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    Target Identification

    Target Identification: is the process of identifying the direct molecular target - for example protein or nucleic acid - of a small molecule. In clinical pharmacology, target identification is aimed at finding the efficacy target of a drug/pharmaceutical or other xenobiotic. The techniques used may be based on principles of biochemistry, biophysics, genetics, chemical biology or other disciplines.

    Webinars

    • MAY 08, 2019 | 6:00 AM
      C.E. CREDITS
      Novel DNA Methylation in Mammals
      Novel DNA Methylation in Mammals
      Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
      Speaker: Tao Wu, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      2
      APR 30, 2019 | 8:00 AM
      Small platform enables big change - Nanotech-assisted discovery of novel biomarkers for disease diagnosis
      Small platform enables big change - Nanotech-assisted discovery...
      DATE: April 30, 2019TIME: 8:00am PDTIumour-derived extracellular vesicles (EVs) are of increasing interest as a resource of diagnostic biomarkers. However, most EV assays require large...
      Speaker: Tony Hu, PhD
      7 2
      APR 25, 2019 | 12:00 PM
      Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges and Threats Posed by Infectious Diseases
      Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges...
      Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
      Speaker: Faramarz Valafar, PhD
      Presented at: Infectious Disease Virtual Event Series 2019
      2
      APR 10, 2019 | 10:30 AM
      CRISPR-Chip: Detection of Unamplified Target Genes via CRISPR/Cas9 Immobilized on a Graphene Biosensors
      CRISPR-Chip: Detection of Unamplified Target Genes via CRISPR/Cas9...
      CRISPR-chip combines two powerful technologies ,CRISPR and Graphene, for rapid detection of nucleic acids. This talk will focus on design and fabrication of CRISPR-chip and its potential util...
      Speaker: Kiana Aran, PhD
      Presented at: Molecular Diagnostics Virtual Event Series 2019
      4
      JAN 31, 2019 | 10:30 AM
      Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries to Improve Process Efficiencies
      Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries...
      Multi-mode chromatography has come to prominence in recent years due to the general utility of multi-mode ligands for product capture and polishing. In particular, their application in flow-t...
      Speaker: Buzz Lobbezoo
      Presented at: BioProcessing Virtual Event Series 2019
      Sponsored By: Astrea Bioseparations
      1
      DEC 06, 2018 | 8:00 AM
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
      DATE:  December 6, 2018TIME:   11:00am EST, 5:00pm CET Introduction Micro-computed tomography (micro-CT) offers significant advantages o...
      Speaker: Rob van 't Hof, BSc, MSc, PhD
      Sponsored By: Bruker Microbiology & Diagnostics
      2
      DEC 06, 2018 | 1:00 AM
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
      DATE:    December 6, 2018TIME:    10:00am CET, 5:00pm CST Intro Micro-computed tomography (micro-CT) offers significant advantage...
      Speaker: Rob van 't Hof, BSc, MSc, PhD
      Sponsored By: Bruker Microbiology & Diagnostics
      8
      NOV 15, 2018 | 4:00 AM
      Generation and application of 3D-organoid cell culture models using human induced pluripotent stem cells (iPSCs) for drug discovery
      Generation and application of 3D-organoid cell culture models...
      Development of physiologically relevant cellular models, with strong translatability to human pathophysiology, is critical for identification and validation of novel therapeutic targets. Cell...
      Speaker: Ryan Hicks
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      10 2
      NOV 14, 2018 | 6:00 AM
      Improving Sepsis Management with Same-Day Results from the Lab
      Improving Sepsis Management with Same-Day Results from the Lab
      Sepsis is the Achilles’ heel of health care. Despite being relatively unknown to the public, it is a top killer in hospitals and the cost burden is crushing to our healthcare system. Mo...
      Speaker: John McDonough
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      2 1
      NOV 08, 2018 | 5:00 PM
      NMR in standardizing biomarkers for personalized medicine: Where do biobanks come in?  (For research use only)
      NMR in standardizing biomarkers for personalized medicine: Where...
      DATE:  November 9, 2018 TIME:   09:00am CST, 10:00am JST, 12:00pm AEDT Perso and precision medicine are rapidly growing areas that require good data to categoriz...
