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    GPCR

    GPCR: G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes. These cell surface receptors act like an inbox for messages in the form of light energy, peptides, lipids, sugars, and proteins. Such messages inform cells about the presence or absence of life-sustaining light or nutrients in their environment, or they convey information sent by other cells.

    Webinars

    • APR 30, 2020 | 8:00 AM
      Uncovering the membrane mechanism of cytokinesis using live cell imaging and subcellular optogenetic tools.
      Uncovering the membrane mechanism of cytokinesis using live cell...
      DATE:April 30, 2020 TIME: 8AM PT, 11AM ET, 4PM BST, 5PM CEST Cytokinesis is the physical separation of two cells that occurs after the completion of mitosis. The mechanism underlying it is v...
      Speaker: Alan Mullan, PhD , Jean Castillo-Badillo, PhD , Claudia Florindo, PhD
      Sponsored By: Andor
      7 2
      MAR 24, 2020 | 10:00 AM
      Save your time on data analysis with new Batch Analysis feature in Axon pCLAMP 11 Software
      Save your time on data analysis with new Batch Analysis feature...
      DATE: March 24, 2020 TIME: 10:00 am PDT, 1:00pm EDT The Clampfit software module is a useful tool to manipulate and analyze electrophysiological data acquired by pCLAMP™ software. Rece...
      Speaker: Jeffrey Tang, Ph.D.
      Sponsored By: Molecular Devices
      10
      JAN 29, 2020 | 9:00 AM
      A case study of protein sample prep strategies for membrane proteins
      A case study of protein sample prep strategies for membrane proteins
      DATE: January 29, 2019 TIME: 9:00am PST Plasma membrane proteins are a difficult subset of proteins to solubilize, purify, quantify, and detect, largely due to the challenge of extracting th...
      Speaker: Barbara Kaboord, PhD
      Sponsored By: Thermo Fisher Scientific
      6
      JAN 14, 2020 | 8:00 AM
      CiPA initiative and validation of high-throughput methods to characterize compound effects in human iPSC-derived cardiomyocytes
      CiPA initiative and validation of high-throughput methods to characterize...
      DATE: January 14, 2019 TIME: 8:00am PST Drug-induced QT interval prolongation and Torsades de Pointes (TdP) arrhythmias are the leading causes for drug withdrawals from market and compound a...
      Speaker: Muthukrishnan Renganathan, PhD , Panida Lertkiatmongkol, PhD , Oksana Sirenko, PhD , Carole Crittenden
      Sponsored By: Molecular Devices, Eurofins Discovery
      3
      JAN 01, 2020 | 6:00 AM
      Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling Using Genetically Encoded Fluorescent Sensors
      Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling...
      Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
      Speaker: Shana Augustin, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      DEC 10, 2019 | 8:00 AM
      Expi293: New Tools for Structural Biology and Difficult to Express Proteins
      Expi293: New Tools for Structural Biology and Difficult to Express...
      DATE: December 10, 2019TIME: 8:00am PST, 11:00am EST In this presentation, we demonstrate the performance of a new range of Expi293 components, including engineered Expi293 cell...
      Speaker: Jon Zmuda, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      7 1
      SEP 25, 2019 | 8:00 AM
      Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
      Expression, Purification and Characterization of Difficult to...
      DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
      Speaker: Anass Jawhari, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      4
      SEP 05, 2019 | 7:00 AM
      The bread and butter method of genomics: How to improve your (q)PCR
      The bread and butter method of genomics: How to improve your (q)PCR
      DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
      Speaker: Tim Schommartz, PhD
      Sponsored By: Eppendorf
      17 1
      FEB 27, 2019 | 1:30 PM
      Advances in Three-Dimensional Cell Culture in Drug Research and Discovery
      Advances in Three-Dimensional Cell Culture in Drug Research and...
      Cellular research is optimal when using physiologically-relevant cell phenotypes and genotypes of human origin. This assertion has accelerated the adoption of primary cells, stem cells, and i...
