Molecular Pathogenesis: research incorporate the study of host-pathogen interactions at the level of cellular and molecular networks with application to the understanding of virulence factors, host resistance to pathogens, and emerging (and resurgent) infectious disease agents.
Severe SARS-CoV-2 infection often leads to development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. In this study, we utiliz...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Self-amplifying RNA replicons are promising candidates for next generation vaccines against human coronaviruses with pandemic potential. Self-amplification of RNAs in host cells generates mo...
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
The ability of single-cell RNA-Seq (scRNA-Seq) to measure the transcriptional basis of heterogeneity between individual cells is transforming biomedical research. It enables the precise &lsq...
Despite available vaccines and treatments, COVID-19 continues to impose a major burden in the world, as a leading cause of hospitalizations and deaths. We and others have been working in te...
This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
DATE: October 09, 2020 TIME: 08:00am PT Traditional culture techniques, as the primary diagnostic tool for infectious diseases, are coming under scrutiny for failing to universally detect in...
GeoMx Digital Spatial Profiling Technology! The GeoMx Digital Spatial Profiler (DSP) is a novel platform developed by NanoString. This leading digital technology offers multiplexed measureme...
Chronic kidney disease (CKD) is a global health threat, affecting over 10% of the world population, including an estimated 37 million Americans. Importantly, glomerular diseases account for...
There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
Therapeutic antibody can provide key protection or lifesaving treatment for those who haven't been or can’t be vaccinated, or when vaccines don’t “take". We galvan...
As part of a large collaborative effort, we have used systems biology approaches to identify host factors that participate in SARS-CoV-2 replication. Protein-protein interactions maps betwee...
Congenital CMV is the most frequent infectious cause of neonatal malformation in developed nations. It is more prevalent than other neonatal conditions such as spina bifida and Down syndrome...
Most currently used conventional influenza vaccines are based on 1940s technology. Advances in immunogen design and vaccine delivery emerging over the last decade open novel opportunities fo...
Date: September 4, 2020 Time: 8:00am (PTD), 11:00am (ETD) Direct detection of viral RNA in human or other animal cells by RNA in situ hybridization (ISH) is a powerful tool to establish the...
DATA: 19 de agosto, 2020 Horário: às 15:00 horas Desde que foi detectado pela primeira vez em Wuhan, China, em 2019, o novo coronavírus SARS-CoV-2 e a doença que...
FECHA: 19 de Agosto, 2020 HORA: 10:00 AM PST 1:00 PM CST Desde que se detectó por primera vez en Wuhan, China, en 2019, el nuevo coronavirus SARS-CoV-2 y la enfermedad que causa, COVI...
DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
DATE: July 8, 2020 TIME: 10:00 am PDT This seminar reviews clinical utility of adopting rapid IDH1/2 testing in both hematological and solid tumors and describes the adjusted workflow develo...
DATE: June 24, 2020 TIME: 9:00am PT, 12:00pm ET Some of the key factors in viral pathogenesis are the molecular mechanisms enabling viral entry into cells. Inhibitors of viral entry are ofte...
Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
Severe SARS-CoV-2 infection often leads to development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. In this study, we utiliz...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Self-amplifying RNA replicons are promising candidates for next generation vaccines against human coronaviruses with pandemic potential. Self-amplification of RNAs in host cells generates mo...
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
The ability of single-cell RNA-Seq (scRNA-Seq) to measure the transcriptional basis of heterogeneity between individual cells is transforming biomedical research. It enables the precise &lsq...
Despite available vaccines and treatments, COVID-19 continues to impose a major burden in the world, as a leading cause of hospitalizations and deaths. We and others have been working in te...
This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
DATE: October 09, 2020 TIME: 08:00am PT Traditional culture techniques, as the primary diagnostic tool for infectious diseases, are coming under scrutiny for failing to universally detect in...
GeoMx Digital Spatial Profiling Technology! The GeoMx Digital Spatial Profiler (DSP) is a novel platform developed by NanoString. This leading digital technology offers multiplexed measureme...
Chronic kidney disease (CKD) is a global health threat, affecting over 10% of the world population, including an estimated 37 million Americans. Importantly, glomerular diseases account for...
There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
Therapeutic antibody can provide key protection or lifesaving treatment for those who haven't been or can’t be vaccinated, or when vaccines don’t “take". We galvan...
As part of a large collaborative effort, we have used systems biology approaches to identify host factors that participate in SARS-CoV-2 replication. Protein-protein interactions maps betwee...
Congenital CMV is the most frequent infectious cause of neonatal malformation in developed nations. It is more prevalent than other neonatal conditions such as spina bifida and Down syndrome...
Most currently used conventional influenza vaccines are based on 1940s technology. Advances in immunogen design and vaccine delivery emerging over the last decade open novel opportunities fo...
Date: September 4, 2020 Time: 8:00am (PTD), 11:00am (ETD) Direct detection of viral RNA in human or other animal cells by RNA in situ hybridization (ISH) is a powerful tool to establish the...
DATA: 19 de agosto, 2020 Horário: às 15:00 horas Desde que foi detectado pela primeira vez em Wuhan, China, em 2019, o novo coronavírus SARS-CoV-2 e a doença que...
FECHA: 19 de Agosto, 2020 HORA: 10:00 AM PST 1:00 PM CST Desde que se detectó por primera vez en Wuhan, China, en 2019, el nuevo coronavirus SARS-CoV-2 y la enfermedad que causa, COVI...
DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
DATE: July 8, 2020 TIME: 10:00 am PDT This seminar reviews clinical utility of adopting rapid IDH1/2 testing in both hematological and solid tumors and describes the adjusted workflow develo...
DATE: June 24, 2020 TIME: 9:00am PT, 12:00pm ET Some of the key factors in viral pathogenesis are the molecular mechanisms enabling viral entry into cells. Inhibitors of viral entry are ofte...
Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
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