      Speaker: Matthias Nauck, PhD
      Sponsored By: Bruker Microbiology & Diagnostics
      3
      NOV 01, 2018 | 12:00 AM
      Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
      Glycosylation and stabilization of programmed death ligand-1 suppresses...
      The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on cancer cell and immune cell interaction, how cancer cells i...
      Speaker: Chia-Wei Li, PhD
      Presented at: Dimension of Time: From Culture to Assay
      1
      OCT 24, 2018 | 6:00 AM
      Applied Hyperspectral Imaging Fundamentals and Case Studies
      Applied Hyperspectral Imaging Fundamentals and Case Studies
      A fast, reliable and low cost characterization of materials/ products as fed to a process, and/or resulting from different processing actions, represents one of the most challenging targets i...
      Speaker: Giuseppe Bonifazi, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      2
      OCT 03, 2018 | 1:30 PM
      Whole-Genome Identification of CRISPR Targets
      Whole-Genome Identification of CRISPR Targets
      Gene editing using CRISPR is a very promising technology, and it has already had a significant impact on a number of research fields. However, while CRISPR makes targeted modifications easier...
      Speaker: Dimitri Perrin, PhD
      Presented at: CRISPR Virtual Event Series 2018
      2
      SEP 18, 2018 | 7:00 AM
      POSTER: Pro-Detect Rapid Assay Lateral Flow Kits for Detecting Protein Tags and Antibody Isotyping
      POSTER: Pro-Detect Rapid Assay Lateral Flow Kits for Detecting...
      Lateral flow assays (LFAs) are rapid, sensitive, and easy-to-use immunoassays for detecting specific target proteins in vitro. Although the LFA format is extremely popular in point-of-care di...
      Speaker: Krishna Vattem, Ph.D.
      Presented at: 3rd Annual 7 Steps of Protein Virtual Event
      1
      SEP 12, 2018 | 12:00 PM
      ONETest PathoGenome: A Target Hybridization-Based Next-Generation Sequencing Assay to Tackle Undiagnosed Infections
      ONETest PathoGenome: A Target Hybridization-Based Next-Generation...
      Every year, approximately 800,000 critically ill patients are hospitals in the USA with undiagnosed infections. The only option is to treat these patients with broad-spectrum antimicrobial th...
      Speaker: Mohammad Qadir, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      1 1
      AUG 07, 2018 | 8:00 AM
      Using Reference Standards to Validate your NGS Oncology Workflow
      Using Reference Standards to Validate your NGS Oncology Workflow
      DATE: August 7, 2018TIME: 08:00AM PDT, 11:00AM EDTWe are currently at an exciting precipice in clinical oncology management, where an increased rate of biomarker identification is drivi...
      Speaker: Hannah Child, PhD
      Sponsored By: Horizon Discovery
      10 1
      JUN 20, 2018 | 12:00 PM
      Precision Medicine: The Way Forward!
      Precision Medicine: The Way Forward!
      Recent advancements in the precision medicine field have presented a great promise to provide innovative solutions to pharmaceutical and healthcare industry to help transform medicine. By fin...
      Speaker: Prasun Mishra, MsC, PhD
      Presented at: Precision Medicine Virtual Event Series 2018
      1
      MAY 10, 2018 | 9:00 AM
      Multi-Omics Approach for Discovering Anti-Folate Drug Resistance Mechanisms in Triple-Negative Breast Cancer: Working Toward the Goal of Personalized Medicine
      Multi-Omics Approach for Discovering Anti-Folate Drug Resistance...
      Triple-negative breast cancer (TNBC) has poor prognosis with frequent relapses and deaths using current standard of care treatments.  Metabolic reprograming is now recognized as a fundam...
      Speaker: Steven Gross, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      Sponsored By: Agilent
      1
      MAR 15, 2018 | 12:00 PM
      Tough Targets, Simple Genotyping -Fast and Easy Protocols to Determine SMN1 and SMN2 Copy Number and APOE Allele Identification
      Tough Targets, Simple Genotyping -Fast and Easy Protocols to Determine...
      Determining the copy number of SMN1 and SMN2 genes is notoriously difficult due to the high level of homology between the two genes. These genes, that are associated with spinal muscular atro...
