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    Public Health

    Public Health: the science and art of preventing disease, prolonging life and promoting human health through organized efforts and informed choices of society, organizations, public and private, communities and individuals." Analyzing the health of a population and the threats is the basis for public health. The "public" in question can be as small as a handful of people, an entire village or it can be as large as several continents, in the case of a pandemic. "Health" takes into account physical, mental and social well-being. It is not merely the absence of disease or infirmity, according to the World Health Organization.

    Webinars

    • MAR 20, 2024 | 8:00 AM
      Introducing the first dual reporter application for Luminex xMAP INTELLIFLEX DR-SE Instruments:  measurement of phosphorylated and total proteins on the same bead
      Introducing the first dual reporter application for Luminex xMAP...
      Luminex and Thermo Fisher Scientific are excited to feature two presentations highlighting the advanced features of the Invitrogen™ Luminex® xMAP® INTELLIFLEX™ DR-SE inst...
      Speaker: Sherry Dunbar, Ph.D., MBA , Sigrun Badrnya, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      11
      MAR 12, 2024 | 10:00 AM
      Circulating inflammatory biomarkers associated with cognitive function and dementia
      Circulating inflammatory biomarkers associated with cognitive...
      Inflammation is associated with cognitive decline and the pathogenesis of Alzheimer's disease, although exact pathways remain elusive. To further explore the role of inflammation, we uti...
      Speaker: Dr. Margaret Doyle
      Sponsored By: Olink Proteomics
      27
      FEB 14, 2024 | 10:00 AM
      C.E. CREDITS
      Knowledge is Power: Unveiling Women's Vaginal and Sexual Health Insights
      Knowledge is Power: Unveiling Women's Vaginal and Sexual Health...
      Women experience a variety of unique sexual health issues that are often under appreciated by the general public and even by healthcare providers. Compared to other populations, cisgender wo...
      Speaker: Olivia Van Gerwen, MD, MPH
      Sponsored By: Thermo Fisher Scientific
      26
      JAN 18, 2024 | 10:00 AM
      STAYING AHEAD OF THE CHANGING HPV TESTING LANDSCAPE: A 360 DEGREE REVIEW
      STAYING AHEAD OF THE CHANGING HPV TESTING LANDSCAPE: A 360 DEGREE...
      In 2020, American Cancer Society released an updated cervical cancer screening guideline calling for primary human papillomavirus (HPV) screening as the preferred strategy. Utility of HPV pr...
      Speaker: Anami Patel, PH.D, MB (ASCP) DLM , Mark Stoler, M.D.
      Sponsored By: Abbott
      20
      DEC 07, 2023 | 11:00 AM
      Seeing is believing - The Power of AI-Trained Digital Imaging in Microbiology: Integrating BD Kiestraâ„¢ Imaging Applications into Microbiology Workflows
      Seeing is believing - The Power of AI-Trained Digital Imaging...
      Abstract text Learning Objectives Webinars will be available for unlimited viewing after live event....
      Speaker: Dr. Christie Vermeiren PHD, FCCM
      Sponsored By: BD
      32
      DEC 01, 2023 | 8:00 AM
      Webinar World AIDS Day: the importance of testing
      Webinar World AIDS Day: the importance of testing
      According to the most recent data from UNAIDS, in 2022, there were around 39 million people living with HIV worldwide. Of these, 5.5 million people were unaware of their diagnosis in 2021. M...
      Speaker: Dr Carolina dos Santos Lázari , Guillermo Orjuela, MD, MSc.
      Sponsored By: Abbott
      23
      DEC 01, 2023 | 6:00 AM
      JOIN US ON WORLD AIDS DAY
      JOIN US ON WORLD AIDS DAY
      In recognition of World AIDS Day, we invite you to discover the innovative work being done to help end the HIV epidemic in some of the hardest hit areas in India. A diagnosis is the first st...
      Speaker: Dr. Gavin Cloherty , Dr. Sunil Solomon
      Sponsored By: Abbott
      22
      NOV 30, 2023 | 12:00 PM
      Revolutionizing Solid Tumor Management: Unleashing the Potential of Liquid Biopsy
      Revolutionizing Solid Tumor Management: Unleashing the Potential...
