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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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Many people picture the classic double-stranded helix when picturing a molecule of DNA, but DNA is also capable of formi ...Written By: Carmen LeitchJAN 10, 2021Cell & Molecular Biology
Mosquitoes are killers; they are thought to be responsible for the deaths of millions of people every year because of th ...Written By: Carmen LeitchJAN 08, 2021Cell & Molecular Biology
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Scientists can learn more about genes and their function by assessing them in different organisms. This kind of genetic ...Written By: Carmen LeitchDEC 29, 2020Immunology
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MAR 14, 2021
Immunology
You might have experienced it yourself or met someone that can not eat a certain food or can not take a specific medicat
...
Written By:
Heba El-wassef
MAR 14, 2021
Genetics & Genomics
Preterm birth is when a baby is born before the 37th week of pregnancy. The liver, lungs & brain undergo a crucial devel
...
Written By:
Carmen Leitch
MAR 13, 2021
Cell & Molecular Biology
Carbohydrates are essential sources of energy, but sugar molecules serve a variety of other biological functions as well
...
Written By:
Carmen Leitch
MAR 01, 2021
Cardiology
Researchers have used a mouse model to show that heart problems can lead to disruptions in gene activity in the memory c
...
Written By:
Carmen Leitch
FEB 26, 2021
Genetics & Genomics
Some genes don't stay in the same place in the genome. Sometimes called jumping genes or transposons, this genetic mater
...
Written By:
Carmen Leitch
FEB 22, 2021
Cell & Molecular Biology
Inside of cells, organelles perform specialized functions to keep biological functions moving, one of which is the ribos
...
Written By:
Carmen Leitch
FEB 18, 2021
Genetics & Genomics
For the first time, researchers have used high resolution images to generate video footage of DNA as it 'dances' inside
...
Written By:
Carmen Leitch
FEB 16, 2021
Microbiology
Viruses that infect bacteria are called phages, and scientists have been interested in whether they can be used to targe
...
Written By:
Carmen Leitch
FEB 15, 2021
Cell & Molecular Biology
The SARS-CoV-2 pandemic virus that causes COVID-19 has now had ample opportunity to infect millions, which has presented
...
Written By:
Carmen Leitch
FEB 15, 2021
Genetics & Genomics
Green tea has been lauded for its medicinal qualities, though it's been difficult to show that definitively. A new study
...
Written By:
Carmen Leitch
FEB 10, 2021
Drug Discovery & Development
In a first-of-its-kind study, scientists from Florida Atlantic University's Schmidt College of Medicine in collabora
...
Written By:
Nouran Amin
FEB 07, 2021
Microbiology
After years of effort, researchers are reporting that there were encouraging results from a phase 1 clinical trial which
...
Written By:
Carmen Leitch
FEB 03, 2021
Clinical & Molecular DX
Rheumatoid arthritis, or RA, is a painful and debilitating autoimmune disorder of the joints, particularly those of the
...
Written By:
Tara Fernandes
JAN 29, 2021
Genetics & Genomics
Humans are far more likely to get several types of cancerous tumors than our closest evolutionary cousins, chimpanzees.
...
Written By:
Carmen Leitch
JAN 24, 2021
Microbiology
To cause the COVID-19 illness, the SARS-CoV-2 virus first has to get into cells. To do so, it uses something called a sp
...
Written By:
Carmen Leitch
JAN 17, 2021
Immunology
In the race for finding the right vaccine for the COVID-19 pandemic, a new vaccine candidate emerged. Researchers at Sta
...
Written By:
Heba El-wassef
JAN 15, 2021
Genetics & Genomics
Many people picture the classic double-stranded helix when picturing a molecule of DNA, but DNA is also capable of formi
...
Written By:
Carmen Leitch
JAN 10, 2021
Cell & Molecular Biology
Mosquitoes are killers; they are thought to be responsible for the deaths of millions of people every year because of th
...
Written By:
Carmen Leitch
JAN 08, 2021
Cell & Molecular Biology
There has long been debate about whether viruses are a form of life, because many of them are only made up of a bit of g
...
Written By:
Carmen Leitch
JAN 08, 2021
Microbiology
Bacterial infections that can't be eliminated with standard drugs, caused by antibiotic-resistant bacteria, are consider
...
Written By:
Carmen Leitch
JAN 02, 2021
Cell & Molecular Biology
Many types of cells have to be able to move around, such as during the development of the body, or when immune cells hav
...
Written By:
Carmen Leitch
DEC 31, 2020
Genetics & Genomics
Scientists can learn more about genes and their function by assessing them in different organisms. This kind of genetic
...
Written By:
Carmen Leitch
DEC 29, 2020
Immunology
Viruses that when administered to patients preferentially attack and kill cancer cells, leaving normal tissues unscathed
...
Written By:
Tara Fernandes
DEC 28, 2020
Drug Discovery & Development
Glioblastoma is a very aggressive and lethal form of brain cancer that responds poorly to chemotherapy in children and a
...
Written By:
Annie Lennon