Neuroinflammation: inflammation of the nervous tissue. Thought to be initiated in response to a variety of cues: infection, traumatic brain injury, toxic metabolites, or autoimmunity.
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Aging is associated with progressive white matter degeneration, which impairs brain structure and function. Defects in myelinating glial cells, combined with chronic neuroinflammation, contr...
BrainXell offers the most comprehensive portfolio of high-purity iPSC-derived human neurons and glia, sourced from control, edited and disease lines, to advance translational research and dr...
Apolipoprotein E epsilon 4 (APOE4) is the primary genetic risk factor for late-onset Alzheimer's disease (AD). APOE4 carriers, especially females, tend to develop gut dysbiosis earlier t...
Drug discovery programs require a robust panel of models and assays to identify and validate drug targets, support compound optimisation, and run mechanistic studies. Fully human in vitro mo...
Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key featu...
C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and result in both loss of C9orf72 protein expression and production of potentially...
We are currently facing an Opioid epidemic and a mental health crisis with increased disconnection and addiction and beginning a psychedelic renaissance. Nociplastic pain is a newer phenomen...
Neurological manifestations, including headache, altered mental status, and stroke, are a major complication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and cor...