      Speaker: Richard Eglen, PhD
      Presented at: Drug Discovery Virtual Event Series 2019
      2
      SEP 11, 2018 | 7:00 AM
      Answering the Challenges of Cell Viability and Reporter Gene Assays Screening Cost and Quality
      Answering the Challenges of Cell Viability and Reporter Gene Assays...
      DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
      Speaker: Vincent Dupriez, PhD , Jeanine Hinterneder, PhD , Maria Kuzikov, MSc
      Sponsored By: Revvity
      5
      MAY 30, 2018 | 12:00 PM
      High Throughput Screening Robotics within the UK Centre for Drug Discovery
      High Throughput Screening Robotics within the UK Centre for Drug...
      AstraZeneca has an ambition to create a porous organisation, seamlessly collaborating with external partners. This desire has led to the establishment of the AstraZeneca-MRC UK Centre for Lea...
      Speaker: Mark Wigglesworth
      Presented at: Lab Automation Virtual Event Series 2018
      1
      MAY 17, 2018 | 8:00 AM
      Optimizing G Protein-Coupled Receptor Expression in Mammalian Cells
      Optimizing G Protein-Coupled Receptor Expression in Mammalian...
      G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets.  However, a detailed mechanistic understanding of their...
      Speaker: Dean Staus, PhD , Laura Wingler, PhD
      Presented at: Gibco ExpressionWorld 2018
      4
      FEB 22, 2018 | 1:30 PM
      Recent Trends in GPCR Drug Discovery: Novel Targets, New Disease Indications, and an Upsurge in Biologics
      Recent Trends in GPCR Drug Discovery: Novel Targets, New Disease...
      GPCRs constitute the largest receptor family in the human genome. Over the years they have proven themselves to be druggable targets accounting for about 1/3 of all drugs on the market today....
      Speaker: Annette Gilchrist, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 22, 2018 | 12:00 PM
      New Structure Based Drug Design Opportunities for GPCRs and Related Transporters
      New Structure Based Drug Design Opportunities for GPCRs and Related...
      Structure based drug design is now well established as a highly efficient approach in pharmaceutical research.  The approach uses atomic level detail structures of target proteins, most...
      Speaker: Sid Topiol, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      2
      FEB 22, 2018 | 10:30 AM
      Illuminating the Druggable GPCR-ome
      Illuminating the Druggable GPCR-ome
      G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many whic...
      Speaker: Bryan L. Roth, MD, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 21, 2018 | 1:30 PM
      Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative Binding Affinities Based on Pre-computed Ensembles
      Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative...
      Rapid, accurate estimation of relative ligand affinities offers the potential to allow computational methods to direct drug design and development.  Towards this goal we have developed t...
      Speaker: Alexander MacKerell, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 21, 2018 | 10:30 AM
      Panel Discussion: Co-development of Drugs and Companion Diagnostics
      Panel Discussion: Co-development of Drugs and Companion Diagnostics
      The distinction between "complementary" and "companion" diagnostics tests confuse many physicians and healthcare professionals. Panelists Professor Thomas Webster (Northea...
      Speaker: Annette Gilchrist, PhD , Martin Shaw , Thomas Webster, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 21, 2018 | 9:00 AM
      New Tools for Understanding Allosteric Signaling in G Protein Coupled Receptors
      New Tools for Understanding Allosteric Signaling in G Protein...
      One-third of FDA-approved drugs target G protein-coupled receptors (GPCRs), transmembrane cell surface proteins that recognize small molecules and polypeptides with diverse chemical scaffolds...
      Speaker: Matthew Eddy, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      OCT 24, 2017 | 9:00 AM
      WEBINAR:  Genome Editing for Functional Genomics and Drug Discovery
      WEBINAR: Genome Editing for Functional Genomics and Drug Discovery
      DATE: October 24, 2017TIME: 09:00am PDT, 12:00pm EDTDoes your work involve disease models? Do you have a need to introduce specific genomic changes in the cells of your choice? Do you w...
