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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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DEC 09, 2021
Genetics & Genomics
Nucleic acid purification is a common technique employed by numerous labs, including academic, pharmaceutical, agricultu
...
Sponsored By:
MilliporeSigma
DEC 06, 2021
Microbiology
Sino Biological Newly Launched A Panel of Research Reagents for SARS-CoV-2 Omicron Variant (B.1.1.529) Beijing, China, D
...
Sponsored By:
Sino Biological
DEC 06, 2021
Cell & Molecular Biology
To meet the demands of cutting-edge biomedical research, NanoString have launched a spatial transcriptomics platform cal
...
DEC 06, 2021
Microbiology
As pathogenic bacteria continue to evolve and find ways to evade common medications, researchers have been racing to dev
...
Written By:
Carmen Leitch
DEC 02, 2021
Microbiology
Crimean-Congo hemorrhagic fever (CCHF) is a deadly disease, which is fatal in about 30 percent of cases. It's caused
...
Written By:
Carmen Leitch
DEC 02, 2021
Cancer
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, accounting for about 90% of pancre
...
Written By:
Katie Kokolus
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Genetics & Genomics
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...
Written By:
Carmen Leitch
NOV 25, 2021
Cancer
Diabetes and cancer are two common diseases that share many similar risk factors. People with diabetes are also at&
...
Written By:
Katie Kokolus
NOV 22, 2021
Health & Medicine
In therapeutic applications, monoclonal antibodies (mAbs) provide highly precise targeting of pathological cells and red
...
NOV 22, 2021
Cell & Molecular Biology
Clinical depression is estimated to impact over 264 million people worldwide in any given year, but it's difficult to tr
...
Written By:
Carmen Leitch
NOV 22, 2021
Microbiology
Though treatments are available, there is no cure or vaccine from HIV, which impacts about 38 million people worldwide.
...
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NOV 07, 2021
Genetics & Genomics
When the COVID-19 pandemic began to impact the world, researchers everywhere sprang into action. But studying an infecti
...
Written By:
Carmen Leitch
NOV 01, 2021
Cell & Molecular Biology
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...
Written By:
Carmen Leitch
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Earth & The Environment
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...
Written By:
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...
Written By:
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Genetics & Genomics
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...
Written By:
Carmen Leitch
OCT 19, 2021
Immunology
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...
Written By:
Tara Fernandes
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Genetics & Genomics
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...
Written By:
Carmen Leitch
OCT 14, 2021
Cancer
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...
Written By:
Katie Kokolus
OCT 07, 2021
Clinical & Molecular DX
Viruses are natures shapeshifters; their genomes are in a constant state of flux as they divide in their hosts. Over tim
...
Written By:
Tara Fernandes
OCT 04, 2021
Cell & Molecular Biology
Neurons signal to one another at crucial junctions called synapses, and synaptic dysfunction is thought to play a role i
...
Written By:
Carmen Leitch
SEP 27, 2021
Microbiology
Rift Valley fever virus is carried by mosquitoes, and when it's passed to livestock including cattle, goats, and sheep,
...
Written By:
Carmen Leitch
SEP 26, 2021
Genetics & Genomics
Muscle diseases that have a genetic basis can cause muscles to waste away, and may lead to a premature death. There aren
...
Written By:
Carmen Leitch
SEP 26, 2021
Cell & Molecular Biology
Humans can produce millions or even billions of antibodies, so only so many can be captured and screened. But those anti
...
Written By:
Carmen Leitch