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    Fundamental research

    Fundamental research, in comparison to applied research, is an area of scientific research that focuses on progressing rudimentary scientific theories with the goal of further understanding scientific basics and making educated predictions on observed phenomena.

    Webinars

    • MAY 31, 2018 | 12:00 PM
      Cas9-Based Genome Engineering
      Cas9-Based Genome Engineering
      I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
      Speaker: Alejandro Chavez, MD, PhD
      Presented at: Lab Automation Virtual Event Series 2018
      2
      MAY 10, 2018 | 9:00 AM
      Multi-Omics Approach for Discovering Anti-Folate Drug Resistance Mechanisms in Triple-Negative Breast Cancer: Working Toward the Goal of Personalized Medicine
      Multi-Omics Approach for Discovering Anti-Folate Drug Resistance...
      Triple-negative breast cancer (TNBC) has poor prognosis with frequent relapses and deaths using current standard of care treatments.  Metabolic reprograming is now recognized as a fundam...
      Speaker: Steven Gross, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      Sponsored By: Agilent
      1
      APR 30, 2018 | 8:00 AM
      Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research Analysis
      Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research...
      Ion mobility/mass spectrometry has tremendous potential for metabolomics, lipidomics, and clinical analysis. Ion mobility can resolve compounds unresolved by LC/MS/MS, provide additional stru...
      Speaker: Richard Yost, PhD
      Sponsored By: Agilent
      6
      APR 12, 2018 | 10:30 AM
      The Genome in 3D: A Clinical Biomarker Platform
      The Genome in 3D: A Clinical Biomarker Platform
      In genomics, as in life, you need to be in the right place at the right time, and you need integrity, to be credible. Since the availability of the human genome sequence, there's been an...
      Speaker: Kevin Little, PhD
      Presented at: Molecular Diagnostics Virtual Event Series 2018
      1
      MAR 28, 2018 | 9:00 AM
      Controlling Terpenes and Cannabinoids in Flower and Extract
      Controlling Terpenes and Cannabinoids in Flower and Extract
      Cannabis and its products are referred to in the USA as Medical Marijuana. The traditional approach tomedical research of a single compound for a single target does not work for cannabis, a...
      Speaker: Markus Roggen, PhD
      Presented at: Cannabis Sciences Virtual Event Series 2018
      3
      MAR 15, 2018 | 7:30 AM
      Keynote Presentation: The Dynamics of the Unconscious Brain Under General Anesthesia
      Keynote Presentation: The Dynamics of the Unconscious Brain Under...
      General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: unconsciousness, amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobi...
      Speaker: Emery N. Brown, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      1
      MAR 14, 2018 | 12:00 PM
      The self-tuning brain: normalizing brain oscillations with neurofeedback
      The self-tuning brain: normalizing brain oscillations with neurofeedback
      Using Hebbian as well as homeostatic models of brain plasticity, the effects of neurofeedback (NFB) are examined from the theoretical perspective of EEG normalization. Within this framework,...
      Speaker: Tomas Ros, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      1
      FEB 21, 2018 | 7:30 AM
      Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular Pathological Epidemiology) and Immuno-MPE for Precision Medicine
      Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular...
      This lecture introduces the evolving paradigm of Molecular Pathological Epidemiology (MPE) as simply as possible.  Any given human disease represents fundamentally heterogeneous process,...
      Speaker: Shuji Ogino, MD, PhD, MS
      Presented at: Drug Discovery Virtual Event Series 2018
      1 1
      FEB 21, 2018 | 6:00 AM
      Using HDAC Inhibitors to Improve Cancer Immunotherapy
      Using HDAC Inhibitors to Improve Cancer Immunotherapy
      We recently reported that HDAC6 is involved in the regulation of a number of immunosuppressive checkpoint proteins, including the Program Death Receptor Ligand 1 (PD-L1). This protein is one...
      Speaker: Alejandro Villagra, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 08, 2018 | 12:00 PM
      Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks
      Data Collection as Environmental Enrichment: Automated Behavioral...
      The translation gap in biomedical research can be attributed in part to differences in how outcomes are assessed in preclinical research and in the clinic. Reasons for these mismatches includ...
