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    Chemical Biology

    Chemical Biology: a scientific discipline spanning the fields of chemistry, biology, and physics. It involves the application of chemical techniques, tools, and analyses, and often compounds produced through synthetic chemistry, to the study and manipulation of biological systems. Chemical biologists attempt to use chemical principles to modulate systems to either investigate the underlying biology or create new function. Chemicals - including natural small molecules, such as lipids, carbohydrates and metals, or non-natural probe or drug molecules - are used to gain insight into biological problems at a mechanistic level.

    Webinars

    • SEP 16, 2015 | 12:00 PM
      The Functionalization of C-H Bonds
      The Functionalization of C-H Bonds
      Among the frontier challenges in chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity while synthesizing and diversifying complex molecules ...
      Speaker: Christina White
      Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
      2
      SEP 16, 2015 | 11:00 AM
      Gut reactions: Understanding and manipulating chemistry from the human microbiota
      Gut reactions: Understanding and manipulating chemistry from the...
      Humans are colonized by vast numbers of symbiotic microorganisms whose metabolisms are inextricably intertwined with our own. To understand how chemical transformations performed by the human...
      Speaker: Emily Balskus
      Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
      3
      SEP 16, 2015 | 10:00 AM
      Catalyzing Translational Innovation
      Catalyzing Translational Innovation
      The process by which observations in the laboratory or the clinic are transformed into demonstrably useful interventions that tangibly improve human health is frequently termed "translation."...
      Speaker: Christopher Austin
      Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
      2
      SEP 16, 2015 | 8:00 AM
      Diversity-Oriented Synthesis for Discovery of Novel Therapeutics
      Diversity-Oriented Synthesis for Discovery of Novel Therapeutics
      Recent evidence demonstrating the importance of structural complexity in advancing compounds to the clinic points to the need for enhancing small molecule screening collections with sp3-rich ...
      Speaker: Lisa Marcaurelle
      Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
      2
      SEP 16, 2015 | 7:00 AM
      Open Science for Rare and Neglected Diseases
      Open Science for Rare and Neglected Diseases
      As a computational scientist I have been fortunate to work with many collaborators to generate biological data to train and test my models. We are in a position with increasing amounts of dat...
      Speaker: Sean Ekins
      Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
      4
      SEP 03, 2015 | 12:00 PM
      CSPA Microbiology Preservative Subcommittee (MPS): Supporting & Enhancing  the Microbiological Quality of Consumer, Household & Industrial Products
      CSPA Microbiology Preservative Subcommittee (MPS): Supporting...
      Consumer, Household, and Industrial (CH&I) formulations have increasingly driven towards more environmentally acceptable ingredients within water-based formulations, microbial control str...
      Speaker: Tony Rook
      Presented at: Microbiology Virtual Event Series 2015
      2
      SEP 02, 2015 | 1:30 PM
      How Anthropogenic Chemicals are Altering the Microbial World
      How Anthropogenic Chemicals are Altering the Microbial World
      The world–as microbes perceive it–is composed of physical and chemical stimuli. These stimuli create conditions that result in life or death for microbes, affecting their survival...
      Speaker: Erica Hartmann, PhD
      Presented at: Microbiology Virtual Event Series 2015
      3
      APR 07, 2015 | 8:30 AM
      Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
      Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
      Date: Tuesday, April 7th, 2015Time: 8:30AM PST, 11:30AM EST, 5:30PM CETThe development of new medicines for Diabetes Type 2 complications has proven to be challenging due to the use of cell...
      Speaker: Roberto Iacone, PhD , Brad Swanson, PhD
      Sponsored By: Cellular Dynamics, Cellular Dynamics
      11 2
      MAR 19, 2015 | 10:30 AM
      Special Lecturer - In Vivo PET /SPECT Imaging of Human Brain Neuroreceptor Systems: 3 Decades of Progress
      Special Lecturer - In Vivo PET /SPECT Imaging of Human Brain Neuroreceptor...
