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    Compound screening

    Compound screening in an important step in the drug discovery pipeline. Performed in a laboratory setting, compound screening identifies compounds in small molecules that have a beneficial biological impact. Once identified, compounds are held in libraries containing information and details in a searchable formal.

    Webinars

    • AUG 30, 2018 | 1:00 AM
      Early disease detection performing NMR - Understanding how a better analysis of metabolites in serum and urine can help  (For research use only)
      Early disease detection performing NMR - Understanding how a better...
      DATE: August 30, 2018TIME:  10:00am CEST, 4:00pm CST The need to quantify urine is valuable because it provides information on chemicals that the body makes naturall...
      Speaker: Elaine Holmes , Claudio Luchinat
      Sponsored By: Bruker Microbiology & Diagnostics
      5 2
      JUN 26, 2018 | 9:00 AM
      Automated In Vivo Efficacy Assessment in Preclinical Lung Disease Models
      Automated In Vivo Efficacy Assessment in Preclinical Lung Disease...
      Treatments for respiratory diseases represent an enormous, unmet medical need with limited therapies currently approved for use. Despite many compounds demonstrating beneficial effects in ani...
      Speaker: Laura Schaevitz, PhD
      Sponsored By: Vium
      6
      MAY 31, 2018 | 7:30 AM
      Keynote Presentation: NCATS Automation Capabilities - Where We Are and Where We Are Going
      Keynote Presentation: NCATS Automation Capabilities - Where We...
      Over the years high throughput screening has evolved from monolithic static systems to modular more dynamic platforms.  At NCATS the approach taken has been to optimize our existing lega...
      Speaker: Sam Michael
      Presented at: Lab Automation Virtual Event Series 2018
      1
      MAY 30, 2018 | 12:00 PM
      High Throughput Screening Robotics within the UK Centre for Drug Discovery
      High Throughput Screening Robotics within the UK Centre for Drug...
      AstraZeneca has an ambition to create a porous organisation, seamlessly collaborating with external partners. This desire has led to the establishment of the AstraZeneca-MRC UK Centre for Lea...
      Speaker: Mark Wigglesworth
      Presented at: Lab Automation Virtual Event Series 2018
      1
      MAY 30, 2018 | 10:30 AM
      Inhibitors of NSD2 Discovered by High-Throughput Screening with a Nucleosome Substrate
      Inhibitors of NSD2 Discovered by High-Throughput Screening with...
      NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ov...
      Speaker: Nathan Coussens, PhD
      Presented at: Lab Automation Virtual Event Series 2018
      1
      MAY 24, 2018 | 9:30 AM
      Turning to a new dimension in cell culture for cancer research
      Turning to a new dimension in cell culture for cancer research
      DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
      Speaker: Carlemi Calitz, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      14 2
      APR 30, 2018 | 8:00 AM
      Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research Analysis
      Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research...
      Ion mobility/mass spectrometry has tremendous potential for metabolomics, lipidomics, and clinical analysis. Ion mobility can resolve compounds unresolved by LC/MS/MS, provide additional stru...
      Speaker: Richard Yost, PhD
      Sponsored By: Agilent
      6
      APR 24, 2018 | 8:00 AM
      KASP genotyping - better by design
      KASP genotyping - better by design
      DATE: April 24, 2018TIME: 8:00AM PSTIn this talk we will cover basic principles of KASP® genotyping chemistry and designing assays that are specific to desired targets. We will go o...
      Speaker: Jonathan Curry, PhD
      Sponsored By: LGC Seracare
      13
      MAR 29, 2018 | 12:00 PM
      A Comprehensive Strategy for Residue Analysis in Cannabis and Industrial Hemp
      A Comprehensive Strategy for Residue Analysis in Cannabis and...
      Pesticide residue screening is a pre-sale requirement for all states which have legalized the recreational or adult use of cannabis and cannabis related products.  In the absence of guid...
      Speaker: Rick Jordan
      Presented at: Cannabis Sciences Virtual Event Series 2018
      Sponsored By: Agilent
      1
      MAR 28, 2018 | 10:00 AM
      Primary Cell Systems:  Offerings and Applications from basic biology and tissue modeling to compound screening
      Primary Cell Systems: Offerings and Applications from basic biology...
      DATE: March 28, 2018TIME: 10:00am PDT, 01:00pm EDTPrimary cells are derived from various tissues typically via dissection, enzymatic dissociation, and subsequent culture in media specif...
