Cancer: is a disease in which abnormal cells divide uncontrollably and destroy body tissue. Cancerous tumors are malignant, which means they can spread into, or invade, nearby tissues.
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The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
Viruses are the causative agents of approximately 12% of human cancers. The most recently discovered herpesvirus, Kaposi’s sarcoma herpesvirus (KSHV) is known to cause three human canc...
The recent outbreak of SARS-CoV-2 underscores the need for understanding the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. Here, we show that...
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutraliz...
Influenza infections are initiated by just a handful of virions infecting a handful of cells, so it is important to understand what happens in single infected cells. I will describe work tha...