      Speaker: Chetana Revankar , Sanjay Kumar
      Sponsored By: Thermo Fisher Scientific
      4 2
      JUL 25, 2017 | 9:00 AM
      WEBINAR: Functional Genomics and Drug Metabolism
      WEBINAR: Functional Genomics and Drug Metabolism
      EVENT DETAILS:DATE: July 25, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science...
      Speaker: David Piper, PhD
      Sponsored By: Thermo Fisher Scientific
      7 1
      JUL 20, 2017 | 10:00 AM
      WEBINAR: Innovative quantitative imaging techniques and their utility in advancing neurobiology research
      WEBINAR: Innovative quantitative imaging techniques and their...
      DATE: July 20, 2017TIME: 10:00am PT, 1:00pm ETPart 1 - Daniel Beacham: Case study showing how CyQUANT Direct Cell Proliferation and Fluo-4 calcium imaging assays were us...
      Speaker: Dan Beacham, Ph.D. , Nicholas Radio Ph.D. , Michael Derr, M.S.
      Sponsored By: Thermo Fisher Scientific/Gibco
      3
      MAY 16, 2017 | 9:00 AM
      WEBINAR: Disease Models
      WEBINAR: Disease Models
      EVENT DETAILS:DATE: May 16, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science our first commit...
      Speaker: David Piper, PhD , Mark Kennedy, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      5 3
      MAY 10, 2017 | 4:00 AM
      Stabilization of native & functional membrane proteins for drug discovery
      Stabilization of native & functional membrane proteins for drug...
      CALIXAR has developed an innovative detergent/surfactant based approach consisting on native isolation and stabilization of therapeutic membrane protein targets such as GPCRs, ion channels, t...
      Speaker: Anass Jawhari, PhD
      Presented at: 2017 Gibco ExpressionWorld
      10 1
      MAY 01, 2017 | 8:00 AM
      Using iPSCs and Genome Engineering to Build Disease Models
      Using iPSCs and Genome Engineering to Build Disease Models
      Developing therapies for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficaciou...
      Speaker: David Piper, PhD
      Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
      1
    APR 30, 2020 | 8:00 AM
    Uncovering the membrane mechanism of cytokinesis using live cell imaging and subcellular optogenetic tools.
    Uncovering the membrane mechanism of cytokinesis using live cell...
    DATE:April 30, 2020 TIME: 8AM PT, 11AM ET, 4PM BST, 5PM CEST Cytokinesis is the physical separation of two cells that occurs after the completion of mitosis. The mechanism underlying it is v...
    Speaker: Alan Mullan, PhD , Jean Castillo-Badillo, PhD , Claudia Florindo, PhD
    Sponsored By: Andor
    7 2
    MAR 24, 2020 | 10:00 AM
    Save your time on data analysis with new Batch Analysis feature in Axon pCLAMP 11 Software
    Save your time on data analysis with new Batch Analysis feature...
    DATE: March 24, 2020 TIME: 10:00 am PDT, 1:00pm EDT The Clampfit software module is a useful tool to manipulate and analyze electrophysiological data acquired by pCLAMP™ software. Rece...
    Speaker: Jeffrey Tang, Ph.D.
    Sponsored By: Molecular Devices
    10
    JAN 29, 2020 | 9:00 AM
    A case study of protein sample prep strategies for membrane proteins
    A case study of protein sample prep strategies for membrane proteins
    DATE: January 29, 2019 TIME: 9:00am PST Plasma membrane proteins are a difficult subset of proteins to solubilize, purify, quantify, and detect, largely due to the challenge of extracting th...
    Speaker: Barbara Kaboord, PhD
    Sponsored By: Thermo Fisher Scientific
    6
    JAN 14, 2020 | 8:00 AM
    CiPA initiative and validation of high-throughput methods to characterize compound effects in human iPSC-derived cardiomyocytes
    CiPA initiative and validation of high-throughput methods to characterize...