      Pathology Perspective: Discover the critical need for genomic testing in cancer and explore the differences between traditional tissue biopsies and liquid genomic profiling. We'll dive i...
      Speaker: Dr. Shuko Harada , Dr. Aakash Desai, MBBS, MPH
      Presented at: Precision Medicine in Solid Tumors
      5
      NOV 08, 2023 | 12:00 PM
      Panel Presentation: Lower Respiratory Tract Infections in Outpatients: Bacterial Causes or Do Viruses Also Matter? with Live Q&A
      Panel Presentation: Lower Respiratory Tract Infections in Outpatients:...
      Acute cough is one of the most common reasons for consulting in primary care thus driving considerable antibiotic use and health-care costs. Currently, identification of microbial etiology i...
      Speaker: Prof. Dr. Greet Ieven, PhD , Israel Figueroa , Jelena Feenstra, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2023
      Sponsored By: Thermo Fisher Scientific
      1
      NOV 08, 2023 | 8:00 AM
      Time to revisit RNA preservation - Synergy Blood Collection Tube
      Time to revisit RNA preservation - Synergy Blood Collection Tube
      SiO2 Materials Science is a company with deep roots in materials science and engineering and a track record of innovative packaging products for pharmaceutical drugs. The company also manufa...
      Speaker: Chris Weikart, PhD , Ishfaq Maksud
      Sponsored By: SIO2 Materials Science
      8
      NOV 08, 2023 | 6:00 AM
      A Simple, High-Throughput Way to Select the Best Antibody-Antigen Pair for Your Lateral Flow Assay with Live Q&A
      A Simple, High-Throughput Way to Select the Best Antibody-Antigen...
      Lateral flow assays (LFA) are simple diagnostic tools that can be used to detect a variety of biomolecules that include biomarkers, pathogens, and environmental contaminants. Many industries...
      Speaker: Shuo Liang, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2023
      Sponsored By: Sartorius
      1
      On Demand
      Navigating ISO 15189: A Blueprint for Quality in Medical Laboratories
      Navigating ISO 15189: A Blueprint for Quality in Medical Laboratories
      Medical laboratories are an integral part of the healthcare system. They supply crucial diagnostic data that underpins disease detection, patient care, and public health management....
      Speaker: Montserrat Valdes, MSc
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2023
      3
      OCT 18, 2023 | 9:00 AM
      HPV Testing Through Different Lenses: Strengthening Lab and Physician Partnerships to Improve Patient Care
      HPV Testing Through Different Lenses: Strengthening Lab and Physician...
      In this webinar, Jenny Meredith, Ph.D., HCLD(ABB), Clinical Microbiology Director at Prisma Health-Upstate joins forces with Sara Ezra, Molecular Supervisor at Pathology Consultants (subsidi...
      Speaker: Sara Ezra , Jenny Meredith, Ph.D., HCLD(ABB)
      Sponsored By: BD
      27
      OCT 12, 2023 | 6:00 AM
      Lower Respiratory Tract Infections in outpatients: bacterial causes or do viruses also matter?
      Lower Respiratory Tract Infections in outpatients: bacterial causes...
      Acute coughing is one of the most common reasons for consulting in primary care thus driving considerable antibiotic use and health-care costs. Currently, identification of microbial etiolog...
      Speaker: Prof. Dr. Greet Ieven, PhD , Israel Figueroa , Jelena Feenstra, PhD
      Sponsored By: Thermo Fisher Scientific
      17
      OCT 11, 2023 | 9:00 PM
      Development of a Novel Targeted NGS Panel for Analysis of DNA Methylation Biomarkers in Lung Cancer Research
      Development of a Novel Targeted NGS Panel for Analysis of DNA...
      Epigenetic modifications such as DNA methylation have long shown promise as potential biomarkers to diagnose and guide treatment of many human diseases, including multiple types of cancers....
      Speaker: Dr. Lucia Anna Muscarella, Ph.D. , Dr. Cristina Guillén, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      20
      SEP 14, 2023 | 11:00 AM
      The need for accurate quantitation of CMV and EBV in the management of transplant patients
      The need for accurate quantitation of CMV and EBV in the management...
