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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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OCT 02, 2019Drug Discovery & Development
Preventing the growth of tumors presents a challenge for scientists in finding a cure to cancer. Now however, researcher ...Written By: Annie LennonSEP 28, 2019Cell & Molecular Biology
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Toxic proteinopathies are a group of inherited diseases that are caused when improperly folded proteins accumulate in th ...Written By: Carmen LeitchAUG 05, 2019Genetics & Genomics
Scientists have improved on a recently-developed method for visualizing the interactions between DNA and proteins.Written By: Carmen LeitchAUG 04, 2019Immunology
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In March, the U.S. Food and Drug Administration approved ketamine nasal spray to treat depression. Ketamine has gotten a ...Written By: Dr. Nina LichtenbergJUL 24, 2019Cell & Molecular Biology
A new study published in Nature reveals an immunity to the CRISPR-Cas9 proteins in humansWritten By: Carly BoydJUL 24, 2019Cell & Molecular Biology
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According to a study published in the Journal of the American Chemical Society (JACS), a new drug-delivery system disgui ...Written By: Nouran AminJUL 18, 2019Genetics & Genomics
Researchers have uncovered a new set of rules that govern cellular decision-making about gene activation.Written By: Carmen LeitchJUL 16, 2019Genetics & Genomics
Schizophrenia is known as one of the most common serious mental illnesses. Characterized by a decreased ability to under ...Written By: Annie LennonJUL 15, 2019Cell & Molecular Biology
Having an understanding of biology requires revealing the relationships and interactions between proteins.Written By: Carmen LeitchJUL 14, 2019Cell & Molecular Biology
There are many potential reasons why skin might itch, but this annoying condition can significantly impact quality of li ...Written By: Carmen LeitchJUL 03, 2019Drug Discovery & Development
Sepsis is a serious medical condition that results from inflammation in the body and can cause fatal multi-organ dysfunc ...Written By: Nouran AminJUN 28, 2019Cancer
Triple-negative breast cancer is not a cancer diagnosis anyone wants to receive. A particularly aggressive form of breas ...Written By: Kathryn DeMuth SullivanJUN 18, 2019Health & Medicine
Norovirus infections also called the "stomach flu," are foodborne viral illnesses that are spread from person- ...Written By: Dena ArutaJUN 13, 2019Cancer
Drug resistance is a major hindrance to cancer treatment. Researchers from Duke University, MIT and the University of Rh ...Written By: Julia TraversJUN 12, 2019Drug Discovery & Development
Targeting tumor cells while avoiding harming healthy tissue remains a growing central challenge in the field of chemothe ...Written By: Nouran AminJUN 10, 2019Genetics & Genomics
Source: Science CRISPR-cas9, commonly referred to simply as CRISPR, is a bacterial immune system that was first used as ...Written By: Amanda Mikyska
OCT 02, 2019
Drug Discovery & Development
Preventing the growth of tumors presents a challenge for scientists in finding a cure to cancer. Now however, researcher
...
Written By:
Annie Lennon
SEP 28, 2019
Cell & Molecular Biology
New study reveals that non-coding RNA effects the progression COPD.
Written By:
Carly Boyd
SEP 24, 2019
Technology
Scientists have recently developed a chip-like device that utilizes tiny magnets that sort large populations of mixed ce
...
Written By:
Nouran Amin
SEP 21, 2019
Cell & Molecular Biology
Every cell type has to carefully control which genes are expressed, and new research has learned more about that process
...
Written By:
Carmen Leitch
SEP 18, 2019
Drug Discovery & Development
In recent years, ketamine has received growing interest for its neuroprotective effects. Known to alleviate symptoms of
...
Written By:
Annie Lennon
AUG 13, 2019
Genetics & Genomics
Researchers are taking a new look at how the cell regulates gene expression.
Written By:
Carmen Leitch
AUG 11, 2019
Immunology
With 10-30% of the population reporting sensitivity to cat dander, you probably know someone with a cat allergy. T
...
Written By:
Amanda Mikyska
AUG 06, 2019
Cell & Molecular Biology
Toxic proteinopathies are a group of inherited diseases that are caused when improperly folded proteins accumulate in th
...
Written By:
Carmen Leitch
AUG 05, 2019
Genetics & Genomics
Scientists have improved on a recently-developed method for visualizing the interactions between DNA and proteins.
Written By:
Carmen Leitch
AUG 04, 2019
Immunology
Hair cells inside the human ear are responsible for sensing and relaying sound to the brain. In all mammals except
...
Written By:
Amanda Mikyska
JUL 31, 2019
Health & Medicine
In March, the U.S. Food and Drug Administration approved ketamine nasal spray to treat depression. Ketamine has gotten a
...
Written By:
Dr. Nina Lichtenberg
JUL 24, 2019
Cell & Molecular Biology
A new study published in Nature reveals an immunity to the CRISPR-Cas9 proteins in humans
Written By:
Carly Boyd
JUL 24, 2019
Cell & Molecular Biology
Simple cell functions like division or metabolism can lead to DNA damage, which can also occur because of normal exposur
...
Written By:
Carmen Leitch
JUL 19, 2019
Drug Discovery & Development
According to a study published in the Journal of the American Chemical Society (JACS), a new drug-delivery system disgui
...
Written By:
Nouran Amin
JUL 18, 2019
Genetics & Genomics
Researchers have uncovered a new set of rules that govern cellular decision-making about gene activation.
Written By:
Carmen Leitch
JUL 16, 2019
Genetics & Genomics
Schizophrenia is known as one of the most common serious mental illnesses. Characterized by a decreased ability to under
...
Written By:
Annie Lennon
JUL 15, 2019
Cell & Molecular Biology
Having an understanding of biology requires revealing the relationships and interactions between proteins.
Written By:
Carmen Leitch
JUL 14, 2019
Cell & Molecular Biology
There are many potential reasons why skin might itch, but this annoying condition can significantly impact quality of li
...
Written By:
Carmen Leitch
JUL 03, 2019
Drug Discovery & Development
Sepsis is a serious medical condition that results from inflammation in the body and can cause fatal multi-organ dysfunc
...
Written By:
Nouran Amin
JUN 28, 2019
Cancer
Triple-negative breast cancer is not a cancer diagnosis anyone wants to receive. A particularly aggressive form of breas
...
Written By:
Kathryn DeMuth Sullivan
JUN 18, 2019
Health & Medicine
Norovirus infections also called the "stomach flu," are foodborne viral illnesses that are spread from person-
...
Written By:
Dena Aruta
JUN 13, 2019
Cancer
Drug resistance is a major hindrance to cancer treatment. Researchers from Duke University, MIT and the University of Rh
...
Written By:
Julia Travers
JUN 12, 2019
Drug Discovery & Development
Targeting tumor cells while avoiding harming healthy tissue remains a growing central challenge in the field of chemothe
...
Written By:
Nouran Amin
JUN 10, 2019
Genetics & Genomics
Source: Science CRISPR-cas9, commonly referred to simply as CRISPR, is a bacterial immune system that was first used as
...
Written By:
Amanda Mikyska