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    Clinical Evaluation

    Clinical Evaluation: is the assessment and analysis of clinical data pertaining to a medical device in order to verify the clinical safety and performance of the device.

    Webinars

    • SEP 08, 2021 | 12:00 AM
      Machine Learning Approaches for Modeling Complex Community Dynamics
      Machine Learning Approaches for Modeling Complex Community Dynamics
      Computational or mathematical modeling generally refers to a mechanism-based formalism that help us test hypotheses, expand our understanding of a system, or make mechanism-aware predictions...
      Speaker: Nicholas Chia, PhD
      Presented at: Microbiology Week Virtual Event Series 2021
      0
      SEP 08, 2021 | 12:00 AM
      SeXX Matters for Respiratory Viral Pathogenesis and Responses to Vaccines
      SeXX Matters for Respiratory Viral Pathogenesis and Responses...
      The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
      Speaker: Sabra L. Klein, PhD
      Presented at: Microbiology Week Virtual Event Series 2021
      0
      JUL 29, 2021 | 10:00 AM
      The importance of simultaneously detecting and differentiating SARS-CoV-2 and influenza during flu season
      The importance of simultaneously detecting and differentiating...
      Date: July 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Experts are predicting an increase in influenza cases and a constant presence of SARS-CoV-2 in the shortly approaching influenza season....
      Speaker: Peter Friebe, Ph.D. , Jelena Feenstra, PhD
      Sponsored By: Thermo Fisher Scientific
      12 1
      JUL 15, 2021 | 8:00 AM
      The Good, the Bad and the Ugly of 45 color panel design: Building to higher dimensional flow cytometry while maintaining biological resolution
      The Good, the Bad and the Ugly of 45 color panel design: Building...
      Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
      Speaker: Seddon Thomas
      Sponsored By: Thermo Fisher Scientific
      7 2
      JUN 30, 2021 | 8:00 AM
      Best practices to recover from an out-of-control event
      Best practices to recover from an out-of-control event
      Quality control results are flagged on a daily basis, and each lab may have different procedures to resolve the issue. As bench technologists are faced with an abrupt stop to their workflow...
      Speaker: Lorin Bachmann, Ph.D.
      Presented at: A Bio-Rad Quality Control Virtual Conference
      41
      JUN 29, 2021 | 10:00 AM
      Approaches for Rapid Genomic Surveillance to Identify SARS-CoV-2 Variants
      Approaches for Rapid Genomic Surveillance to Identify SARS-CoV-2...
      Date: June 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SARS-CoV-2 continues to evolve and surveillance of variants is a necessity. Routine analysis of genetic sequence data allows the identif...
      Speaker: Donna Wolk, MHA, PhD, D(ABMM)
      Sponsored By: Diasorin
      16
      JUN 29, 2021 | 7:00 AM
      One Academic Medical Center's Experience with the Unyvero Multiplex Platform for Testing Bronchoalveolar Lavage Fluids: Analytical and Clinical Assessment
      One Academic Medical Center's Experience with the Unyvero Multiplex...
      Date: June 29, 2021 Time: 7:00am (PDT), 10:00am (EDT) The Unyvero Lower Respiratory Tract Panel demonstrated reliable concordance with culture based methods for organism identification from...
      Speaker: Dr. James Snyder , Dr. Wes Hoffmann
      Sponsored By: OpGen
      5
      JUN 17, 2021 | 11:00 AM
      Humoral response after SARS-CoV-2 mRNA vaccine in a cohort of hemodialysis patients and kidney transplant recipients
      Humoral response after SARS-CoV-2 mRNA vaccine in a cohort of...
      Date: June 17, 2021 Time: 11:00am PDT, 8:00pm CET BACKGROUND Kidney transplant recipients and patients on hemodialysis are immunocompromised populations excluded from vaccine trials. Data ar...
      Speaker: Prof. Sébastien Hantz, MD, Ph.D.
      Sponsored By: Diasorin
      11 2
      MAY 20, 2021 | 6:00 AM
      Understanding and Managing Challenging Samples in your Laboratory
      Understanding and Managing Challenging Samples in your Laboratory
      Date: May 20, 2021 Time: 6:00am (PDT), 9:00am (EDT), 2:00pm (BST) In this webinar, Dr Rachel Marrington, Deputy Director, and Finlay MacKenzie, Director, at Birmingham Quality UK NEQAS, will...