      In the United States, over 40,000 transplantations are performed annually. Ensuring post-transplant success requires diligent monitoring of infectious diseases that are associated with a wid...
      Speaker: Dr. Scott Curry , Dr. Julie Hirschhorn
      Sponsored By: Abbott
      23
      SEP 07, 2023 | 10:30 AM
      Talking Diagnostics: A "Culture" Moving to PCR
      Talking Diagnostics: A "Culture" Moving to PCR
      Laboratories performing diagnostic testing for infectious diseases have an obligation to meet the needs of multiple patient populations....
      Speaker: Dr. Michael Perry
      Presented at: Microbiology Week Virtual Event Series 2023
      Sponsored By: Thermo Fisher Scientific
      6
      SEP 07, 2023 | 8:00 AM
      Quest Diagnostics with Covaris launches automated NGS platform, optimizing workflows to maximize lab economics
      Quest Diagnostics with Covaris launches automated NGS platform,...
      Advancements in Next Generation Sequencing (NGS) are changing the genomics industry, favoring those with scale. Quest Diagnostics' clinical expertise, combined with our infrastructure, p...
      Speaker: Ryan Serra, BSc. and Ph.D. , Matthew Gallen, MPH , Sameer Vasantgadkar
      Sponsored By: Covaris, Inc.
      12
      SEP 06, 2023 | 10:30 AM
      Advancing RSV Research: Expanding Therapeutic Options with Recombinant Antibodies and Antigens with Live Q&A
      Advancing RSV Research: Expanding Therapeutic Options with Recombinant...
      Human respiratory syncytial virus (RSV) remains a significant public health concern, particularly for vulnerable populations such as infants, young children, and immunocompromised individua...
      Speaker: Mohammad S. Safiarian, PhD
      Presented at: Microbiology Week Virtual Event Series 2023
      Sponsored By: Sino Biological
      2
      SEP 06, 2023 | 7:30 AM
      Keynote Presentation: Pathogen Discovery and Diagnostic Tools for Pandemic Preparedness and Prevention with Live Q&A
      Keynote Presentation: Pathogen Discovery and Diagnostic Tools...
      Emerging viruses like SARS, SARS-CoV-2, MERS-CoV, Hendra, Nipah, West Nile, sin nombre, LuJo, MERS, Powassan, dengue, chikungunya, zika, Ebola, and Marburg pose a growing threat to public he...
      Speaker: Nischay Mishra, PhD
      Presented at: Microbiology Week Virtual Event Series 2023
      5
      AUG 24, 2023 | 8:30 PM
      How to choose clinically relevant targets for your infectious disease panels
      How to choose clinically relevant targets for your infectious...
      When building your own infectious disease molecular panels there are many paths to consider. In this interview, we ask Marcus Cognetti and Dr. Ari Frenkel what approach is required to create...
      Speaker: Ari Frenkel, MD , Marcus Cognetti
      Sponsored By: Thermo Fisher Scientific
      23 1
      AUG 17, 2023 | 8:00 AM
      Current Landscape of Respiratory Illnesses and the Role of Multiplex Target Testing
      Current Landscape of Respiratory Illnesses and the Role of Multiplex...
      Globally millions of individuals get sick, hundreds of thousands are hospitalized, and tens of thousands die from respiratory viruses such as Influenza and Respiratory Syncytial Virus (RSV)...
      Speaker: Dr. Stefan Riedel, MD, PhD , Dr. Cameron Wolfe
      Sponsored By: Abbott
      23
      JUL 26, 2023 | 8:30 PM
      Automated image analysis reduces user-to-user variability in flow cytometry gating strategies
      Automated image analysis reduces user-to-user variability in flow...
      Differences in how users gate populations within experiments are major sources of variability in flow cytometry data analysis. Incorporating automated image analysis can substantially reduce...
      Speaker: Erin Taylor
      Sponsored By: Thermo Fisher Scientific
      11
      JUL 26, 2023 | 3:10 PM
      Harnessing iNKT Cells for "Off-The-Shelf" Cancer Therapy
      Harnessing iNKT Cells for "Off-The-Shelf" Cancer Therapy
      Cell-based immunotherapy has become the new-generation cancer medicine, and “off-the-shelf” cell products that can be manufactured at large scale and distributed readily to treat...