      Speaker: David Kuninger, PhD , Rhonda Newman, PhD
      Sponsored By: Thermo Fisher Scientific
      7 3
      FEB 01, 2018 | 7:00 PM
      In vitro research method for screening inhibitors of protein translation
      In vitro research method for screening inhibitors of protein translation
      In vitro translation (IVT), or cell-free expression, offers a unique and powerful research tool to screen for translational inhibitors that regulate both cellular and viral protein expression...
      Speaker: Krishna Vattem, Ph.D.
      Presented at: Gibco ExpressionWorld 2018
      2
      JAN 31, 2018 | 8:00 AM
      High Content Screening-Based Phenotypic Analysis Of Organotypic 3D Bronchial Tissues
      High Content Screening-Based Phenotypic Analysis Of Organotypic...
      One of the goals of the “3Rs principle” is to replace in vivo testing methodologies with in vitro procedures on human cells, followed by computational systems biology modelling to...
      Speaker: Diego Marescotti, PhD
      Presented at: Protein and Cell Analysis Education Series
      Sponsored By: Thermo Fisher Scientific
      9 1
      NOV 14, 2017 | 9:00 AM
      WEBINAR: CRISPRa tools for transcriptional activation studies
      WEBINAR: CRISPRa tools for transcriptional activation studies
      DATE: November 14, 2017TIME: 09:00am PST, 12:00pm ESTThe CRISPR-Cas9 system has been adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and av...
      Speaker: Žaklina Strezoska , Benedict Cross
      Sponsored By: Dharmacon, a Horizon Discovery Group Company
      11 4
      NOV 09, 2017 | 10:00 AM
      Eliminating inherent genome editing bottlenecks in iPSCs to build physiologically relevant disease models
      Eliminating inherent genome editing bottlenecks in iPSCs to build...
      Therapeutic development for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficac...
      Speaker: Erik Willems, PhD
      Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
      3
      NOV 01, 2017 | 12:00 PM
      WEBINAR: Simplified imaging for quantifying biological complexity of iPSC-derived cardiomyocytes and neurons
      WEBINAR: Simplified imaging for quantifying biological complexity...
      DATE: November 1, 2017TIME:  12:00 PM PT, 3:00 PM ETThere is a current focus in biology towards developing more complex and physiologically relevant in vitro assays and cell models...
      Speaker: Oksana Sirenko, PhD
      Sponsored By: Molecular Devices
      5
      OCT 24, 2017 | 7:00 AM
      WEBINAR: Biomarker Discovery: Metabolomics Differentiates Known Disease Classifications of Prostate Cancer
      WEBINAR: Biomarker Discovery: Metabolomics Differentiates Known...
      DATE: October, 24, 2017TIME:  7:00 AM PDT Metabolomics focuses on the chemical processes central to cellular metabolism. A robust mass spectrometry solution for screening...
      Speaker: Timothy Garrett, PhD
      Sponsored By: SCIEX
      4 1
      OCT 12, 2017 | 6:00 AM
      Inference of gene signatures associated with response and resistance to targeted and immunotherapies
      Inference of gene signatures associated with response and resistance...
      We developed two computational methods, CARE and TIDE, to predict response and resistance to targeted therapies and immunotherapies. CARE infers gene signatures of targeted therapy response b...
      Speaker: Xiaole Shirley Liu, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      OCT 01, 2017 | 12:00 AM
      Addressing the scalability of human iPSC-derived neurons for HTS implementation and phenotypic screening
      Addressing the scalability of human iPSC-derived neurons for HTS...
      Traditional high throughput screening (HTS) assays for neuronal targets employ non-human primary neuronal cells due to the scale necessary for HTS. Isolation of mouse primary neurons can be u...
      Speaker: BanuPriya Sridharan
      Presented at: 6th annual 24 Hours of Stem Cells™ virtual event
      2
      JUL 01, 2017 | 8:00 AM
      iPSC-derived neural cells for drug discovery of mitochondrial brain diseases
      iPSC-derived neural cells for drug discovery of mitochondrial...
      Mitochondrial defects represent a common pathogenetic mechanism associated with neurodegeneration. At the same time, mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases...
      Speaker: Alessandro Prigione
      Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
      2
      JUN 07, 2017 | 9:00 AM
      WEBINAR: Generation of purified human iPSC derived cardiomyocytes using clinically relevant workflow
      WEBINAR: Generation of purified human iPSC derived cardiomyocytes...
