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    Drug Design

    Drug Design: often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.

    Webinars

    • DEC 03, 2020 | 4:30 PM
      An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
      An Iterative Approach to Structure-based in silico to in vivo...
      This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
      Speaker: Garth Ehrlich, PhD, FAAAS
      Presented at: Coronavirus Series
      5
      DEC 02, 2020 | 8:00 AM
      Optimize your bioprocess - From shaker to bioreactor
      Optimize your bioprocess - From shaker to bioreactor
      DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
      Speaker: Ines Hartmann , David Solbach
      Sponsored By: Eppendorf
      11
      NOV 19, 2020 | 9:00 AM
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
      Speaker: Amal Hassan Ali
      Sponsored By: Thermo Fisher Scientific
      16 1
      NOV 12, 2020 | 10:00 AM
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
      Speaker: Tilman Schlothauer, Ph.D
      Sponsored By: Roche CustomBiotech
      3
      NOV 05, 2020 | 12:00 AM
      The importance of educating patients and their physicians on opioid use: lessons learned from medical cases
      The importance of educating patients and their physicians on opioid...
      Urine drug testing has become an essential part of the management of patients with chronic pain. Testing provides objective information regarding drug compliance, diversion, and abuse to med...
      Speaker: Alan H.B. Wu, PhD, DABACC
      Presented at: Opioid Crisis Virtual Event Series 2020
      1
      NOV 04, 2020 | 8:00 AM
      Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
      Overcoming barriers to productivity in HCS - An image-to-answer...
      Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
      Speaker: William Marshall , David Egan, PhD
      Sponsored By: Cytiva
      2
      OCT 08, 2020 | 12:00 PM
      ZooMAb® Antibodies- a Novel Recombinant Antibody Technology
      ZooMAb® Antibodies- a Novel Recombinant Antibody Technology
      Antibodies have become one of the most important tools in life science research, allowing the detection, quantitation, and determination of changes in proteins and other molecules with respe...
      Speaker: Wayne Speckmann, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      2
      OCT 08, 2020 | 7:30 AM
      Keynote Presentation: RNA Splicing and Ancestry-related Molecular Targets in Precision Oncology and Cancer Disparities
      Keynote Presentation: RNA Splicing and Ancestry-related Molecular...
      Individuals of under-represented minority ancestry are at disproportional risk for higher incidence and mortality rates for particular cancers. The unequal burden of cancer in certain racial...
      Speaker: Steven R. Patierno, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      4
      OCT 08, 2020 | 6:00 AM
      Looking for Evidence-Based Oncology? T̶r̶y̶ Do Targeted Proteomics!
      Looking for Evidence-Based Oncology? T̶r̶y̶ Do Targeted Proteomics!
      Every patient is different and so is every tumor! The term “personalized oncology” today is largely associated with sequencing approaches. Current publications proof more and mor...
      Speaker: Christian Regenbrecht, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      Sponsored By: Luminex - A DiaSorin Company
      1
      OCT 07, 2020 | 10:30 AM
      Immune correlates of TP53 mutational status in acute myeloid leukemia
      Immune correlates of TP53 mutational status in acute myeloid leukemia
      Tumor phenotypes are dictated not only by the neoplastic cell component, but also by the tumor microenvironment (TME), which is inherently immuno-suppressive, is equipped to hamper effector...
      Speaker: Dr. Sergio Rutella
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      Sponsored By: NanoString Technologies
      1
      SEP 30, 2020 | 10:30 AM
      Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
      Straightforward CRISPR knockout: Leveraging predesigned synthetic...
      CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
      Speaker: James Goldmeyer, PhD
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: Horizon Discovery
      3 1
      SEP 30, 2020 | 9:00 AM
      Massively parallel microbial genome engineering using the Onyxâ„¢ Platform
      Massively parallel microbial genome engineering using the Onyxâ„¢...
      While transformative, first-generation CRISPR technologies remain limited across multiple important dimensions including scalability, editing efficiency, types of modifications available, an...
      Speaker: Nandini Krishnamurthy, PhD
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: Inscripta
      2
      SEP 30, 2020 | 7:30 AM
      Keynote Presentation: Functionalizing Genome Editing Techniques on a Broad Range of Cellular Targets
      Keynote Presentation: Functionalizing Genome Editing Techniques...
      Genome Engineering allows the easy manipulation of genomes down to the nucleotide level. Targeted deep sequencing enables the detection and quantification of low-frequency editing events. Ho...
      Speaker: Shondra Miller, PhD/Director
      Presented at: CRISPR Virtual Event Series 2020
      1
      SEP 30, 2020 | 6:00 AM
      Enhancing efficiency and specificity with improved CRISPR components and a new CRISPR analysis pipeline
      Enhancing efficiency and specificity with improved CRISPR components...
      Genome editing with an expanded CRISPR-Cas tool set increases the opportunity to make intentional, targeted changes in the genome. Furthermore, improved specificity of genome editing and abi...
      Speaker: Ashley Jacobi
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: IDT
      2
      SEP 30, 2020 | 12:00 AM
