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Cell Line Development
Cell Line Development: Stable cell lines are widely used in a number of important applications including biologics (e.g. recombinant protein and monoclonal antibody) production, drug screening, and gene functional studies. The process of developing stable cell lines often starts with transfecting selected host cells, typically CHO or HEK 293 cells, with desired plasmids. After transfection, researchers then screen and quantify high-expressing clones. Once these high producers are identified, the cell lines and/or the proteins produced by the cells are validated. The manual screening methods traditionally used for cell line development are time-consuming and labor-intensive, creating a great demand for high-throughput, automated solutions for such efforts.
MAY 25, 2021 | 8:00 AM
Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
APR 21, 2021 | 11:00 AM
DATE: April 21, 2021 TIME: 11:00am PDT Cell counting is an integral part of processes that use living cells. Most labs have standard operating procedures (SOP) for counting cells. Many facto...
APR 20, 2021 | 3:00 PM
Bridging a deep understanding of molecular profiles with clinical information is critical to developing innovative precision medicine tools in oncology. Discovery’s recently launched S...
APR 07, 2021 | 9:00 AM
One challenge pharmaceutical companies face, is moving promising biotherapeutic products into the clinic as fast as safely possible. Devoting the correct amount of time and resources to earl...
APR 07, 2021 | 7:00 AM
DATE: April 7, 2021 TIME: 7:00am PDT Abstract: Learning objectives: Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provider of continu...
APR 07, 2021 | 12:00 AM
Demand for high-value biologics, a rapidly growing pipeline, and pressure from competition, time-to-market and regulators, necessitate novel biomanufacturing approaches, including Quality by...
APR 07, 2021 | 12:00 AM
Potency is a critical quality attribute of biological products, defined by the US FDA as the specific ability of the product to cause the required therapeutically clinical benefit. Potency a...
MAR 31, 2021 | 8:00 AM
Date: March 31, 2021 Time: 08:00am PST CytoFLEX SRT has enabled researcher lead self-service sorting. The need for a cell sorting expert to setup and maintain the sorter status is now necess...
MAR 23, 2021 | 9:00 AM
Date: March 23, 2021 Time: 9:00am (PST), 12:00pm (EST) The chromatin regulators CBP and p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional reg...
FEB 24, 2021 | 12:00 PM
Stable cell lines are critical tools of cellular assays in drug discovery and development. Over-expressing cell lines are needed to screen for hits, while functional cell lines are needed fo...
FEB 09, 2021 | 9:00 AM
Date: February 9, 2020 Time: 9:00am (PST), 12:00pm (EST) 90% of breast cancer mortality is caused by distant metastasis, a process that involves both dissemination of cancer cells to distant...
DEC 17, 2020 | 9:00 AM
Date: December 17, 2020 Time: 9:00am (PST), 12:00pm (EST) Correlative light and electron microscopy (CLEM) advances biological discoveries by merging different microscopes and imaging moda...
DEC 15, 2020 | 10:00 AM
DATE: December 15, 2020 TIME: 10:00am PST Scientists from Thermo Fisher Scientific will walk us through the world of microorganisms. They will discuss their most recent research on viruses,...
DEC 04, 2020 | 9:00 AM
Date: December 4, 2020 Time: 9:00am PST, 12:00pm EST Activation of Myeloid cells and interferon release is an early response to infection. The 3-marker combination (CD169/CD64/HLA-DR) gives...
DEC 03, 2020 | 12:00 AM
Antibody tests are important tools to assess the efficacy of vaccine candidates and to derive suitable vaccination modalities. High specificity and sensitivity are of great importance for th...
NOV 19, 2020 | 3:00 PM
Two aspects of the Cost of Quality are important in the medical laboratory—the theory behind the quality cost types and the application of those cost types to laboratory activities. Th...
