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I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
The next step towards more biomimetic in vitro models is the design of multi-organ devices, which allow for communication of different tissue types. Combining physiologically relevant organ m...
Cell-based assays are more biologically relevant than biochemical assays yet significantly more scalable than in vivo experiments. However, care must be taken in sample preparation to e...
Over the years high throughput screening has evolved from monolithic static systems to modular more dynamic platforms. At NCATS the approach taken has been to optimize our existing lega...
This talk will reflect on what we can expect from the lab of the future and explore avenues towards such a digital lab. A major component of a digital lab is integration of instruments, syste...
Synthetic biology is a new set of tools and techniques for engineering biology. Its earliest applications were in biotech-related fields like medicine and agriculture, but today it’s be...
AstraZeneca has an ambition to create a porous organisation, seamlessly collaborating with external partners. This desire has led to the establishment of the AstraZeneca-MRC UK Centre for Lea...
NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ov...
In this webinar Automation Meets Cell Separation as we will discuss the benefits of automating cell isolation processes in laboratories of variable size and sample throughput, and go into det...
Growing living human cells in vitro for basic research, drug discovery and reparative/regenerative medicine is challenged by the difficulty in developing methods for reproducibly and cost eff...
The pharmaceutical industry’s productivity crisis is well known with >90% of drug candidates failing in clinical testing, primarily due to unexpected toxicity or lack of efficacy. &n...
Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
Getting started with an unfamiliar life science research application or a new product can always present challenges. LabCoat Live SmartStart Training is a professional interactive education e...
Studying the molecular machinery of cells from atomic detail to the cellular context and beyond is a great challenge for cell biology. It is hugely important to zoom into the atom-by-atom arr...
Reliable expression of recombinant proteins in human or CHO cells is essential for many aspects of biomedical research and drug development but is often hampered by low expression yields that...
Mammalian transient expression has become an effective method to provide recombinant proteins in a short time. Therefore, mammalian transient expression systems are applied to a great extend...
DATE: May 17, 2018TIME: 9:00AM PSTLearn how to provide the greatest protection for you and your evidence with the latest enclosures designed specifically for forensic labs. This w...
G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets. However, a detailed mechanistic understanding of their...
The Baculovirus Expression Vector System (BEVS) is one of the major platforms for recombinant protein production. Unlike mammalian expression systems that have long since transitioned to seru...
The ExpiCHO and Expi293 transient expression systems offer all-in-one solutions for generating high-titer recombinant proteins for a broad range of research applications including candidate d...
Many research laboratories use the ExpiCHO Expression System to transiently produce candidate biomolecules for biologics development. However, after the lead candidate is found, a stable cell...
I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
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