Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
DATE: August 29th, 2017TIME: 9:00am PT, 12:00pm ET Antibodies are frequently produced from a cell line that has been screened to ensure the protein is expressed with th...
DATE: June 28, 2017TIME: 9:00AM PDT, 12:00PM EDT, 6:00PM CESTMany RNA binding proteins (RBPs) regulate the selection of alternative polyA sites. To understand their regulatory principle...
DATE: June 6, 2017TIME: 8:00am PT, 11:00am ETEarly detection of protein biomarkers is critical to the study of human disease (cancer, neurobiology, inflammation/autoimmunity, etc)....
The commercialization of micro and nanofluidic devices has had promise for providing novel solutions to deliver high throughput, more efficient, integrated biological and chemical analysis to...
DATE: May 18, 2017TIME: 8:00AM PDT, 11:00AM ETIt is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad applicat...
Successful scientific studies rely on reagent quality and reproducibility. As the market increasingly fills with reagent producers, there has been growing demand to apply additional l...
G protein coupled receptors (GPCRs) are the targets of 30-40% of all approved drugs. However many approaches successfully applied to drug discovery for soluble protein targets have made a lim...
DATE: March 14, 2017TIME: 8:00AM PST, 11:00AM ESTSurface Plasmon Resonance (SPR) is a widely-used label-free technique to characterize a variety of molecular interactions. SPR is...
DATE: December 13, 2016TIME: 8:00 AM PT, 11:00 AM ETUnderstanding physiological mechanisms regulating growth and nutrient deposition in rainbow trout is central to establish production...
DATE: November 23rd, 2016TIME: 8:00AM PT, 11:00AM ETThe structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store ep...
Bulk analysis often leads to conclusions that assume averages reflect the dominant biological mechanism operating within an entire population. To fully understand how cellular heterogeneity c...
We describe a novel method to measure 1,25(OH)2D. Briefly, this method was built on four pillars: (1) the nuclear vitamin D receptor (VDR)`s ligand binding domain (LBD) as a capture mol...
DATE: September 20, 2016
TIME: 8:00am PST, 11:00 EST
Studies of cell-substrate interactions are important for an array of biotechnology applications. The nature of specific, recepto...
Multi-Drug Resistant Organisms (MDROs) are becoming a bigger and bigger concern throughout the world. Antibiotic resistance forms and spreads faster than pharmaceutical companies have been ab...
This presentation will be demonstrating several different approaches to explore the diversity, function, and ecology of microbial communities. In Metagenomics, the sequencing of DNA dir...
Virus Ecology is a field that is gaining momentum, fueled in part by metagenomic studies from many environments previously ignored. Biodiversity studies of plant viruses show that they...
The global trend towards industrialization and urbanization has led to ever more people living and working indoors. Some studies estimate that humans in industrialized countries spend as much...
ME/CFS is a debilitating disease with a controversial history and multiple names. The Institute of Medicine recently recommended renaming the disease “Systemic Exertion Intoleranc...
The Infectious Diseases Pathology Branch of the Centers for Disease Control and Prevention (CDC) routinely receives autopsy and biopsy tissues for diagnostic evaluation. These tissues are typ...
Our speaker, Wenjie Xu, Ph.D., will present his publication data demonstrating how nCounter® technology can advance your infectious disease research faster and more accurately with unprec...
The research community has begun correlating the makeup of individual microbiomes with disorders and diseases such as obesity, atherosclerosis and cancer. To accomplish this, researchers must...
It is well accepted that microorganisms can exist as self-organized communities attached to surfaces and one another (i.e., biofilm), often surrounded by extracellular polymeric substances (E...
Healthcare associated infections can be a consequence of a microbiome alteration. Increasingly, treatment and prevention strategies focus on manipulating host microbiota, the two most common...
Community acquired pneumonia affects over 5 million Americans and 6 million Europeans annually. Typically 5-10% will be admitted to hospital. It is a condition that more often affects the eld...
