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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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MAR 09, 2017Health & Medicine
JUPITER, FL – March 9, 2017 – Scientists on the Florida campus of The Scripps Research Institute (TSRI) have ...Written By: The Scripps Research Institute (TSRI)MAR 08, 2017Chemistry & Physics
New TSRI Study Points to Potential Strategy to Kill Cancer Cells LA JOLLA, CA – March 8, 2017 – Research fin ...Written By: The Scripps Research Institute (TSRI)MAR 01, 2017Cancer
A sinister brain tumor that claims the lives of every affected child may now be stopped with a new molecule drug. The br ...FEB 27, 2017Immunology
Thanks to the innate immune response, humans have an immediately-acting defense mechanism set in place against invading ...Written By: Kara MarkerFEB 26, 2017Cell & Molecular Biology
The body relies on proteins for many functions; they are the essential building blocks of cells and work in maintenance, ...Written By: Carmen LeitchFEB 24, 2017Cell & Molecular Biology
Genes are the blueprint for an organism, they contain the instructions to build functional cells. But those instructiona ...Written By: Carmen LeitchFEB 18, 2017Cancer
Using small-molecule sugars, scientists successfully made artificial tags for cancer cells that otherwise blended in wit ...FEB 14, 2017Cardiology
There is a new algorithm-based diagnostic test on the table for a dangerous heart condition, and doctors could apply it ...Written By: Kara MarkerFEB 08, 2017Cardiology
A giant x-ray microscope from the UK national synchrotron facility revealed the structure and dynamics of a protein call ...Written By: Kara MarkerFEB 06, 2017Microbiology
JUPITER, FL – February 6, 2017 – The most frightening aspect of Zika virus has been its ability to produce s ...Written By: The Scripps Research Institute (TSRI)FEB 06, 2017Cell & Molecular Biology
For several years, scientists have known that a protein called activity-dependent neuroprotective protein, ADNP, is muta ...Written By: Carmen LeitchJAN 24, 2017Chemistry & Physics
Engineers want to use peptides—small proteins that carry out essential tasks in our cells—to construct bioel ...Written By: Futurity (futurity.org)JAN 20, 2017Videos
Snakes, scorpions, and jellyfish have one thing in common - they all contain venom designed to inflict pain, incapacitat ...JAN 19, 2017Clinical & Molecular DX
LA JOLLA, CA – January 19, 2017 – A team led by scientists at The Scripps Research Institute (TSRI) has deve ...Written By: The Scripps Research Institute (TSRI)JAN 18, 2017Cell & Molecular Biology
While cholesterol is primarily found in the cell membrane, its role there is not well understood. Researchers at the Uni ...Written By: Carmen LeitchJAN 12, 2017Cell & Molecular Biology
LA JOLLA, CA – January 12, 2017 – Scientists at The Scripps Research Institute (TSRI) have discovered a prot ...Written By: The Scripps Research Institute (TSRI)JAN 07, 2017Cancer
Peppers are in the spotlight again this week as scientists reveal the biological mechanism behind the anticancer effects ...JAN 05, 2017Neuroscience
JUPITER, FL – January 5, 2017 – Biologists on the Florida campus of The Scripps Research Institute (TSRI) ha ...Written By: The Scripps Research Institute (TSRI)DEC 30, 2016Cancer
An experimental drug that was originally intended to work for male contraception may also work to shrink testicular canc ...DEC 29, 2016Cancer
JUPITER, FL – December 29, 2016 – A new study led by scientists from the Florida campus of The Scripps Resea ...Written By: The Scripps Research Institute (TSRI)DEC 29, 2016Clinical & Molecular DX
JUPITER, FL – December 29, 2016 – Breast cancer researchers from the Florida campus of The Scripps Research ...Written By: The Scripps Research Institute (TSRI)DEC 21, 2016Clinical & Molecular DX
LA JOLLA, CA – December 21, 2016 – A new study led by scientists at The Scripps Research Institute (TSRI) is ...Written By: The Scripps Research Institute (TSRI)DEC 19, 2016Cell & Molecular Biology
There are vast swaths of genomic regions that don't code for protein, once nicknamed and thought of as junk DNA and RNA. ...Written By: Carmen Leitch
MAR 09, 2017
Health & Medicine
JUPITER, FL – March 9, 2017 – Scientists on the Florida campus of The Scripps Research Institute (TSRI) have
...