      Speaker: Ryan Donnelly
      Presented at: Neuroscience Virtual Event Series 2018
      Sponsored By: Canon BioMedical
      2
      MAR 15, 2018 | 10:30 AM
      An Emerging Role of DNA Damage-Repair in Huntington's Disease
      An Emerging Role of DNA Damage-Repair in Huntington's Disease
      Machine learning approaches to pattern discovery in protein-protein interaction networks of Huntington’s disease brain and model organisms are revealing novel connections of the disease...
      Speaker: Animesh Ray, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      2
      FEB 22, 2018 | 7:30 AM
      Keynote Presentation: Predictive Biomarkers to Diagnostic Tests - Scientific and Regulatory Consideration in Development of Companion Diagnostic Tests
      Keynote Presentation: Predictive Biomarkers to Diagnostic Tests...
      The path form biomarker discovery to conversion to a clinically useful companion diagnostic test presents many challenges. The talk will outline the regulatory requirements to developing a su...
      Speaker: Janaki Veeraraghavan, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      NOV 29, 2017 | 10:00 AM
      WEBINAR: RAS Oncoproteins: Therapeutic Vulnerabilities
      WEBINAR: RAS Oncoproteins: Therapeutic Vulnerabilities
      DATE: November 29, 2017TIME: 10:00 AM PSTThe three human RAS genes (HRAS, KRAS and NRAS) encode four highly related RAS small GTPases (HRAS, KRAS4A, KRAS4B and NRAS). RAS proteins funct...
      Speaker: Adrienne Cox, PhD
      Sponsored By: ACD - A Bio-Techne Brand
      7 2
      NOV 14, 2017 | 9:00 AM
      WEBINAR: CRISPRa tools for transcriptional activation studies
      WEBINAR: CRISPRa tools for transcriptional activation studies
      DATE: November 14, 2017TIME: 09:00am PST, 12:00pm ESTThe CRISPR-Cas9 system has been adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and av...
      Speaker: Žaklina Strezoska , Benedict Cross
      Sponsored By: Dharmacon, a Horizon Discovery Group Company
      11 4
      NOV 09, 2017 | 10:00 AM
      Eliminating inherent genome editing bottlenecks in iPSCs to build physiologically relevant disease models
      Eliminating inherent genome editing bottlenecks in iPSCs to build...
      Therapeutic development for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficac...
      Speaker: Erik Willems, PhD
      Presented at: 5th annual 24 Hours of Stem Cellsâ„¢ virtual event
      3
    MAY 08, 2019 | 6:00 AM
    C.E. CREDITS
    Novel DNA Methylation in Mammals
    Novel DNA Methylation in Mammals
    Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
    Speaker: Tao Wu, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    2
    APR 30, 2019 | 8:00 AM
    Small platform enables big change - Nanotech-assisted discovery of novel biomarkers for disease diagnosis
    Small platform enables big change - Nanotech-assisted discovery...
    DATE: April 30, 2019TIME: 8:00am PDTIumour-derived extracellular vesicles (EVs) are of increasing interest as a resource of diagnostic biomarkers. However, most EV assays require large...
    Speaker: Tony Hu, PhD
    7 2
    APR 25, 2019 | 12:00 PM
    Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges and Threats Posed by Infectious Diseases
    Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges...
    Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
    Speaker: Faramarz Valafar, PhD
    Presented at: Infectious Disease Virtual Event Series 2019
    2
    APR 10, 2019 | 10:30 AM
    CRISPR-Chip: Detection of Unamplified Target Genes via CRISPR/Cas9 Immobilized on a Graphene Biosensors
    CRISPR-Chip: Detection of Unamplified Target Genes via CRISPR/Cas9...
    CRISPR-chip combines two powerful technologies ,CRISPR and Graphene, for rapid detection of nucleic acids. This talk will focus on design and fabrication of CRISPR-chip and its potential util...
    Speaker: Kiana Aran, PhD
    Presented at: Molecular Diagnostics Virtual Event Series 2019
    4
    JAN 31, 2019 | 10:30 AM
    Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries to Improve Process Efficiencies
    Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries...
    Multi-mode chromatography has come to prominence in recent years due to the general utility of multi-mode ligands for product capture and polishing. In particular, their application in flow-t...
    Speaker: Buzz Lobbezoo
    Presented at: BioProcessing Virtual Event Series 2019
    Sponsored By: Astrea Bioseparations
    1
     
     
  • DEC 06, 2018 | 8:00 AM
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
    DATE:  December 6, 2018TIME:   11:00am EST, 5:00pm CET Introduction Micro-computed tomography (micro-CT) offers significant advantages o...