      In vivo delivery of Cas9 ribonucleoprotein and donor DNA with gold nanoparticles
      In vivo delivery of Cas9 ribonucleoprotein and donor DNA with...
      Cas9 based therapeutics have the potential to revolutionize the treatment of genetic diseases. However, safe and effective methods for delivering Cas9 protein, gRNA and donor DNA need to be...
      Speaker: Niren Murthy
      Presented at: CRISPR Virtual Event Series 2020
      4
      SEP 30, 2020 | 12:00 AM
      CRISPR/Cas9 as a tool to model and study cancer - insights and lessons learned
      CRISPR/Cas9 as a tool to model and study cancer - insights and...
      Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize the...
      Speaker: Grace R. Anderson, PhD
      Presented at: CRISPR Virtual Event Series 2020
      2
      SEP 30, 2020 | 12:00 AM
      An Automated Integrated Multiple Assay Platform utilizing CRISPR-based Transistors for CRISPR Quality Control Applications
      An Automated Integrated Multiple Assay Platform utilizing CRISPR-based...
      Learning Objectives: 1. Using an optics- and label-free approach to CRISPR research 2. Explain current approaches to selecting the most robust gRNA for CRISPR assays 3. The opportunities tha...
      Speaker: Kiana Aran, PhD
      Presented at: CRISPR Virtual Event Series 2020
      1
      SEP 10, 2020 | 6:00 AM
      Structure-guided design of SARS-CoV-2 antivirals
      Structure-guided design of SARS-CoV-2 antivirals
      Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is spreading rapidly across the world and was announced as a “global pandemic” by the World Health Organization (WHO) o...
      Speaker: Quan Wang, PhD , Renhong Yan, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      Sponsored By: Thermo Fisher Scientific
      2
      SEP 10, 2020 | 12:00 AM
      Host responses to SARS-CoV-2
      Host responses to SARS-CoV-2
      The host response to infection is a critical determinant of virus pathogenicity. Emerging viruses require the host cellular machinery to replicate and successfully infect new hosts, and must...
      Speaker: Angela L. Rasmussen, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      2
      SEP 09, 2020 | 7:30 AM
      Using cryo-EM for designing next-gen therapeutics against HIV
      Using cryo-EM for designing next-gen therapeutics against HIV
      HIV currently infects almost 40 million people worldwide. The virus is responsible for ~2 million new infections per year and ~1 million deaths. Like all retroviruses, HIV integrates a viral...
      Speaker: Dmitry Lyumkis, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      Sponsored By: Thermo Fisher Scientific
      1
      SEP 03, 2020 | 11:00 AM
      Filtered Fume Hoods: Expert insight on improving your lab's green initiative
      Filtered Fume Hoods: Expert insight on improving your lab's green...
      DATE: September 3, 2020 TIME: 9:00 am PDT, 12:00 pm EDT So many considerations go into a lab. How many fume hoods do I need? What chemicals can they handle and how often? What about ducting?...
      Speaker: Kasey Fulmer , Kenneth Crooks
      Sponsored By: Labconco
      11
      SEP 03, 2020 | 9:00 AM
      The Complexities of SV Analytical Ultracentrifugation: AAVs are not Simple, Binary Systems
      The Complexities of SV Analytical Ultracentrifugation: AAVs are...
      DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
      Speaker: Dr. Lake Paul
      Sponsored By: Beckman Coulter Life Sciences
      12
      AUG 27, 2020 | 7:00 AM
      Atlas of the SARS-CoV-2 Proteome
      Atlas of the SARS-CoV-2 Proteome
      DATE: August 27, 2020 TIME: 7:00am PT Novel anti-viral medications, including biologics and small molecule inhibitors, as well as serologic diagnostic tool sets are in urgent demand to fight...
      Speaker: Yuning Chen, Ph.D.
      Sponsored By: Sino Biological
      32 3
      AUG 26, 2020 | 8:00 AM
      Bio-Layer Interferometry as a strategic platform to validate covalent "proximity inducing" small molecules with synthetic tumor Immunotherapeutic applications
      Bio-Layer Interferometry as a strategic platform to validate covalent...
      DATE: August 26, 2020 TIME: 8:00 am PDT The host immune "recognition" of cancer forms the basis of modern tumor immmunotherapy, a highly targeted treatment option with the demonstr...
      Speaker: Anthony Rullo , Nilshad Salim, Ph.D.
      Sponsored By: Sartorius
      13
    DEC 03, 2020 | 4:30 PM
    An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
    An Iterative Approach to Structure-based in silico to in vivo...
    This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
    Speaker: Garth Ehrlich, PhD, FAAAS
    Presented at: Coronavirus Series
    5
    DEC 02, 2020 | 8:00 AM
    Optimize your bioprocess - From shaker to bioreactor
    Optimize your bioprocess - From shaker to bioreactor
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    Speaker: Ines Hartmann , David Solbach
    Sponsored By: Eppendorf
    11
    NOV 19, 2020 | 9:00 AM
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
    Speaker: Amal Hassan Ali
    Sponsored By: Thermo Fisher Scientific
    16 1
    NOV 12, 2020 | 10:00 AM
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
    Speaker: Tilman Schlothauer, Ph.D
    Sponsored By: Roche CustomBiotech
    3
    NOV 05, 2020 | 12:00 AM
    The importance of educating patients and their physicians on opioid use: lessons learned from medical cases
    The importance of educating patients and their physicians on opioid...
    Urine drug testing has become an essential part of the management of patients with chronic pain. Testing provides objective information regarding drug compliance, diversion, and abuse to med...
    Speaker: Alan H.B. Wu, PhD, DABACC
    Presented at: Opioid Crisis Virtual Event Series 2020
    1
     