Written By:
The Scripps Research Institute (TSRI)
MAR 08, 2017
Chemistry & Physics
New TSRI Study Points to Potential Strategy to Kill Cancer Cells LA JOLLA, CA – March 8, 2017 – Research fin
...
Written By:
The Scripps Research Institute (TSRI)
MAR 01, 2017
Cancer
A sinister brain tumor that claims the lives of every affected child may now be stopped with a new molecule drug. The br
...
FEB 27, 2017
Immunology
Thanks to the innate immune response, humans have an immediately-acting defense mechanism set in place against invading
...
Written By:
Kara Marker
FEB 26, 2017
Cell & Molecular Biology
The body relies on proteins for many functions; they are the essential building blocks of cells and work in maintenance,
...
Written By:
Carmen Leitch
FEB 24, 2017
Cell & Molecular Biology
Genes are the blueprint for an organism, they contain the instructions to build functional cells. But those instructiona
...
Written By:
Carmen Leitch
FEB 18, 2017
Cancer
Using small-molecule sugars, scientists successfully made artificial tags for cancer cells that otherwise blended in wit
...
FEB 14, 2017
Cardiology
There is a new algorithm-based diagnostic test on the table for a dangerous heart condition, and doctors could apply it
...
Written By:
Kara Marker
FEB 08, 2017
Cardiology
A giant x-ray microscope from the UK national synchrotron facility revealed the structure and dynamics of a protein call
...
Written By:
Kara Marker
FEB 06, 2017
Microbiology
JUPITER, FL – February 6, 2017 – The most frightening aspect of Zika virus has been its ability to produce s
...
Written By:
The Scripps Research Institute (TSRI)
FEB 06, 2017
Cell & Molecular Biology
For several years, scientists have known that a protein called activity-dependent neuroprotective protein, ADNP, is muta
...
Written By:
Carmen Leitch
JAN 24, 2017
Chemistry & Physics
Engineers want to use peptides—small proteins that carry out essential tasks in our cells—to construct bioel
...
Written By:
Futurity (futurity.org)
JAN 20, 2017
Videos
Snakes, scorpions, and jellyfish have one thing in common - they all contain venom designed to inflict pain, incapacitat
...
JAN 19, 2017
Clinical & Molecular DX
LA JOLLA, CA – January 19, 2017 – A team led by scientists at The Scripps Research Institute (TSRI) has deve
...
Written By:
The Scripps Research Institute (TSRI)
JAN 18, 2017
Cell & Molecular Biology
While cholesterol is primarily found in the cell membrane, its role there is not well understood. Researchers at the Uni
...
Written By:
Carmen Leitch
JAN 12, 2017
Cell & Molecular Biology
LA JOLLA, CA – January 12, 2017 – Scientists at The Scripps Research Institute (TSRI) have discovered a prot
...
Written By:
The Scripps Research Institute (TSRI)
JAN 07, 2017
Cancer
Peppers are in the spotlight again this week as scientists reveal the biological mechanism behind the anticancer effects
...
JAN 05, 2017
Neuroscience
JUPITER, FL – January 5, 2017 – Biologists on the Florida campus of The Scripps Research Institute (TSRI) ha
...
Written By:
The Scripps Research Institute (TSRI)
DEC 30, 2016
Cancer
An experimental drug that was originally intended to work for male contraception may also work to shrink testicular canc
...
DEC 29, 2016
Cancer
JUPITER, FL – December 29, 2016 – A new study led by scientists from the Florida campus of The Scripps Resea
...
Written By:
The Scripps Research Institute (TSRI)
DEC 29, 2016
Clinical & Molecular DX
JUPITER, FL – December 29, 2016 – Breast cancer researchers from the Florida campus of The Scripps Research
...
Written By:
The Scripps Research Institute (TSRI)
DEC 21, 2016
Clinical & Molecular DX
LA JOLLA, CA – December 21, 2016 – A new study led by scientists at The Scripps Research Institute (TSRI) is
...
Written By:
The Scripps Research Institute (TSRI)
DEC 19, 2016
Cell & Molecular Biology
There are vast swaths of genomic regions that don't code for protein, once nicknamed and thought of as junk DNA and RNA.
...
Written By:
Carmen Leitch