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    In-Vivo Research

    In-Vivo Research: Studies that are in vivo are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism. Examples of investigations in vivo include: the pathogenesis of disease by comparing the effects of bacterial infection with the effects of purified bacterial toxins; the development of antibiotics, antiviral drugs, and new drugs generally; and new surgical procedures.

    Webinars

    • JUL 29, 2020 | 2:00 PM
      Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells
      Route of 41BB/41BBL costimulation determines effector function...
      B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H...
      Speaker: Christopher DeRenzo, MD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 29, 2020 | 11:00 AM
      STAT3 phosphorylation during phagocytosis is required to activate autophagy and prevent macrophage immuno-senescence
      STAT3 phosphorylation during phagocytosis is required to activate...
      Background: Acute liver injury (ALI) is characterised by hepatocyte death and liver inflammation. Macrophages play a pivotal role in ALI by phagocytosing dead cells and producing pro-regener...
      Speaker: Lara Campana, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      2
      JUL 29, 2020 | 12:00 AM
      3D Culture Methods and Imaging Considerations
      3D Culture Methods and Imaging Considerations
      The use of three‐dimensional (3D) culture models is rapidly expanding due to their recognition as representing more structurally and physiologically relevant models of in vivo biology. 3D ce...
      Speaker: Brad Larson , Valerie Sodi, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 29, 2020 | 12:00 AM
      Phenotypic and MoA Analysis of Anti-Metastatic Molecules using 3D Tumoroid Invasion Assays, Kinetic Ligand Binding, and Cellular Microscopy
      Phenotypic and MoA Analysis of Anti-Metastatic Molecules using...
      Metastasis is the main cause of death in cancer patients and one of the most complex biological processes in human diseases (Hanahan et al., 2011). The development of therapies designed to f...
      Speaker: Brad Larson
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 29, 2020 | 12:00 AM
      Automated Media Exchange for Long Term Spheroid Assays Using MultiFlo FX's new AMX Module
      Automated Media Exchange for Long Term Spheroid Assays Using MultiFlo...
      Three dimensional (3D) spheroidal cell models have become a mainstay in life science research to provide the most in vivo-like environment. Performing media exchanges and washes with unattac...
      Speaker: Brad Larson
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      2
      JUL 22, 2020 | 10:00 AM
      Molecular Diagnostic Solutions in a Pandemic: Planning for the 2020/2021 Flu Season with the Implementation of the ePlex® Respiratory Pathogen Panel 2
      Molecular Diagnostic Solutions in a Pandemic: Planning for the...
      DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
      Speaker: Heba Mostafa, MD, PhD, D(ABMM)
      Sponsored By: GenMark Dx
      27 13
      JUL 15, 2020 | 9:00 AM
      Calidad Más Allá de las Cifras
      Calidad Más Allá de las Cifras
      DATE: 15 Julio 2020 TIME: 11:00 COT, 09:00am PDT En esta conferencia tratamos de explorar el concepto profundo, holístico y existencial de la calidad , mucho más allá de...
      Speaker: Esteban Echavarría, MD
      Sponsored By: Abbott
      9 1
      JUL 07, 2020 | 6:00 AM
      Single-cell mapping of human brain cancer reveals tumor-driven education of tumor-associated leukocytes
      Single-cell mapping of human brain cancer reveals tumor-driven...
      Brain malignancies can either originate from within the CNS (gliomas) or invade from other locations in the body (metastases). A highly immunosuppressive tumor microenvironment (TME) influen...
      Speaker: Burkhard Becher, PhD
      Presented at: Fluidigm Infectious Disease and Oncology Virtual Summit
      1
      JUL 02, 2020 | 12:15 PM
      Authenticating human cells: Knowing exactly what is in your test tube
      Authenticating human cells: Knowing exactly what is in your test...
      The study of human development and diseases relies on analysis of samples obtained and manipulated ex vivo. It is critical in such studies to know the provenance and confirm that the identit...
      Speaker: Steve Jackson, PhD
      Presented at: APJ Virtual Genetic Solutions Tour 2020
      1
      JUN 30, 2020 | 8:00 AM
      Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex Technology
      Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex...
