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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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DEC 01, 2016Cell & Molecular Biology
As the brain develops, neurons are created from a special type of neural stem call called radial glia. Researchers at Du ...Written By: Carmen LeitchNOV 30, 2016Cell & Molecular Biology
All of the information needed for building an organism is contained within its genome, present in every cell. When new p ...Written By: Carmen LeitchNOV 30, 2016Microbiology
Leprosy. We’ve all heard of it, but do you really know what causes it? What does the word make you think of ...Written By: Kerry EvansNOV 29, 2016Cardiology
Scientists have identified a protein that binds to LDL cholesterol and helps transport it. Blocking the protein might of ...Written By: Futurity (futurity.org)NOV 26, 2016Cell & Molecular Biology
First detected by Santiago Ramón y Cajal, there are strange droplets in the cytoplasm of cells that are not well ...Written By: Carmen LeitchNOV 21, 2016Cancer
Scripps Florida Scientists Create Innovative Drug Design Strategy to Improve Breast Cancer TreatmentJUPITER, FL – November 21, 2016 – While there have been advances in the treatment of hormone-driven breast c ...Written By: The Scripps Research Institute (TSRI)NOV 05, 2016Cell & Molecular Biology
Genetic information has to be copied in order to eventually create the proteins that are needed for an organism to funct ...Written By: Carmen LeitchNOV 03, 2016Cell & Molecular Biology
Researchers at the University of Illinois Chicago (UIC) have learned more about how two common antibiotics, chlorampheni ...Written By: Carmen LeitchNOV 03, 2016Microbiology
LA JOLLA, CA – November 3, 2016 – A new study co-led by scientists at The Scripps Research Institute (TSRI) ...Written By: The Scripps Research Institute (TSRI)OCT 31, 2016Immunology
Immune responses can be unequal and misguided, resulting in certain conditions like allergies and autoimmune disorders. ...Written By: Kara MarkerOCT 29, 2016Cell & Molecular Biology
"If you have a damaged cell, you don't want it to replicate," explained computational biophysicist Rommie ...Written By: Carmen LeitchOCT 29, 2016Cell & Molecular Biology
The mechanisms that underlie physiological processes involve complex relationships between molecules. The proteins of a ...Written By: Carmen LeitchOCT 25, 2016Immunology
LA JOLLA, CA—October 24, 2016—Researchers have been trying for decades to develop a vaccine against the glob ...Written By: The Scripps Research Institute (TSRI)OCT 21, 2016Health & Medicine
JUPITER, FL — October 20, 2016 – In a discovery that advances the understanding of how marijuana works in th ...Written By: The Scripps Research Institute (TSRI)OCT 14, 2016Cardiology
With the prick of a finger, diabetics can easily test their blood-glucose levels, and now scientists are calling for the ...Written By: Kara MarkerOCT 12, 2016Immunology
The key ingredient in the recipe that make staphylococcus and streptococcus infections so dangerous? Superantigen toxins ...Written By: Kara MarkerOCT 02, 2016Cell & Molecular Biology
Decoy sequences of DNA are able to interfere with gene expression, and in ways that are not yet well understood. New fin ...Written By: Carmen LeitchSEP 28, 2016Genetics & Genomics
Image Credit: Noel Clark, University of Colorado LA JOLLA, CA – September 28, 2016 – A new study led by scie ...Written By: The Scripps Research Institute (TSRI)SEP 27, 2016Microbiology
Anthrax is commonly found in soil and can be ingested by animals. It is relatively rare for it to affect people but when ...Written By: Carmen LeitchSEP 24, 2016Cell & Molecular Biology
Cells use proteins as placeholders or bookmarks that help the cells to pick up where they left off when gene expression ...Written By: Carmen LeitchSEP 16, 2016Cell & Molecular Biology
LA JOLLA, CA – September 16, 2016 – Scientists at The Scripps Research Institute (TSRI) have brought physics ...Written By: The Scripps Research Institute (TSRI)SEP 14, 2016Immunology
From the first scientist to ever discover broadly neutralizing antibodies, a new candidate for protection from influenza ...Written By: Kara MarkerSEP 13, 2016Immunology
Klebsiella pneumoniae, AKA the “nightmare bacteria,” causes multiple infections including pneumonia, urinary ...Written By: Kara MarkerSEP 11, 2016Cell & Molecular Biology
Junk DNA refers to regions of the genome that did not at first appear to have any function or relevance. Research over t ...Written By: Carmen Leitch
DEC 01, 2016
Cell & Molecular Biology
As the brain develops, neurons are created from a special type of neural stem call called radial glia. Researchers at Du
...
