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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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FEB 05, 2018
Cell & Molecular Biology
Scientists are leaving no stone unturned in the search for new antibiotics. Now a peptide that can destroy biofilms has
...
Written By:
Carmen Leitch
JAN 31, 2018
Cell & Molecular Biology
Around 1.6 percent of adults take antipsychotic medication, according to one study, but their mode of efficacy is not we
...
Written By:
Carmen Leitch
DEC 19, 2017
Drug Discovery & Development
Group resolves D4 dopamine receptor crystal structure for drug discovery
Written By:
Courtney Schaal
DEC 18, 2017
Cell & Molecular Biology
Researchers have uncovered revealing new details about a mysterious class of proteins, and the work could help researche
...
Written By:
Carmen Leitch
NOV 27, 2017
Immunology
One of the viruses responsible for the itchy and runny nose, headache, and sore throat we associate with the common cold
...
Written By:
Kara Marker
NOV 24, 2017
Genetics & Genomics
Children that suffer from epidermolysis bullosa, sometimes called butterfly children because of their fragile skin, face
...
Written By:
Carmen Leitch
NOV 21, 2017
Cardiology
A common ingredient in cancer drugs could also be used to treat hypertension, or high blood pressure. From Georgetown Un
...
Written By:
Kara Marker
NOV 20, 2017
Cannabis Sciences
Your body has its own built-in cannabis system.
Written By:
Loren DeVito
NOV 18, 2017
Immunology
Without the inflammasome, the immune response to invading pathogens would be severely flawed. This protein conglomerate
...
Written By:
Kara Marker
NOV 10, 2017
Immunology
The only way to overcome multidrug-resistant bacteria is to design a drug that bacteria have never encountered. In a new
...
Written By:
Kara Marker
NOV 06, 2017
Genetics & Genomics
Chromatin remodeling is related to Fragile X Syndrome and autism; it now presents a great therapeutic target for treatme
...
Written By:
Carmen Leitch
OCT 30, 2017
Cell & Molecular Biology
Scientists have been trying to develop a vaccine for HIV for many years, but unusual characteristics of the virus have m
...
Written By:
Carmen Leitch
OCT 10, 2017
Drug Discovery & Development
After nearly a decade of searching, scientists from the Albert Einstein College of Medicine have found a molecule that k
...
OCT 06, 2017
Chemistry & Physics
The lasso peptide Benenodin-1. Credit: RCSB The 2016 Nobel Prize in Chemistry honored three of the most esteemed scienti
...
Written By:
Daniel Duan
OCT 02, 2017
Clinical & Molecular DX
Instead of the usual hour-long wait for routine lab results, a new blood test could allow doctors to diagnose a heart at
...
SEP 20, 2017
Cell & Molecular Biology
By studying the genetics behind butterfly wing patterns, researchers understand how a single gene can create limitless p
...
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Carmen Leitch
SEP 19, 2017
Cell & Molecular Biology
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SEP 16, 2017
Cancer
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...
SEP 10, 2017
Microbiology
Inflammation is a common feature of many diseases, and researchers wanted to know more about whether dormant bacteria ar
...
Written By:
Carmen Leitch
SEP 08, 2017
Cell & Molecular Biology
A critical signaling protein can send messages that are interpreted in different ways by different cells.
Written By:
Carmen Leitch
AUG 31, 2017
Neuroscience
Serotonin is an essential neurotransmitter. It's a chemical that regulates some vital functions in the body like moo
...
Written By:
Brenda Kelley Kim
AUG 16, 2017
Cancer
A protein from the “shaggy ink cap” mushroom may be a lethal fighter against leukemia cells, scientists repo
...
AUG 15, 2017
Cardiology
Inflammation in the liver and boosted cholesterol levels in the blood vessels create the perfect storm for vascular dise
...
Written By:
Kara Marker
AUG 15, 2017
Chemistry & Physics
A common vascular disorder among male at or over 50, abdominal aortic aneurysm (AAA) is a localized blood filled bulge o
...
Written By:
Daniel Duan