Small Molecule: Within the fields of molecular biology and pharmacology, a small molecule is a low molecular weight organic compound that may regulate a biological process, with a size on the order of 1 nm. Most drugs are small molecules.
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CRISPR-Cas9 has been widely adapted for use in transcriptional modulation and epigenetic engineering with deactivated Cas9 (dCas9) systems to enable CRISPR interference (CRISPRi) and CRISPR...
The discovery of covalent inhibitors has become a powerful strategy in drug development due to their ability to form irreversible bonds with target proteins, resulting in enhanced therapeuti...
Join us for an expert-led webinar with Adham Ahmed as he delves into the intricacies of developing robust and reliable reversed-phase chromatography methods. This session will cover critical...
Developing and validating RUO targeted quantitative methods for clinical applications presents many challenges to researchers. Resulting LC-MSn methods cover diverse molecular classes of com...
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that i...
Solute carriers include numerous uptake transporters that serve as major regulators of drug absorption, disposition, and clearance. Indeed, drug interactions or genetic variation that alter...
Cancer genome alterations that cause cancer cells to grow also confer vulnerabilities, which normal cells lack. The challenge is that, for the majority of cancers, we do not understand the r...
Quantifying critical quality attributes accurately and precisely is an important aspect of regulatory compliance. There is greater demand to optimize processes by integrating advanced analyt...
Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key featu...