      Speaker: Finlay MacKenzie , Dr. Rachel Marrington , Els Melis , Natalie Mullee
      Sponsored By: Ortho Clinical Diagnostics
      29
      MAY 13, 2021 | 8:00 AM
      Physicochemical Characterization of Antibody-Drug Conjugates
      Physicochemical Characterization of Antibody-Drug Conjugates
      Date: May 13, 2021 Time: 8:00am (PDT), 11:00am (EDT) Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and r...
      Speaker: Shawn Owens, Ph.D. , Jason Lin, Ph.D
      Sponsored By: RedShiftBio
      6 1
      APR 28, 2021 | 7:00 AM
      Host genome analysis of structural variations by Optical Genome Mapping in patients with severe COVID-19
      Host genome analysis of structural variations by Optical Genome...
      Date: April 28, 2021 Time: 7:00am (PDT), 10:00am (EDT) The varied clinical manifestations and outcomes in patients with SARS-CoV-2 infections implicate a role of host-genetics in the predisp...
      Speaker: Ravindra Kolhe, MD, PhD
      Sponsored By: Bionano
      9 2
      APR 21, 2021 | 10:00 AM
      Putting Serological SARS-CoV-2 Testing into Context
      Putting Serological SARS-CoV-2 Testing into Context
      Date: April 21, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Serological testing for SARS-CoV-2 has been steadily adopted into clinical practice over the course of this pandemic. In this webinar,...
      Speaker: Sarah Wheeler, PhD , Veronica Luzzi, PhD, DABCC, FACB , Eduard Grebe, PhD
      Sponsored By: Bio-Rad Laboratories
      21 2
      APR 20, 2021 | 3:00 PM
      Panel Presentation: Accelerating precision oncology with matched FFPE and plasma biospecimens characterized using Discovery's SpecimenSeqâ„¢ NGS Service and QIAGEN's QIAseq Multimodal Panels
      Panel Presentation: Accelerating precision oncology with matched...
      Bridging a deep understanding of molecular profiles with clinical information is critical to developing innovative precision medicine tools in oncology. Discovery’s recently launched S...
      Speaker: Nathan Henson, MS , Donald Skifter, PhD, MBA
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: QIAGEN
      2
      APR 20, 2021 | 11:00 AM
      Microbial Identification and Confirmation using the Bruker MALDI Biotyper®:  The Contract Laboratory Perspective
      Microbial Identification and Confirmation using the Bruker MALDI...
      Date: April 20, 2021 Time: 11:00am (PST), 2:00pm (EST) Identification and confirmation of microbial isolates is crucial in the analysis workflow, providing decision-makers the information...
      Speaker: Wesley Thompson
      Sponsored By: Bruker Microbiology & Infection Diagnostics
      18 1
      APR 14, 2021 | 9:00 AM
      Keynote Presentation: What the NIH Serosurvey Tells Us So Far and Why We Should Try to Develop a Broadly Protective/Universal Beta-Coronavirus Vaccine
      Keynote Presentation: What the NIH Serosurvey Tells Us So Far...
      Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates. To address this, we analyzed seropositivity in US adults who ha...
      Speaker: Matthew J. Memoli, MD, MS
      Presented at: Coronavirus Series
      1
      APR 07, 2021 | 7:30 AM
      Keynote Presentation: A Convenient Self-Cleaving Affinity Tag for Research and Manufacturing Applications
      Keynote Presentation: A Convenient Self-Cleaving Affinity Tag...
      Although affinity tag methods for protein purification have greatly accelerated research in laboratories throughout the world, the presence of the tag on the purified target can modify the t...
      Speaker: David Wood
      Presented at: Bioprocessing Virtual Event Series 2021
      2
      MAR 25, 2021 | 8:00 AM
      Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry Approach to Drug Discovery
      Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry...
      Date: March 25, 2021 Time: 8:00am (PDT), 11:00am (EDT) Visikol is a biotechnology company focused on advanced imaging, digital pathology and 3D cell culture assays that has developed a un...
      Speaker: Michael Johnson, PhD
      Sponsored By: Leica Biosystems
      6
      MAR 24, 2021 | 7:30 AM
      Keynote Presentation: Medical Cannabis for Children
      Keynote Presentation: Medical Cannabis for Children
      Approximately 1 out of every 3 children with epilepsy do not respond to conventional medications, resulting in significant disruption in quality of life. The CDC states that one in 54 childr...
      Speaker: Bonni Goldstein, MD
      Presented at: Cannabis Sciences Virtual Event Series 2021
      1
      FEB 24, 2021 | 12:00 PM
      Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
      Deep Mechanistic profiling of immune oncology drug combinations...
