Follow
Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
-
OCT 24, 2018Drug Discovery & Development
Since Halloween is around the corner, it is science-fiction season and some may choose to celebrate by watching movies f ...Written By: Nouran AminOCT 06, 2018Drug Discovery & Development
Scientists at Stevens Institute of Technology have designed a new class of molecules that may hold the potential to add ...Written By: Nouran AminOCT 05, 2018Cancer
As cancer is one of the most challenging diseases in our world, many efforts have been put into researching new ways for ...Written By: Heba El-wassefOCT 01, 2018Genetics & Genomics
Cells have to carry around a huge amount of genetic material, and usually that DNA is about 1000 times longer than the c ...Written By: Carmen LeitchSEP 20, 2018Genetics & Genomics
Not all liquids mix, like oil and water; the phenomenon is called liquid-liquid phase separation. We're learning more ab ...Written By: Carmen LeitchSEP 18, 2018Drug Discovery & Development
Fighting disease using the immune system is the body’s most prized possession and it does so by utilizing immunoth ...Written By: Nouran AminSEP 12, 2018Genetics & Genomics
Controlling gene expression will improve the production of important molecules in bacteria, like therapeutics or biofuel ...Written By: Carmen LeitchSEP 09, 2018Technology
Synthetic DNA technology was used to engineer a novel eCD4-Ig anti-HIV agent while enhancing its potency ‘in vivo& ...Written By: Nouran AminAUG 19, 2018Technology
Researchers at the University of Illinois have adapted to new CRISPR gene-editing technology that causes the cell's ...Written By: Nouran AminAUG 18, 2018Videos
Over an organism’s life, cells keep on dividing and with each division the risk of acquiring a mutation that may l ...Written By: Nouran AminAUG 01, 2018Drug Discovery & Development
According to a paper in the Proceedings of the National Academy of Sciences, a research team led by Dr. Vishal Gohil of ...Written By: Nouran AminJUL 24, 2018Cancer
CRISPR gene editing came about based on transfection and transduction type models of genetic transfer. There is potenti ...Written By: Mauri BrueggemanJUL 22, 2018Cell & Molecular Biology
Researchers are getting closer to creating targeted therapies that are delivered directly where needed.Written By: Carmen LeitchJUL 16, 2018Immunology
A recent study has shown that T cell receptors are dispersed across the T cell surface, as opposed to clustered, to allo ...Written By: Caitlin WilliamsJUL 13, 2018Drug Discovery & Development
Recent research in a mouse model of fragile X syndrome (FXS), scheduled for publication in Neuropsychopharmacology, show ...Written By: Nouran AminJUL 10, 2018Cancer
Researchers utilized genome-wide association studies to identify a variant SNP within a gene at 14q11.2 which is linked ...Written By: Mauri BrueggemanJUL 06, 2018Cell & Molecular Biology
Scientists have now identified two combinations of small molecules that tamp down a protein called STING.Written By: Carmen LeitchJUL 05, 2018Cell & Molecular Biology
Scientists want to learn more about the role of a specific protein in neurodegenerative disease that comes from impact t ...Written By: Carmen LeitchJUN 27, 2018Cell & Molecular Biology
Scientists discovered something new about the behavior of an organelle called ribosomes in cancer cells.Written By: Carmen LeitchJUN 16, 2018Clinical & Molecular DX
New technology combing therapeutic agents and diagnostics (theranostics) can be used to deliver drugs to cancer cells. F ...Written By: Kara MarkerJUN 13, 2018Cell & Molecular Biology
Hailed as a revolutionary technique that had many potential applications, two new studies show that we should proceed wi ...Written By: Carmen LeitchJUN 13, 2018Chemistry & Physics
The ingredient of seashells is mostly calcium carbonate, the same chemical you can find in limestone, eggs shells, and g ...Written By: Daniel DuanJUN 12, 2018Cancer
CD44 is a known cell surface protein involved in numerous interactions; it is overexpressed in cancerous tissue and its ...Written By: Mauri BrueggemanJUN 01, 2018Immunology
The unique activity of estrogen hormones and their cell receptors in the female body may explain why women are more like ...Written By: Kara Marker
OCT 24, 2018
Drug Discovery & Development
Since Halloween is around the corner, it is science-fiction season and some may choose to celebrate by watching movies f
...
