Drug metabolism is the term used to portray the biotransformation of drug substances in the body so they can be killed all the more without any problem. Most of metabolic cycles that include drugs happen in the liver, as the chemicals that encourage the responses are concentrated there.
In the past several years, there has been an increase in drug testing associated with chronic pain. Immunoassays are the most common method for initial screening which can test for a specific...
PrPC is a conserved lipid-raft associated, GPI-anchored cell membrane glycoprotein. Misfolding of cellular PrPC into the pathogenic PrPSc results in Prion disease, an untreatable and fatal ne...
DATE: June 15, 2016TIME: 08:00AM PDT, 11:00AM EDT, 3:00PM GMT Positron Emission Tomography (PET) is a 3-dimensional, quantitative imaging technology that has robust clinical trans...
Circulating tumor cells (CTCs) is an emerging source used molecular cancer diagnostics. Through expression profiling of CTCs, it allows a deeper understanding about which metabolic pathways e...
A recently discovered communication system used by cells to send messages across the human body promises to revolutionize our understanding of disease and how we treat it. Technologies based...
The reproducibility of animal studies is now critical to ensure that limited resources are used wisely and that efforts yield useable knowledge. At this time, IACUCs and other similar a...
Appropriate dosing of pharmaceuticals is critical to prevent sub-therapeutic efficacy or the occurrence of adverse events. However, genetic variability may significantly influence an individu...
DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
The Warburg effect or aerobic glycolysis is a well-known cancer metabolism phenomenon and serves as an established test for tumor detection with FDG-PET scanning technology. Cancer cells swit...
Humans are colonized by vast numbers of symbiotic microorganisms whose metabolisms are inextricably intertwined with our own. To understand how chemical transformations performed by the human...
Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
Date: Tuesday, April 7th, 2015Time: 8:30AM PST, 11:30AM EST, 5:30PM CETThe development of new medicines for Diabetes Type 2 complications has proven to be challenging due to the use of cell...
Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metab...
Soiled-bedding sentinels are not always efficient in detecting pathogens in rodent colonies. In this context, PCR-based testing can be more sensitive and is being advocated as adjunct to trad...
Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
The eukaryotic translation initiation factor eIF4E is an oncogene elevated in an estimated 30% of cancers. The traditional view is that eIF4E drives proliferation and survival by increasing t...
Bone turnover markers (BTM) are biological markers of bone remodeling (turnover). The entire skeleton is replaced every 10 years by remodeling, a process constantly going on at different phas...
Pharmcogenomics (PGx) is the 2nd potential clinical application of genomic medicine, preceded by genomic application for cancer. In the recently published, 2012 Institute of Medicine report o...
Obesity is a disease. It was once not considered to be a disease and to be a matter of will power and gluttony. It was also the case that we once thought that fat tissue had no metabolic func...
Variability of vitamin D results remains a hot topic today as more options are available to laboratories. This webinar examines how clinical and analytical factors such as vitamin D binding...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
The zebrafish, Danio rerio, is an ideal model organism to address a broad array of biomedical questions, and is now widely employed to answer questions about aging, behavior, cancer, growth,...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
In the past several years, there has been an increase in drug testing associated with chronic pain. Immunoassays are the most common method for initial screening which can test for a specific...
PrPC is a conserved lipid-raft associated, GPI-anchored cell membrane glycoprotein. Misfolding of cellular PrPC into the pathogenic PrPSc results in Prion disease, an untreatable and fatal ne...
DATE: June 15, 2016TIME: 08:00AM PDT, 11:00AM EDT, 3:00PM GMT Positron Emission Tomography (PET) is a 3-dimensional, quantitative imaging technology that has robust clinical trans...
Circulating tumor cells (CTCs) is an emerging source used molecular cancer diagnostics. Through expression profiling of CTCs, it allows a deeper understanding about which metabolic pathways e...
A recently discovered communication system used by cells to send messages across the human body promises to revolutionize our understanding of disease and how we treat it. Technologies based...
The reproducibility of animal studies is now critical to ensure that limited resources are used wisely and that efforts yield useable knowledge. At this time, IACUCs and other similar a...
Appropriate dosing of pharmaceuticals is critical to prevent sub-therapeutic efficacy or the occurrence of adverse events. However, genetic variability may significantly influence an individu...
DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
The Warburg effect or aerobic glycolysis is a well-known cancer metabolism phenomenon and serves as an established test for tumor detection with FDG-PET scanning technology. Cancer cells swit...
Humans are colonized by vast numbers of symbiotic microorganisms whose metabolisms are inextricably intertwined with our own. To understand how chemical transformations performed by the human...
Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
Date: Tuesday, April 7th, 2015Time: 8:30AM PST, 11:30AM EST, 5:30PM CETThe development of new medicines for Diabetes Type 2 complications has proven to be challenging due to the use of cell...
Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metab...
Soiled-bedding sentinels are not always efficient in detecting pathogens in rodent colonies. In this context, PCR-based testing can be more sensitive and is being advocated as adjunct to trad...
Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
The eukaryotic translation initiation factor eIF4E is an oncogene elevated in an estimated 30% of cancers. The traditional view is that eIF4E drives proliferation and survival by increasing t...
Bone turnover markers (BTM) are biological markers of bone remodeling (turnover). The entire skeleton is replaced every 10 years by remodeling, a process constantly going on at different phas...
Pharmcogenomics (PGx) is the 2nd potential clinical application of genomic medicine, preceded by genomic application for cancer. In the recently published, 2012 Institute of Medicine report o...
Obesity is a disease. It was once not considered to be a disease and to be a matter of will power and gluttony. It was also the case that we once thought that fat tissue had no metabolic func...
Variability of vitamin D results remains a hot topic today as more options are available to laboratories. This webinar examines how clinical and analytical factors such as vitamin D binding...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
The zebrafish, Danio rerio, is an ideal model organism to address a broad array of biomedical questions, and is now widely employed to answer questions about aging, behavior, cancer, growth,...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
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