High Throughput Screening: a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry[1][2]. Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can rapidly identify active compounds, antibodies, or genes that modulate a particular biomolecular pathway.
Whole genome sequencing of bacterial isolates via next-generation sequencing is becoming a standard approach for clinical microbiology and bio-surveillance labs seeking to conduct outbreak in...
Every year, approximately 800,000 critically ill patients are hospitals in the USA with undiagnosed infections. The only option is to treat these patients with broad-spectrum antimicrobial th...
Some bacteria can use an electrode as an electron donor for respiration, generating an electrical current in the process. We are trying to understand a bacterial community that uses electrici...
The ongoing research and scientific debate on pathophysiology, classification, nomenclature and diagnosis of antiphospholipid syndrome illustrates the complexity of cellular membranes, their...
Whooping cough caused by Bordetella infection has resurged in recent years. Dr. Karissa Culbreath will discuss the clinical presentation of Bordetella infection and its public health im...
Antibiotic resistance is a national and global public health crisis. Each year in the United States (US), at least 2 million people become infected with antibiotic-resistant bacteria an...
There are new generations of comprehensive multiplex molecular panels available for infectious diseases syndromic diagnostics. They are able to rapidly detect and identify the most common pat...
Next-generation DNA sequencing has opened new possibilities for microbial water quality monitoring, particularly for addressing emerging concerns like antibiotic resistance and opportunistic...
The WHO has set ambitious targets for eliminating TB in low-incidence countries such as the US and Canada. While it’s true that the majority of TB cases in these settings arise from rea...
DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
DATE: August 30, 2018TIME: 11:00am EDT, 5:00pm CEST The need to quantify urine is valuable because it provides information on chemicals that the body makes naturally, as well...
DATE: August 30, 2018TIME: 10:00am CEST, 4:00pm CST The need to quantify urine is valuable because it provides information on chemicals that the body makes naturall...
With the advent of cost effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
DATE: June 28, 2018TIME: 9:00AM PDTStep up your biologics stability screening with HunkyMany methods for studying protein stability and aggregation are qualitative, which can c...
Treatments for respiratory diseases represent an enormous, unmet medical need with limited therapies currently approved for use. Despite many compounds demonstrating beneficial effects in ani...
The miniaturized total chemical analysis system has been successfully repurposed over the past twenty years or so for engineering cellular microenvironments which more faithfully mimic in viv...
I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
The next step towards more biomimetic in vitro models is the design of multi-organ devices, which allow for communication of different tissue types. Combining physiologically relevant organ m...
Cell-based assays are more biologically relevant than biochemical assays yet significantly more scalable than in vivo experiments. However, care must be taken in sample preparation to e...
Over the years high throughput screening has evolved from monolithic static systems to modular more dynamic platforms. At NCATS the approach taken has been to optimize our existing lega...
This talk will reflect on what we can expect from the lab of the future and explore avenues towards such a digital lab. A major component of a digital lab is integration of instruments, syste...
Synthetic biology is a new set of tools and techniques for engineering biology. Its earliest applications were in biotech-related fields like medicine and agriculture, but today it’s be...
AstraZeneca has an ambition to create a porous organisation, seamlessly collaborating with external partners. This desire has led to the establishment of the AstraZeneca-MRC UK Centre for Lea...
NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ov...
Whole genome sequencing of bacterial isolates via next-generation sequencing is becoming a standard approach for clinical microbiology and bio-surveillance labs seeking to conduct outbreak in...
Every year, approximately 800,000 critically ill patients are hospitals in the USA with undiagnosed infections. The only option is to treat these patients with broad-spectrum antimicrobial th...
Some bacteria can use an electrode as an electron donor for respiration, generating an electrical current in the process. We are trying to understand a bacterial community that uses electrici...
The ongoing research and scientific debate on pathophysiology, classification, nomenclature and diagnosis of antiphospholipid syndrome illustrates the complexity of cellular membranes, their...
Whooping cough caused by Bordetella infection has resurged in recent years. Dr. Karissa Culbreath will discuss the clinical presentation of Bordetella infection and its public health im...
Antibiotic resistance is a national and global public health crisis. Each year in the United States (US), at least 2 million people become infected with antibiotic-resistant bacteria an...
There are new generations of comprehensive multiplex molecular panels available for infectious diseases syndromic diagnostics. They are able to rapidly detect and identify the most common pat...
Next-generation DNA sequencing has opened new possibilities for microbial water quality monitoring, particularly for addressing emerging concerns like antibiotic resistance and opportunistic...
The WHO has set ambitious targets for eliminating TB in low-incidence countries such as the US and Canada. While it’s true that the majority of TB cases in these settings arise from rea...
DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
DATE: August 30, 2018TIME: 11:00am EDT, 5:00pm CEST The need to quantify urine is valuable because it provides information on chemicals that the body makes naturally, as well...
DATE: August 30, 2018TIME: 10:00am CEST, 4:00pm CST The need to quantify urine is valuable because it provides information on chemicals that the body makes naturall...
With the advent of cost effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
DATE: June 28, 2018TIME: 9:00AM PDTStep up your biologics stability screening with HunkyMany methods for studying protein stability and aggregation are qualitative, which can c...
Treatments for respiratory diseases represent an enormous, unmet medical need with limited therapies currently approved for use. Despite many compounds demonstrating beneficial effects in ani...
The miniaturized total chemical analysis system has been successfully repurposed over the past twenty years or so for engineering cellular microenvironments which more faithfully mimic in viv...
I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
The next step towards more biomimetic in vitro models is the design of multi-organ devices, which allow for communication of different tissue types. Combining physiologically relevant organ m...
Cell-based assays are more biologically relevant than biochemical assays yet significantly more scalable than in vivo experiments. However, care must be taken in sample preparation to e...
Over the years high throughput screening has evolved from monolithic static systems to modular more dynamic platforms. At NCATS the approach taken has been to optimize our existing lega...
This talk will reflect on what we can expect from the lab of the future and explore avenues towards such a digital lab. A major component of a digital lab is integration of instruments, syste...
Synthetic biology is a new set of tools and techniques for engineering biology. Its earliest applications were in biotech-related fields like medicine and agriculture, but today it’s be...
AstraZeneca has an ambition to create a porous organisation, seamlessly collaborating with external partners. This desire has led to the establishment of the AstraZeneca-MRC UK Centre for Lea...
NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ov...
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