DATE: August 29th, 2017TIME: 9:00am PT, 12:00pm ET Antibodies are frequently produced from a cell line that has been screened to ensure the protein is expressed with th...
DATE: June 28, 2017TIME: 9:00AM PDT, 12:00PM EDT, 6:00PM CESTMany RNA binding proteins (RBPs) regulate the selection of alternative polyA sites. To understand their regulatory principle...
DATE: June 6, 2017TIME: 8:00am PT, 11:00am ETEarly detection of protein biomarkers is critical to the study of human disease (cancer, neurobiology, inflammation/autoimmunity, etc)....
The commercialization of micro and nanofluidic devices has had promise for providing novel solutions to deliver high throughput, more efficient, integrated biological and chemical analysis to...
DATE: May 18, 2017TIME: 8:00AM PDT, 11:00AM ETIt is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad applicat...
Successful scientific studies rely on reagent quality and reproducibility. As the market increasingly fills with reagent producers, there has been growing demand to apply additional l...
G protein coupled receptors (GPCRs) are the targets of 30-40% of all approved drugs. However many approaches successfully applied to drug discovery for soluble protein targets have made a lim...
DATE: March 14, 2017TIME: 8:00AM PST, 11:00AM ESTSurface Plasmon Resonance (SPR) is a widely-used label-free technique to characterize a variety of molecular interactions. SPR is...
DATE: December 13, 2016TIME: 8:00 AM PT, 11:00 AM ETUnderstanding physiological mechanisms regulating growth and nutrient deposition in rainbow trout is central to establish production...
DATE: November 23rd, 2016TIME: 8:00AM PT, 11:00AM ETThe structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store ep...
Bulk analysis often leads to conclusions that assume averages reflect the dominant biological mechanism operating within an entire population. To fully understand how cellular heterogeneity c...
We describe a novel method to measure 1,25(OH)2D. Briefly, this method was built on four pillars: (1) the nuclear vitamin D receptor (VDR)`s ligand binding domain (LBD) as a capture mol...
DATE: September 20, 2016
TIME: 8:00am PST, 11:00 EST
Studies of cell-substrate interactions are important for an array of biotechnology applications. The nature of specific, recepto...
Multi-Drug Resistant Organisms (MDROs) are becoming a bigger and bigger concern throughout the world. Antibiotic resistance forms and spreads faster than pharmaceutical companies have been ab...
This presentation will be demonstrating several different approaches to explore the diversity, function, and ecology of microbial communities. In Metagenomics, the sequencing of DNA dir...
Virus Ecology is a field that is gaining momentum, fueled in part by metagenomic studies from many environments previously ignored. Biodiversity studies of plant viruses show that they...
The global trend towards industrialization and urbanization has led to ever more people living and working indoors. Some studies estimate that humans in industrialized countries spend as much...
ME/CFS is a debilitating disease with a controversial history and multiple names. The Institute of Medicine recently recommended renaming the disease “Systemic Exertion Intoleranc...
The Infectious Diseases Pathology Branch of the Centers for Disease Control and Prevention (CDC) routinely receives autopsy and biopsy tissues for diagnostic evaluation. These tissues are typ...
Our speaker, Wenjie Xu, Ph.D., will present his publication data demonstrating how nCounter® technology can advance your infectious disease research faster and more accurately with unprec...
The research community has begun correlating the makeup of individual microbiomes with disorders and diseases such as obesity, atherosclerosis and cancer. To accomplish this, researchers must...
It is well accepted that microorganisms can exist as self-organized communities attached to surfaces and one another (i.e., biofilm), often surrounded by extracellular polymeric substances (E...
Healthcare associated infections can be a consequence of a microbiome alteration. Increasingly, treatment and prevention strategies focus on manipulating host microbiota, the two most common...
Community acquired pneumonia affects over 5 million Americans and 6 million Europeans annually. Typically 5-10% will be admitted to hospital. It is a condition that more often affects the eld...
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