      Speaker: Dr. Lili Yang
      Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
      4
    MAR 20, 2024 | 8:00 AM
    Introducing the first dual reporter application for Luminex xMAP INTELLIFLEX DR-SE Instruments:  measurement of phosphorylated and total proteins on the same bead
    Introducing the first dual reporter application for Luminex xMAP...
    Luminex and Thermo Fisher Scientific are excited to feature two presentations highlighting the advanced features of the Invitrogen™ Luminex® xMAP® INTELLIFLEX™ DR-SE inst...
    Speaker: Sherry Dunbar, Ph.D., MBA , Sigrun Badrnya, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    11
    MAR 12, 2024 | 10:00 AM
    Circulating inflammatory biomarkers associated with cognitive function and dementia
    Circulating inflammatory biomarkers associated with cognitive...
    Inflammation is associated with cognitive decline and the pathogenesis of Alzheimer's disease, although exact pathways remain elusive. To further explore the role of inflammation, we uti...
    Speaker: Dr. Margaret Doyle
    Sponsored By: Olink Proteomics
    27
    FEB 14, 2024 | 10:00 AM
    C.E. CREDITS
    Knowledge is Power: Unveiling Women's Vaginal and Sexual Health Insights
    Knowledge is Power: Unveiling Women's Vaginal and Sexual Health...
    Women experience a variety of unique sexual health issues that are often under appreciated by the general public and even by healthcare providers. Compared to other populations, cisgender wo...
    Speaker: Olivia Van Gerwen, MD, MPH
    Sponsored By: Thermo Fisher Scientific
    26
    JAN 18, 2024 | 10:00 AM
    STAYING AHEAD OF THE CHANGING HPV TESTING LANDSCAPE: A 360 DEGREE REVIEW
    STAYING AHEAD OF THE CHANGING HPV TESTING LANDSCAPE: A 360 DEGREE...
    In 2020, American Cancer Society released an updated cervical cancer screening guideline calling for primary human papillomavirus (HPV) screening as the preferred strategy. Utility of HPV pr...
    Speaker: Anami Patel, PH.D, MB (ASCP) DLM , Mark Stoler, M.D.
    Sponsored By: Abbott
    20
    DEC 07, 2023 | 11:00 AM
    Seeing is believing - The Power of AI-Trained Digital Imaging in Microbiology: Integrating BD Kiestraâ„¢ Imaging Applications into Microbiology Workflows
    Seeing is believing - The Power of AI-Trained Digital Imaging...
    Abstract text Learning Objectives Webinars will be available for unlimited viewing after live event....
    Speaker: Dr. Christie Vermeiren PHD, FCCM
    Sponsored By: BD
    32
     
     
  • DEC 01, 2023 | 8:00 AM
    Webinar World AIDS Day: the importance of testing
    Webinar World AIDS Day: the importance of testing
    According to the most recent data from UNAIDS, in 2022, there were around 39 million people living with HIV worldwide. Of these, 5.5 million people were unaware of their diagnosis in 2021. M...
    Speaker: Dr Carolina dos Santos Lázari , Guillermo Orjuela, MD, MSc.
    Sponsored By: Abbott
    23
    DEC 01, 2023 | 6:00 AM
    JOIN US ON WORLD AIDS DAY
    JOIN US ON WORLD AIDS DAY
    In recognition of World AIDS Day, we invite you to discover the innovative work being done to help end the HIV epidemic in some of the hardest hit areas in India. A diagnosis is the first st...
    Speaker: Dr. Gavin Cloherty , Dr. Sunil Solomon
    Sponsored By: Abbott
    22
    NOV 30, 2023 | 12:00 PM
    Revolutionizing Solid Tumor Management: Unleashing the Potential of Liquid Biopsy
    Revolutionizing Solid Tumor Management: Unleashing the Potential...
    Pathology Perspective: Discover the critical need for genomic testing in cancer and explore the differences between traditional tissue biopsies and liquid genomic profiling. We'll dive i...
