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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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MAY 06, 2019Cancer
Malignant rhabdoid tumor (MRT) is one of the worst cancer diagnoses a child can receive. While it is uncommon (or perhap ...Written By: Kathryn DeMuth SullivanMAY 01, 2019Health & Medicine
A team of international scientists has defined a new type of dementia that closely mimics the symptoms of Alzheimer&rsqu ...Written By: Tiffany DazetMAR 25, 2019Cell & Molecular Biology
Honeybee queen larvae are held in a specific orientation using protein rich "royal jelly" that directs their development ...Written By: Carly BoydMAR 18, 2019Health & Medicine
Scientists uncover new "viral oncogenes" that allow HPV to turn healthy cells into cancer cells, while evading the immun ...Written By: Carly BoydMAR 14, 2019Technology
Certain mammals, including humans, can see a limited range of wavelengths of light known as visible light. The visible l ...Written By: Nouran AminFEB 28, 2019Cannabis Sciences
Scientists from the University of California, Berkeley, have been able to extract cannabis compounds not from the c ...Written By: Amy LoriauxFEB 26, 2019Genetics & Genomics
Estimates vary but there are around 20,000 proteins that encode for protein in the human genome. So what's the rest for?Written By: Carmen LeitchFEB 21, 2019Cell & Molecular Biology
If a species wants to survive, genetic information has to be passed successfully from one generation to the next.Written By: Carmen LeitchFEB 14, 2019Cell & Molecular Biology
Cigarette smokers become addicted to nicotine, a highly addictive substance that is absorbed through the skin, mouth, an ...Written By: Carmen LeitchFEB 05, 2019Genetics & Genomics
For an organism to function properly, genes have to be turned on or off in the right places at the right times.Written By: Carmen LeitchFEB 05, 2019Microbiology
Bacteria have to be able to defend themselves from other microbes, making some microbes valuable producers of antibiotic ...Written By: Carmen LeitchJAN 09, 2019Cannabis Sciences
There are many of the uses of medical marijuana. Glaucoma, chronic pain, irritable bowel syndrome, anxiety disorders, fi ...Written By: Amy LoriauxJAN 09, 2019Cannabis Sciences
Cannabidiol (CBD) oils have been reported to have amazing health effects, from pain relief to anxiety relief to even can ...Written By: Amy LoriauxJAN 06, 2019Health & Medicine
When gastric acid secretion is increased, there is a greater risk of developing motility disorders, such as GERD, peptic ...Written By: Dena ArutaJAN 05, 2019Cell & Molecular Biology
The structure of a huge receptor in the body, which binds to vitamin B12, has now been elucidated.Written By: Carmen LeitchJAN 03, 2019Cannabis Sciences
The nervous system, the cardiovascular system, the skeletal system, the endocrine system; these are all physiological sy ...Written By: Amy LoriauxDEC 26, 2018Immunology
A team from Scripps Research has found a molecular cause of a group of rare autoimmune disorders in which the immune sys ...Written By: Nicholas BreehlDEC 26, 2018Genetics & Genomics
Scientists have long been seeking to understand aging. Researchers found age-related changes in cell-free DNA.Written By: Carmen LeitchDEC 12, 2018Immunology
A group of researchers describes the biophysical and structural characteristics of an immune regulating protein called h ...Written By: Nicholas BreehlDEC 11, 2018Immunology
Research reveals a genetic mutation causes a protein binding site to alter its structure resulting in the development of ...Written By: Nicholas BreehlDEC 09, 2018Cannabis Sciences
The human endocannabinoid system (ECS) is one of the body's largest network of neurotransmitters, receptors, and neu ...Written By: Amy LoriauxNOV 20, 2018Cell & Molecular Biology
In the long run, some cancer therapeutics may be doing more harm than good.Written By: Carmen LeitchNOV 06, 2018Cannabis Sciences
Now that I've got your attention, we can talk science now. Yes, there is actually relatively new study which measure ...Written By: Amy LoriauxNOV 02, 2018Cell & Molecular Biology
A molecule that has been a focus of cancer research has been found to be a significant regulator of metabolism.Written By: Carmen Leitch
MAY 06, 2019
Cancer
Malignant rhabdoid tumor (MRT) is one of the worst cancer diagnoses a child can receive. While it is uncommon (or perhap
...