      Since the discovery and maturing of in vitro techniques that characterized neurotransmitter receptor systems in animal and human brain and subsequent development of in vitro and in vivo autor...
      Speaker: Dean Wong, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2015
      12
      FEB 05, 2015 | 6:00 AM
      C.E. CREDITS
      Improving the Post-Operative Recovery of Rodents through Nutrition and Enrichment
      Improving the Post-Operative Recovery of Rodents through Nutrition...
      Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metab...
      Speaker: Jaime Lecker, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2015
      11
      NOV 12, 2014 | 8:00 AM
      Hallmarks of cancer - Detect and quantify cell death signatures with high content imaging
      Hallmarks of cancer - Detect and quantify cell death signatures...
      Dr. Oliver Kepp will be presenting on:Immunogenic cell death fingerprinting utilizing a high-throughput screening approachThe strategy of immunogenic cell death fingerprinting has been design...
      Speaker: Oliver Kepp, PhD and Jayne A. Hesley
      Sponsored By: Molecular Devices, Molecular Devices
      33
      OCT 30, 2014 | 3:00 PM
      Probing cancer metabolism using isotope tracers to identify therapeutic targets
      Probing cancer metabolism using isotope tracers to identify therapeutic...
      Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) compromise their normal activity and induce NADPH-dependent (D)2-hydroxyglutarate (2HG) production within the cytosol or m...
      Speaker: Christian Metallo, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      16
      OCT 30, 2014 | 1:30 PM
      Dissecting cancer signaling pathways with chemical scalpels
      Dissecting cancer signaling pathways with chemical scalpels
      Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
      Speaker: Nadya Tarasova, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      14
      SEP 24, 2014 | 3:00 PM
      Site-directed ligand discovery for cryptic sites and other challenging targets
      Site-directed ligand discovery for cryptic sites and other challenging...
      Protein-protein interactions and allosterically regulated enzymes have been challenging but important targets for probe- and drug discovery. We and others have found that fragment-based lead...
      Speaker: Michelle Arkin, PhD
      Presented at: Advances in Drug Discovery and Development
      20
      SEP 24, 2014 | 2:00 PM
      Targeting Lysine Acetylation in Cancer
      Targeting Lysine Acetylation in Cancer
      Master regulatory transcription factors localize to the genome in a manner influenced by chromatin accessibility and influencing global chromatin structure. With an interest in understanding...
      Speaker: Jay Bradner, MD
      Presented at: Advances in Drug Discovery and Development
      18
      SEP 24, 2014 | 2:00 PM
      Design of protein structures, functions and assemblies
      Design of protein structures, functions and assemblies
      I will describe recent advances in computational protein design which allow the generation of new protein structures and functions. I will describe the use of these methods to design ultra-s...
      Speaker: David Baker, PhD
      Presented at: Advances in Drug Discovery and Development
      32
      SEP 24, 2014 | 10:00 AM
      Keynote, The Promises and Challenges of Next-Generation Therapeutics
      Keynote, The Promises and Challenges of Next-Generation Therapeutics
      The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
      Speaker: Greg Verdine, PhD
      Presented at: Advances in Drug Discovery and Development
      14
      SEP 24, 2014 | 10:00 AM
      The Promises and Challenges of Next-Generation Therapeutics
      The Promises and Challenges of Next-Generation Therapeutics
      The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
      Speaker: Greg Verdine, PhD
      Presented at: Advances in Drug Discovery and Development
      12
      SEP 24, 2014 | 8:00 AM
      Role of Academic Institutions in Target Selection
      Role of Academic Institutions in Target Selection
      Target selection is arguably the most important decision in all drug discovery and development activities. No amount of great science can overcome the selection of the wrong target. The rapid...
      Speaker: Michael A. Foley, Ph.D.