    Speaker: Rob van 't Hof, BSc, MSc, PhD
    Sponsored By: Bruker Microbiology & Diagnostics
    2
    DEC 06, 2018 | 1:00 AM
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
    DATE:    December 6, 2018TIME:    10:00am CET, 5:00pm CST Intro Micro-computed tomography (micro-CT) offers significant advantage...
    Speaker: Rob van 't Hof, BSc, MSc, PhD
    Sponsored By: Bruker Microbiology & Diagnostics
    8
    NOV 15, 2018 | 4:00 AM
    Generation and application of 3D-organoid cell culture models using human induced pluripotent stem cells (iPSCs) for drug discovery
    Generation and application of 3D-organoid cell culture models...
    Development of physiologically relevant cellular models, with strong translatability to human pathophysiology, is critical for identification and validation of novel therapeutic targets. Cell...
    Speaker: Ryan Hicks
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    10 2
    NOV 14, 2018 | 6:00 AM
    Improving Sepsis Management with Same-Day Results from the Lab
    Improving Sepsis Management with Same-Day Results from the Lab
    Sepsis is the Achilles’ heel of health care. Despite being relatively unknown to the public, it is a top killer in hospitals and the cost burden is crushing to our healthcare system. Mo...
    Speaker: John McDonough
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    2 1
    NOV 08, 2018 | 5:00 PM
    NMR in standardizing biomarkers for personalized medicine: Where do biobanks come in?  (For research use only)
    NMR in standardizing biomarkers for personalized medicine: Where...
    DATE:  November 9, 2018 TIME:   09:00am CST, 10:00am JST, 12:00pm AEDT Perso and precision medicine are rapidly growing areas that require good data to categoriz...
    Speaker: Matthias Nauck, PhD
    Sponsored By: Bruker Microbiology & Diagnostics
    3
     
     
  • NOV 01, 2018 | 12:00 AM
    Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
    Glycosylation and stabilization of programmed death ligand-1 suppresses...
    The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on cancer cell and immune cell interaction, how cancer cells i...
    Speaker: Chia-Wei Li, PhD
    Presented at: Dimension of Time: From Culture to Assay
    1
    OCT 24, 2018 | 6:00 AM
    Applied Hyperspectral Imaging Fundamentals and Case Studies
    Applied Hyperspectral Imaging Fundamentals and Case Studies
    A fast, reliable and low cost characterization of materials/ products as fed to a process, and/or resulting from different processing actions, represents one of the most challenging targets i...
    Speaker: Giuseppe Bonifazi, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    2
    OCT 03, 2018 | 1:30 PM
    Whole-Genome Identification of CRISPR Targets
    Whole-Genome Identification of CRISPR Targets
    Gene editing using CRISPR is a very promising technology, and it has already had a significant impact on a number of research fields. However, while CRISPR makes targeted modifications easier...
    Speaker: Dimitri Perrin, PhD
    Presented at: CRISPR Virtual Event Series 2018
    2
    SEP 18, 2018 | 7:00 AM
    POSTER: Pro-Detect Rapid Assay Lateral Flow Kits for Detecting Protein Tags and Antibody Isotyping
    POSTER: Pro-Detect Rapid Assay Lateral Flow Kits for Detecting...
    Lateral flow assays (LFAs) are rapid, sensitive, and easy-to-use immunoassays for detecting specific target proteins in vitro. Although the LFA format is extremely popular in point-of-care di...
    Speaker: Krishna Vattem, Ph.D.
    Presented at: 3rd Annual 7 Steps of Protein Virtual Event
    1
    SEP 12, 2018 | 12:00 PM
    ONETest PathoGenome: A Target Hybridization-Based Next-Generation Sequencing Assay to Tackle Undiagnosed Infections
    ONETest PathoGenome: A Target Hybridization-Based Next-Generation...
    Every year, approximately 800,000 critically ill patients are hospitals in the USA with undiagnosed infections. The only option is to treat these patients with broad-spectrum antimicrobial th...
