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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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DEC 27, 2019Microbiology
It takes a long time for a drug to be approved for use in humans; repurposing existing drugs is one way to get around th ...Written By: Carmen LeitchDEC 21, 2019Drug Discovery & Development
Scientists at the University of Nottingham are seeking new ways to improve vaccine use in the protection against the bac ...Written By: Nouran AminDEC 19, 2019Technology
Although artificial intelligence has many advantages in the drug discovery process, challenges still remain--one being t ...Written By: Nouran AminDEC 15, 2019Microbiology
The fatality rate of Nipah virus has an estimated range of 40 to 75 percentWritten By: Carmen LeitchDEC 09, 2019Immunology
Group A Streptococcus (GAS), the bacterial species famous for sore throat infections, have a secret weapon for circumven ...Written By: Kara MarkerDEC 08, 2019Microbiology
When we get a cut, we easily put a bandage on it and it heals, but internal wounds can be much harder to treat.Written By: Carmen LeitchDEC 05, 2019Chemistry & Physics
Cryonics ("Cryo" related to Greek word for "cold") is a highly controversial method to deep freeze a ...Written By: Daniel DuanDEC 01, 2019Cell & Molecular Biology
Since the CRISPR gene editor was created, researchers around the world have tweaked and refined the tool to use it in a ...Written By: Carmen LeitchNOV 27, 2019Immunology
Human cells employ an intricate tagging system to manage protein activity in the body. By “tagging” a protei ...Written By: Kara MarkerNOV 26, 2019Clinical & Molecular DX
Blurred or double vision, and in extreme cases, complete vision loss are amongst the earliest symptoms of multiple scler ...Written By: Tara FernandesNOV 25, 2019Drug Discovery & Development
Every year, around 700,000 people are estimated to die from drug-resistant infections thanks to our overuse of antibioti ...Written By: Annie LennonNOV 18, 2019Drug Discovery & Development
Sickle cell disease affects approximately 100,000 Americans. Currently, the only available cure for the disease is a cos ...Written By: Annie LennonNOV 14, 2019Cell & Molecular Biology
Misfolded proteins, also called prions, can cause a host of problems, including neurodegenerative disorders.Written By: Carmen LeitchNOV 03, 2019Cell & Molecular Biology
Molecules and drugs move among cells and bind to receptors on the cell surface, which can initiate a cascade of reaction ...Written By: Carmen LeitchOCT 31, 2019Cell & Molecular Biology
Researchers have known that proteins can insulate electrical flow, but their power as conductors has only recently been ...Written By: Carmen LeitchOCT 30, 2019Genetics & Genomics
Researchers have learned why mutations in the ANT gene lead to heart problems.Written By: Carmen LeitchOCT 29, 2019Microbiology
Instead of designing a new flu vaccine every year, researchers have made a breakthrough that may lead to a single vaccin ...Written By: Carmen LeitchOCT 23, 2019Immunology
Delivering gluten to the body in a friendly, harmless package may be the way for people with celiac disease to finally h ...Written By: Kara MarkerOCT 22, 2019Genetics & Genomics
In recent years, scientists have found that a phenomenon called phase separation plays a critical role in the functions ...Written By: Carmen LeitchOCT 22, 2019Cell & Molecular Biology
Scientists in the Bertozzi at Staford University have published surprising observations of glycan sugars attached direct ...Written By: Amanda MikyskaOCT 16, 2019Drug Discovery & Development
A publication in Nature Communications describes a therapeutic that can avoid the side-effects of insulin in diabetic tr ...Written By: Nouran AminOCT 14, 2019Immunology
Vaccines to prevent Ebola are still in their infancy, with experimental-only versions being used only in the most dire o ...Written By: Kara MarkerOCT 09, 2019Drug Discovery & Development
Researchers have used personalized medicine to develop a tailor-made genetic treatment for a girl diagnosed with a rare ...Written By: Annie LennonOCT 02, 2019Genetics & Genomics
Scientists have now used a technique called deep mutagenesis to reveal more about amyotrophic lateral sclerosis.Written By: Carmen Leitch
DEC 27, 2019
Microbiology
It takes a long time for a drug to be approved for use in humans; repurposing existing drugs is one way to get around th
...