    DATE: January 14, 2019 TIME: 8:00am PST Drug-induced QT interval prolongation and Torsades de Pointes (TdP) arrhythmias are the leading causes for drug withdrawals from market and compound a...
    Speaker: Muthukrishnan Renganathan, PhD , Panida Lertkiatmongkol, PhD , Oksana Sirenko, PhD , Carole Crittenden
    Sponsored By: Molecular Devices, Eurofins Discovery
    3
    JAN 01, 2020 | 6:00 AM
    Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling Using Genetically Encoded Fluorescent Sensors
    Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling...
    Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
    Speaker: Shana Augustin, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
     
     
  • DEC 10, 2019 | 8:00 AM
    Expi293: New Tools for Structural Biology and Difficult to Express Proteins
    Expi293: New Tools for Structural Biology and Difficult to Express...
    DATE: December 10, 2019TIME: 8:00am PST, 11:00am EST In this presentation, we demonstrate the performance of a new range of Expi293 components, including engineered Expi293 cell...
    Speaker: Jon Zmuda, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    7 1
    SEP 25, 2019 | 8:00 AM
    Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
    Expression, Purification and Characterization of Difficult to...
    DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
    Speaker: Anass Jawhari, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    4
    SEP 05, 2019 | 7:00 AM
    The bread and butter method of genomics: How to improve your (q)PCR
    The bread and butter method of genomics: How to improve your (q)PCR
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    Speaker: Tim Schommartz, PhD
    Sponsored By: Eppendorf
    17 1
    FEB 27, 2019 | 1:30 PM
    Advances in Three-Dimensional Cell Culture in Drug Research and Discovery
    Advances in Three-Dimensional Cell Culture in Drug Research and...
    Cellular research is optimal when using physiologically-relevant cell phenotypes and genotypes of human origin. This assertion has accelerated the adoption of primary cells, stem cells, and i...
    Speaker: Richard Eglen, PhD
    Presented at: Drug Discovery Virtual Event Series 2019
    2
    SEP 11, 2018 | 7:00 AM
    Answering the Challenges of Cell Viability and Reporter Gene Assays Screening Cost and Quality
    Answering the Challenges of Cell Viability and Reporter Gene Assays...
    DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
    Speaker: Vincent Dupriez, PhD , Jeanine Hinterneder, PhD , Maria Kuzikov, MSc
    Sponsored By: Revvity
    5
     
     
  • MAY 30, 2018 | 12:00 PM
    High Throughput Screening Robotics within the UK Centre for Drug Discovery
    High Throughput Screening Robotics within the UK Centre for Drug...
    AstraZeneca has an ambition to create a porous organisation, seamlessly collaborating with external partners. This desire has led to the establishment of the AstraZeneca-MRC UK Centre for Lea...
    Speaker: Mark Wigglesworth
    Presented at: Lab Automation Virtual Event Series 2018
    1
    MAY 17, 2018 | 8:00 AM
    Optimizing G Protein-Coupled Receptor Expression in Mammalian Cells
    Optimizing G Protein-Coupled Receptor Expression in Mammalian...
    G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets.  However, a detailed mechanistic understanding of their...
    Speaker: Dean Staus, PhD , Laura Wingler, PhD
    Presented at: Gibco ExpressionWorld 2018
    4
    FEB 22, 2018 | 1:30 PM
    Recent Trends in GPCR Drug Discovery: Novel Targets, New Disease Indications, and an Upsurge in Biologics
    Recent Trends in GPCR Drug Discovery: Novel Targets, New Disease...
    GPCRs constitute the largest receptor family in the human genome. Over the years they have proven themselves to be druggable targets accounting for about 1/3 of all drugs on the market today....
    Speaker: Annette Gilchrist, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    FEB 22, 2018 | 12:00 PM
    New Structure Based Drug Design Opportunities for GPCRs and Related Transporters
    New Structure Based Drug Design Opportunities for GPCRs and Related...
    Structure based drug design is now well established as a highly efficient approach in pharmaceutical research.  The approach uses atomic level detail structures of target proteins, most...