      Presented at: Advances in Drug Discovery and Development
      32
      SEP 24, 2014 | 8:00 AM
      Approaches to antibacterial discovery:  New strategies and technologies to address a challenging field
      Approaches to antibacterial discovery: New strategies and technologies...
      Antibiotics are among the most important advances in the history of modern medicine. They turned often acutely fatal infections into treatable indications with radical cures. Antibiotics co...
      Speaker: Jennifer Leeds, PhD
      Presented at: Advances in Drug Discovery and Development
      22
      SEP 24, 2014 | 5:00 AM
      Algorithmic Drug Design (Prerecorded)
      Algorithmic Drug Design (Prerecorded)
      Since leaving Pfizer to go back to academia in 2007, Andrew Hopkins (University of Dundee, UK) has been a leading researcher in the search for new informatics and computational methods to imp...
      Speaker: Andrew Hopkins, FRSC
      Presented at: Advances in Drug Discovery and Development
      28
      AUG 20, 2014 | 7:15 AM
      Establishing cell-free biology for the production of therapeutics, materials, and chemicals
      Establishing cell-free biology for the production of therapeutics,...
      Imagine a world in which we could adapt biology to manufacture any therapeutic, material, or chemical from renewable resources, both quickly and on demand. Industrial biotechnology is one of...
      Speaker: Michael C Jewett, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2014
      11
      APR 17, 2014 | 11:00 AM
      A Novel Method of Active Paraffin Removal
      A Novel Method of Active Paraffin Removal
        Formalin Fixation and Paraffin Embedding (FFPE) of tissue samples is a routine practice by pathologists; the technique enables high quality preservation of structural information. However, ...
      Speaker: Hamid Khoja, PhD,
      Sponsored By: Covaris, Covaris
      78
      MAR 19, 2014 | 1:00 PM
      Engineering reproducible neural tissue from pluripotent stem cells
      Engineering reproducible neural tissue from pluripotent stem cells
      The Willerth lab investigates how to engineer neural tissue by combining pluripotent stem cells, controlled drug delivery and biomaterial scaffolds. When generating these replacement tissues,...
      Speaker: Stephanie Willerth, PhD
      Presented at: Neuroscience Virtual Event Series 2014
      70
    SEP 16, 2015 | 12:00 PM
    The Functionalization of C-H Bonds
    The Functionalization of C-H Bonds
    Among the frontier challenges in chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity while synthesizing and diversifying complex molecules ...
    Speaker: Christina White
    Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
    2
    SEP 16, 2015 | 11:00 AM
    Gut reactions: Understanding and manipulating chemistry from the human microbiota
    Gut reactions: Understanding and manipulating chemistry from the...
    Humans are colonized by vast numbers of symbiotic microorganisms whose metabolisms are inextricably intertwined with our own. To understand how chemical transformations performed by the human...
    Speaker: Emily Balskus
    Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
    3
    SEP 16, 2015 | 10:00 AM
    Catalyzing Translational Innovation
    Catalyzing Translational Innovation
    The process by which observations in the laboratory or the clinic are transformed into demonstrably useful interventions that tangibly improve human health is frequently termed "translation."...
    Speaker: Christopher Austin
    Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
    2
    SEP 16, 2015 | 8:00 AM
    Diversity-Oriented Synthesis for Discovery of Novel Therapeutics
    Diversity-Oriented Synthesis for Discovery of Novel Therapeutics
    Recent evidence demonstrating the importance of structural complexity in advancing compounds to the clinic points to the need for enhancing small molecule screening collections with sp3-rich ...
    Speaker: Lisa Marcaurelle
    Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
    2
    SEP 16, 2015 | 7:00 AM
    Open Science for Rare and Neglected Diseases
    Open Science for Rare and Neglected Diseases
    As a computational scientist I have been fortunate to work with many collaborators to generate biological data to train and test my models. We are in a position with increasing amounts of dat...