Written By:
Carmen Leitch
DEC 21, 2019
Drug Discovery & Development
Scientists at the University of Nottingham are seeking new ways to improve vaccine use in the protection against the bac
...
Written By:
Nouran Amin
DEC 19, 2019
Technology
Although artificial intelligence has many advantages in the drug discovery process, challenges still remain--one being t
...
Written By:
Nouran Amin
DEC 15, 2019
Microbiology
The fatality rate of Nipah virus has an estimated range of 40 to 75 percent
Written By:
Carmen Leitch
DEC 09, 2019
Immunology
Group A Streptococcus (GAS), the bacterial species famous for sore throat infections, have a secret weapon for circumven
...
Written By:
Kara Marker
DEC 08, 2019
Microbiology
When we get a cut, we easily put a bandage on it and it heals, but internal wounds can be much harder to treat.
Written By:
Carmen Leitch
DEC 05, 2019
Chemistry & Physics
Cryonics ("Cryo" related to Greek word for "cold") is a highly controversial method to deep freeze a
...
Written By:
Daniel Duan
DEC 01, 2019
Cell & Molecular Biology
Since the CRISPR gene editor was created, researchers around the world have tweaked and refined the tool to use it in a
...
Written By:
Carmen Leitch
NOV 27, 2019
Immunology
Human cells employ an intricate tagging system to manage protein activity in the body. By “tagging” a protei
...
Written By:
Kara Marker
NOV 26, 2019
Clinical & Molecular DX
Blurred or double vision, and in extreme cases, complete vision loss are amongst the earliest symptoms of multiple scler
...
Written By:
Tara Fernandes
NOV 25, 2019
Drug Discovery & Development
Every year, around 700,000 people are estimated to die from drug-resistant infections thanks to our overuse of antibioti
...
Written By:
Annie Lennon
NOV 18, 2019
Drug Discovery & Development
Sickle cell disease affects approximately 100,000 Americans. Currently, the only available cure for the disease is a cos
...
Written By:
Annie Lennon
NOV 14, 2019
Cell & Molecular Biology
Misfolded proteins, also called prions, can cause a host of problems, including neurodegenerative disorders.
Written By:
Carmen Leitch
NOV 03, 2019
Cell & Molecular Biology
Molecules and drugs move among cells and bind to receptors on the cell surface, which can initiate a cascade of reaction
...
Written By:
Carmen Leitch
OCT 31, 2019
Cell & Molecular Biology
Researchers have known that proteins can insulate electrical flow, but their power as conductors has only recently been
...
Written By:
Carmen Leitch
OCT 30, 2019
Genetics & Genomics
Researchers have learned why mutations in the ANT gene lead to heart problems.
Written By:
Carmen Leitch
OCT 29, 2019
Microbiology
Instead of designing a new flu vaccine every year, researchers have made a breakthrough that may lead to a single vaccin
...
Written By:
Carmen Leitch
OCT 23, 2019
Immunology
Delivering gluten to the body in a friendly, harmless package may be the way for people with celiac disease to finally h
...
Written By:
Kara Marker
OCT 22, 2019
Genetics & Genomics
In recent years, scientists have found that a phenomenon called phase separation plays a critical role in the functions
...
Written By:
Carmen Leitch
OCT 22, 2019
Cell & Molecular Biology
Scientists in the Bertozzi at Staford University have published surprising observations of glycan sugars attached direct
...
Written By:
Amanda Mikyska
OCT 16, 2019
Drug Discovery & Development
A publication in Nature Communications describes a therapeutic that can avoid the side-effects of insulin in diabetic tr
...
Written By:
Nouran Amin
OCT 14, 2019
Immunology
Vaccines to prevent Ebola are still in their infancy, with experimental-only versions being used only in the most dire o
...
Written By:
Kara Marker
OCT 09, 2019
Drug Discovery & Development
Researchers have used personalized medicine to develop a tailor-made genetic treatment for a girl diagnosed with a rare
...
Written By:
Annie Lennon
OCT 02, 2019
Genetics & Genomics
Scientists have now used a technique called deep mutagenesis to reveal more about amyotrophic lateral sclerosis.
Written By:
Carmen Leitch