      With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
      Speaker: Jason Frazier , Sarah Warren, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      Sponsored By: NanoString Technologies
      2
      FEB 24, 2021 | 9:00 AM
      Keynote Panel Presentation: Biomarker assays - bioanalytical meets CLIA
      Keynote Panel Presentation: Biomarker assays - bioanalytical meets...
      Reliable diagnostic, prognostic, predictive, pharmacodynamic, and pharmacokinetic biomarkers are critical to assure correct patient selection, drug dosing, and monitoring. Being able to iden...
      Speaker: Andrew Roche, PhD , Roger Hayes, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      1
      FEB 24, 2021 | 12:00 AM
      Evolution of a Platform-Based Non-Clinical Safety Assessment Approach for Vaccines
      Evolution of a Platform-Based Non-Clinical Safety Assessment Approach...
      Platform based therapeutics and vaccines offer a unique opportunity to simplify and streamline the drug development process. Moderna has taken the approach of harnessing the power of mRNA as...
      Speaker: Joseph J. Senn, PhD, DABT
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      2
      FEB 24, 2021 | 12:00 AM
      Multi-diagnostic approaches for patient selection in immuno-oncology
      Multi-diagnostic approaches for patient selection in immuno-oncology
      The development of different classes of immunotherapies that target cancer cells continues to be a rapidly growing area of research. The development of diagnostic tests which can predict pat...
      Speaker: Cindy Spittle
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      1
      FEB 23, 2021 | 8:00 AM
      Quantitation of free light chains in serum and the need for standardization
      Quantitation of free light chains in serum and the need for standardization
      Date: February 23, 2021 Time: 8:00am (PST), 11:00am (EST) The analysis of serum free light chains (FLC) is now standard of care in the screening, diagnosis, and monitoring of patients suspec...
      Speaker: Dr. Kazunori Murata
      Sponsored By: Binding Site
      7
      FEB 09, 2021 | 9:00 AM
      Development and analytical validation of prognostic biomarkers for metastasis
      Development and analytical validation of prognostic biomarkers...
      Date: February 9, 2020 Time: 9:00am (PST), 12:00pm (EST) 90% of breast cancer mortality is caused by distant metastasis, a process that involves both dissemination of cancer cells to distant...
      Speaker: David Entenberg, PhD
      Sponsored By: Visiopharm®
      20
    SEP 08, 2021 | 12:00 AM
    Machine Learning Approaches for Modeling Complex Community Dynamics
    Machine Learning Approaches for Modeling Complex Community Dynamics
    Computational or mathematical modeling generally refers to a mechanism-based formalism that help us test hypotheses, expand our understanding of a system, or make mechanism-aware predictions...
    Speaker: Nicholas Chia, PhD
    Presented at: Microbiology Week Virtual Event Series 2021
    0
    SEP 08, 2021 | 12:00 AM
    SeXX Matters for Respiratory Viral Pathogenesis and Responses to Vaccines
    SeXX Matters for Respiratory Viral Pathogenesis and Responses...
    The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
    Speaker: Sabra L. Klein, PhD
    Presented at: Microbiology Week Virtual Event Series 2021
    0
    JUL 29, 2021 | 10:00 AM
    The importance of simultaneously detecting and differentiating SARS-CoV-2 and influenza during flu season
    The importance of simultaneously detecting and differentiating...
    Date: July 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Experts are predicting an increase in influenza cases and a constant presence of SARS-CoV-2 in the shortly approaching influenza season....
    Speaker: Peter Friebe, Ph.D. , Jelena Feenstra, PhD
    Sponsored By: Thermo Fisher Scientific
    12 1
    JUL 15, 2021 | 8:00 AM
    The Good, the Bad and the Ugly of 45 color panel design: Building to higher dimensional flow cytometry while maintaining biological resolution
    The Good, the Bad and the Ugly of 45 color panel design: Building...
    Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
    Speaker: Seddon Thomas
    Sponsored By: Thermo Fisher Scientific
    7 2
    JUN 30, 2021 | 8:00 AM
    Best practices to recover from an out-of-control event
    Best practices to recover from an out-of-control event
    Quality control results are flagged on a daily basis, and each lab may have different procedures to resolve the issue. As bench technologists are faced with an abrupt stop to their workflow...
    Speaker: Lorin Bachmann, Ph.D.
    Presented at: A Bio-Rad Quality Control Virtual Conference
    41
     
     
  • JUN 29, 2021 | 10:00 AM
    Approaches for Rapid Genomic Surveillance to Identify SARS-CoV-2 Variants
    Approaches for Rapid Genomic Surveillance to Identify SARS-CoV-2...