Written By:
Kathryn DeMuth Sullivan
MAY 01, 2019
Health & Medicine
A team of international scientists has defined a new type of dementia that closely mimics the symptoms of Alzheimer&rsqu
...
Written By:
Tiffany Dazet
MAR 25, 2019
Cell & Molecular Biology
Honeybee queen larvae are held in a specific orientation using protein rich "royal jelly" that directs their development
...
Written By:
Carly Boyd
MAR 18, 2019
Health & Medicine
Scientists uncover new "viral oncogenes" that allow HPV to turn healthy cells into cancer cells, while evading the immun
...
Written By:
Carly Boyd
MAR 14, 2019
Technology
Certain mammals, including humans, can see a limited range of wavelengths of light known as visible light. The visible l
...
Written By:
Nouran Amin
FEB 28, 2019
Cannabis Sciences
Scientists from the University of California, Berkeley, have been able to extract cannabis compounds not from the c
...
Written By:
Amy Loriaux
FEB 26, 2019
Genetics & Genomics
Estimates vary but there are around 20,000 proteins that encode for protein in the human genome. So what's the rest for?
Written By:
Carmen Leitch
FEB 21, 2019
Cell & Molecular Biology
If a species wants to survive, genetic information has to be passed successfully from one generation to the next.
Written By:
Carmen Leitch
FEB 14, 2019
Cell & Molecular Biology
Cigarette smokers become addicted to nicotine, a highly addictive substance that is absorbed through the skin, mouth, an
...
Written By:
Carmen Leitch
FEB 05, 2019
Genetics & Genomics
For an organism to function properly, genes have to be turned on or off in the right places at the right times.
Written By:
Carmen Leitch
FEB 05, 2019
Microbiology
Bacteria have to be able to defend themselves from other microbes, making some microbes valuable producers of antibiotic
...
Written By:
Carmen Leitch
JAN 09, 2019
Cannabis Sciences
There are many of the uses of medical marijuana. Glaucoma, chronic pain, irritable bowel syndrome, anxiety disorders, fi
...
Written By:
Amy Loriaux
JAN 09, 2019
Cannabis Sciences
Cannabidiol (CBD) oils have been reported to have amazing health effects, from pain relief to anxiety relief to even can
...
Written By:
Amy Loriaux
JAN 06, 2019
Health & Medicine
When gastric acid secretion is increased, there is a greater risk of developing motility disorders, such as GERD, peptic
...
Written By:
Dena Aruta
JAN 05, 2019
Cell & Molecular Biology
The structure of a huge receptor in the body, which binds to vitamin B12, has now been elucidated.
Written By:
Carmen Leitch
JAN 03, 2019
Cannabis Sciences
The nervous system, the cardiovascular system, the skeletal system, the endocrine system; these are all physiological sy
...
Written By:
Amy Loriaux
DEC 26, 2018
Immunology
A team from Scripps Research has found a molecular cause of a group of rare autoimmune disorders in which the immune sys
...
Written By:
Nicholas Breehl
DEC 26, 2018
Genetics & Genomics
Scientists have long been seeking to understand aging. Researchers found age-related changes in cell-free DNA.
Written By:
Carmen Leitch
DEC 12, 2018
Immunology
A group of researchers describes the biophysical and structural characteristics of an immune regulating protein called h
...
Written By:
Nicholas Breehl
DEC 11, 2018
Immunology
Research reveals a genetic mutation causes a protein binding site to alter its structure resulting in the development of
...
Written By:
Nicholas Breehl
DEC 09, 2018
Cannabis Sciences
The human endocannabinoid system (ECS) is one of the body's largest network of neurotransmitters, receptors, and neu
...
Written By:
Amy Loriaux
NOV 20, 2018
Cell & Molecular Biology
In the long run, some cancer therapeutics may be doing more harm than good.
Written By:
Carmen Leitch
NOV 06, 2018
Cannabis Sciences
Now that I've got your attention, we can talk science now. Yes, there is actually relatively new study which measure
...
Written By:
Amy Loriaux
NOV 02, 2018
Cell & Molecular Biology
A molecule that has been a focus of cancer research has been found to be a significant regulator of metabolism.
Written By:
Carmen Leitch