Written By:
Carmen Leitch
NOV 30, 2016
Cell & Molecular Biology
All of the information needed for building an organism is contained within its genome, present in every cell. When new p
...
Written By:
Carmen Leitch
NOV 30, 2016
Microbiology
Leprosy. We’ve all heard of it, but do you really know what causes it? What does the word make you think of
...
Written By:
Kerry Evans
NOV 29, 2016
Cardiology
Scientists have identified a protein that binds to LDL cholesterol and helps transport it. Blocking the protein might of
...
Written By:
Futurity (futurity.org)
NOV 26, 2016
Cell & Molecular Biology
First detected by Santiago Ramón y Cajal, there are strange droplets in the cytoplasm of cells that are not well
...
Written By:
Carmen Leitch
NOV 21, 2016
Cancer
Scripps Florida Scientists Create Innovative Drug Design Strategy to Improve Breast Cancer Treatment
JUPITER, FL – November 21, 2016 – While there have been advances in the treatment of hormone-driven breast c
...
Written By:
The Scripps Research Institute (TSRI)
NOV 05, 2016
Cell & Molecular Biology
Genetic information has to be copied in order to eventually create the proteins that are needed for an organism to funct
...
Written By:
Carmen Leitch
NOV 03, 2016
Cell & Molecular Biology
Researchers at the University of Illinois Chicago (UIC) have learned more about how two common antibiotics, chlorampheni
...
Written By:
Carmen Leitch
NOV 03, 2016
Microbiology
LA JOLLA, CA – November 3, 2016 – A new study co-led by scientists at The Scripps Research Institute (TSRI)
...
Written By:
The Scripps Research Institute (TSRI)
OCT 31, 2016
Immunology
Immune responses can be unequal and misguided, resulting in certain conditions like allergies and autoimmune disorders.
...
Written By:
Kara Marker
OCT 29, 2016
Cell & Molecular Biology
"If you have a damaged cell, you don't want it to replicate," explained computational biophysicist Rommie
...
Written By:
Carmen Leitch
OCT 29, 2016
Cell & Molecular Biology
The mechanisms that underlie physiological processes involve complex relationships between molecules. The proteins of a
...
Written By:
Carmen Leitch
OCT 25, 2016
Immunology
LA JOLLA, CA—October 24, 2016—Researchers have been trying for decades to develop a vaccine against the glob
...
Written By:
The Scripps Research Institute (TSRI)
OCT 21, 2016
Health & Medicine
JUPITER, FL — October 20, 2016 – In a discovery that advances the understanding of how marijuana works in th
...
Written By:
The Scripps Research Institute (TSRI)
OCT 14, 2016
Cardiology
With the prick of a finger, diabetics can easily test their blood-glucose levels, and now scientists are calling for the
...
Written By:
Kara Marker
OCT 12, 2016
Immunology
The key ingredient in the recipe that make staphylococcus and streptococcus infections so dangerous? Superantigen toxins
...
Written By:
Kara Marker
OCT 02, 2016
Cell & Molecular Biology
Decoy sequences of DNA are able to interfere with gene expression, and in ways that are not yet well understood. New fin
...
Written By:
Carmen Leitch
SEP 28, 2016
Genetics & Genomics
Image Credit: Noel Clark, University of Colorado LA JOLLA, CA – September 28, 2016 – A new study led by scie
...
Written By:
The Scripps Research Institute (TSRI)
SEP 27, 2016
Microbiology
Anthrax is commonly found in soil and can be ingested by animals. It is relatively rare for it to affect people but when
...
Written By:
Carmen Leitch
SEP 24, 2016
Cell & Molecular Biology
Cells use proteins as placeholders or bookmarks that help the cells to pick up where they left off when gene expression
...
Written By:
Carmen Leitch
SEP 16, 2016
Cell & Molecular Biology
LA JOLLA, CA – September 16, 2016 – Scientists at The Scripps Research Institute (TSRI) have brought physics
...
Written By:
The Scripps Research Institute (TSRI)
SEP 14, 2016
Immunology
From the first scientist to ever discover broadly neutralizing antibodies, a new candidate for protection from influenza
...
Written By:
Kara Marker
SEP 13, 2016
Immunology
Klebsiella pneumoniae, AKA the “nightmare bacteria,” causes multiple infections including pneumonia, urinary
...
Written By:
Kara Marker
SEP 11, 2016
Cell & Molecular Biology
Junk DNA refers to regions of the genome that did not at first appear to have any function or relevance. Research over t
...
Written By:
Carmen Leitch