      DATE: June 30, 2020 TIME: 8:00am PT, 11:00am Understanding the tumor microenvironment (TME) is essential for the development of effective treatments for cancer patients. Traditional multi...
      Speaker: Chifei Sun
      Sponsored By: Leica Biosystems
      19
      JUN 24, 2020 | 9:00 AM
      Advanced quantitative fluorescence microscopy to probe the molecular dynamics of viral entry.
      Advanced quantitative fluorescence microscopy to probe the molecular...
      DATE: June 24, 2020 TIME: 9:00am PT, 12:00pm ET Some of the key factors in viral pathogenesis are the molecular mechanisms enabling viral entry into cells. Inhibitors of viral entry are ofte...
      Speaker: Luis Alvarez, Ph.D.
      Sponsored By: Leica Microsystems
      15 1
      JUN 18, 2020 | 9:00 AM
      Unveiling the role of T cell dysfunction in the development and progression of glioblastoma
      Unveiling the role of T cell dysfunction in the development and...
      DATE: June 18, 2020 TIME: 9:00am PDT, 12:00pm EDT Despite the success of immunotherapy against several malignancies including melanoma and lung adenocarcinoma, glioblastoma remains the excep...
      Speaker: Felipe Galvez Cancino, Ph.D.
      Sponsored By: Thermo Fisher Scientific/Gibco
      18 2
      JUN 18, 2020 | 8:00 AM
      Cracking Cellular Metabolism
      Cracking Cellular Metabolism
      Are you interested in Novel Sample Prep and gaining Powerful Insights with Discovery-based LC/MS Workflows? In this session, we will demonstrate a complete untargeted metabolomics workflow f...
      Speaker: Mark Sartain, PhD , Genevieve Van de Bittner, PhD
      Presented at: Agilent's Virtual Mass Spectacular!
      2
      JUN 17, 2020 | 3:00 PM
      Surgery as (Un)Usual: Development of Rodent Intracerebroventricular injection Capabilities During COVID-19
      Surgery as (Un)Usual: Development of Rodent Intracerebroventricular...
      Bringing a new research surgical model into production is always a challenging endeavor, and it has become much more challenging with the emergence of the Covid-19 pandemic. The virus’...
      Speaker: Matthew Flegal, BS, SRS
      Presented at: Coronavirus Series
      1
      JUN 03, 2020 | 8:00 AM
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
      Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
      Speaker: Alexander David Borowsky, MD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Leica Biosystems
      1
      JUN 03, 2020 | 12:00 AM
      Cell Cycle Regulation of Morphogenetic Processes during Development
      Cell Cycle Regulation of Morphogenetic Processes during Development
      During organismal development, differential regulation of the cell cycle is critical to many cell biological processes, including cell migration, cell fate specification and differentiation....
      Speaker: Rebecca Adikes, PhD
      Presented at: Cell & Developmental Biology Virtual Meeting
      2
      JUN 03, 2020 | 12:00 AM
      Uncovering Mammary Gland-Resident Macrophages by 3D and Intravital Imaging
      Uncovering Mammary Gland-Resident Macrophages by 3D and Intravital...
      The mammary gland is a unique organ that develops predominantly after birth and undergoes dramatic remodelling in reproductive phases. Macrophages have been implicated in mammary gland funct...
      Speaker: Caleb Dawson, PhD
      Presented at: Cell & Developmental Biology Virtual Meeting
      1
      JUN 03, 2020 | 12:00 AM
      Overcoming cell therapy barriers in the suppressive tumor microenvironment with engineered proteins
      Overcoming cell therapy barriers in the suppressive tumor microenvironment...
      1. Identify 3 barriers to immune cell response to cancer 2. List 3 approaches to overcome immunosuppressive barriers to bolster the immune response to cancer 3. Explain how fusion proteins c...
      Speaker: Shannon K. Oda, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      JUN 02, 2020 | 7:00 AM
      Harnessing the Power of Protein Expression Systems in Vaccine Development
      Harnessing the Power of Protein Expression Systems in Vaccine...