    Speaker: Sean Ekins
    Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
    4
     
     
  • SEP 03, 2015 | 12:00 PM
    CSPA Microbiology Preservative Subcommittee (MPS): Supporting & Enhancing  the Microbiological Quality of Consumer, Household & Industrial Products
    CSPA Microbiology Preservative Subcommittee (MPS): Supporting...
    Consumer, Household, and Industrial (CH&I) formulations have increasingly driven towards more environmentally acceptable ingredients within water-based formulations, microbial control str...
    Speaker: Tony Rook
    Presented at: Microbiology Virtual Event Series 2015
    2
    SEP 02, 2015 | 1:30 PM
    How Anthropogenic Chemicals are Altering the Microbial World
    How Anthropogenic Chemicals are Altering the Microbial World
    The world–as microbes perceive it–is composed of physical and chemical stimuli. These stimuli create conditions that result in life or death for microbes, affecting their survival...
    Speaker: Erica Hartmann, PhD
    Presented at: Microbiology Virtual Event Series 2015
    3
    APR 07, 2015 | 8:30 AM
    Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
    Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
    Date: Tuesday, April 7th, 2015Time: 8:30AM PST, 11:30AM EST, 5:30PM CETThe development of new medicines for Diabetes Type 2 complications has proven to be challenging due to the use of cell...
    Speaker: Roberto Iacone, PhD , Brad Swanson, PhD
    Sponsored By: Cellular Dynamics, Cellular Dynamics
    11 2
    MAR 19, 2015 | 10:30 AM
    Special Lecturer - In Vivo PET /SPECT Imaging of Human Brain Neuroreceptor Systems: 3 Decades of Progress
    Special Lecturer - In Vivo PET /SPECT Imaging of Human Brain Neuroreceptor...
    Since the discovery and maturing of in vitro techniques that characterized neurotransmitter receptor systems in animal and human brain and subsequent development of in vitro and in vivo autor...
    Speaker: Dean Wong, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2015
    12
    FEB 05, 2015 | 6:00 AM
    C.E. CREDITS
    Improving the Post-Operative Recovery of Rodents through Nutrition and Enrichment
    Improving the Post-Operative Recovery of Rodents through Nutrition...
    Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metab...
    Speaker: Jaime Lecker, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2015
    11
     
     
  • NOV 12, 2014 | 8:00 AM
    Hallmarks of cancer - Detect and quantify cell death signatures with high content imaging
    Hallmarks of cancer - Detect and quantify cell death signatures...
    Dr. Oliver Kepp will be presenting on:Immunogenic cell death fingerprinting utilizing a high-throughput screening approachThe strategy of immunogenic cell death fingerprinting has been design...
    Speaker: Oliver Kepp, PhD and Jayne A. Hesley
    Sponsored By: Molecular Devices, Molecular Devices
    33
    OCT 30, 2014 | 3:00 PM
    Probing cancer metabolism using isotope tracers to identify therapeutic targets
    Probing cancer metabolism using isotope tracers to identify therapeutic...
    Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) compromise their normal activity and induce NADPH-dependent (D)2-hydroxyglutarate (2HG) production within the cytosol or m...
    Speaker: Christian Metallo, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    16
    OCT 30, 2014 | 1:30 PM
    Dissecting cancer signaling pathways with chemical scalpels
    Dissecting cancer signaling pathways with chemical scalpels
    Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
    Speaker: Nadya Tarasova, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    14
    SEP 24, 2014 | 3:00 PM
    Site-directed ligand discovery for cryptic sites and other challenging targets
    Site-directed ligand discovery for cryptic sites and other challenging...
    Protein-protein interactions and allosterically regulated enzymes have been challenging but important targets for probe- and drug discovery. We and others have found that fragment-based lead...