    Date: June 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SARS-CoV-2 continues to evolve and surveillance of variants is a necessity. Routine analysis of genetic sequence data allows the identif...
    Speaker: Donna Wolk, MHA, PhD, D(ABMM)
    Sponsored By: Diasorin
    16
    JUN 29, 2021 | 7:00 AM
    One Academic Medical Center's Experience with the Unyvero Multiplex Platform for Testing Bronchoalveolar Lavage Fluids: Analytical and Clinical Assessment
    One Academic Medical Center's Experience with the Unyvero Multiplex...
    Date: June 29, 2021 Time: 7:00am (PDT), 10:00am (EDT) The Unyvero Lower Respiratory Tract Panel demonstrated reliable concordance with culture based methods for organism identification from...
    Speaker: Dr. James Snyder , Dr. Wes Hoffmann
    Sponsored By: OpGen
    5
    JUN 17, 2021 | 11:00 AM
    Humoral response after SARS-CoV-2 mRNA vaccine in a cohort of hemodialysis patients and kidney transplant recipients
    Humoral response after SARS-CoV-2 mRNA vaccine in a cohort of...
    Date: June 17, 2021 Time: 11:00am PDT, 8:00pm CET BACKGROUND Kidney transplant recipients and patients on hemodialysis are immunocompromised populations excluded from vaccine trials. Data ar...
    Speaker: Prof. Sébastien Hantz, MD, Ph.D.
    Sponsored By: Diasorin
    11 2
    MAY 20, 2021 | 6:00 AM
    Understanding and Managing Challenging Samples in your Laboratory
    Understanding and Managing Challenging Samples in your Laboratory
    Date: May 20, 2021 Time: 6:00am (PDT), 9:00am (EDT), 2:00pm (BST) In this webinar, Dr Rachel Marrington, Deputy Director, and Finlay MacKenzie, Director, at Birmingham Quality UK NEQAS, will...
    Speaker: Finlay MacKenzie , Dr. Rachel Marrington , Els Melis , Natalie Mullee
    Sponsored By: Ortho Clinical Diagnostics
    29
    MAY 13, 2021 | 8:00 AM
    Physicochemical Characterization of Antibody-Drug Conjugates
    Physicochemical Characterization of Antibody-Drug Conjugates
    Date: May 13, 2021 Time: 8:00am (PDT), 11:00am (EDT) Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and r...
    Speaker: Shawn Owens, Ph.D. , Jason Lin, Ph.D
    Sponsored By: RedShiftBio
    6 1
     
     
  • APR 28, 2021 | 7:00 AM
    Host genome analysis of structural variations by Optical Genome Mapping in patients with severe COVID-19
    Host genome analysis of structural variations by Optical Genome...
    Date: April 28, 2021 Time: 7:00am (PDT), 10:00am (EDT) The varied clinical manifestations and outcomes in patients with SARS-CoV-2 infections implicate a role of host-genetics in the predisp...
    Speaker: Ravindra Kolhe, MD, PhD
    Sponsored By: Bionano
    9 2
    APR 21, 2021 | 10:00 AM
    Putting Serological SARS-CoV-2 Testing into Context
    Putting Serological SARS-CoV-2 Testing into Context
    Date: April 21, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Serological testing for SARS-CoV-2 has been steadily adopted into clinical practice over the course of this pandemic. In this webinar,...
    Speaker: Sarah Wheeler, PhD , Veronica Luzzi, PhD, DABCC, FACB , Eduard Grebe, PhD
    Sponsored By: Bio-Rad Laboratories
    21 2
    APR 20, 2021 | 3:00 PM
    Panel Presentation: Accelerating precision oncology with matched FFPE and plasma biospecimens characterized using Discovery's SpecimenSeqâ„¢ NGS Service and QIAGEN's QIAseq Multimodal Panels
    Panel Presentation: Accelerating precision oncology with matched...
    Bridging a deep understanding of molecular profiles with clinical information is critical to developing innovative precision medicine tools in oncology. Discovery’s recently launched S...
    Speaker: Nathan Henson, MS , Donald Skifter, PhD, MBA
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: QIAGEN
    2
    APR 20, 2021 | 11:00 AM
    Microbial Identification and Confirmation using the Bruker MALDI Biotyper®:  The Contract Laboratory Perspective
    Microbial Identification and Confirmation using the Bruker MALDI...
