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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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AUG 01, 2017Immunology
Scientists have known for a while that HIV hides in the body, undetected by the immune system and unaffected by antiretr ...Written By: Kara MarkerJUL 27, 2017Cell & Molecular Biology
Calcium is the most common mineral in the body, and 99 percent of it is stored in the bones and teeth, where it fulfills ...Written By: Kara MarkerJUL 26, 2017Immunology
A study that was initially designed to simply study T cell homeostasis ended up yielding surprising results. A recently ...Written By: Kara MarkerJUL 17, 2017Cell & Molecular Biology
Bisphenol A (BPA) is used frequently in food packaging, and it has gotten into our bodies. New research could help repla ...Written By: Carmen LeitchJUL 14, 2017Cell & Molecular Biology
CRISPR-Cas9 is a gene editing tool has tremendous potential, and researchers are working to improve it.Written By: Carmen LeitchJUL 11, 2017Cell & Molecular Biology
Mitochondria carry a small amount of their own DNA. If there are mutations in that DNA, they can cause serious disease.Written By: Carmen LeitchJUL 11, 2017Health & Medicine
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to targe ...Written By: The Scripps Research Institute (TSRI)JUL 06, 2017Cardiology
The marine invertebrate Botryllus schlosseri - AKA the star ascidian - has more in common with humans that you&rs ...Written By: Kara MarkerJUL 03, 2017Immunology
The immune system recruits many different types of cells that specialize in ridding the body of pathogens like bacteria ...Written By: Kara MarkerJUL 03, 2017Cardiology
Two small proteins, elastin and collagen, make up a dynamic duo that promote a sturdy foundation of tensile strength and ...Written By: Kara MarkerJUN 29, 2017Cancer
Most cancers kill by invading distant parts of the body where treatment is more difficult to reach. But cancer’s a ...JUN 21, 2017Immunology
There’s a new vaccine to protect against high cholesterol and its consequences: atherosclerotic plaques tha ...Written By: Kara MarkerJUN 14, 2017Cell & Molecular Biology
The Myasthenia Gravis Foundation of America thinks the disease is more common than thought. New work has revealed more a ...Written By: Carmen LeitchJUN 14, 2017Immunology
Diagnostic tests for a rare autoimmune disease called anti-phospholipid antibody syndrome (APS) are unreliable, and trea ...Written By: Kara MarkerJUN 13, 2017Drug Discovery & Development
A monoclonal antibody-based drug called SYN0012 is currently being investigated in human clinical trials for the ...Written By: Kara MarkerJUN 12, 2017Cell & Molecular Biology
Scientists are taking a new approach in the fight against the flu. They have engineered a protein that acts to stop the ...Written By: Carmen LeitchJUN 09, 2017Cardiology
A natural sugar called trehalose reduces plaques associated with atherosclerosis and heart disease by improving t ...Written By: Kara MarkerJUN 06, 2017Health & Medicine
Treating the heart after the damage has already been done is difficult, but it’s the only option when a sudden hea ...Written By: Kara MarkerJUN 05, 2017Health & Medicine
Why can’t cardiac tissue repair itself? Maybe if Baylor College of Medicine scientists can figure it out, they can ...Written By: Kara MarkerMAY 25, 2017Cardiology
The development of a blood clot could be very beneficial or very dangerous, depending on the situation. On one ha ...Written By: Kara MarkerMAY 19, 2017Cell & Molecular Biology
Researchers have found that a folk remedy to decrease fertility have the ability to block an important part of the ferti ...Written By: Carmen LeitchMAR 28, 2017Genetics & Genomics
TSRI Scientists Reveal How Viruses Disable Bacterial Immune Systems LA JOLLA, CA – March 28, 2017 – Picture ...Written By: The Scripps Research Institute (TSRI)MAR 22, 2017Microbiology
Heliobacter pylori is known to be a human pathogen; it can thrive in the acidic environment of the stomach and cause ulc ...Written By: Carmen LeitchMAR 21, 2017Cancer
You’ve heard of virus causing cancer. Now here’s a virus that can fight cancer. To selectively destroy cance ...
AUG 01, 2017
Immunology
Scientists have known for a while that HIV hides in the body, undetected by the immune system and unaffected by antiretr
...