      DATE: June 2, 2020 TIME: 7:00am PT, 10:00am ET In just a few months COVID-19 has risen from a regional crisis to a global threat, and drug makers are now scrambling to develop vaccines aimed...
      Speaker: Roland Leathers, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      15 1
      MAY 20, 2020 | 7:30 AM
      Keynote Presentation: Bridging Multiscale Physiological Systems via Microfluidics- from single cell to tissue-scale to organ-scale
      Keynote Presentation: Bridging Multiscale Physiological Systems...
      Precision medicine is the paradigm to develop treatments for patients based on molecular-targets that are effective in vivo when administered. In addition to identifying the molecular and ce...
      Speaker: Abraham Lee
      Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
      1
      MAY 20, 2020 | 12:00 AM
      Acoustic Ejection Mass Spectrometry for High-Throughput Analysis
      Acoustic Ejection Mass Spectrometry for High-Throughput Analysis
      We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray io...
      Speaker: Luke Ghislain, PhD
      Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
      1 1
      MAY 14, 2020 | 11:00 AM
      Transparent, reliable and reproducible animal research: the ARRIVE guidelines 2.0
      Transparent, reliable and reproducible animal research: the ARRIVE...
      Concerns about the quality of published animal research include inefficient or flawed study design, inappropriate statistical analysis and incomplete reporting. The ARRIVE guidelines were de...
      Speaker: Nathalie Percie du Sert, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2020
      2
      MAY 14, 2020 | 9:00 AM
      PANEL: Experimental design and the reproducibility crisis: pitfalls, power, and practical best practice
      PANEL: Experimental design and the reproducibility crisis: pitfalls,...
      The justification of sample size is one of the hardest sections of a proposal an IACUC (ethical review board) has to assess, yet is arguably one of the most important (1). This is a key oppo...
      Speaker: Joseph Garner, PhD , Brianna Gaskill, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2020
      1
      MAY 14, 2020 | 7:30 AM
      Sex bias in preclinical research, why it exists and how to drive change
      Sex bias in preclinical research, why it exists and how to drive...
      Inherent in research, is the simplification of a complex world into a testing space to explore cause and effect. Across preclinical research, questions are being raised on the testing space...
      Speaker: Natasha Karp, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2020
      2
    JUL 29, 2020 | 2:00 PM
    Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells
    Route of 41BB/41BBL costimulation determines effector function...
    B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H...
    Speaker: Christopher DeRenzo, MD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 29, 2020 | 11:00 AM
    STAT3 phosphorylation during phagocytosis is required to activate autophagy and prevent macrophage immuno-senescence
    STAT3 phosphorylation during phagocytosis is required to activate...
    Background: Acute liver injury (ALI) is characterised by hepatocyte death and liver inflammation. Macrophages play a pivotal role in ALI by phagocytosing dead cells and producing pro-regener...
    Speaker: Lara Campana, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    2
    JUL 29, 2020 | 12:00 AM
    3D Culture Methods and Imaging Considerations
    3D Culture Methods and Imaging Considerations
    The use of three‐dimensional (3D) culture models is rapidly expanding due to their recognition as representing more structurally and physiologically relevant models of in vivo biology. 3D ce...
    Speaker: Brad Larson , Valerie Sodi, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 29, 2020 | 12:00 AM
    Phenotypic and MoA Analysis of Anti-Metastatic Molecules using 3D Tumoroid Invasion Assays, Kinetic Ligand Binding, and Cellular Microscopy
    Phenotypic and MoA Analysis of Anti-Metastatic Molecules using...
    Metastasis is the main cause of death in cancer patients and one of the most complex biological processes in human diseases (Hanahan et al., 2011). The development of therapies designed to f...
    Speaker: Brad Larson
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 29, 2020 | 12:00 AM
    Automated Media Exchange for Long Term Spheroid Assays Using MultiFlo FX's new AMX Module
    Automated Media Exchange for Long Term Spheroid Assays Using MultiFlo...
    Three dimensional (3D) spheroidal cell models have become a mainstay in life science research to provide the most in vivo-like environment. Performing media exchanges and washes with unattac...