    Speaker: Sid Topiol, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    2
    FEB 22, 2018 | 10:30 AM
    Illuminating the Druggable GPCR-ome
    Illuminating the Druggable GPCR-ome
    G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many whic...
    Speaker: Bryan L. Roth, MD, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
     
     
  • FEB 21, 2018 | 1:30 PM
    Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative Binding Affinities Based on Pre-computed Ensembles
    Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative...
    Rapid, accurate estimation of relative ligand affinities offers the potential to allow computational methods to direct drug design and development.  Towards this goal we have developed t...
    Speaker: Alexander MacKerell, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    FEB 21, 2018 | 10:30 AM
    Panel Discussion: Co-development of Drugs and Companion Diagnostics
    Panel Discussion: Co-development of Drugs and Companion Diagnostics
    The distinction between "complementary" and "companion" diagnostics tests confuse many physicians and healthcare professionals. Panelists Professor Thomas Webster (Northea...
    Speaker: Annette Gilchrist, PhD , Martin Shaw , Thomas Webster, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    FEB 21, 2018 | 9:00 AM
    New Tools for Understanding Allosteric Signaling in G Protein Coupled Receptors
    New Tools for Understanding Allosteric Signaling in G Protein...
    One-third of FDA-approved drugs target G protein-coupled receptors (GPCRs), transmembrane cell surface proteins that recognize small molecules and polypeptides with diverse chemical scaffolds...
    Speaker: Matthew Eddy, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    OCT 24, 2017 | 9:00 AM
    WEBINAR:  Genome Editing for Functional Genomics and Drug Discovery
    WEBINAR: Genome Editing for Functional Genomics and Drug Discovery
    DATE: October 24, 2017TIME: 09:00am PDT, 12:00pm EDTDoes your work involve disease models? Do you have a need to introduce specific genomic changes in the cells of your choice? Do you w...
    Speaker: Chetana Revankar , Sanjay Kumar
    Sponsored By: Thermo Fisher Scientific
    4 2
    JUL 25, 2017 | 9:00 AM
    WEBINAR: Functional Genomics and Drug Metabolism
    WEBINAR: Functional Genomics and Drug Metabolism
    EVENT DETAILS:DATE: July 25, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science...
    Speaker: David Piper, PhD
    Sponsored By: Thermo Fisher Scientific
    7 1
     
     
  • JUL 20, 2017 | 10:00 AM
    WEBINAR: Innovative quantitative imaging techniques and their utility in advancing neurobiology research
    WEBINAR: Innovative quantitative imaging techniques and their...
    DATE: July 20, 2017TIME: 10:00am PT, 1:00pm ETPart 1 - Daniel Beacham: Case study showing how CyQUANT Direct Cell Proliferation and Fluo-4 calcium imaging assays were us...
    Speaker: Dan Beacham, Ph.D. , Nicholas Radio Ph.D. , Michael Derr, M.S.
    Sponsored By: Thermo Fisher Scientific/Gibco
    3
    MAY 16, 2017 | 9:00 AM
    WEBINAR: Disease Models
    WEBINAR: Disease Models
    EVENT DETAILS:DATE: May 16, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science our first commit...
    Speaker: David Piper, PhD , Mark Kennedy, Ph.D.
    Sponsored By: Thermo Fisher Scientific
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    MAY 10, 2017 | 4:00 AM
    Stabilization of native & functional membrane proteins for drug discovery
    Stabilization of native & functional membrane proteins for drug...
    CALIXAR has developed an innovative detergent/surfactant based approach consisting on native isolation and stabilization of therapeutic membrane protein targets such as GPCRs, ion channels, t...
    Speaker: Anass Jawhari, PhD
    Presented at: 2017 Gibco ExpressionWorld
    10 1
    MAY 01, 2017 | 8:00 AM
    Using iPSCs and Genome Engineering to Build Disease Models
    Using iPSCs and Genome Engineering to Build Disease Models
    Developing therapies for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficaciou...
    Speaker: David Piper, PhD
    Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
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