Written By:
Kara Marker
JUL 27, 2017
Cell & Molecular Biology
Calcium is the most common mineral in the body, and 99 percent of it is stored in the bones and teeth, where it fulfills
...
Written By:
Kara Marker
JUL 26, 2017
Immunology
A study that was initially designed to simply study T cell homeostasis ended up yielding surprising results. A recently
...
Written By:
Kara Marker
JUL 17, 2017
Cell & Molecular Biology
Bisphenol A (BPA) is used frequently in food packaging, and it has gotten into our bodies. New research could help repla
...
Written By:
Carmen Leitch
JUL 14, 2017
Cell & Molecular Biology
CRISPR-Cas9 is a gene editing tool has tremendous potential, and researchers are working to improve it.
Written By:
Carmen Leitch
JUL 11, 2017
Cell & Molecular Biology
Mitochondria carry a small amount of their own DNA. If there are mutations in that DNA, they can cause serious disease.
Written By:
Carmen Leitch
JUL 11, 2017
Health & Medicine
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to targe
...
Written By:
The Scripps Research Institute (TSRI)
JUL 06, 2017
Cardiology
The marine invertebrate Botryllus schlosseri - AKA the star ascidian - has more in common with humans that you&rs
...
Written By:
Kara Marker
JUL 03, 2017
Immunology
The immune system recruits many different types of cells that specialize in ridding the body of pathogens like bacteria
...
Written By:
Kara Marker
JUL 03, 2017
Cardiology
Two small proteins, elastin and collagen, make up a dynamic duo that promote a sturdy foundation of tensile strength and
...
Written By:
Kara Marker
JUN 29, 2017
Cancer
Most cancers kill by invading distant parts of the body where treatment is more difficult to reach. But cancer’s a
...
JUN 21, 2017
Immunology
There’s a new vaccine to protect against high cholesterol and its consequences: atherosclerotic plaques tha
...
Written By:
Kara Marker
JUN 14, 2017
Cell & Molecular Biology
The Myasthenia Gravis Foundation of America thinks the disease is more common than thought. New work has revealed more a
...
Written By:
Carmen Leitch
JUN 14, 2017
Immunology
Diagnostic tests for a rare autoimmune disease called anti-phospholipid antibody syndrome (APS) are unreliable, and trea
...
Written By:
Kara Marker
JUN 13, 2017
Drug Discovery & Development
A monoclonal antibody-based drug called SYN0012 is currently being investigated in human clinical trials for the
...
Written By:
Kara Marker
JUN 12, 2017
Cell & Molecular Biology
Scientists are taking a new approach in the fight against the flu. They have engineered a protein that acts to stop the
...
Written By:
Carmen Leitch
JUN 09, 2017
Cardiology
A natural sugar called trehalose reduces plaques associated with atherosclerosis and heart disease by improving t
...
Written By:
Kara Marker
JUN 06, 2017
Health & Medicine
Treating the heart after the damage has already been done is difficult, but it’s the only option when a sudden hea
...
Written By:
Kara Marker
JUN 05, 2017
Health & Medicine
Why can’t cardiac tissue repair itself? Maybe if Baylor College of Medicine scientists can figure it out, they can
...
Written By:
Kara Marker
MAY 25, 2017
Cardiology
The development of a blood clot could be very beneficial or very dangerous, depending on the situation. On one ha
...
Written By:
Kara Marker
MAY 19, 2017
Cell & Molecular Biology
Researchers have found that a folk remedy to decrease fertility have the ability to block an important part of the ferti
...
Written By:
Carmen Leitch
MAR 28, 2017
Genetics & Genomics
TSRI Scientists Reveal How Viruses Disable Bacterial Immune Systems LA JOLLA, CA – March 28, 2017 – Picture
...
Written By:
The Scripps Research Institute (TSRI)
MAR 22, 2017
Microbiology
Heliobacter pylori is known to be a human pathogen; it can thrive in the acidic environment of the stomach and cause ulc
...
Written By:
Carmen Leitch
MAR 21, 2017
Cancer
You’ve heard of virus causing cancer. Now here’s a virus that can fight cancer. To selectively destroy cance
...