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Drug Discovery
Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.
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DEC 06, 2018 | 8:00 AM
DATE: December 6, 2018TIME: 11:00am EST, 5:00pm CET Introduction Micro-computed tomography (micro-CT) offers significant advantages o...DEC 06, 2018 | 1:00 AM
DATE: December 6, 2018TIME: 10:00am CET, 5:00pm CST Intro Micro-computed tomography (micro-CT) offers significant advantage...DEC 05, 2018 | 9:00 AM
DATE: December 5, 2018TIME: 9:00AM PDTThe mouse is a critical, increasingly used model system in biomedical research and preclinical drug discovery. While technological advances en...DEC 04, 2018 | 7:00 AM
DATE: December 4, 2018TIME: 4:00pm CET PSCs represent an important tool in a wide range of applications, including basic research, disease...DEC 03, 2018 | 11:00 PM
DATE: December 4, 2018TIME: 8:00am CET PSCs represent an important tool in a wide range of applications, including basic research, disease...NOV 21, 2018 | 9:00 AM
DATE: November 21,2018TIME: 09:00am PST, 12:00pm EST Vaginal infections are a source of considerable morbidity among women. It is estimated that there are more than 10...NOV 15, 2018 | 10:00 AM
DATE: November 15, 2018TIME: 10:00am PT, 1:00pm ET Multiplex fluorescence immunohistochemistry offers a window into the biology of human disease, enabling the ana...Speaker: Traci DeGeer, BS, HT (ASCP) HTL, QIHC , Alexander KlimowiczSponsored By: Leica BiosystemsNOV 15, 2018 | 9:00 AM
Watch how to passage feeder-free Pluripotent Stem Cells (PSCs) cultured in Essential 8 medium using EDTA. Learn the best practices to help ensure successful passage of your cells....NOV 15, 2018 | 8:00 AM
CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...NOV 15, 2018 | 7:00 AM
The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...NOV 15, 2018 | 4:00 AM
Development of physiologically relevant cellular models, with strong translatability to human pathophysiology, is critical for identification and validation of novel therapeutic targets. Cell...NOV 14, 2018 | 3:00 PM
Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...NOV 07, 2018 | 8:00 PM
DATE: November 7, 2018TIME: 8:00PM PSTExosomes have been shown to have significant roles in cancer including disease progression acting in the tumor micro-environment, metasta...NOV 07, 2018 | 7:00 AM
DATE: November 7, 2018TIME: 7:00AM PDTExosomes have been shown to have significant roles in cancer including disease progression acting in the tumor micro-environment, metastasis a...NOV 06, 2018 | 12:00 AM
The last decade has seen a significant shift in the way that mammalian cells are used in biomedical science. Researchers are increasingly turning from simple, reductionist recombinant cells t...NOV 05, 2018 | 12:00 AM
Biomedical researchers are increasingly using advanced human cell models for translational biology and therapeutic discovery studies. These include patient-specific samples, cultured micro-ti...NOV 02, 2018 | 12:00 AM
Despite exciting recent developments in neuroscience, identifying novel, truly effective treatments for patients with neurological and psychiatric conditions remains highly challenging. There...NOV 01, 2018 | 12:00 AM
Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell t...NOV 01, 2018 | 12:00 AM
Integrated protocols and live-cell analysis solutions for different 3D tumor modelsIn the search for greater clinical translation, cancer researchers are increasingly turning to more comp...NOV 01, 2018 | 12:00 AM
Kinetic antibody internalization assays using live-cell analysisMonoclonal antibodies (mAb) and antibody-drug conjugates (ADCs) are widely used biological therapeutics. A key property of...NOV 01, 2018 | 12:00 AM
Deriving deeper biological insight & improving productivity in immune-cell biologyThe most common in vitro methods for immunologists to analyze cells of the immune system are flow cyt...OCT 30, 2018 | 10:00 AM
DATE: October 30, 2018TIME: 10:00am PT, 1:00pm ET Identification and quantification of post-translational modifications (PTM) presents a unique challenge to proteomic studies...OCT 23, 2018 | 7:00 AM
DATE: October 23, 2018TIME: 7:00AM PDTHigh Throughput Screening for the European Lead Factory (ELF) has been performed at Pivot Park Screening Centre (PPSC). 72 HTS campaigns have...OCT 11, 2018 | 10:30 AM
Two projects looking at novel approaches to targeting inflammatory breast cancer will be presented. Inflammatory breast cancer (IBC) is a unique, understudied, and most lethal subtype account...Speaker: Kevin Williams, PhD
DEC 06, 2018 | 8:00 AM
DATE: December 6, 2018TIME: 11:00am EST, 5:00pm CET Introduction Micro-computed tomography (micro-CT) offers significant advantages o...