    Speaker: Brad Larson
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    2
     
     
  • JUL 22, 2020 | 10:00 AM
    Molecular Diagnostic Solutions in a Pandemic: Planning for the 2020/2021 Flu Season with the Implementation of the ePlex® Respiratory Pathogen Panel 2
    Molecular Diagnostic Solutions in a Pandemic: Planning for the...
    DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
    Speaker: Heba Mostafa, MD, PhD, D(ABMM)
    Sponsored By: GenMark Dx
    27 13
    JUL 15, 2020 | 9:00 AM
    Calidad Más Allá de las Cifras
    Calidad Más Allá de las Cifras
    DATE: 15 Julio 2020 TIME: 11:00 COT, 09:00am PDT En esta conferencia tratamos de explorar el concepto profundo, holístico y existencial de la calidad , mucho más allá de...
    Speaker: Esteban Echavarría, MD
    Sponsored By: Abbott
    9 1
    JUL 07, 2020 | 6:00 AM
    Single-cell mapping of human brain cancer reveals tumor-driven education of tumor-associated leukocytes
    Single-cell mapping of human brain cancer reveals tumor-driven...
    Brain malignancies can either originate from within the CNS (gliomas) or invade from other locations in the body (metastases). A highly immunosuppressive tumor microenvironment (TME) influen...
    Speaker: Burkhard Becher, PhD
    Presented at: Fluidigm Infectious Disease and Oncology Virtual Summit
    1
    JUL 02, 2020 | 12:15 PM
    Authenticating human cells: Knowing exactly what is in your test tube
    Authenticating human cells: Knowing exactly what is in your test...
    The study of human development and diseases relies on analysis of samples obtained and manipulated ex vivo. It is critical in such studies to know the provenance and confirm that the identit...
    Speaker: Steve Jackson, PhD
    Presented at: APJ Virtual Genetic Solutions Tour 2020
    1
    JUN 30, 2020 | 8:00 AM
    Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex Technology
    Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex...
    DATE: June 30, 2020 TIME: 8:00am PT, 11:00am Understanding the tumor microenvironment (TME) is essential for the development of effective treatments for cancer patients. Traditional multi...
    Speaker: Chifei Sun
    Sponsored By: Leica Biosystems
    19
     
     
  • JUN 24, 2020 | 9:00 AM
    Advanced quantitative fluorescence microscopy to probe the molecular dynamics of viral entry.
    Advanced quantitative fluorescence microscopy to probe the molecular...
    DATE: June 24, 2020 TIME: 9:00am PT, 12:00pm ET Some of the key factors in viral pathogenesis are the molecular mechanisms enabling viral entry into cells. Inhibitors of viral entry are ofte...
    Speaker: Luis Alvarez, Ph.D.
    Sponsored By: Leica Microsystems
    15 1
    JUN 18, 2020 | 9:00 AM
    Unveiling the role of T cell dysfunction in the development and progression of glioblastoma
    Unveiling the role of T cell dysfunction in the development and...
    DATE: June 18, 2020 TIME: 9:00am PDT, 12:00pm EDT Despite the success of immunotherapy against several malignancies including melanoma and lung adenocarcinoma, glioblastoma remains the excep...
    Speaker: Felipe Galvez Cancino, Ph.D.
    Sponsored By: Thermo Fisher Scientific/Gibco
    18 2
    JUN 18, 2020 | 8:00 AM
    Cracking Cellular Metabolism
    Cracking Cellular Metabolism
    Are you interested in Novel Sample Prep and gaining Powerful Insights with Discovery-based LC/MS Workflows? In this session, we will demonstrate a complete untargeted metabolomics workflow f...
    Speaker: Mark Sartain, PhD , Genevieve Van de Bittner, PhD
    Presented at: Agilent's Virtual Mass Spectacular!
    2
    JUN 17, 2020 | 3:00 PM
    Surgery as (Un)Usual: Development of Rodent Intracerebroventricular injection Capabilities During COVID-19
    Surgery as (Un)Usual: Development of Rodent Intracerebroventricular...
    Bringing a new research surgical model into production is always a challenging endeavor, and it has become much more challenging with the emergence of the Covid-19 pandemic. The virus’...