      Speaker: Jamie Ahloy Dallaire, MSc, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2018
      5
      JAN 31, 2018 | 8:00 AM
      High Content Screening-Based Phenotypic Analysis Of Organotypic 3D Bronchial Tissues
      High Content Screening-Based Phenotypic Analysis Of Organotypic...
      One of the goals of the “3Rs principle” is to replace in vivo testing methodologies with in vitro procedures on human cells, followed by computational systems biology modelling to...
      Speaker: Diego Marescotti, PhD
      Presented at: Protein and Cell Analysis Education Series
      Sponsored By: Thermo Fisher Scientific
      9 1
      NOV 28, 2017 | 7:00 AM
      WEBINAR: Thiol-linked alkylation for the metabolic sequencing of RNA
      WEBINAR: Thiol-linked alkylation for the metabolic sequencing...
      DATE: November 28, 2017TIME: 7:00AM PT, 10:00AM ET, 4:00PM CETGene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes in RNA species at stea...
      Speaker: Stefan Ameres, PhD
      Sponsored By: Lexogen
      6
      NOV 16, 2017 | 10:00 AM
      WEBINAR: Tracking neural network activity in the B-27™ Plus Neuronal Culture System with a Maestro Pro MEA platform
      WEBINAR: Tracking neural network activity in the B-27™ Plus Neuronal...
      DATE: November 16, 2017TIME: 10:00am PST, 1:00pm EST, Neuronal networks play a fundamental role in the brain, with many diseases linked to disruptions in network activity.  Cell-ba...
      Speaker: Daniel Millard, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      6
      NOV 09, 2017 | 6:00 AM
      Biosafety Risk Assessment Fundamentals for Clinical Laboratories
      Biosafety Risk Assessment Fundamentals for Clinical Laboratories
      This session will review and describe the basic steps of a biosafety risk assessment for clinical laboratories.  The risk of exposure to infectious agents exists in every clinical labora...
      Speaker: Michael Pentella, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
      9
      OCT 12, 2017 | 10:30 AM
      Hypersecretion of fibroblast-derived exosomes during chemotherapy promotes pancreatic cancer chemoresistance
      Hypersecretion of fibroblast-derived exosomes during chemotherapy...
      Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
      Speaker: Reginald Hill, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      OCT 11, 2017 | 12:00 PM
      Examining Cancer with the minION: Methylation and Structural Variation
      Examining Cancer with the minION: Methylation and Structural Variation
      Nanopore sequencing has enormous potential for application to cancer, but specifically offers advantages into two main arenas, epigenetics and structural variation. Methylation is well-known...
      Speaker: Winston Timp, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      Sponsored By: Oxford Nanopore Technologies
      1
      SEP 28, 2017 | 12:00 PM
      Back to basics: Fundamental concepts and special considerations in RNA isolation
      Back to basics: Fundamental concepts and special considerations...
      How are your RNA yields? Some sample types present special challenges in RNA purification and analysis. In this webinar, we will discuss and provide tips for the following topics: &b...
      Speaker: Abhishek Sharma
      Presented at: Cell Biology Virtual Event Series 2017
      2
      SEP 27, 2017 | 1:30 PM
      Evolutionary Cell Biology is a powerful paradigm to study complex biological systems
      Evolutionary Cell Biology is a powerful paradigm to study complex...
      Although the cell is commonly referred to as “the most basic unit of life”, it is actually so complex that despite over 350 years of research we are still far from fully understan...
      Speaker: Idan Frumkin, PhD
      Presented at: Cell Biology Virtual Event Series 2017
      1
      SEP 27, 2017 | 6:00 AM
      Regulation of microtubule plus-end dynamics during axon guidance and cell migration
      Regulation of microtubule plus-end dynamics during axon guidance...
      A fundamental question in neuronal development is how growth cone cytoskeletal dynamics are coordinated to promote accurate axonal navigation. To address this question, we focus on microtubul...
      Speaker: Laura Lowery, PhD
      Presented at: Cell Biology Virtual Event Series 2017
      1
      JUL 20, 2017 | 8:00 AM
      WEBINAR: Application of targeted next-generation sequencing (NGS) panels in neurodevelopmental disorder research
      WEBINAR: Application of targeted next-generation sequencing (NGS)...
