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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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MAY 30, 2018Drug Discovery & Development
Recent research has studied the effects of a protein, called apolipoprotein A-I binding protein (AIBP), in mice with che ...Written By: Nouran AminMAY 24, 2018Immunology
Scientists have discovered a new molecular pathway connecting brain and gut that if learned how to control, may be able ...Written By: Nouran AminMAY 23, 2018Cell & Molecular Biology
As the lens forms during development, its cells have to degrade some of their own parts.Written By: Carmen LeitchMAY 22, 2018Cancer
Novel PD-L1/TGF-ß fusion protein for HPV-associated cancers enters phase II clinical trial. Oncology researchers excite ...Written By: Mauri BrueggemanMAY 21, 2018Cancer
Epigenetics is defined and outlined as important in gene expression and a possible cause for cancer development & as a t ...Written By: Mauri BrueggemanMAY 16, 2018Immunology
Scientists have found evidence for potential antibody-based therapeutics to treat more than one hemorrhagic fever virus ...Written By: Kara MarkerMAY 14, 2018Cell & Molecular Biology
Researchers found nanostructures on butterfly wings with a unique optical characteristic - they are almost completely tr ...Written By: Carmen LeitchMAY 09, 2018Neuroscience
Despite thousands of research studies and millions of dollars dedicated to clinical trials, a drug to treat Alzheimer ...Written By: Brenda Kelley KimMAY 01, 2018Cell & Molecular Biology
A new field that is growing in popularity is palaeoproteomics, the study of ancient proteins.Written By: Carmen LeitchAPR 26, 2018Cannabis Sciences
The endocannabinoid system is the body’s system that regulates an array of other systems in the body. It wor ...Written By: Melissa MooreAPR 26, 2018Health & Medicine
While it's necessary to get enough vitamin D in your diet or from the sun, there's another reason some experts a ...Written By: Brenda Kelley KimAPR 24, 2018Drug Discovery & Development
Investigators at University of Lincoln in the UK have developed a new technique using nanotechnology which may deliver d ...Written By: Nouran AminAPR 15, 2018Drug Discovery & Development
A study published in Nature Medicine examines a monoclonal antibody isolated from the blood of individuals vaccinated fo ...Written By: Nouran AminAPR 12, 2018Cannabis Sciences
Endocannabinoids are lipophilic ligands that act as signaling molecules which are synthesized from glycerophospho ...Written By: Melissa MooreAPR 12, 2018Genetics & Genomics
Researchers have long wondered about the role of junk DNA, vast amounts of repetitive genetic material in our genomes th ...Written By: Carmen LeitchAPR 09, 2018Drug Discovery & Development
Transthyretin amyloidosis (ATTR) is a slowly progressive disease characterized by the buildup of abnormal deposits of a ...Written By: Nouran AminAPR 09, 2018Immunology
An important cellular reaction mediates part of the immune system responsible for tolerance. Without tolerance, the immu ...Written By: Kara MarkerAPR 06, 2018Cell & Molecular Biology
The research team of Professor Akihiro Kusumi used fluorescent markers and a new imaging technique to watch proteins dan ...Written By: Carmen LeitchAPR 02, 2018Drug Discovery & Development
DNA-encoded chemical library (DECL), containing about 35 million different drugs, is a new screening method devel ...Written By: Nouran AminMAR 20, 2018Cancer
Cancer induced reduction in antiviral immune responseWritten By:MAR 15, 2018Microbiology
New work reveals how the marine food web is directly impacted by atmospheric carbon dioxide.Written By: Carmen LeitchMAR 02, 2018Cannabis Sciences
Study to develop method for CB2R expression and ligand engagement to further therapeutic research using CB2R agonists fo ...Written By: Mauri BrueggemanFEB 21, 2018Chemistry & Physics
Eerie and distinctive, the smell of a dead body comes mainly from small molecules known as diamines, products of degrada ...Written By: Daniel DuanFEB 17, 2018Clinical & Molecular DX
After five years of optimizing, researchers from the Scripps Research Institute (TSRI) have come up with the best candid ...Written By: Kara Marker
MAY 30, 2018
Drug Discovery & Development
Recent research has studied the effects of a protein, called apolipoprotein A-I binding protein (AIBP), in mice with che
...