    Speaker: Matthew Flegal, BS, SRS
    Presented at: Coronavirus Series
    1
    JUN 03, 2020 | 8:00 AM
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
    Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
    Speaker: Alexander David Borowsky, MD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Leica Biosystems
    1
     
     
  • JUN 03, 2020 | 12:00 AM
    Cell Cycle Regulation of Morphogenetic Processes during Development
    Cell Cycle Regulation of Morphogenetic Processes during Development
    During organismal development, differential regulation of the cell cycle is critical to many cell biological processes, including cell migration, cell fate specification and differentiation....
    Speaker: Rebecca Adikes, PhD
    Presented at: Cell & Developmental Biology Virtual Meeting
    2
    JUN 03, 2020 | 12:00 AM
    Uncovering Mammary Gland-Resident Macrophages by 3D and Intravital Imaging
    Uncovering Mammary Gland-Resident Macrophages by 3D and Intravital...
    The mammary gland is a unique organ that develops predominantly after birth and undergoes dramatic remodelling in reproductive phases. Macrophages have been implicated in mammary gland funct...
    Speaker: Caleb Dawson, PhD
    Presented at: Cell & Developmental Biology Virtual Meeting
    1
    JUN 03, 2020 | 12:00 AM
    Overcoming cell therapy barriers in the suppressive tumor microenvironment with engineered proteins
    Overcoming cell therapy barriers in the suppressive tumor microenvironment...
    1. Identify 3 barriers to immune cell response to cancer 2. List 3 approaches to overcome immunosuppressive barriers to bolster the immune response to cancer 3. Explain how fusion proteins c...
    Speaker: Shannon K. Oda, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
    JUN 02, 2020 | 7:00 AM
    Harnessing the Power of Protein Expression Systems in Vaccine Development
    Harnessing the Power of Protein Expression Systems in Vaccine...
    DATE: June 2, 2020 TIME: 7:00am PT, 10:00am ET In just a few months COVID-19 has risen from a regional crisis to a global threat, and drug makers are now scrambling to develop vaccines aimed...
    Speaker: Roland Leathers, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    15 1
    MAY 20, 2020 | 7:30 AM
    Keynote Presentation: Bridging Multiscale Physiological Systems via Microfluidics- from single cell to tissue-scale to organ-scale
    Keynote Presentation: Bridging Multiscale Physiological Systems...
    Precision medicine is the paradigm to develop treatments for patients based on molecular-targets that are effective in vivo when administered. In addition to identifying the molecular and ce...
    Speaker: Abraham Lee
    Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
    1
     
     
  • MAY 20, 2020 | 12:00 AM
    Acoustic Ejection Mass Spectrometry for High-Throughput Analysis
    Acoustic Ejection Mass Spectrometry for High-Throughput Analysis
    We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray io...
    Speaker: Luke Ghislain, PhD
    Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
    1 1
    MAY 14, 2020 | 11:00 AM
    Transparent, reliable and reproducible animal research: the ARRIVE guidelines 2.0
    Transparent, reliable and reproducible animal research: the ARRIVE...
    Concerns about the quality of published animal research include inefficient or flawed study design, inappropriate statistical analysis and incomplete reporting. The ARRIVE guidelines were de...
    Speaker: Nathalie Percie du Sert, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2020
    2
    MAY 14, 2020 | 9:00 AM
    PANEL: Experimental design and the reproducibility crisis: pitfalls, power, and practical best practice
    PANEL: Experimental design and the reproducibility crisis: pitfalls,...
    The justification of sample size is one of the hardest sections of a proposal an IACUC (ethical review board) has to assess, yet is arguably one of the most important (1). This is a key oppo...
    Speaker: Joseph Garner, PhD , Brianna Gaskill, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2020
    1
    MAY 14, 2020 | 7:30 AM
    Sex bias in preclinical research, why it exists and how to drive change
    Sex bias in preclinical research, why it exists and how to drive...
    Inherent in research, is the simplification of a complex world into a testing space to explore cause and effect. Across preclinical research, questions are being raised on the testing space...
    Speaker: Natasha Karp, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2020
    2
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