      DATE: July 20, 2017TIME: 8:00am PT, 11:00am ET, 5:00pm CESTNeurodevelopmental disorders (NDDs) are clinically and etiologically highly heterogeneous and are characterized by a...
      Speaker: Alessandra Murgia , Francisco Hernandez-Guzman
      Sponsored By: Thermo Fisher Scientific - Ion Torrent
      5
      JUL 01, 2017 | 8:00 AM
      Mechanisms for Assembling and Resolving Naïve Pluripotency
      Mechanisms for Assembling and Resolving Naïve Pluripotency
      The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous fa...
      Speaker: Jacob Hanna
      Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
      4
      JUL 01, 2017 | 8:00 AM
      Genomic profiling reveals novel PAX7 targets CD54, integrin α9β1 and SDC2, as markers for isolation of human ES/iPS cell-derived muscle progenitors
      Genomic profiling reveals novel PAX7 targets CD54, integrin α9β1...
      Therapeutic application of pluripotent stem (PS) cell-derived products represents the ultimate goal of stem cell research. In order to apply this technology to patients, it is fundamental to ...
      Speaker: Alessandro Magli
      Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
      1
      JUL 01, 2017 | 8:00 AM
      Patient-specific hiPSCs for understanding diabetes disease mechanisms
      Patient-specific hiPSCs for understanding diabetes disease mechanisms
      Diabetes is a debilitating chronic disease that is spirally out of control. Fundamentally, the progressive failure of pancreatic beta cells results in decreased insulin secretion, ultimately ...
      Speaker: Adrian Teo
      Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
      3
      MAY 25, 2017 | 7:30 AM
      Microfluidics without Borders: Commercialization Perspectives of High Throughput Applications for Acoustic Droplet Ejection Technology
      Microfluidics without Borders: Commercialization Perspectives...
      The commercialization of micro and nanofluidic devices has had promise for providing novel solutions to deliver high throughput, more efficient, integrated biological and chemical analysis to...
      Speaker: Sammy Datwani, PhD
      Presented at: Lab Automation Virtual Event Series 2017
      1
    MAY 31, 2018 | 12:00 PM
    Cas9-Based Genome Engineering
    Cas9-Based Genome Engineering
    I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
    Speaker: Alejandro Chavez, MD, PhD
    Presented at: Lab Automation Virtual Event Series 2018
    2
    MAY 10, 2018 | 9:00 AM
    Multi-Omics Approach for Discovering Anti-Folate Drug Resistance Mechanisms in Triple-Negative Breast Cancer: Working Toward the Goal of Personalized Medicine
    Multi-Omics Approach for Discovering Anti-Folate Drug Resistance...
    Triple-negative breast cancer (TNBC) has poor prognosis with frequent relapses and deaths using current standard of care treatments.  Metabolic reprograming is now recognized as a fundam...
    Speaker: Steven Gross, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    Sponsored By: Agilent
    1
    APR 30, 2018 | 8:00 AM
    Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research Analysis
    Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research...
    Ion mobility/mass spectrometry has tremendous potential for metabolomics, lipidomics, and clinical analysis. Ion mobility can resolve compounds unresolved by LC/MS/MS, provide additional stru...
    Speaker: Richard Yost, PhD
    Sponsored By: Agilent
    6
    APR 12, 2018 | 10:30 AM
    The Genome in 3D: A Clinical Biomarker Platform
    The Genome in 3D: A Clinical Biomarker Platform
    In genomics, as in life, you need to be in the right place at the right time, and you need integrity, to be credible. Since the availability of the human genome sequence, there's been an...
    Speaker: Kevin Little, PhD
    Presented at: Molecular Diagnostics Virtual Event Series 2018
    1
    MAR 28, 2018 | 9:00 AM
    Controlling Terpenes and Cannabinoids in Flower and Extract
    Controlling Terpenes and Cannabinoids in Flower and Extract
    Cannabis and its products are referred to in the USA as Medical Marijuana. The traditional approach tomedical research of a single compound for a single target does not work for cannabis, a...