    Speaker: Dr. Shuko Harada , Dr. Aakash Desai, MBBS, MPH
    Presented at: Precision Medicine in Solid Tumors
    5
    NOV 08, 2023 | 12:00 PM
    Panel Presentation: Lower Respiratory Tract Infections in Outpatients: Bacterial Causes or Do Viruses Also Matter? with Live Q&A
    Panel Presentation: Lower Respiratory Tract Infections in Outpatients:...
    Acute cough is one of the most common reasons for consulting in primary care thus driving considerable antibiotic use and health-care costs. Currently, identification of microbial etiology i...
    Speaker: Prof. Dr. Greet Ieven, PhD , Israel Figueroa , Jelena Feenstra, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2023
    Sponsored By: Thermo Fisher Scientific
    1
    NOV 08, 2023 | 8:00 AM
    Time to revisit RNA preservation - Synergy Blood Collection Tube
    Time to revisit RNA preservation - Synergy Blood Collection Tube
    SiO2 Materials Science is a company with deep roots in materials science and engineering and a track record of innovative packaging products for pharmaceutical drugs. The company also manufa...
    Speaker: Chris Weikart, PhD , Ishfaq Maksud
    Sponsored By: SIO2 Materials Science
    8
     
     
  • NOV 08, 2023 | 6:00 AM
    A Simple, High-Throughput Way to Select the Best Antibody-Antigen Pair for Your Lateral Flow Assay with Live Q&A
    A Simple, High-Throughput Way to Select the Best Antibody-Antigen...
    Lateral flow assays (LFA) are simple diagnostic tools that can be used to detect a variety of biomolecules that include biomarkers, pathogens, and environmental contaminants. Many industries...
    Speaker: Shuo Liang, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2023
    Sponsored By: Sartorius
    1
    On Demand
    Navigating ISO 15189: A Blueprint for Quality in Medical Laboratories
    Navigating ISO 15189: A Blueprint for Quality in Medical Laboratories
    Medical laboratories are an integral part of the healthcare system. They supply crucial diagnostic data that underpins disease detection, patient care, and public health management....
    Speaker: Montserrat Valdes, MSc
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2023
    3
    OCT 18, 2023 | 9:00 AM
    HPV Testing Through Different Lenses: Strengthening Lab and Physician Partnerships to Improve Patient Care
    HPV Testing Through Different Lenses: Strengthening Lab and Physician...
    In this webinar, Jenny Meredith, Ph.D., HCLD(ABB), Clinical Microbiology Director at Prisma Health-Upstate joins forces with Sara Ezra, Molecular Supervisor at Pathology Consultants (subsidi...
    Speaker: Sara Ezra , Jenny Meredith, Ph.D., HCLD(ABB)
    Sponsored By: BD
    27
    OCT 12, 2023 | 6:00 AM
    Lower Respiratory Tract Infections in outpatients: bacterial causes or do viruses also matter?
    Lower Respiratory Tract Infections in outpatients: bacterial causes...
    Acute coughing is one of the most common reasons for consulting in primary care thus driving considerable antibiotic use and health-care costs. Currently, identification of microbial etiolog...
    Speaker: Prof. Dr. Greet Ieven, PhD , Israel Figueroa , Jelena Feenstra, PhD
    Sponsored By: Thermo Fisher Scientific
    17
    OCT 11, 2023 | 9:00 PM
    Development of a Novel Targeted NGS Panel for Analysis of DNA Methylation Biomarkers in Lung Cancer Research
    Development of a Novel Targeted NGS Panel for Analysis of DNA...
    Epigenetic modifications such as DNA methylation have long shown promise as potential biomarkers to diagnose and guide treatment of many human diseases, including multiple types of cancers....
    Speaker: Dr. Lucia Anna Muscarella, Ph.D. , Dr. Cristina Guillén, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    20
     
     
  • SEP 14, 2023 | 11:00 AM
    The need for accurate quantitation of CMV and EBV in the management of transplant patients
    The need for accurate quantitation of CMV and EBV in the management...
    In the United States, over 40,000 transplantations are performed annually. Ensuring post-transplant success requires diligent monitoring of infectious diseases that are associated with a wid...