     
  • NOV 04, 2020 | 8:00 AM
    Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
    Overcoming barriers to productivity in HCS - An image-to-answer...
    Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
    Speaker: William Marshall , David Egan, PhD
    Sponsored By: Cytiva
    2
    OCT 08, 2020 | 12:00 PM
    ZooMAb® Antibodies- a Novel Recombinant Antibody Technology
    ZooMAb® Antibodies- a Novel Recombinant Antibody Technology
    Antibodies have become one of the most important tools in life science research, allowing the detection, quantitation, and determination of changes in proteins and other molecules with respe...
    Speaker: Wayne Speckmann, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    2
    OCT 08, 2020 | 7:30 AM
    Keynote Presentation: RNA Splicing and Ancestry-related Molecular Targets in Precision Oncology and Cancer Disparities
    Keynote Presentation: RNA Splicing and Ancestry-related Molecular...
    Individuals of under-represented minority ancestry are at disproportional risk for higher incidence and mortality rates for particular cancers. The unequal burden of cancer in certain racial...
    Speaker: Steven R. Patierno, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    4
    OCT 08, 2020 | 6:00 AM
    Looking for Evidence-Based Oncology? T̶r̶y̶ Do Targeted Proteomics!
    Looking for Evidence-Based Oncology? T̶r̶y̶ Do Targeted Proteomics!
    Every patient is different and so is every tumor! The term “personalized oncology” today is largely associated with sequencing approaches. Current publications proof more and mor...
    Speaker: Christian Regenbrecht, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    Sponsored By: Luminex - A DiaSorin Company
    1
    OCT 07, 2020 | 10:30 AM
    Immune correlates of TP53 mutational status in acute myeloid leukemia
    Immune correlates of TP53 mutational status in acute myeloid leukemia
    Tumor phenotypes are dictated not only by the neoplastic cell component, but also by the tumor microenvironment (TME), which is inherently immuno-suppressive, is equipped to hamper effector...
    Speaker: Dr. Sergio Rutella
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    Sponsored By: NanoString Technologies
    1
     