DEC 06, 2018 | 1:00 AM
DATE: December 6, 2018TIME: 10:00am CET, 5:00pm CST Intro Micro-computed tomography (micro-CT) offers significant advantage...
DEC 05, 2018 | 9:00 AM
DATE: December 5, 2018TIME: 9:00AM PDTThe mouse is a critical, increasingly used model system in biomedical research and preclinical drug discovery. While technological advances en...
DEC 04, 2018 | 7:00 AM
DATE: December 4, 2018TIME: 4:00pm CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
DEC 03, 2018 | 11:00 PM
DATE: December 4, 2018TIME: 8:00am CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
NOV 21, 2018 | 9:00 AM
DATE: November 21,2018TIME: 09:00am PST, 12:00pm EST Vaginal infections are a source of considerable morbidity among women. It is estimated that there are more than 10...
NOV 15, 2018 | 10:00 AM
DATE: November 15, 2018TIME: 10:00am PT, 1:00pm ET Multiplex fluorescence immunohistochemistry offers a window into the biology of human disease, enabling the ana...
Speaker:
Traci DeGeer, BS, HT (ASCP) HTL, QIHC
, Alexander Klimowicz
Sponsored By: Leica Biosystems
NOV 15, 2018 | 9:00 AM
Watch how to passage feeder-free Pluripotent Stem Cells (PSCs) cultured in Essential 8 medium using EDTA. Learn the best practices to help ensure successful passage of your cells....
NOV 15, 2018 | 8:00 AM
CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...
NOV 15, 2018 | 7:00 AM
The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
NOV 15, 2018 | 4:00 AM
Development of physiologically relevant cellular models, with strong translatability to human pathophysiology, is critical for identification and validation of novel therapeutic targets. Cell...
NOV 14, 2018 | 3:00 PM
Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
NOV 07, 2018 | 8:00 PM
DATE: November 7, 2018TIME: 8:00PM PSTExosomes have been shown to have significant roles in cancer including disease progression acting in the tumor micro-environment, metasta...
NOV 07, 2018 | 7:00 AM
DATE: November 7, 2018TIME: 7:00AM PDTExosomes have been shown to have significant roles in cancer including disease progression acting in the tumor micro-environment, metastasis a...
NOV 06, 2018 | 12:00 AM
The last decade has seen a significant shift in the way that mammalian cells are used in biomedical science. Researchers are increasingly turning from simple, reductionist recombinant cells t...
NOV 05, 2018 | 12:00 AM
Biomedical researchers are increasingly using advanced human cell models for translational biology and therapeutic discovery studies. These include patient-specific samples, cultured micro-ti...
NOV 02, 2018 | 12:00 AM
Despite exciting recent developments in neuroscience, identifying novel, truly effective treatments for patients with neurological and psychiatric conditions remains highly challenging. There...
NOV 01, 2018 | 12:00 AM
Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell t...
NOV 01, 2018 | 12:00 AM
Integrated protocols and live-cell analysis solutions for different 3D tumor modelsIn the search for greater clinical translation, cancer researchers are increasingly turning to more comp...
NOV 01, 2018 | 12:00 AM
Kinetic antibody internalization assays using live-cell analysisMonoclonal antibodies (mAb) and antibody-drug conjugates (ADCs) are widely used biological therapeutics. A key property of...
NOV 01, 2018 | 12:00 AM
Deriving deeper biological insight & improving productivity in immune-cell biologyThe most common in vitro methods for immunologists to analyze cells of the immune system are flow cyt...
OCT 30, 2018 | 10:00 AM
DATE: October 30, 2018TIME: 10:00am PT, 1:00pm ET Identification and quantification of post-translational modifications (PTM) presents a unique challenge to proteomic studies...
OCT 23, 2018 | 7:00 AM
DATE: October 23, 2018TIME: 7:00AM PDTHigh Throughput Screening for the European Lead Factory (ELF) has been performed at Pivot Park Screening Centre (PPSC). 72 HTS campaigns have...
OCT 11, 2018 | 10:30 AM
Two projects looking at novel approaches to targeting inflammatory breast cancer will be presented. Inflammatory breast cancer (IBC) is a unique, understudied, and most lethal subtype account...
Speaker:
Kevin Williams, PhD