    Speaker: Dr. Scott Curry , Dr. Julie Hirschhorn
    Sponsored By: Abbott
    23
    SEP 07, 2023 | 10:30 AM
    Talking Diagnostics: A "Culture" Moving to PCR
    Talking Diagnostics: A "Culture" Moving to PCR
    Laboratories performing diagnostic testing for infectious diseases have an obligation to meet the needs of multiple patient populations....
    Speaker: Dr. Michael Perry
    Presented at: Microbiology Week Virtual Event Series 2023
    Sponsored By: Thermo Fisher Scientific
    6
    SEP 07, 2023 | 8:00 AM
    Quest Diagnostics with Covaris launches automated NGS platform, optimizing workflows to maximize lab economics
    Quest Diagnostics with Covaris launches automated NGS platform,...
    Advancements in Next Generation Sequencing (NGS) are changing the genomics industry, favoring those with scale. Quest Diagnostics' clinical expertise, combined with our infrastructure, p...
    Speaker: Ryan Serra, BSc. and Ph.D. , Matthew Gallen, MPH , Sameer Vasantgadkar
    Sponsored By: Covaris, Inc.
    12
    SEP 06, 2023 | 10:30 AM
    Advancing RSV Research: Expanding Therapeutic Options with Recombinant Antibodies and Antigens with Live Q&A
    Advancing RSV Research: Expanding Therapeutic Options with Recombinant...
    Human respiratory syncytial virus (RSV) remains a significant public health concern, particularly for vulnerable populations such as infants, young children, and immunocompromised individua...
    Speaker: Mohammad S. Safiarian, PhD
    Presented at: Microbiology Week Virtual Event Series 2023
    Sponsored By: Sino Biological
    2
    SEP 06, 2023 | 7:30 AM
    Keynote Presentation: Pathogen Discovery and Diagnostic Tools for Pandemic Preparedness and Prevention with Live Q&A
    Keynote Presentation: Pathogen Discovery and Diagnostic Tools...
    Emerging viruses like SARS, SARS-CoV-2, MERS-CoV, Hendra, Nipah, West Nile, sin nombre, LuJo, MERS, Powassan, dengue, chikungunya, zika, Ebola, and Marburg pose a growing threat to public he...
    Speaker: Nischay Mishra, PhD
    Presented at: Microbiology Week Virtual Event Series 2023
    5
     
     
  • AUG 24, 2023 | 8:30 PM
    How to choose clinically relevant targets for your infectious disease panels
    How to choose clinically relevant targets for your infectious...
    When building your own infectious disease molecular panels there are many paths to consider. In this interview, we ask Marcus Cognetti and Dr. Ari Frenkel what approach is required to create...
    Speaker: Ari Frenkel, MD , Marcus Cognetti
    Sponsored By: Thermo Fisher Scientific
    23 1
    AUG 17, 2023 | 8:00 AM
    Current Landscape of Respiratory Illnesses and the Role of Multiplex Target Testing
    Current Landscape of Respiratory Illnesses and the Role of Multiplex...
    Globally millions of individuals get sick, hundreds of thousands are hospitalized, and tens of thousands die from respiratory viruses such as Influenza and Respiratory Syncytial Virus (RSV)...
    Speaker: Dr. Stefan Riedel, MD, PhD , Dr. Cameron Wolfe
    Sponsored By: Abbott
    23
    JUL 26, 2023 | 8:30 PM
    Automated image analysis reduces user-to-user variability in flow cytometry gating strategies
    Automated image analysis reduces user-to-user variability in flow...
    Differences in how users gate populations within experiments are major sources of variability in flow cytometry data analysis. Incorporating automated image analysis can substantially reduce...
    Speaker: Erin Taylor
    Sponsored By: Thermo Fisher Scientific
    11
    JUL 26, 2023 | 3:10 PM
    Harnessing iNKT Cells for "Off-The-Shelf" Cancer Therapy
    Harnessing iNKT Cells for "Off-The-Shelf" Cancer Therapy
    Cell-based immunotherapy has become the new-generation cancer medicine, and “off-the-shelf” cell products that can be manufactured at large scale and distributed readily to treat...
    Speaker: Dr. Lili Yang
    Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
    4
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