    Date: April 20, 2021 Time: 11:00am (PST), 2:00pm (EST) Identification and confirmation of microbial isolates is crucial in the analysis workflow, providing decision-makers the information...
    Speaker: Wesley Thompson
    Sponsored By: Bruker Microbiology & Infection Diagnostics
    18 1
    APR 14, 2021 | 9:00 AM
    Keynote Presentation: What the NIH Serosurvey Tells Us So Far and Why We Should Try to Develop a Broadly Protective/Universal Beta-Coronavirus Vaccine
    Keynote Presentation: What the NIH Serosurvey Tells Us So Far...
    Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates. To address this, we analyzed seropositivity in US adults who ha...
    Speaker: Matthew J. Memoli, MD, MS
    Presented at: Coronavirus Series
    1
     
     
  • APR 07, 2021 | 7:30 AM
    Keynote Presentation: A Convenient Self-Cleaving Affinity Tag for Research and Manufacturing Applications
    Keynote Presentation: A Convenient Self-Cleaving Affinity Tag...
    Although affinity tag methods for protein purification have greatly accelerated research in laboratories throughout the world, the presence of the tag on the purified target can modify the t...
    Speaker: David Wood
    Presented at: Bioprocessing Virtual Event Series 2021
    2
    MAR 25, 2021 | 8:00 AM
    Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry Approach to Drug Discovery
    Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry...
    Date: March 25, 2021 Time: 8:00am (PDT), 11:00am (EDT) Visikol is a biotechnology company focused on advanced imaging, digital pathology and 3D cell culture assays that has developed a un...
    Speaker: Michael Johnson, PhD
    Sponsored By: Leica Biosystems
    6
    MAR 24, 2021 | 7:30 AM
    Keynote Presentation: Medical Cannabis for Children
    Keynote Presentation: Medical Cannabis for Children
    Approximately 1 out of every 3 children with epilepsy do not respond to conventional medications, resulting in significant disruption in quality of life. The CDC states that one in 54 childr...
    Speaker: Bonni Goldstein, MD
    Presented at: Cannabis Sciences Virtual Event Series 2021
    1
    FEB 24, 2021 | 12:00 PM
    Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
    Deep Mechanistic profiling of immune oncology drug combinations...
    With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
    Speaker: Jason Frazier , Sarah Warren, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    Sponsored By: NanoString Technologies
    2
    FEB 24, 2021 | 9:00 AM
    Keynote Panel Presentation: Biomarker assays - bioanalytical meets CLIA
    Keynote Panel Presentation: Biomarker assays - bioanalytical meets...
    Reliable diagnostic, prognostic, predictive, pharmacodynamic, and pharmacokinetic biomarkers are critical to assure correct patient selection, drug dosing, and monitoring. Being able to iden...
    Speaker: Andrew Roche, PhD , Roger Hayes, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    1
     
     
  • FEB 24, 2021 | 12:00 AM
    Evolution of a Platform-Based Non-Clinical Safety Assessment Approach for Vaccines
    Evolution of a Platform-Based Non-Clinical Safety Assessment Approach...
    Platform based therapeutics and vaccines offer a unique opportunity to simplify and streamline the drug development process. Moderna has taken the approach of harnessing the power of mRNA as...
    Speaker: Joseph J. Senn, PhD, DABT
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    2
    FEB 24, 2021 | 12:00 AM
    Multi-diagnostic approaches for patient selection in immuno-oncology
    Multi-diagnostic approaches for patient selection in immuno-oncology
    The development of different classes of immunotherapies that target cancer cells continues to be a rapidly growing area of research. The development of diagnostic tests which can predict pat...
    Speaker: Cindy Spittle
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    1
    FEB 23, 2021 | 8:00 AM
    Quantitation of free light chains in serum and the need for standardization
    Quantitation of free light chains in serum and the need for standardization
    Date: February 23, 2021 Time: 8:00am (PST), 11:00am (EST) The analysis of serum free light chains (FLC) is now standard of care in the screening, diagnosis, and monitoring of patients suspec...
    Speaker: Dr. Kazunori Murata
    Sponsored By: Binding Site
    7
    FEB 09, 2021 | 9:00 AM
    Development and analytical validation of prognostic biomarkers for metastasis
    Development and analytical validation of prognostic biomarkers...
    Date: February 9, 2020 Time: 9:00am (PST), 12:00pm (EST) 90% of breast cancer mortality is caused by distant metastasis, a process that involves both dissemination of cancer cells to distant...
    Speaker: David Entenberg, PhD
    Sponsored By: Visiopharm®
    20
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