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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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DEC 28, 2020Immunology
Scientists at the National Institutes of Health have identified new antibody-based weapons in the fight against COVID-19 ...Written By: Tara FernandesDEC 27, 2020Cell & Molecular Biology
Antibodies are naturally used by the body to bind targets on pathogens and neutralize them, and these specific interacti ...Written By: Carmen LeitchDEC 27, 2020Drug Discovery & Development
Researchers found that attacking a cell’s mitochondria can starve cancer cells. The study involves a possible ther ...Written By: Nouran AminDEC 24, 2020Microbiology
The UK recently reported that it had detected a new variant of the SARS-CoV-2 pandemic virus, which causes COVID-19. Thi ...Written By: Carmen LeitchDEC 23, 2020Immunology
Once the coronavirus enters the body, the immune system springs into action, producing antibodies that bind to and neutr ...Written By: Tara FernandesDEC 23, 2020Cell & Molecular Biology
Cytokines are a group of molecules that are involved in several processes including cell signaling and inflammation, the ...Written By: Carmen LeitchDEC 22, 2020Technology
Some diseases, such as metastatic breast cancer are known as “undruggable” or best described as unresponsive ...Written By: Nouran AminDEC 21, 2020Cancer
Many of today’s drugs come from vast libraries of synthetic compounds built by chemists for big pharma. This drug ...Written By: Jasper CantrellDEC 15, 2020Cancer
New research from scientists at the UCLA Jonsson Comprehensive Cancer Center showcases a novel combination therapy that ...Written By: Kathryn DeMuth SullivanDEC 08, 2020Cardiology
The complexity of life works in many ways. Proteins, the primary things doing work in cells, can be modified after being ...Written By: Jasper CantrellDEC 07, 2020Immunology
Smoking increases the risk of lung diseases by affecting the lungs in many ways. It irritates the lungs making ...Written By: Heba El-wassefDEC 01, 2020Cell & Molecular Biology
The genome has instructions for creating and maintaining an organism, but most biological functions involve their transl ...Written By: Carmen LeitchNOV 28, 2020Microbiology
A mosquito-borne virus called VEEV has been emerging in South America. It causes symptoms that make it difficult to dist ...Written By: Carmen LeitchNOV 26, 2020Drug Discovery & Development
Reduced food intake, known as dietary restriction, leads to a longer lifespan in many animals and can improve health in ...Written By: Nouran AminNOV 23, 2020Cell & Molecular Biology
If a key isn't cut quite right, it might need a special jiggle to get it into a lock in the right way. Scientists have n ...Written By: Carmen LeitchNOV 23, 2020Genetics & Genomics
Clinicians have identified a patient with a rare inherited disorder that disrupts the production of fresh blood cells, a ...Written By: Carmen LeitchNOV 23, 2020Microbiology
The pathogenic bacterium that causes tuberculosis, Mycobacterium tuberculosis, does not multiply quickly, so researchers ...Written By: Carmen LeitchNOV 23, 2020Drug Discovery & Development
Therapeutically relevant ion channels have inspired researchers to look into drugs that can regulate their activity. Ion ...Written By: Nouran AminNOV 22, 2020Microbiology
Rotaviruses are the biggest reason why young children get diarrhea. It's estimated that 215,000 kids die every year from ...Written By: Carmen LeitchNOV 22, 2020Cell & Molecular Biology
ChIP-Seq is a tool for analyzing the interactions between DNA and the proteins that bind to it, which influences gene ac ...Written By: Carmen LeitchNOV 18, 2020Drug Discovery & Development
At the present moment, there are no inhibitors that target protease activity of the novel SARS-CoV-2. The main proteases ...Written By: Nouran AminNOV 12, 2020Technology
Researchers have recently developed a unique virtual reality (VR) tool that can help in drug development? Particularly, ...Written By: Nouran AminNOV 12, 2020Cardiology
Cardiovascular disease is something that, in most cases, is within our ability to control. A healthy diet and active lif ...Written By: Jasper CantrellNOV 09, 2020Microbiology
Camelids, which include llamas, alpacas and camels have immune systems that generate two kinds of antibodies when confro ...Written By: Carmen Leitch
DEC 28, 2020
Immunology
Scientists at the National Institutes of Health have identified new antibody-based weapons in the fight against COVID-19
...
