In Vivo: are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Inefficient knock-in of transgene cargos limits the potential of cell-based medicines. In this study, we used a CRISPR nuclease that targets a site within an exon of an essential gene and de...
Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
This webinar will provide an overview of the antibody discovery process, from target validation to candidate selection, highlighting the critical steps involved in developing effective antib...
RNA interference (RNAi) offers a fast and easy system to study gene functions. However, the traditionally used small interfering RNAs (siRNAs) can exhibit pronounced and problematic off-targ...
Quality sample preparation is fundamental to the analytical process. Tissue Processing is the most complex and one of the longest step in the histology workflow. The quality of the processed...
Date: May 31, 2023 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CET) Single-cell genomics has facilitated the understanding of mechanisms involved in various biological processes such as tumor...
Date: May 09, 2023 Time: 5:00am (PDT), 8:00pm (EDT), 2:00pm (CEST) Advances in high content imaging (HCI) have improved the use of cell culture to make a large number of comparisons within i...
Date: March 30, 2023 Time: 5:00pm (PST), 8:00pm (EST) March 31, 2023 9:00am (JST) Chimeric antigen receptor T cell (CAR-T) therapy is still challenging in targeting solid malignancies. The q...
Date: March 30, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Join the Gibco Cell Culture Heroes webinar featuring Heather Beasley, PhD as she presents "SLC25A46 as a Novel Mitoc...
Preclinical research and development are the cornerstone of modern drug discovery. A variety of biological systems including in vitro, 3D cultures, and organoids are essential tools, with ul...
Animal models present a unique opportunity to understand molecular mechanisms of pathological changes involved in cognitive dysfunction in neurological disorders. However, most of the work f...
Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Both diseases are characterized by abnormal aggregates in the brain, which incl...