     
  • SEP 30, 2020 | 10:30 AM
    Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
    Straightforward CRISPR knockout: Leveraging predesigned synthetic...
    CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
    Speaker: James Goldmeyer, PhD
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: Horizon Discovery
    3 1
    SEP 30, 2020 | 9:00 AM
    Massively parallel microbial genome engineering using the Onyxâ„¢ Platform
    Massively parallel microbial genome engineering using the Onyxâ„¢...
    While transformative, first-generation CRISPR technologies remain limited across multiple important dimensions including scalability, editing efficiency, types of modifications available, an...
    Speaker: Nandini Krishnamurthy, PhD
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: Inscripta
    2
    SEP 30, 2020 | 7:30 AM
    Keynote Presentation: Functionalizing Genome Editing Techniques on a Broad Range of Cellular Targets
    Keynote Presentation: Functionalizing Genome Editing Techniques...
    Genome Engineering allows the easy manipulation of genomes down to the nucleotide level. Targeted deep sequencing enables the detection and quantification of low-frequency editing events. Ho...
    Speaker: Shondra Miller, PhD/Director
    Presented at: CRISPR Virtual Event Series 2020
    1
    SEP 30, 2020 | 6:00 AM
    Enhancing efficiency and specificity with improved CRISPR components and a new CRISPR analysis pipeline
    Enhancing efficiency and specificity with improved CRISPR components...
    Genome editing with an expanded CRISPR-Cas tool set increases the opportunity to make intentional, targeted changes in the genome. Furthermore, improved specificity of genome editing and abi...
    Speaker: Ashley Jacobi
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: IDT
    2
    SEP 30, 2020 | 12:00 AM
    In vivo delivery of Cas9 ribonucleoprotein and donor DNA with gold nanoparticles
    In vivo delivery of Cas9 ribonucleoprotein and donor DNA with...
    Cas9 based therapeutics have the potential to revolutionize the treatment of genetic diseases. However, safe and effective methods for delivering Cas9 protein, gRNA and donor DNA need to be...
    Speaker: Niren Murthy
    Presented at: CRISPR Virtual Event Series 2020
    4
     
     
  • SEP 30, 2020 | 12:00 AM
    CRISPR/Cas9 as a tool to model and study cancer - insights and lessons learned
    CRISPR/Cas9 as a tool to model and study cancer - insights and...
    Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize the...
    Speaker: Grace R. Anderson, PhD
    Presented at: CRISPR Virtual Event Series 2020
    2
    SEP 30, 2020 | 12:00 AM
    An Automated Integrated Multiple Assay Platform utilizing CRISPR-based Transistors for CRISPR Quality Control Applications
    An Automated Integrated Multiple Assay Platform utilizing CRISPR-based...
    Learning Objectives: 1. Using an optics- and label-free approach to CRISPR research 2. Explain current approaches to selecting the most robust gRNA for CRISPR assays 3. The opportunities tha...
    Speaker: Kiana Aran, PhD
    Presented at: CRISPR Virtual Event Series 2020
    1
    SEP 10, 2020 | 6:00 AM
    Structure-guided design of SARS-CoV-2 antivirals
    Structure-guided design of SARS-CoV-2 antivirals
    Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is spreading rapidly across the world and was announced as a “global pandemic” by the World Health Organization (WHO) o...
    Speaker: Quan Wang, PhD , Renhong Yan, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    Sponsored By: Thermo Fisher Scientific
    2
    SEP 10, 2020 | 12:00 AM
    Host responses to SARS-CoV-2
    Host responses to SARS-CoV-2
    The host response to infection is a critical determinant of virus pathogenicity. Emerging viruses require the host cellular machinery to replicate and successfully infect new hosts, and must...
    Speaker: Angela L. Rasmussen, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    2
    SEP 09, 2020 | 7:30 AM
    Using cryo-EM for designing next-gen therapeutics against HIV
    Using cryo-EM for designing next-gen therapeutics against HIV
    HIV currently infects almost 40 million people worldwide. The virus is responsible for ~2 million new infections per year and ~1 million deaths. Like all retroviruses, HIV integrates a viral...
    Speaker: Dmitry Lyumkis, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    Sponsored By: Thermo Fisher Scientific
    1
     
     
  • SEP 03, 2020 | 11:00 AM
    Filtered Fume Hoods: Expert insight on improving your lab's green initiative
    Filtered Fume Hoods: Expert insight on improving your lab's green...
    DATE: September 3, 2020 TIME: 9:00 am PDT, 12:00 pm EDT So many considerations go into a lab. How many fume hoods do I need? What chemicals can they handle and how often? What about ducting?...
    Speaker: Kasey Fulmer , Kenneth Crooks
    Sponsored By: Labconco
    11
    SEP 03, 2020 | 9:00 AM
    The Complexities of SV Analytical Ultracentrifugation: AAVs are not Simple, Binary Systems
    The Complexities of SV Analytical Ultracentrifugation: AAVs are...
    DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
    Speaker: Dr. Lake Paul
    Sponsored By: Beckman Coulter Life Sciences
    12
    AUG 27, 2020 | 7:00 AM
    Atlas of the SARS-CoV-2 Proteome
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