Written By:
Tara Fernandes
DEC 27, 2020
Cell & Molecular Biology
Antibodies are naturally used by the body to bind targets on pathogens and neutralize them, and these specific interacti
...
Written By:
Carmen Leitch
DEC 27, 2020
Drug Discovery & Development
Researchers found that attacking a cell’s mitochondria can starve cancer cells. The study involves a possible ther
...
Written By:
Nouran Amin
DEC 24, 2020
Microbiology
The UK recently reported that it had detected a new variant of the SARS-CoV-2 pandemic virus, which causes COVID-19. Thi
...
Written By:
Carmen Leitch
DEC 23, 2020
Immunology
Once the coronavirus enters the body, the immune system springs into action, producing antibodies that bind to and neutr
...
Written By:
Tara Fernandes
DEC 23, 2020
Cell & Molecular Biology
Cytokines are a group of molecules that are involved in several processes including cell signaling and inflammation, the
...
Written By:
Carmen Leitch
DEC 22, 2020
Technology
Some diseases, such as metastatic breast cancer are known as “undruggable” or best described as unresponsive
...
Written By:
Nouran Amin
DEC 21, 2020
Cancer
Many of today’s drugs come from vast libraries of synthetic compounds built by chemists for big pharma. This drug
...
Written By:
Jasper Cantrell
DEC 15, 2020
Cancer
New research from scientists at the UCLA Jonsson Comprehensive Cancer Center showcases a novel combination therapy that
...
Written By:
Kathryn DeMuth Sullivan
DEC 08, 2020
Cardiology
The complexity of life works in many ways. Proteins, the primary things doing work in cells, can be modified after being
...
Written By:
Jasper Cantrell
DEC 07, 2020
Immunology
Smoking increases the risk of lung diseases by affecting the lungs in many ways. It irritates the lungs making
...
Written By:
Heba El-wassef
DEC 01, 2020
Cell & Molecular Biology
The genome has instructions for creating and maintaining an organism, but most biological functions involve their transl
...
Written By:
Carmen Leitch
NOV 28, 2020
Microbiology
A mosquito-borne virus called VEEV has been emerging in South America. It causes symptoms that make it difficult to dist
...
Written By:
Carmen Leitch
NOV 26, 2020
Drug Discovery & Development
Reduced food intake, known as dietary restriction, leads to a longer lifespan in many animals and can improve health in
...
Written By:
Nouran Amin
NOV 23, 2020
Cell & Molecular Biology
If a key isn't cut quite right, it might need a special jiggle to get it into a lock in the right way. Scientists have n
...
Written By:
Carmen Leitch
NOV 23, 2020
Genetics & Genomics
Clinicians have identified a patient with a rare inherited disorder that disrupts the production of fresh blood cells, a
...
Written By:
Carmen Leitch
NOV 23, 2020
Microbiology
The pathogenic bacterium that causes tuberculosis, Mycobacterium tuberculosis, does not multiply quickly, so researchers
...
Written By:
Carmen Leitch
NOV 23, 2020
Drug Discovery & Development
Therapeutically relevant ion channels have inspired researchers to look into drugs that can regulate their activity. Ion
...
Written By:
Nouran Amin
NOV 22, 2020
Microbiology
Rotaviruses are the biggest reason why young children get diarrhea. It's estimated that 215,000 kids die every year from
...
Written By:
Carmen Leitch
NOV 22, 2020
Cell & Molecular Biology
ChIP-Seq is a tool for analyzing the interactions between DNA and the proteins that bind to it, which influences gene ac
...
Written By:
Carmen Leitch
NOV 18, 2020
Drug Discovery & Development
At the present moment, there are no inhibitors that target protease activity of the novel SARS-CoV-2. The main proteases
...
Written By:
Nouran Amin
NOV 12, 2020
Technology
Researchers have recently developed a unique virtual reality (VR) tool that can help in drug development? Particularly,
...
Written By:
Nouran Amin
NOV 12, 2020
Cardiology
Cardiovascular disease is something that, in most cases, is within our ability to control. A healthy diet and active lif
...
Written By:
Jasper Cantrell
NOV 09, 2020
Microbiology
Camelids, which include llamas, alpacas and camels have immune systems that generate two kinds of antibodies when confro
...
Written By:
Carmen Leitch