    Speaker: Michelle Arkin, PhD
    Presented at: Advances in Drug Discovery and Development
    20
    SEP 24, 2014 | 2:00 PM
    Targeting Lysine Acetylation in Cancer
    Targeting Lysine Acetylation in Cancer
    Master regulatory transcription factors localize to the genome in a manner influenced by chromatin accessibility and influencing global chromatin structure. With an interest in understanding...
    Speaker: Jay Bradner, MD
    Presented at: Advances in Drug Discovery and Development
    18
     
     
  • SEP 24, 2014 | 2:00 PM
    Design of protein structures, functions and assemblies
    Design of protein structures, functions and assemblies
    I will describe recent advances in computational protein design which allow the generation of new protein structures and functions. I will describe the use of these methods to design ultra-s...
    Speaker: David Baker, PhD
    Presented at: Advances in Drug Discovery and Development
    32
    SEP 24, 2014 | 10:00 AM
    Keynote, The Promises and Challenges of Next-Generation Therapeutics
    Keynote, The Promises and Challenges of Next-Generation Therapeutics
    The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
    Speaker: Greg Verdine, PhD
    Presented at: Advances in Drug Discovery and Development
    14
    SEP 24, 2014 | 10:00 AM
    The Promises and Challenges of Next-Generation Therapeutics
    The Promises and Challenges of Next-Generation Therapeutics
    The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
    Speaker: Greg Verdine, PhD
    Presented at: Advances in Drug Discovery and Development
    12
    SEP 24, 2014 | 8:00 AM
    Role of Academic Institutions in Target Selection
    Role of Academic Institutions in Target Selection
    Target selection is arguably the most important decision in all drug discovery and development activities. No amount of great science can overcome the selection of the wrong target. The rapid...
    Speaker: Michael A. Foley, Ph.D.
    Presented at: Advances in Drug Discovery and Development
    32
    SEP 24, 2014 | 8:00 AM
    Approaches to antibacterial discovery:  New strategies and technologies to address a challenging field
    Approaches to antibacterial discovery: New strategies and technologies...
    Antibiotics are among the most important advances in the history of modern medicine. They turned often acutely fatal infections into treatable indications with radical cures. Antibiotics co...
    Speaker: Jennifer Leeds, PhD
    Presented at: Advances in Drug Discovery and Development
    22
     
     
  • SEP 24, 2014 | 5:00 AM
    Algorithmic Drug Design (Prerecorded)
    Algorithmic Drug Design (Prerecorded)
    Since leaving Pfizer to go back to academia in 2007, Andrew Hopkins (University of Dundee, UK) has been a leading researcher in the search for new informatics and computational methods to imp...
    Speaker: Andrew Hopkins, FRSC
    Presented at: Advances in Drug Discovery and Development
    28
    AUG 20, 2014 | 7:15 AM
    Establishing cell-free biology for the production of therapeutics, materials, and chemicals
    Establishing cell-free biology for the production of therapeutics,...
    Imagine a world in which we could adapt biology to manufacture any therapeutic, material, or chemical from renewable resources, both quickly and on demand. Industrial biotechnology is one of...
    Speaker: Michael C Jewett, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2014
    11
    APR 17, 2014 | 11:00 AM
    A Novel Method of Active Paraffin Removal
    A Novel Method of Active Paraffin Removal
      Formalin Fixation and Paraffin Embedding (FFPE) of tissue samples is a routine practice by pathologists; the technique enables high quality preservation of structural information. However, ...
    Speaker: Hamid Khoja, PhD,
    Sponsored By: Covaris, Covaris
    78
    MAR 19, 2014 | 1:00 PM
    Engineering reproducible neural tissue from pluripotent stem cells
    Engineering reproducible neural tissue from pluripotent stem cells
    The Willerth lab investigates how to engineer neural tissue by combining pluripotent stem cells, controlled drug delivery and biomaterial scaffolds. When generating these replacement tissues,...
    Speaker: Stephanie Willerth, PhD
    Presented at: Neuroscience Virtual Event Series 2014
    70
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