: Christopher DiMaioAUG 24, 2021Genetics & Genomics
Some rare genetic disorders impair a critical molecule that has to be replaced, or serious disease or disability will oc ...Written By: Carmen LeitchAUG 22, 2021Genetics & Genomics
One of the most difficult aspects of gene therapy might be ensuring that it gets into the right cells safely so it can h ...Written By: Carmen LeitchAUG 13, 2021Cell & Molecular Biology
We've learned a lot about the virus that causes COVID-19, SARS-CoV-2, in the past year and a half. Researchers know the ...Written By: Carmen LeitchAUG 12, 2021Immunology
Australian researchers have found a new molecular binding site on the coronavirus that causes COVID-19, a discovery that ...Written By: Tara FernandesAUG 03, 2021Immunology
Antibodies are specialized proteins produced as part of the body's immune response. Neutralizing antibodies bind to ...Written By: Tara FernandesAUG 01, 2021Drug Discovery & Development
A naturally-occurring compound called farnesol found in berries and other fruits prevents and reverses Parkinson's-a ...Written By: Annie LennonJUL 28, 2021Microbiology
Histones are proteins that are used to organize and compact DNA. Some giant viruses called Marseilleviridae have also be ...Written By: Carmen LeitchJUL 27, 2021Cell & Molecular Biology
In recent years, scientists java turned their attention to small antibodies that are produced by animals like sharks, ca ...Written By: Carmen LeitchJUL 23, 2021Genetics & Genomics
As imaging tools continue to get more sophisticated, researchers have been able to get a look at more biological process ...Written By: Carmen LeitchJUL 23, 2021Cancer
A new drug can kill between 95 and 100% of cancer cells in mice with human estrogen-receptor-positive breast cancer. The ...Written By: Annie LennonJUL 19, 2021Cell & Molecular Biology
Adenosine triphosphate (ATP) is a molecule that provides crucial energy to activate a wide array of biological processes ...Written By: Carmen LeitchJUL 19, 2021Microbiology
Viral infections are difficult to treat - antibiotics only work against bacteria - and there are few effective antibodie ...Written By: Carmen LeitchJUL 16, 2021Cancer
Exercise releases molecules into the bloodstream that reduce the growth of bowel cancer cells, say researchers from the ...Written By: Annie LennonJUL 05, 2021Cell & Molecular Biology
In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our ...Written By: Carmen LeitchJUL 04, 2021Genetics & Genomics
Rett syndrome is a neurological disorder that mostly affects girls; affected individuals develop normally until they're ...Written By: Carmen LeitchJUN 22, 2021Cell & Molecular Biology
Cells exist in three dimensions, and they have a dynamic skeleton and filaments that help them maintain and stabilize th ...Written By: Carmen LeitchJUN 21, 2021Genetics & Genomics
Most people think of viruses as nasty pathogens that can infect cells. Though it's taken time and testing, researche ...Written By: Carmen LeitchJUN 17, 2021Drug Discovery & Development
US drugmaker, Regeneron, in a partnership with Oxford University, has found that its new drug is capable of reducing COV ...Written By: Annie LennonJUN 16, 2021Immunology
Researchers at King’s College London have discovered a new antiviral target to combat COVID-19: the galectin-3-bin ...Written By: Tara Fernandes
SEP 24, 2021
Drug Discovery & Development
Two drugs delivered via the nose have shown promise for improving symptoms of Parkinson's disease in mice. The corre
...
Written By:
Annie Lennon
SEP 24, 2021
Drug Discovery & Development
The World Health Organization (WHO) has recommended a combination of two antibody treatments for patients at risk of adv
...
Written By:
Annie Lennon
SEP 20, 2021
Cancer
For the past several decades, cancer antigen 125 (CA 125), a protein located on the surface of ovarian cancer cells, has
...
Written By:
Katie Kokolus
AUG 31, 2021
Clinical & Molecular DX
Cellular stains are organic fluorescent dyes or fluorescent conjugates designed to localize to a specific organelle or c
...
AUG 27, 2021
Health & Medicine
Since their discovery, there has been an interest in how ABO blood groups and infectious diseases may be related. In add
...
Written By:
Christopher DiMaio
AUG 24, 2021
Genetics & Genomics
Some rare genetic disorders impair a critical molecule that has to be replaced, or serious disease or disability will oc
...
Written By:
Carmen Leitch
AUG 22, 2021
Genetics & Genomics
One of the most difficult aspects of gene therapy might be ensuring that it gets into the right cells safely so it can h
...
Written By:
Carmen Leitch
AUG 13, 2021
Cell & Molecular Biology
We've learned a lot about the virus that causes COVID-19, SARS-CoV-2, in the past year and a half. Researchers know the
...
Written By:
Carmen Leitch
AUG 12, 2021
Immunology
Australian researchers have found a new molecular binding site on the coronavirus that causes COVID-19, a discovery that
...
Written By:
Tara Fernandes
AUG 03, 2021
Immunology
Antibodies are specialized proteins produced as part of the body's immune response. Neutralizing antibodies bind to
...
Written By:
Tara Fernandes
AUG 01, 2021
Drug Discovery & Development
A naturally-occurring compound called farnesol found in berries and other fruits prevents and reverses Parkinson's-a
...
Written By:
Annie Lennon
JUL 28, 2021
Microbiology
Histones are proteins that are used to organize and compact DNA. Some giant viruses called Marseilleviridae have also be
...
Written By:
Carmen Leitch
JUL 27, 2021
Cell & Molecular Biology
In recent years, scientists java turned their attention to small antibodies that are produced by animals like sharks, ca
...
Written By:
Carmen Leitch
JUL 23, 2021
Genetics & Genomics
As imaging tools continue to get more sophisticated, researchers have been able to get a look at more biological process
...
Written By:
Carmen Leitch
JUL 23, 2021
Cancer
A new drug can kill between 95 and 100% of cancer cells in mice with human estrogen-receptor-positive breast cancer. The
...
Written By:
Annie Lennon
JUL 19, 2021
Cell & Molecular Biology
Adenosine triphosphate (ATP) is a molecule that provides crucial energy to activate a wide array of biological processes
...
Written By:
Carmen Leitch
JUL 19, 2021
Microbiology
Viral infections are difficult to treat - antibiotics only work against bacteria - and there are few effective antibodie
...
Written By:
Carmen Leitch
JUL 16, 2021
Cancer
Exercise releases molecules into the bloodstream that reduce the growth of bowel cancer cells, say researchers from the
...
Written By:
Annie Lennon
JUL 05, 2021
Cell & Molecular Biology
In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our
...
Written By:
Carmen Leitch
JUL 04, 2021
Genetics & Genomics
Rett syndrome is a neurological disorder that mostly affects girls; affected individuals develop normally until they're
...
Written By:
Carmen Leitch
JUN 22, 2021
Cell & Molecular Biology
Cells exist in three dimensions, and they have a dynamic skeleton and filaments that help them maintain and stabilize th
...
Written By:
Carmen Leitch
JUN 21, 2021
Genetics & Genomics
Most people think of viruses as nasty pathogens that can infect cells. Though it's taken time and testing, researche
...
Written By:
Carmen Leitch
JUN 17, 2021
Drug Discovery & Development
US drugmaker, Regeneron, in a partnership with Oxford University, has found that its new drug is capable of reducing COV
...
Written By:
Annie Lennon
JUN 16, 2021
Immunology
Researchers at King’s College London have discovered a new antiviral target to combat COVID-19: the galectin-3-bin
...
Written By:
Tara Fernandes