      DATE: June 7, 2017TIME: 9:00AM PDT, 12:00PM EDTPluripotent stem cells (PSCs) offer an unlimited source of human cardiovascular cells for research and the development of cardiac regenera...
      Speaker: Todd Herron, BS, PhD
      Sponsored By: Miltenyi Biotec
      5 1
      MAY 25, 2017 | 9:00 AM
      Clinical Core Lab Design: From Looking Up to Looking Down
      Clinical Core Lab Design: From Looking Up to Looking Down
      The nature of work in the clinical core lab has changed over the years from beakers of liquids, specimens and compounds on countertops to sophisticated equipment with prepackaged reagents and...
      Speaker: Tammy Germini
      Presented at: Lab Automation Virtual Event Series 2017
      1
      MAY 24, 2017 | 1:30 PM
      Lab-on-a-printer™ - a multi-material 3D bioprinting platform for building living tissues on demand
      Lab-on-a-printer™ - a multi-material 3D bioprinting platform for...
      Drug development is a costly and time consuming process, poor translation of data from pre-clinical studies to the clinic is a major contributor as late-stage drug failure is very expensive....
      Speaker: Sam Wadsworth, PhD
      Presented at: Lab Automation Virtual Event Series 2017
      2
      MAY 24, 2017 | 9:00 AM
      Fully Automated 3D Cell Culture for Human Cells
      Fully Automated 3D Cell Culture for Human Cells
      The consistent and optimized production of living human cells for drug discovery and regenerative medicine faces many challenges including the need for cost effective large scale expansion, i...
      Speaker: Robin Felder, PhD
      Presented at: Lab Automation Virtual Event Series 2017
      2
      MAY 24, 2017 | 6:00 AM
      Exploring Pharmacological Interactions with Matrix: The Innovations and Challenges of NCATS Drug Combination HTS Platform
      Exploring Pharmacological Interactions with Matrix: The Innovations...
      Acoustic dispensing technology has allowed for compound plating to be highly customizable depending upon scientific needs.  The ability to dispense compounds from a single well to any we...
      Speaker: Kelli Wilson, PhD
      Presented at: Lab Automation Virtual Event Series 2017
      3 1
    AUG 30, 2018 | 1:00 AM
    Early disease detection performing NMR - Understanding how a better analysis of metabolites in serum and urine can help  (For research use only)
    Early disease detection performing NMR - Understanding how a better...
    DATE: August 30, 2018TIME:  10:00am CEST, 4:00pm CST The need to quantify urine is valuable because it provides information on chemicals that the body makes naturall...
    Speaker: Elaine Holmes , Claudio Luchinat
    Sponsored By: Bruker Microbiology & Diagnostics
    5 2
    JUN 26, 2018 | 9:00 AM
    Automated In Vivo Efficacy Assessment in Preclinical Lung Disease Models
    Automated In Vivo Efficacy Assessment in Preclinical Lung Disease...
    Treatments for respiratory diseases represent an enormous, unmet medical need with limited therapies currently approved for use. Despite many compounds demonstrating beneficial effects in ani...
    Speaker: Laura Schaevitz, PhD
    Sponsored By: Vium
    6
    MAY 31, 2018 | 7:30 AM
    Keynote Presentation: NCATS Automation Capabilities - Where We Are and Where We Are Going
    Keynote Presentation: NCATS Automation Capabilities - Where We...
    Over the years high throughput screening has evolved from monolithic static systems to modular more dynamic platforms.  At NCATS the approach taken has been to optimize our existing lega...
    Speaker: Sam Michael
    Presented at: Lab Automation Virtual Event Series 2018
    1
    MAY 30, 2018 | 12:00 PM
    High Throughput Screening Robotics within the UK Centre for Drug Discovery
    High Throughput Screening Robotics within the UK Centre for Drug...
    AstraZeneca has an ambition to create a porous organisation, seamlessly collaborating with external partners. This desire has led to the establishment of the AstraZeneca-MRC UK Centre for Lea...
    Speaker: Mark Wigglesworth
    Presented at: Lab Automation Virtual Event Series 2018
    1
    MAY 30, 2018 | 10:30 AM
    Inhibitors of NSD2 Discovered by High-Throughput Screening with a Nucleosome Substrate
    Inhibitors of NSD2 Discovered by High-Throughput Screening with...
    NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ov...
    Speaker: Nathan Coussens, PhD
    Presented at: Lab Automation Virtual Event Series 2018
    1
     
     
  • MAY 24, 2018 | 9:30 AM
    Turning to a new dimension in cell culture for cancer research
    Turning to a new dimension in cell culture for cancer research
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    Speaker: Carlemi Calitz, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    14 2
    APR 30, 2018 | 8:00 AM
    Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research Analysis
    Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research...
    Ion mobility/mass spectrometry has tremendous potential for metabolomics, lipidomics, and clinical analysis. Ion mobility can resolve compounds unresolved by LC/MS/MS, provide additional stru...
    Speaker: Richard Yost, PhD
    Sponsored By: Agilent
    6
    APR 24, 2018 | 8:00 AM
    KASP genotyping - better by design
    KASP genotyping - better by design
    DATE: April 24, 2018TIME: 8:00AM PSTIn this talk we will cover basic principles of KASP® genotyping chemistry and designing assays that are specific to desired targets. We will go o...
    Speaker: Jonathan Curry, PhD
    Sponsored By: LGC Seracare
    13
    MAR 29, 2018 | 12:00 PM
    A Comprehensive Strategy for Residue Analysis in Cannabis and Industrial Hemp
    A Comprehensive Strategy for Residue Analysis in Cannabis and...
    Pesticide residue screening is a pre-sale requirement for all states which have legalized the recreational or adult use of cannabis and cannabis related products.  In the absence of guid...
    Speaker: Rick Jordan
    Presented at: Cannabis Sciences Virtual Event Series 2018
    Sponsored By: Agilent
    1
    MAR 28, 2018 | 10:00 AM
    Primary Cell Systems:  Offerings and Applications from basic biology and tissue modeling to compound screening
    Primary Cell Systems: Offerings and Applications from basic biology...
    DATE: March 28, 2018TIME: 10:00am PDT, 01:00pm EDTPrimary cells are derived from various tissues typically via dissection, enzymatic dissociation, and subsequent culture in media specif...
    Speaker: David Kuninger, PhD , Rhonda Newman, PhD
    Sponsored By: Thermo Fisher Scientific
    7 3
     
     
  • FEB 01, 2018 | 7:00 PM
    In vitro research method for screening inhibitors of protein translation
    In vitro research method for screening inhibitors of protein translation
    In vitro translation (IVT), or cell-free expression, offers a unique and powerful research tool to screen for translational inhibitors that regulate both cellular and viral protein expression...
    Speaker: Krishna Vattem, Ph.D.
    Presented at: Gibco ExpressionWorld 2018
    2
    JAN 31, 2018 | 8:00 AM
    High Content Screening-Based Phenotypic Analysis Of Organotypic 3D Bronchial Tissues
    High Content Screening-Based Phenotypic Analysis Of Organotypic...
    One of the goals of the “3Rs principle” is to replace in vivo testing methodologies with in vitro procedures on human cells, followed by computational systems biology modelling to...
    Speaker: Diego Marescotti, PhD
    Presented at: Protein and Cell Analysis Education Series
    Sponsored By: Thermo Fisher Scientific
    9 1
    NOV 14, 2017 | 9:00 AM
    WEBINAR: CRISPRa tools for transcriptional activation studies
    WEBINAR: CRISPRa tools for transcriptional activation studies
    DATE: November 14, 2017TIME: 09:00am PST, 12:00pm ESTThe CRISPR-Cas9 system has been adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and av...
    Speaker: Žaklina Strezoska , Benedict Cross
    Sponsored By: Dharmacon, a Horizon Discovery Group Company
    11 4
    NOV 09, 2017 | 10:00 AM
    Eliminating inherent genome editing bottlenecks in iPSCs to build physiologically relevant disease models
    Eliminating inherent genome editing bottlenecks in iPSCs to build...
    Therapeutic development for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficac...
    Speaker: Erik Willems, PhD
    Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
    3
    NOV 01, 2017 | 12:00 PM
    WEBINAR: Simplified imaging for quantifying biological complexity of iPSC-derived cardiomyocytes and neurons
    WEBINAR: Simplified imaging for quantifying biological complexity...
    DATE: November 1, 2017TIME:  12:00 PM PT, 3:00 PM ETThere is a current focus in biology towards developing more complex and physiologically relevant in vitro assays and cell models...