    Speaker: Markus Roggen, PhD
    Presented at: Cannabis Sciences Virtual Event Series 2018
    3
     
     
  • MAR 15, 2018 | 7:30 AM
    Keynote Presentation: The Dynamics of the Unconscious Brain Under General Anesthesia
    Keynote Presentation: The Dynamics of the Unconscious Brain Under...
    General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: unconsciousness, amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobi...
    Speaker: Emery N. Brown, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    1
    MAR 14, 2018 | 12:00 PM
    The self-tuning brain: normalizing brain oscillations with neurofeedback
    The self-tuning brain: normalizing brain oscillations with neurofeedback
    Using Hebbian as well as homeostatic models of brain plasticity, the effects of neurofeedback (NFB) are examined from the theoretical perspective of EEG normalization. Within this framework,...
    Speaker: Tomas Ros, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    1
    FEB 21, 2018 | 7:30 AM
    Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular Pathological Epidemiology) and Immuno-MPE for Precision Medicine
    Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular...
    This lecture introduces the evolving paradigm of Molecular Pathological Epidemiology (MPE) as simply as possible.  Any given human disease represents fundamentally heterogeneous process,...
    Speaker: Shuji Ogino, MD, PhD, MS
    Presented at: Drug Discovery Virtual Event Series 2018
    1 1
    FEB 21, 2018 | 6:00 AM
    Using HDAC Inhibitors to Improve Cancer Immunotherapy
    Using HDAC Inhibitors to Improve Cancer Immunotherapy
    We recently reported that HDAC6 is involved in the regulation of a number of immunosuppressive checkpoint proteins, including the Program Death Receptor Ligand 1 (PD-L1). This protein is one...
    Speaker: Alejandro Villagra, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    FEB 08, 2018 | 12:00 PM
    Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks
    Data Collection as Environmental Enrichment: Automated Behavioral...
    The translation gap in biomedical research can be attributed in part to differences in how outcomes are assessed in preclinical research and in the clinic. Reasons for these mismatches includ...
    Speaker: Jamie Ahloy Dallaire, MSc, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2018
    5
     
     
  • JAN 31, 2018 | 8:00 AM
    High Content Screening-Based Phenotypic Analysis Of Organotypic 3D Bronchial Tissues
    High Content Screening-Based Phenotypic Analysis Of Organotypic...
    One of the goals of the “3Rs principle” is to replace in vivo testing methodologies with in vitro procedures on human cells, followed by computational systems biology modelling to...
    Speaker: Diego Marescotti, PhD
    Presented at: Protein and Cell Analysis Education Series
    Sponsored By: Thermo Fisher Scientific
    9 1
    NOV 28, 2017 | 7:00 AM
    WEBINAR: Thiol-linked alkylation for the metabolic sequencing of RNA
    WEBINAR: Thiol-linked alkylation for the metabolic sequencing...
    DATE: November 28, 2017TIME: 7:00AM PT, 10:00AM ET, 4:00PM CETGene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes in RNA species at stea...
    Speaker: Stefan Ameres, PhD
    Sponsored By: Lexogen
    6
    NOV 16, 2017 | 10:00 AM
    WEBINAR: Tracking neural network activity in the B-27™ Plus Neuronal Culture System with a Maestro Pro MEA platform
    WEBINAR: Tracking neural network activity in the B-27™ Plus Neuronal...
    DATE: November 16, 2017TIME: 10:00am PST, 1:00pm EST, Neuronal networks play a fundamental role in the brain, with many diseases linked to disruptions in network activity.  Cell-ba...
    Speaker: Daniel Millard, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    6
    NOV 09, 2017 | 6:00 AM
    Biosafety Risk Assessment Fundamentals for Clinical Laboratories
    Biosafety Risk Assessment Fundamentals for Clinical Laboratories
    This session will review and describe the basic steps of a biosafety risk assessment for clinical laboratories.  The risk of exposure to infectious agents exists in every clinical labora...
    Speaker: Michael Pentella, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
    9
    OCT 12, 2017 | 10:30 AM
    Hypersecretion of fibroblast-derived exosomes during chemotherapy promotes pancreatic cancer chemoresistance
    Hypersecretion of fibroblast-derived exosomes during chemotherapy...
    Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
    Speaker: Reginald Hill, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
     
     
  • OCT 11, 2017 | 12:00 PM
    Examining Cancer with the minION: Methylation and Structural Variation
    Examining Cancer with the minION: Methylation and Structural Variation
    Nanopore sequencing has enormous potential for application to cancer, but specifically offers advantages into two main arenas, epigenetics and structural variation. Methylation is well-known...
    Speaker: Winston Timp, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    Sponsored By: Oxford Nanopore Technologies
    1
    SEP 28, 2017 | 12:00 PM
    Back to basics: Fundamental concepts and special considerations in RNA isolation
    Back to basics: Fundamental concepts and special considerations...
    How are your RNA yields? Some sample types present special challenges in RNA purification and analysis. In this webinar, we will discuss and provide tips for the following topics: &b...
    Speaker: Abhishek Sharma
    Presented at: Cell Biology Virtual Event Series 2017
    2
    SEP 27, 2017 | 1:30 PM
    Evolutionary Cell Biology is a powerful paradigm to study complex biological systems
    Evolutionary Cell Biology is a powerful paradigm to study complex...
    Although the cell is commonly referred to as “the most basic unit of life”, it is actually so complex that despite over 350 years of research we are still far from fully understan...
    Speaker: Idan Frumkin, PhD
    Presented at: Cell Biology Virtual Event Series 2017
    1
    SEP 27, 2017 | 6:00 AM
    Regulation of microtubule plus-end dynamics during axon guidance and cell migration
    Regulation of microtubule plus-end dynamics during axon guidance...
    A fundamental question in neuronal development is how growth cone cytoskeletal dynamics are coordinated to promote accurate axonal navigation. To address this question, we focus on microtubul...
    Speaker: Laura Lowery, PhD
    Presented at: Cell Biology Virtual Event Series 2017
    1
    JUL 20, 2017 | 8:00 AM
    WEBINAR: Application of targeted next-generation sequencing (NGS) panels in neurodevelopmental disorder research
    WEBINAR: Application of targeted next-generation sequencing (NGS)...
    DATE: July 20, 2017TIME: 8:00am PT, 11:00am ET, 5:00pm CESTNeurodevelopmental disorders (NDDs) are clinically and etiologically highly heterogeneous and are characterized by a...
    Speaker: Alessandra Murgia , Francisco Hernandez-Guzman
    Sponsored By: Thermo Fisher Scientific - Ion Torrent
    5
     
     
  • JUL 01, 2017 | 8:00 AM
    Mechanisms for Assembling and Resolving Naïve Pluripotency
    Mechanisms for Assembling and Resolving Naïve Pluripotency
    The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous fa...
    Speaker: Jacob Hanna
    Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
    4
    JUL 01, 2017 | 8:00 AM
    Genomic profiling reveals novel PAX7 targets CD54, integrin α9β1 and SDC2, as markers for isolation of human ES/iPS cell-derived muscle progenitors
    Genomic profiling reveals novel PAX7 targets CD54, integrin α9β1...
    Therapeutic application of pluripotent stem (PS) cell-derived products represents the ultimate goal of stem cell research. In order to apply this technology to patients, it is fundamental to ...
    Speaker: Alessandro Magli
    Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
    1
    JUL 01, 2017 | 8:00 AM
    Patient-specific hiPSCs for understanding diabetes disease mechanisms
    Patient-specific hiPSCs for understanding diabetes disease mechanisms
    Diabetes is a debilitating chronic disease that is spirally out of control. Fundamentally, the progressive failure of pancreatic beta cells results in decreased insulin secretion, ultimately ...
    Speaker: Adrian Teo
    Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
    3
    MAY 25, 2017 | 7:30 AM
    Microfluidics without Borders: Commercialization Perspectives of High Throughput Applications for Acoustic Droplet Ejection Technology
    Microfluidics without Borders: Commercialization Perspectives...
    The commercialization of micro and nanofluidic devices has had promise for providing novel solutions to deliver high throughput, more efficient, integrated biological and chemical analysis to...
    Speaker: Sammy Datwani, PhD
    Presented at: Lab Automation Virtual Event Series 2017
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