    Speaker: Mohammad Qadir, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    1 1
     
     
  • AUG 07, 2018 | 8:00 AM
    Using Reference Standards to Validate your NGS Oncology Workflow
    Using Reference Standards to Validate your NGS Oncology Workflow
    DATE: August 7, 2018TIME: 08:00AM PDT, 11:00AM EDTWe are currently at an exciting precipice in clinical oncology management, where an increased rate of biomarker identification is drivi...
    Speaker: Hannah Child, PhD
    Sponsored By: Horizon Discovery
    10 1
    JUN 20, 2018 | 12:00 PM
    Precision Medicine: The Way Forward!
    Precision Medicine: The Way Forward!
    Recent advancements in the precision medicine field have presented a great promise to provide innovative solutions to pharmaceutical and healthcare industry to help transform medicine. By fin...
    Speaker: Prasun Mishra, MsC, PhD
    Presented at: Precision Medicine Virtual Event Series 2018
    1
    MAY 10, 2018 | 9:00 AM
    Multi-Omics Approach for Discovering Anti-Folate Drug Resistance Mechanisms in Triple-Negative Breast Cancer: Working Toward the Goal of Personalized Medicine
    Multi-Omics Approach for Discovering Anti-Folate Drug Resistance...
    Triple-negative breast cancer (TNBC) has poor prognosis with frequent relapses and deaths using current standard of care treatments.  Metabolic reprograming is now recognized as a fundam...
    Speaker: Steven Gross, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    Sponsored By: Agilent
    1
    MAR 15, 2018 | 12:00 PM
    Tough Targets, Simple Genotyping -Fast and Easy Protocols to Determine SMN1 and SMN2 Copy Number and APOE Allele Identification
    Tough Targets, Simple Genotyping -Fast and Easy Protocols to Determine...
    Determining the copy number of SMN1 and SMN2 genes is notoriously difficult due to the high level of homology between the two genes. These genes, that are associated with spinal muscular atro...
    Speaker: Ryan Donnelly
    Presented at: Neuroscience Virtual Event Series 2018
    Sponsored By: Canon BioMedical
    2
    MAR 15, 2018 | 10:30 AM
    An Emerging Role of DNA Damage-Repair in Huntington's Disease
    An Emerging Role of DNA Damage-Repair in Huntington's Disease
    Machine learning approaches to pattern discovery in protein-protein interaction networks of Huntington’s disease brain and model organisms are revealing novel connections of the disease...
    Speaker: Animesh Ray, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    2
     
     
  • FEB 22, 2018 | 7:30 AM
    Keynote Presentation: Predictive Biomarkers to Diagnostic Tests - Scientific and Regulatory Consideration in Development of Companion Diagnostic Tests
    Keynote Presentation: Predictive Biomarkers to Diagnostic Tests...
    The path form biomarker discovery to conversion to a clinically useful companion diagnostic test presents many challenges. The talk will outline the regulatory requirements to developing a su...
    Speaker: Janaki Veeraraghavan, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    NOV 29, 2017 | 10:00 AM
    WEBINAR: RAS Oncoproteins: Therapeutic Vulnerabilities
    WEBINAR: RAS Oncoproteins: Therapeutic Vulnerabilities
    DATE: November 29, 2017TIME: 10:00 AM PSTThe three human RAS genes (HRAS, KRAS and NRAS) encode four highly related RAS small GTPases (HRAS, KRAS4A, KRAS4B and NRAS). RAS proteins funct...
    Speaker: Adrienne Cox, PhD
    Sponsored By: ACD - A Bio-Techne Brand
    7 2
    NOV 14, 2017 | 9:00 AM
    WEBINAR: CRISPRa tools for transcriptional activation studies
    WEBINAR: CRISPRa tools for transcriptional activation studies
    DATE: November 14, 2017TIME: 09:00am PST, 12:00pm ESTThe CRISPR-Cas9 system has been adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and av...
    Speaker: Žaklina Strezoska , Benedict Cross
    Sponsored By: Dharmacon, a Horizon Discovery Group Company
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    NOV 09, 2017 | 10:00 AM
    Eliminating inherent genome editing bottlenecks in iPSCs to build physiologically relevant disease models
    Eliminating inherent genome editing bottlenecks in iPSCs to build...
    Therapeutic development for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficac...
    Speaker: Erik Willems, PhD
    Presented at: 5th annual 24 Hours of Stem Cellsâ„¢ virtual event
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