Written By:
Nouran Amin
MAY 24, 2018
Immunology
Scientists have discovered a new molecular pathway connecting brain and gut that if learned how to control, may be able
...
Written By:
Nouran Amin
MAY 23, 2018
Cell & Molecular Biology
As the lens forms during development, its cells have to degrade some of their own parts.
Written By:
Carmen Leitch
MAY 22, 2018
Cancer
Novel PD-L1/TGF-ß fusion protein for HPV-associated cancers enters phase II clinical trial. Oncology researchers excite
...
Written By:
Mauri Brueggeman
MAY 21, 2018
Cancer
Epigenetics is defined and outlined as important in gene expression and a possible cause for cancer development & as a t
...
Written By:
Mauri Brueggeman
MAY 16, 2018
Immunology
Scientists have found evidence for potential antibody-based therapeutics to treat more than one hemorrhagic fever virus
...
Written By:
Kara Marker
MAY 14, 2018
Cell & Molecular Biology
Researchers found nanostructures on butterfly wings with a unique optical characteristic - they are almost completely tr
...
Written By:
Carmen Leitch
MAY 09, 2018
Neuroscience
Despite thousands of research studies and millions of dollars dedicated to clinical trials, a drug to treat Alzheimer
...
Written By:
Brenda Kelley Kim
MAY 01, 2018
Cell & Molecular Biology
A new field that is growing in popularity is palaeoproteomics, the study of ancient proteins.
Written By:
Carmen Leitch
APR 26, 2018
Cannabis Sciences
The endocannabinoid system is the body’s system that regulates an array of other systems in the body. It wor
...
Written By:
Melissa Moore
APR 26, 2018
Health & Medicine
While it's necessary to get enough vitamin D in your diet or from the sun, there's another reason some experts a
...
Written By:
Brenda Kelley Kim
APR 24, 2018
Drug Discovery & Development
Investigators at University of Lincoln in the UK have developed a new technique using nanotechnology which may deliver d
...
Written By:
Nouran Amin
APR 15, 2018
Drug Discovery & Development
A study published in Nature Medicine examines a monoclonal antibody isolated from the blood of individuals vaccinated fo
...
Written By:
Nouran Amin
APR 12, 2018
Cannabis Sciences
Endocannabinoids are lipophilic ligands that act as signaling molecules which are synthesized from glycerophospho
...
Written By:
Melissa Moore
APR 12, 2018
Genetics & Genomics
Researchers have long wondered about the role of junk DNA, vast amounts of repetitive genetic material in our genomes th
...
Written By:
Carmen Leitch
APR 09, 2018
Drug Discovery & Development
Transthyretin amyloidosis (ATTR) is a slowly progressive disease characterized by the buildup of abnormal deposits of a
...
Written By:
Nouran Amin
APR 09, 2018
Immunology
An important cellular reaction mediates part of the immune system responsible for tolerance. Without tolerance, the immu
...
Written By:
Kara Marker
APR 06, 2018
Cell & Molecular Biology
The research team of Professor Akihiro Kusumi used fluorescent markers and a new imaging technique to watch proteins dan
...
Written By:
Carmen Leitch
APR 02, 2018
Drug Discovery & Development
DNA-encoded chemical library (DECL), containing about 35 million different drugs, is a new screening method devel
...
Written By:
Nouran Amin
MAR 20, 2018
Cancer
Cancer induced reduction in antiviral immune response
Written By:
MAR 15, 2018
Microbiology
New work reveals how the marine food web is directly impacted by atmospheric carbon dioxide.
Written By:
Carmen Leitch
MAR 02, 2018
Cannabis Sciences
Study to develop method for CB2R expression and ligand engagement to further therapeutic research using CB2R agonists fo
...
Written By:
Mauri Brueggeman
FEB 21, 2018
Chemistry & Physics
Eerie and distinctive, the smell of a dead body comes mainly from small molecules known as diamines, products of degrada
...
Written By:
Daniel Duan
FEB 17, 2018
Clinical & Molecular DX
After five years of optimizing, researchers from the Scripps Research Institute (TSRI) have come up with the best candid
...
Written By:
Kara Marker