Written By:
Nouran Amin
OCT 06, 2018
Drug Discovery & Development
Scientists at Stevens Institute of Technology have designed a new class of molecules that may hold the potential to add
...
Written By:
Nouran Amin
OCT 05, 2018
Cancer
As cancer is one of the most challenging diseases in our world, many efforts have been put into researching new ways for
...
Written By:
Heba El-wassef
OCT 01, 2018
Genetics & Genomics
Cells have to carry around a huge amount of genetic material, and usually that DNA is about 1000 times longer than the c
...
Written By:
Carmen Leitch
SEP 20, 2018
Genetics & Genomics
Not all liquids mix, like oil and water; the phenomenon is called liquid-liquid phase separation. We're learning more ab
...
Written By:
Carmen Leitch
SEP 18, 2018
Drug Discovery & Development
Fighting disease using the immune system is the body’s most prized possession and it does so by utilizing immunoth
...
Written By:
Nouran Amin
SEP 12, 2018
Genetics & Genomics
Controlling gene expression will improve the production of important molecules in bacteria, like therapeutics or biofuel
...
Written By:
Carmen Leitch
SEP 09, 2018
Technology
Synthetic DNA technology was used to engineer a novel eCD4-Ig anti-HIV agent while enhancing its potency ‘in vivo&
...
Written By:
Nouran Amin
AUG 19, 2018
Technology
Researchers at the University of Illinois have adapted to new CRISPR gene-editing technology that causes the cell's
...
Written By:
Nouran Amin
AUG 18, 2018
Videos
Over an organism’s life, cells keep on dividing and with each division the risk of acquiring a mutation that may l
...
Written By:
Nouran Amin
AUG 01, 2018
Drug Discovery & Development
According to a paper in the Proceedings of the National Academy of Sciences, a research team led by Dr. Vishal Gohil of
...
Written By:
Nouran Amin
JUL 24, 2018
Cancer
CRISPR gene editing came about based on transfection and transduction type models of genetic transfer. There is potenti
...
Written By:
Mauri Brueggeman
JUL 22, 2018
Cell & Molecular Biology
Researchers are getting closer to creating targeted therapies that are delivered directly where needed.
Written By:
Carmen Leitch
JUL 16, 2018
Immunology
A recent study has shown that T cell receptors are dispersed across the T cell surface, as opposed to clustered, to allo
...
Written By:
Caitlin Williams
JUL 13, 2018
Drug Discovery & Development
Recent research in a mouse model of fragile X syndrome (FXS), scheduled for publication in Neuropsychopharmacology, show
...
Written By:
Nouran Amin
JUL 10, 2018
Cancer
Researchers utilized genome-wide association studies to identify a variant SNP within a gene at 14q11.2 which is linked
...
Written By:
Mauri Brueggeman
JUL 06, 2018
Cell & Molecular Biology
Scientists have now identified two combinations of small molecules that tamp down a protein called STING.
Written By:
Carmen Leitch
JUL 05, 2018
Cell & Molecular Biology
Scientists want to learn more about the role of a specific protein in neurodegenerative disease that comes from impact t
...
Written By:
Carmen Leitch
JUN 27, 2018
Cell & Molecular Biology
Scientists discovered something new about the behavior of an organelle called ribosomes in cancer cells.
Written By:
Carmen Leitch
JUN 16, 2018
Clinical & Molecular DX
New technology combing therapeutic agents and diagnostics (theranostics) can be used to deliver drugs to cancer cells. F
...
Written By:
Kara Marker
JUN 13, 2018
Cell & Molecular Biology
Hailed as a revolutionary technique that had many potential applications, two new studies show that we should proceed wi
...
Written By:
Carmen Leitch
JUN 13, 2018
Chemistry & Physics
The ingredient of seashells is mostly calcium carbonate, the same chemical you can find in limestone, eggs shells, and g
...
Written By:
Daniel Duan
JUN 12, 2018
Cancer
CD44 is a known cell surface protein involved in numerous interactions; it is overexpressed in cancerous tissue and its
...
Written By:
Mauri Brueggeman
JUN 01, 2018
Immunology
The unique activity of estrogen hormones and their cell receptors in the female body may explain why women are more like
...
Written By:
Kara Marker