    Speaker: Oksana Sirenko, PhD
    Sponsored By: Molecular Devices
    5
     
     
  • OCT 24, 2017 | 7:00 AM
    WEBINAR: Biomarker Discovery: Metabolomics Differentiates Known Disease Classifications of Prostate Cancer
    WEBINAR: Biomarker Discovery: Metabolomics Differentiates Known...
    DATE: October, 24, 2017TIME:  7:00 AM PDT Metabolomics focuses on the chemical processes central to cellular metabolism. A robust mass spectrometry solution for screening...
    Speaker: Timothy Garrett, PhD
    Sponsored By: SCIEX
    4 1
    OCT 12, 2017 | 6:00 AM
    Inference of gene signatures associated with response and resistance to targeted and immunotherapies
    Inference of gene signatures associated with response and resistance...
    We developed two computational methods, CARE and TIDE, to predict response and resistance to targeted therapies and immunotherapies. CARE infers gene signatures of targeted therapy response b...
    Speaker: Xiaole Shirley Liu, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
    OCT 01, 2017 | 12:00 AM
    Addressing the scalability of human iPSC-derived neurons for HTS implementation and phenotypic screening
    Addressing the scalability of human iPSC-derived neurons for HTS...
    Traditional high throughput screening (HTS) assays for neuronal targets employ non-human primary neuronal cells due to the scale necessary for HTS. Isolation of mouse primary neurons can be u...
    Speaker: BanuPriya Sridharan
    Presented at: 6th annual 24 Hours of Stem Cells™ virtual event
    2
    JUL 01, 2017 | 8:00 AM
    iPSC-derived neural cells for drug discovery of mitochondrial brain diseases
    iPSC-derived neural cells for drug discovery of mitochondrial...
    Mitochondrial defects represent a common pathogenetic mechanism associated with neurodegeneration. At the same time, mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases...
    Speaker: Alessandro Prigione
    Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
    2
    JUN 07, 2017 | 9:00 AM
    WEBINAR: Generation of purified human iPSC derived cardiomyocytes using clinically relevant workflow
    WEBINAR: Generation of purified human iPSC derived cardiomyocytes...
    DATE: June 7, 2017TIME: 9:00AM PDT, 12:00PM EDTPluripotent stem cells (PSCs) offer an unlimited source of human cardiovascular cells for research and the development of cardiac regenera...
    Speaker: Todd Herron, BS, PhD
    Sponsored By: Miltenyi Biotec
    5 1
     
     
  • MAY 25, 2017 | 9:00 AM
    Clinical Core Lab Design: From Looking Up to Looking Down
    Clinical Core Lab Design: From Looking Up to Looking Down
    The nature of work in the clinical core lab has changed over the years from beakers of liquids, specimens and compounds on countertops to sophisticated equipment with prepackaged reagents and...
    Speaker: Tammy Germini
    Presented at: Lab Automation Virtual Event Series 2017
    1
    MAY 24, 2017 | 1:30 PM
    Lab-on-a-printer™ - a multi-material 3D bioprinting platform for building living tissues on demand
    Lab-on-a-printer™ - a multi-material 3D bioprinting platform for...
    Drug development is a costly and time consuming process, poor translation of data from pre-clinical studies to the clinic is a major contributor as late-stage drug failure is very expensive....
    Speaker: Sam Wadsworth, PhD
    Presented at: Lab Automation Virtual Event Series 2017
    2
    MAY 24, 2017 | 9:00 AM
    Fully Automated 3D Cell Culture for Human Cells
    Fully Automated 3D Cell Culture for Human Cells
    The consistent and optimized production of living human cells for drug discovery and regenerative medicine faces many challenges including the need for cost effective large scale expansion, i...
    Speaker: Robin Felder, PhD
    Presented at: Lab Automation Virtual Event Series 2017
    2
    MAY 24, 2017 | 6:00 AM
    Exploring Pharmacological Interactions with Matrix: The Innovations and Challenges of NCATS Drug Combination HTS Platform
    Exploring Pharmacological Interactions with Matrix: The Innovations...
    Acoustic dispensing technology has allowed for compound plating to be highly customizable depending upon scientific needs.  The ability to dispense compounds from a single well to any we...
    Speaker: Kelli Wilson, PhD
    Presented at: Lab Automation Virtual Event Series 2017
    3 1
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